ES2133529T3 - Procedimiento para tipificar aislamientos de hcv. - Google Patents

Procedimiento para tipificar aislamientos de hcv.

Info

Publication number
ES2133529T3
ES2133529T3 ES94901891T ES94901891T ES2133529T3 ES 2133529 T3 ES2133529 T3 ES 2133529T3 ES 94901891 T ES94901891 T ES 94901891T ES 94901891 T ES94901891 T ES 94901891T ES 2133529 T3 ES2133529 T3 ES 2133529T3
Authority
ES
Spain
Prior art keywords
hcv
nucleotide
isolated
test
insulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94901891T
Other languages
English (en)
Inventor
Geert Maertens
Lieven Stuyver
Rudi Rossau
Heuverswyn Hugo Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujirebio Europe NV SA
Original Assignee
Innogenetics NV SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26132445&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2133529(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Innogenetics NV SA filed Critical Innogenetics NV SA
Application granted granted Critical
Publication of ES2133529T3 publication Critical patent/ES2133529T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Treatment Of Water By Oxidation Or Reduction (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA TIPIFICAR GENES DE CUALQUIER AISLADO DE HCV PRESENTE EN UNA MUESTRA BIOLOGICA, PREVIAMENTE IDENTIFICADA POR SER POSITIVA HCV, Y PARA CLASIFICAR DICHO AISLADO SEGUN EL PORCENTAJE DE HOMOLOGIA CON OTROS AISLADOS HCV QUE CONSTAN DE LOS PASOS DE: ENTRANDO EN CONTACTO DICHA MUESTRA EN LA QUE LOS RIBONUCLEOTIDOS O DESOXIRIBONUCLEOTIDOS SE HAN HECHO ACCESIBLES, SI SE NECESITA, BAJO DESNATURIZACION ADECUADA, CON AL MENOS UNA PRUEBA DE UNOS 10 A UNOS 40 NUCLEOTIDOS, TENIENDO DICHA PRUEBA TENDENCIA A HIBRIZARSE A UNA REGION EN EL DOMINIO QUE SE EXTIENDE DESDE UN NUCLEOTIDO EN LA POSICION -291 A UN NUCLEOTIDO EN LA POSICION -66 DE LA REGION 5'' NO TRADUCIDA DE UNO DE LOS AISLADOS DE HCV REPRESENTADOS POR SUS SECUENCIAS DE CDNA, CON DICHA NUMERACION DE LA POSICION COMENZANDO CON EL PRIMER CODON DE ATG DEL MARCO DE LECTURA ABIERTO CODIFICANDO LA POLIPROTEINA, O DICHA PRUEBA QUE ES COMPLEMENTARIA A LAS PRUEBAS ARRIBA DEFINIDAS; DETECTANDO LOS COMPLEJOS LA POSIBILIDAD FORMADA ENTRE DICHA PRUEBA Y LA SECUENCIA DE NUCLEOTIDO DEL AISLADO HCV PARA SER IDENTIFICADO.
ES94901891T 1992-11-27 1993-11-26 Procedimiento para tipificar aislamientos de hcv. Expired - Lifetime ES2133529T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92403222 1992-11-27
EP93402129 1993-08-31

Publications (1)

Publication Number Publication Date
ES2133529T3 true ES2133529T3 (es) 1999-09-16

Family

ID=26132445

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94901891T Expired - Lifetime ES2133529T3 (es) 1992-11-27 1993-11-26 Procedimiento para tipificar aislamientos de hcv.

Country Status (13)

