ES2133142T3 - Compuestos de n-arilheteroarilalquil-imidazol-2-ona para el tratamiento de trastornos circulatorios. - Google Patents
Compuestos de n-arilheteroarilalquil-imidazol-2-ona para el tratamiento de trastornos circulatorios.Info
- Publication number
- ES2133142T3 ES2133142T3 ES92911354T ES92911354T ES2133142T3 ES 2133142 T3 ES2133142 T3 ES 2133142T3 ES 92911354 T ES92911354 T ES 92911354T ES 92911354 T ES92911354 T ES 92911354T ES 2133142 T3 ES2133142 T3 ES 2133142T3
- Authority
- ES
- Spain
- Prior art keywords
- butyl
- phenethyl
- chem
- compounds
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 4-methylbutyl Chemical group 0.000 abstract 9
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001145 hydrido group Chemical group *[H] 0.000 abstract 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 125000006176 2-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 229940123413 Angiotensin II antagonist Drugs 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- WZELXJBMMZFDDU-UHFFFAOYSA-N Imidazol-2-one Chemical class O=C1N=CC=N1 WZELXJBMMZFDDU-UHFFFAOYSA-N 0.000 abstract 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004212 difluorophenyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- UFUASNAHBMBJIX-UHFFFAOYSA-N propan-1-one Chemical group CC[C]=O UFUASNAHBMBJIX-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Transceivers (AREA)
- Mobile Radio Communication Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE DESCRIBEN COMPUESTOS DEL TIPO N-ARILHETEROARILALQUILO IMIDAZOL2-UNO Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES CIRCULATORIAS COMO HIPERTENSION Y FALLOS CONGESTIVOS DEL CORAZON. LOS COMPUESTOS DE PARTICULAR INTERES SON ANTAGONISTAS II ANGIOTENSINA DE FORMULA (I) EN DONDE A ESTA SELECCIONADA DE (A), (B), (C), (D), (E) Y (F), EN DONDE M ES 1; R1 ESTA SELECCIONADO DE METILO, ETILO, N-PROPILO, ISOPROPILO, N-BUTILO, SEC-BUTILO, ISOBUTILO, TERT-BUTILO, 4METILBUTILO, 2-ETILBUTILO, N-PENTILO, NEOPENTILO, FENILO, METILFENILO, DIFLUOROFENILO, BENZILO, FENETILO, CICLOHEXILO, CICLOHEXILMETILO, CICLOHEXILMETILO, CICLOHEXANOIL, 1-OXOCICLOHEXILETILO, BENZOILO, 1-OXO-2 OPROPILO, 1OXOBUTILO, 1-OXOPENTILO Y 2-HIDROXIBUTILO; DONDE R0 ES HIDRIDO; DONDE R2 ESTA SELECCIONADO DE METILO, ETILO, N-PRPILO, ISOPROPILO, NBUTILO, SECBUTILO, ISOBUTILO, TRET-BUTILO, N-PENTILO, ISOPENTILO, NEOPENTILO, FENILO, BENZILO, FENETILO, CICLOHEXILO, CICLOHEXILMETILO, PROPILTIO, BUTILTIO, Y HIDROXIALQUILO; DONDE CADA R3,R4,R&,R8,R9, R10 Y R11 SON HIDRIDO Y R5 DEBE SELECCIONARSE DE COOH, SH, PO3H2, SO3H, CONHNH2, CONHNHSO2CF3, OH, (G), (H) E (I) DONDE CADA R42 Y R43 SON INDEPENDIENTEMENTE SELECCIONADOS DE CLORO, CIANO, NITRO, TRIFLUOROMETILO, METOXICARBONILO, TRIFLUORO METILSULFONILO,; O UN TAUTOMERO O SAL DEL MISMO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/681,011 US5164403A (en) | 1991-04-05 | 1991-04-05 | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2133142T3 true ES2133142T3 (es) | 1999-09-01 |
Family
ID=24733424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92911354T Expired - Lifetime ES2133142T3 (es) | 1991-04-05 | 1992-04-01 | Compuestos de n-arilheteroarilalquil-imidazol-2-ona para el tratamiento de trastornos circulatorios. |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US5164403A (es) |
| EP (2) | EP0579766B1 (es) |
| AT (1) | ATE180779T1 (es) |
| AU (1) | AU1927892A (es) |
| CA (1) | CA2104794A1 (es) |
| DE (1) | DE69229341T2 (es) |
| DK (1) | DK0579766T3 (es) |
| ES (1) | ES2133142T3 (es) |
| GR (1) | GR3030892T3 (es) |
| IE (2) | IE921079A1 (es) |
