ES2133152T3 - Composicion de tiotepa liofilizada estable. - Google Patents

Composicion de tiotepa liofilizada estable.

Info

Publication number
ES2133152T3
ES2133152T3 ES94117666T ES94117666T ES2133152T3 ES 2133152 T3 ES2133152 T3 ES 2133152T3 ES 94117666 T ES94117666 T ES 94117666T ES 94117666 T ES94117666 T ES 94117666T ES 2133152 T3 ES2133152 T3 ES 2133152T3
Authority
ES
Spain
Prior art keywords
composition
tiotepa
stable lyophilized
agent
stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94117666T
Other languages
English (en)
Inventor
Mannching S Ku
Jorge Velez
Joe Hoffman
Lourdes Zamora
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2133152T3 publication Critical patent/ES2133152T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UNA COMPOSICION LIOFILIZADA ESTABLE DEL TIOTEPA DE AGENTE DE ALQUILACION ANTITUMORAL Y UN METODO PARA PREPARAR TAL COMPOSICION POR COLIOFILIZACION DEL INGREDIENTE ACTIVO CON UN AGENTE DE ALCALIZACION FARMACEUTICAMENTE ACEPTABLE.
ES94117666T 1993-11-09 1994-11-09 Composicion de tiotepa liofilizada estable. Expired - Lifetime ES2133152T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15050193A 1993-11-09 1993-11-09

Publications (1)

Publication Number Publication Date
ES2133152T3 true ES2133152T3 (es) 1999-09-01

Family

ID=22534834

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94117666T Expired - Lifetime ES2133152T3 (es) 1993-11-09 1994-11-09 Composicion de tiotepa liofilizada estable.

Country Status (28)

Country Link
US (1) US5561121A (es)
EP (1) EP0656211B1 (es)
JP (1) JP3726255B2 (es)
KR (1) KR100348382B1 (es)
CN (1) CN1111130A (es)
AR (1) AR023045A2 (es)
AT (1) ATE180670T1 (es)
AU (1) AU690143B2 (es)
CA (1) CA2135265A1 (es)
CZ (1) CZ287052B6 (es)
DE (1) DE69418832T2 (es)
DK (1) DK0656211T3 (es)
ES (1) ES2133152T3 (es)
FI (1) FI116036B (es)
GR (1) GR3031122T3 (es)
HU (1) HU218216B (es)
IL (1) IL111534A (es)
NO (1) NO305274B1 (es)
NZ (1) NZ264861A (es)
PE (1) PE22995A1 (es)
PH (1) PH31219A (es)
PL (1) PL176984B1 (es)
RU (1) RU2134112C1 (es)
SG (1) SG63584A1 (es)
SI (1) SI0656211T1 (es)
SK (1) SK280840B6 (es)
TW (1) TW344662B (es)
ZA (1) ZA948833B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9726343D0 (en) * 1997-12-13 1998-02-11 Auffret Anthony The use of excipients to accelerate freeze-drying
EP1399131A2 (en) * 2001-06-08 2004-03-24 Powderject Vaccines, Inc. Spray freeze-dried compositions
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
WO2010036702A1 (en) 2008-09-25 2010-04-01 Cephalon, Inc. Liquid formulations of bendamustine
UA109109C2 (uk) 2009-01-15 2015-07-27 Сефалон, Інк. Кристалічна форма вільної основи бендамустину (варіанти) та фармацевтична композиція для лікування раку (варіанти)
CA2850513A1 (en) * 2011-09-29 2013-04-04 Janssen Pharmaceutica Nv Process for the preparation of sulfamide derivatives
CN104349417B (zh) * 2013-08-07 2017-11-21 中国科学院声学研究所 基于短生命周期的区域性水下通信网的组网方法
WO2018227112A1 (en) 2017-06-09 2018-12-13 The Trustees Of Columbia University In The City Of New York Short tat oligomers for drug delivery
CN109956972A (zh) * 2017-12-22 2019-07-02 四川科瑞德凯华制药有限公司 塞替派晶型i及其制备方法和用途
CN110917146A (zh) * 2019-12-03 2020-03-27 黑龙江福和制药集团股份有限公司 一种塞替派粉针及其制备方法
CN115919784A (zh) * 2022-12-23 2023-04-07 四川汇宇制药股份有限公司 一种注射用塞替派的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2670347A (en) * 1952-01-08 1954-02-23 American Cyanamid Co Thiophosphoric acid derivatives and method of preparing the same
GB845823A (en) * 1957-09-19 1960-08-24 Sumitomo Chemical Co Stabilised compositions comprising therapeutic imine derivatives and the preparation thereof
DE1951822C3 (de) * 1969-10-14 1980-12-11 Kowa Co., Ltd., Nagoya, Aichi (Japan) Pharmazeutisches Präparat zur Krebsbehandlung
DE2925009A1 (de) * 1979-06-21 1981-01-08 Basf Ag Zubereitung fuer substanzen, verfahren zu deren herstellung und deren verwendung
WO1984001506A1 (en) * 1982-10-13 1984-04-26 Univ Birmingham Pharmaceutical preparations for use in antitumour therapy
DE3484584D1 (de) * 1983-10-14 1991-06-20 Sumitomo Pharma Injektionen mit verzoegerter abgabe.
CH676508A5 (es) * 1986-10-13 1991-01-31 Anawa Lab Ag
US4918199A (en) * 1988-01-21 1990-04-17 American Cyanamid Company Process for producing thiotepa
US5122367A (en) * 1989-03-31 1992-06-16 Massachusetts Institute Of Technology Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone
EP0419890A3 (en) * 1989-09-29 1991-05-29 American Cyanamid Company Stable pharmaceutical formulations for antineoplastic compounds having more than one ethyleneimine group, and method

