ES2133163T3 - Esteres (o tioesteres) del acido n-acilsulfamico y esteres (o tioesteres) del acido n-sulfonilcarbamico como agentes hipercolesterolemicos. - Google Patents

Esteres (o tioesteres) del acido n-acilsulfamico y esteres (o tioesteres) del acido n-sulfonilcarbamico como agentes hipercolesterolemicos.

Info

Publication number
ES2133163T3
ES2133163T3 ES94916734T ES94916734T ES2133163T3 ES 2133163 T3 ES2133163 T3 ES 2133163T3 ES 94916734 T ES94916734 T ES 94916734T ES 94916734 T ES94916734 T ES 94916734T ES 2133163 T3 ES2133163 T3 ES 2133163T3
Authority
ES
Spain
Prior art keywords
thioesters
esters
acid
hypercolesterolemic
acilsulfamic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94916734T
Other languages
English (en)
Inventor
Helen Tsenwhei Lee
Joseph Armand Picard
Drago Robert Sliskovic
Wendell Wierenga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/223,932 external-priority patent/US5491172A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2133163T3 publication Critical patent/ES2133163T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS UTILES PARA LA REGULACION DEL COLESTEROL DE FORMULA (I) Y METODOS PARA LA UTILIZACION DE LOS MISMOS Y COMPOSICIONES FARMACEUTICAS A PARTIR DE ELLOS. EN LA FORMULA (I) X E Y SON OXIGENO, AZUFRE, O (CR''R''''){SUB,N} EN DONDE {SUB,N} ES DE 1 A 4; R ES HIDROGENO, ALQUILO, O BENCILO; R{SUB,1} Y R{SUB,2} ES FENILO, FENILO SUSTITUIDO, NAFTILO, NAFTILO SUSTITUIDO, UN GRUPO ARALQUILO, UNA CADENA DE ALQUILO, ADAMANTILO, O UN GRUPO CICLOALQUILO.
ES94916734T 1993-05-14 1994-05-11 Esteres (o tioesteres) del acido n-acilsulfamico y esteres (o tioesteres) del acido n-sulfonilcarbamico como agentes hipercolesterolemicos. Expired - Lifetime ES2133163T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6251593A 1993-05-14 1993-05-14
US08/223,932 US5491172A (en) 1993-05-14 1994-04-13 N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents

Publications (1)

Publication Number Publication Date
ES2133163T3 true ES2133163T3 (es) 1999-09-01

Family

ID=26742358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94916734T Expired - Lifetime ES2133163T3 (es) 1993-05-14 1994-05-11 Esteres (o tioesteres) del acido n-acilsulfamico y esteres (o tioesteres) del acido n-sulfonilcarbamico como agentes hipercolesterolemicos.

Country Status (21)

Country Link
US (1) US5633287A (es)
EP (1) EP0698010B1 (es)
JP (1) JP3704149B2 (es)
AT (1) ATE178891T1 (es)
AU (1) AU681152B2 (es)
CA (1) CA2158268C (es)
CZ (1) CZ290683B6 (es)
DE (1) DE69417885T2 (es)
DK (1) DK0698010T3 (es)
ES (1) ES2133163T3 (es)
FI (1) FI955438A7 (es)
GR (1) GR3030356T3 (es)
HU (1) HU223044B1 (es)
IL (1) IL109431A (es)
NO (1) NO305861B1 (es)
NZ (1) NZ266689A (es)
PH (1) PH30943A (es)
RU (1) RU2137756C1 (es)
SG (1) SG47056A1 (es)
SK (1) SK282790B6 (es)
WO (1) WO1994026702A1 (es)

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Also Published As

Publication number Publication date
EP0698010B1 (en) 1999-04-14
AU681152B2 (en) 1997-08-21
PH30943A (en) 1997-12-23
FI955438L (fi) 1995-11-10
NO305861B1 (no) 1999-08-09
AU6831194A (en) 1994-12-12
NO954564L (no) 1996-01-11
DE69417885T2 (de) 1999-09-30
GR3030356T3 (en) 1999-09-30
EP0698010A1 (en) 1996-02-28
US5633287A (en) 1997-05-27
FI955438A0 (fi) 1995-11-10
CZ296695A3 (en) 1996-09-11
NO954564D0 (no) 1995-11-13
SK282790B6 (sk) 2002-12-03
JPH08510256A (ja) 1996-10-29
HU223044B1 (hu) 2004-03-01
IL109431A (en) 2001-01-11
HUT72653A (en) 1996-05-28
WO1994026702A1 (en) 1994-11-24
SK139695A3 (en) 1996-11-06
CA2158268C (en) 2006-11-07
JP3704149B2 (ja) 2005-10-05
HU9502811D0 (en) 1995-11-28
CZ290683B6 (cs) 2002-09-11
NZ266689A (en) 1997-11-24
DE69417885D1 (de) 1999-05-20
FI955438A7 (fi) 1995-11-10
ATE178891T1 (de) 1999-04-15
IL109431A0 (en) 1994-07-31
CA2158268A1 (en) 1994-11-24
RU2137756C1 (ru) 1999-09-20
DK0698010T3 (da) 1999-10-25
SG47056A1 (en) 1998-03-20

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