| WO (1) | WO1992017469A2 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861420A (en) * | 1991-04-05 | 1999-01-19 | G. D. Searle & Co. | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders |
| US5164403A (en) * | 1991-04-05 | 1992-11-17 | G. D. Searle & Co. | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders |
| DK0643704T3 (da) * | 1991-11-18 | 2004-01-19 | Merck & Co Inc | Tetrazolylphenylboronsyremellemprodukter til syntese af All-receptor antagonister |
| GB9218449D0 (en) | 1992-08-29 | 1992-10-14 | Boots Co Plc | Therapeutic agents |
| JPH08502285A (ja) * | 1992-10-13 | 1996-03-12 | ジー．ディー．サール アンド カンパニー | 循環系障害処置用ｎ−アリールヘテロアリールアルキル１−シクロアルキル−イミダゾール−２−オン化合物 |
| CA2143193A1 (en) * | 1992-10-13 | 1994-04-28 | David B. Reitz | N-arylheteroarylalkyl 1-phenyl-imidazol-2-one compounds for treatment of circulatory disorders |
| EP0690854B1 (en) * | 1993-03-24 | 2000-07-12 | G.D. Searle & Co. | 1-phenyl-imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders |
| DE4316077A1 (de) * | 1993-05-13 | 1994-11-17 | Bayer Ag | Substituierte Mono- und Bihydridylmethylpyridone |
| DE4320432A1 (de) * | 1993-06-21 | 1994-12-22 | Bayer Ag | Substituierte Mono- und Bipyridylmethylderivate |
| US5780492A (en) * | 1996-04-03 | 1998-07-14 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU6013998A (en) * | 1996-12-30 | 1998-07-31 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5939439A (en) * | 1996-12-30 | 1999-08-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6093737A (en) * | 1996-12-30 | 2000-07-25 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6127390A (en) * | 1997-10-02 | 2000-10-03 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| US7091232B2 (en) * | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7323485B2 (en) * | 2002-05-21 | 2008-01-29 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7358269B2 (en) | 2002-05-21 | 2008-04-15 | Allergan, Inc. | 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one |
| WO2004065383A2 (en) | 2003-01-16 | 2004-08-05 | Teva Pharmaceutical Industries Ltd. | Novel synthesis of irbesartan |
| WO2008127349A2 (en) * | 2006-08-15 | 2008-10-23 | Novartis Ag | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level |
| RU2439062C2 (ru) | 2006-10-19 | 2012-01-10 | Ф.Хоффманн-Ля Рош Аг | Производные имидазолона и имидазолидинона как 11в-hsd1 ингибиторы при диабете |
| US7803940B2 (en) | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
| MX2009013293A (es) | 2007-06-04 | 2010-02-15 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| EA201592263A1 (ru) | 2013-06-05 | 2016-05-31 | Синерджи Фармасьютикалз, Инк. | Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE621842A (es) * | 1962-08-27 | |||
| IT1052119B (it) * | 1972-10-16 | 1981-06-20 | Sigma Tau Ind Farmaceuti | Derivati del triazolinone e procedimento per la loro preparazione |
| CA1122222A (en) * | 1978-06-15 | 1982-04-20 | Frederick Cassidy | Novel 1,2,4-triazolidine-3,5-dione derivatives |
| DD160447A1 (de) * | 1981-03-26 | 1983-08-03 | Johannes Dost | Herbizide mittel, die 1,2,4-triazolinone-(5) enthalten |
| IL69407A (en) * | 1982-08-23 | 1987-10-20 | Warner Lambert Co | 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them |
| US4600430A (en) * | 1985-02-22 | 1986-07-15 | Eli Lilly And Company | Pyridinylimidazolidinone compounds |
| US4816463A (en) * | 1986-04-01 | 1989-03-28 | Warner-Lambert Company | Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity |
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| US5028610A (en) * | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