Also Published As

Publication number Publication date
NO305274B1 (no) 1999-05-03
ATE180670T1 (de) 1999-06-15
NO944256L (no) 1995-05-10
AR023045A2 (es) 2002-09-04
AU7768994A (en) 1995-05-18
RU94040150A (ru) 1996-09-20
AU690143B2 (en) 1998-04-23
SI0656211T1 (en) 1999-08-31
PE22995A1 (es) 1995-09-08
US5561121A (en) 1996-10-01
ZA948833B (en) 1995-07-14
FI116036B (fi) 2005-09-15
IL111534A0 (en) 1995-01-24
HUT70762A (en) 1995-10-30
SK280840B6 (sk) 2000-08-14
FI945252L (fi) 1995-05-10
CZ287052B6 (en) 2000-08-16
SK135294A3 (en) 1996-01-10
PH31219A (en) 1998-05-05
DE69418832T2 (de) 1999-09-23
DE69418832D1 (de) 1999-07-08
GR3031122T3 (en) 1999-12-31
NO944256D0 (no) 1994-11-08
CZ271894A3 (en) 1995-07-12
CA2135265A1 (en) 1995-05-10
RU2134112C1 (ru) 1999-08-10
TW344662B (en) 1998-11-11
FI945252A0 (fi) 1994-11-08
KR100348382B1 (ko) 2002-11-23
HU218216B (hu) 2000-06-28
DK0656211T3 (da) 1999-11-15
HU9403210D0 (en) 1995-01-30
CN1111130A (zh) 1995-11-08
SG63584A1 (en) 1999-03-30
PL305752A1 (en) 1995-05-15
EP0656211B1 (en) 1999-06-02
EP0656211A1 (en) 1995-06-07
IL111534A (en) 1999-06-20
PL176984B1 (pl) 1999-08-31
JPH07196517A (ja) 1995-08-01
JP3726255B2 (ja) 2005-12-14
NZ264861A (en) 1995-10-26
HK1011283A1 (en) 1999-07-09

Similar Documents

Publication Publication Date Title
CA2111002A1 (en) Non-Chlorofluorocarbon Aerosol Formulations
MX9304975A (es) Una composicion en polvo para inhalacion y procedimiento para preparar la misma.
MY129356A (en) Electrospun pharmaceutical compositions
ES2156839T1 (es) Medicamento que contiene alginato e implante para tratar la fibrosis.
AR013117A1 (es) Una composicion farmaceutica solida en forma de comprimido que comprende un derivado de benzofurano con actividad antiarritmica adaptada para administracion oral
ES2096103T3 (es) Preparacion de comprimidos de resistencia incrementada.
EP1736147A3 (en) Non-chlorofluorocarbon aerosol formulations
CA2004598A1 (en) Medicinal aerosol formulations
ES2117015T3 (es) Composiciones que contienen sumatriptan.
DK0703786T3 (da) Anvendelse af nona- og dekapeptider til fremstilling af et lægemiddel til behandling af AIDS
AU2553992A (en) Bone-growth-stimulating composition
SG77626A1 (en) Compositions and methods for topical administration of pharmaceutically active agents
ES2159591T3 (es) Composicion de liberacion controlada.
WO1995017156A3 (en) Ethanol substitutes
PT918507E (pt) Formulacoes em aerossol
DE69033970D1 (de) Huperzin a analoge verbindungen
AR019699A1 (es) Composicion farmaceutica para el tratamiento de disfuncion de la evacuacion y uso de la misma para la preparacion de un agente terapeutico
AR023045A2 (es) Composicion de tiotepa secada por congelacion para administracion parenteral
AU8332791A (en) Oral pharmaceutical compositions containing melatonin
ES2120962T3 (es) Composicion antivirica.
MX9306296A (es) Composiciones anestesicas y su uso.
IL105475A (en) PHARMACEUTICAL COMPOSITIONS CONTAINING 1a, 24(R) - DIHYDROXY-22(E)-DEHYDRO- VITAMIN D3 FOR TREATING OSTEOPOROSIS
BR9508021A (pt) Composição farmacêutica para o tratamento de distúrbios esquizofrênicos, uso de um agente imunossupressor, e, processo de tratamento de um paciente esquizofrênico
TW366284B (en) Pharmaceutical antitussive composition of delta-receptor antagonist
ES2181915T3 (es) Ctla-8 en combinacionpn con g-csf y il-6, y uso de ctla-8 para tratar infecciones.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 656211

Country of ref document: ES