ES2132096T3 - Pseudopeptidos y peptidos caracterizados por una parte metilo cetona sustituida en la terminacion c como inhibidores de tiol proteasa. - Google Patents

Pseudopeptidos y peptidos caracterizados por una parte metilo cetona sustituida en la terminacion c como inhibidores de tiol proteasa.

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Publication number
ES2132096T3
ES2132096T3 ES92111129T ES92111129T ES2132096T3 ES 2132096 T3 ES2132096 T3 ES 2132096T3 ES 92111129 T ES92111129 T ES 92111129T ES 92111129 T ES92111129 T ES 92111129T ES 2132096 T3 ES2132096 T3 ES 2132096T3
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Prior art keywords
protease
tiol
pseudopeptides
inhibitors
termination
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ES92111129T
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English (en)
Spanish (es)
Inventor
Ryoichi Ando
Naoko Ando
Hirokazu Masuda
Yasuhiro Morinaka
Chizuko Takahashi
Yoshikuni Tamao
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Mitsubishi Chemical Corp
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Mitsubishi Chemical Corp
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Life Sciences & Earth Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
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  • Peptides Or Proteins (AREA)
ES92111129T 1991-07-01 1992-07-01 Pseudopeptidos y peptidos caracterizados por una parte metilo cetona sustituida en la terminacion c como inhibidores de tiol proteasa. Expired - Lifetime ES2132096T3 (es)

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JP16067491 1991-07-01
JP27790591 1991-10-24
JP34366891 1991-12-25

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ES2132096T3 true ES2132096T3 (es) 1999-08-16

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US (2) US5639783A (fr)
EP (1) EP0525420B1 (fr)
JP (1) JP3190431B2 (fr)
KR (1) KR100228505B1 (fr)
AT (1) ATE179974T1 (fr)
CA (1) CA2072834A1 (fr)
DE (1) DE69229151T2 (fr)
DK (1) DK0525420T3 (fr)
ES (1) ES2132096T3 (fr)
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TR201807316T4 (tr) 2012-10-12 2018-06-21 Bristol Myers Squibb Co Bir faktör XIa inhibitörünün kristalli formları.
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EP3160513B1 (fr) 2014-06-30 2020-02-12 Glykos Finland Oy Dérivé de saccharide d'une charge utile toxique et conjugués d'anticorps de celui-ci
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GR3030837T3 (en) 1999-11-30
DE69229151D1 (de) 1999-06-17
JP3190431B2 (ja) 2001-07-23
KR930002335A (ko) 1993-02-23
US5639783A (en) 1997-06-17
DK0525420T3 (da) 1999-11-01
ATE179974T1 (de) 1999-05-15
US5834508A (en) 1998-11-10
TW239144B (fr) 1995-01-21
EP0525420A1 (fr) 1993-02-03
CA2072834A1 (fr) 1993-01-02
DE69229151T2 (de) 1999-11-25
KR100228505B1 (ko) 1999-11-01
JPH05246968A (ja) 1993-09-24
EP0525420B1 (fr) 1999-05-12

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