| US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
| GB8911854D0 (en) * | 1989-05-23 | 1989-07-12 | Ici Plc | Heterocyclic compounds |
| IE64514B1 (en) * | 1989-05-23 | 1995-08-09 | Zeneca Ltd | Azaindenes |
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| US5218677A (en) * | 1989-05-30 | 1993-06-08 | International Business Machines Corporation | Computer system high speed link method and means |
| US5164407A (en) * | 1989-07-03 | 1992-11-17 | Merck & Co., Inc. | Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists |
| EP0409332A3 (en) * | 1989-07-19 | 1991-08-07 | Merck & Co. Inc. | Substituted triazoles as angiotensin ii antagonists |
| DE69024556T2 (de) * | 1989-07-28 | 1996-10-17 | Merck & Co Inc | Substituierte Triazolinone, Triazolinthione und Triazolinimine als Angiotensin II-Antagonisten |
| DE69013607T2 (de) * | 1989-08-02 | 1995-03-02 | Takeda Chemical Industries Ltd | Pyrazol-Derivate, Verfahren zu deren Herstellung und Anwendung. |
| EP0531382A1 (en) * | 1990-05-25 | 1993-03-17 | G.D. Searle & Co. | N-substituted-1,2,4-triazolone compounds for treatment of cardiovascular disorders |
| IL99372A0 (en) * | 1990-09-10 | 1992-08-18 | Ciba Geigy Ag | Azacyclic compounds |
| GB9019839D0 (en) * | 1990-09-11 | 1990-10-24 | Smith Kline French Lab | Compounds |
| US5087634A (en) * | 1990-10-31 | 1992-02-11 | G. D. Searle & Co. | N-substituted imidazol-2-one compounds for treatment of circulatory disorders |
| US5164403A (en) * | 1991-04-05 | 1992-11-17 | G. D. Searle & Co. | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders |
-
1991
- 1991-04-05 US US07/681,011 patent/US5164403A/en not_active Expired - Lifetime
-
1992
- 1992-04-01 EP EP92911354A patent/EP0579766B1/en not_active Expired - Lifetime
- 1992-04-01 AT AT92911354T patent/ATE180779T1/de not_active IP Right Cessation
- 1992-04-01 DE DE69229341T patent/DE69229341T2/de not_active Expired - Fee Related
- 1992-04-01 WO PCT/US1992/002439 patent/WO1992017469A2/en not_active Ceased
- 1992-04-01 US US08/107,742 patent/US5441970A/en not_active Expired - Lifetime
- 1992-04-01 CA CA002104794A patent/CA2104794A1/en not_active Abandoned
- 1992-04-01 AU AU19278/92A patent/AU1927892A/en not_active Abandoned
- 1992-04-01 DK DK92911354T patent/DK0579766T3/da active
- 1992-04-01 ES ES92911354T patent/ES2133142T3/es not_active Expired - Lifetime
- 1992-04-03 IE IE107992A patent/IE921079A1/en unknown
- 1992-04-06 IE IE109592A patent/IE921095A1/en unknown
- 1992-04-06 EP EP92106050A patent/EP0508393B1/en not_active Expired - Lifetime
- 1992-10-13 US US07/960,603 patent/US5451592A/en not_active Expired - Lifetime
-
1993
- 1993-07-01 US US08/086,959 patent/US5643906A/en not_active Expired - Fee Related
-
1999
- 1999-07-30 GR GR990401973T patent/GR3030892T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0579766B1 (en) | 1999-06-02 |
| US5164403A (en) | 1992-11-17 |
| DE69229341T2 (de) | 1999-10-14 |
| US5643906A (en) | 1997-07-01 |
| DK0579766T3 (da) | 1999-06-23 |
| IE921095A1 (en) | 1992-10-07 |
| GR3030892T3 (en) | 1999-11-30 |
| IE921079A1 (en) | 1992-10-07 |
| US5451592A (en) | 1995-09-19 |
| WO1992017469A3 (en) | 1992-11-12 |
| CA2104794A1 (en) | 1992-10-06 |
| EP0508393B1 (en) | 1999-06-02 |
| ATE180779T1 (de) | 1999-06-15 |
| US5441970A (en) | 1995-08-15 |
| DE69229341D1 (de) | 1999-07-08 |
| WO1992017469A2 (en) | 1992-10-15 |
| EP0579766A1 (en) | 1994-01-26 |
| EP0508393A1 (en) | 1992-10-14 |
| AU1927892A (en) | 1992-11-02 |
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