Country Link
US (8) US5846704A (es)
EP (3) EP0905258A3 (es)
JP (2) JP4251407B2 (es)
AT (2) ATE507312T1 (es)
AU (1) AU681612B2 (es)
CA (1) CA2128528C (es)
DE (2) DE69324678T2 (es)
DK (1) DK0637342T3 (es)
ES (1) ES2133529T3 (es)
GR (1) GR3030641T3 (es)
HK (1) HK1047961A1 (es)
SG (1) SG46456A1 (es)
WO (1) WO1994012670A2 (es)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69324678T2 (de) * 1992-11-27 1999-12-09 Naamloze Vennootschap Innogenetics S.A., Gent Verfahren zur typisierung von hcv-isolaten
US7258977B1 (en) 1992-11-27 2007-08-21 Innogenetics N.V. Process for typing of HCV isolates
CN1071977C (zh) * 1993-03-05 2001-09-26 杰姆斯达发展公司 使用压缩码作电视节目录像时间排定的装置与方法
EP0984068B1 (en) * 1993-04-27 2012-03-28 Innogenetics N.V. Sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents
US7255997B1 (en) 1993-04-27 2007-08-14 N.V. Innogenetics S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
US5830635A (en) * 1995-03-31 1998-11-03 Agnello; Vincent Method of detecting hepatitis C virus in tissues
US20020081577A1 (en) * 1995-06-06 2002-06-27 Robert L. Kilkuskie Oligonucleotides speciific for hepatitis c virus
BR9704637A (pt) * 1996-01-26 1998-06-09 Innogenetics Nv Processo para deteção de mutações induzidas por droga no gene de transcrição reversa
ZA973367B (en) 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
FR2750505B1 (fr) * 1996-06-27 1998-10-16 Appligene Oncor Procede de preparation de supports d'analyse de substances chimiques ou biologiques presentant un ensemble ordonne de zones de reaction
CA2276462C (en) 1996-12-31 2007-06-12 High Throughput Genomics, Inc. Multiplexed molecular analysis system apparatus and method
US7101672B2 (en) * 1998-05-05 2006-09-05 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
IL122299A (en) * 1997-11-25 2003-11-23 Broadcom Corp Video encoding device
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
WO1999060158A1 (en) * 1998-05-19 1999-11-25 Laboratory Of Molecular Biophotonics Solid phase for detecting nucleic acid and method for detecting nucleic acid
AR019932A1 (es) 1998-07-17 2002-03-27 United Video Properties Inc Una disposicion de guias de programacion televisiva interactivas que tiene multiples dispositivos dentro de una residencia de un grupo familiar y un método que la emplea
AR020608A1 (es) 1998-07-17 2002-05-22 United Video Properties Inc Un metodo y una disposicion para suministrar a un usuario acceso remoto a una guia de programacion interactiva por un enlace de acceso remoto
US6638714B1 (en) * 1999-02-03 2003-10-28 Ortho-Clinical Diagnostics, Inc. Oligonucleotide primers for efficient detection of hepatitis C virus (HCV) and methods of use thereof
AU2006203092B2 (en) * 1999-02-03 2009-11-12 Ortho-Clinical Diagnostics, Inc. Oligonucleotide primers for efficient detection of hepatitis C virus (HCV) and methods of use thereof
US6623919B1 (en) * 1999-02-03 2003-09-23 Ortho-Clinical Diagnostics, Inc Oligonucleotide primers for efficient multiplex detection of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) and methods of use thereof
GB0016836D0 (en) * 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (1)
US6586584B2 (en) 2001-01-29 2003-07-01 Becton, Dickinson And Company Sequences and methods for detection of Hepatitis C virus
KR100461715B1 (ko) * 2001-03-27 2004-12-17 가부시끼가이샤 도시바 질환과 관련된 핵산의 검출 방법
WO2002090572A2 (en) * 2001-05-09 2002-11-14 Third Wave Technologies, Inc. Nucleic acid detection in pooled samples
US7196183B2 (en) * 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US7877273B2 (en) * 2002-01-08 2011-01-25 Fredric David Abramson System and method for evaluating and providing nutrigenomic data, information and advice
GB0200526D0 (en) * 2002-01-11 2002-02-27 Science And Technology The Methods
FR2855832B1 (fr) 2003-06-03 2007-09-14 Biomerieux Sa Procede de diagnostic et/ou de pronostic d'un syndrome septique
FR2857375B1 (fr) 2003-07-10 2007-11-09 Biomerieux Sa Procede de detection et/ou d'identification de bacteries de genre staphylococcus
US8124747B2 (en) 2003-08-29 2012-02-28 Innogenetics HCV clade and prototype sequences thereof
EP1536024B1 (en) * 2003-08-29 2016-08-17 Fujirebio Europe N.V. New hepatitis c virus clade and phototype sequences thereof
CA2552949C (en) 2004-01-07 2012-10-02 Third Wave Technologies, Inc. Determination of hepatitis c virus genotype
US20090209432A1 (en) * 2004-04-06 2009-08-20 Flinders Technologies Pty. Ltd. Detecting targets using nucleic acids having both a variable region and a conserved region
US8806533B1 (en) 2004-10-08 2014-08-12 United Video Properties, Inc. System and method for using television information codes
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
US8927208B2 (en) 2005-03-30 2015-01-06 Labo Bio-Medical Investments B.V. Identification of beta-papillomavirus DNA by type-specific reverse hybridization
US7919242B2 (en) * 2005-06-30 2011-04-05 Roche Molecular Systems, Inc. Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
US20070207455A1 (en) * 2005-11-17 2007-09-06 Third Wave Technologies, Inc. Compositions and methods for detecting an HCV-1 subtype
WO2007087310A2 (en) * 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Nucleic acid analysis using sequence tokens
FR2906537A1 (fr) 2006-09-28 2008-04-04 Biomerieux Sa Procede de diagnostic in vitro du cancer broncho-pulmonaire par detection des transcrits majoritaires alternatifs du gene klk8 codant la kallicreine 8 et son utilisation pour le pronostic de survie
EP2527474A1 (en) 2006-10-20 2012-11-28 Innogenetics N.V. Methodology for analysis of sequence variations within the HCV NS3/4A genomic region
EP2463390A1 (en) 2006-10-20 2012-06-13 Innogenetics N.V. Methodology for analysis of sequence variations within the HCV NS5B genomic region
US8418206B2 (en) 2007-03-22 2013-04-09 United Video Properties, Inc. User defined rules for assigning destinations of content
WO2009022939A1 (en) * 2007-08-09 2009-02-19 Uchrezhdenie Rossiiskoi Akademii Nauk Institut Molekulyarnoi Biologii Im. V.A. Engelgardta Ran (Imb Ran) Method for identifying the genotype and subtype of hepatitis c virus on a biological microchip
US8601526B2 (en) 2008-06-13 2013-12-03 United Video Properties, Inc. Systems and methods for displaying media content and media guidance information
KR101755037B1 (ko) 2008-12-29 2017-07-19 주식회사 엘지화학 핵산 염색제를 이용한 실시간 중합효소 연쇄반응을 통한 ｈｃｖ 검출방법
US20100240049A1 (en) * 2009-01-16 2010-09-23 Cepheid Methods of Detecting Cervical Cancer
CN102301008B (zh) 2009-01-19 2015-05-13 生物梅里埃公司 用于确定患者发生医院内感染的易感性以及确立败血性综合征进展的预后的方法
US20100323344A1 (en) * 2009-06-18 2010-12-23 Ferguson Monique R Detection of hepatitis C virus RNA
US9204193B2 (en) 2010-05-14 2015-12-01 Rovi Guides, Inc. Systems and methods for media detection and filtering using a parental control logging application
US9422598B2 (en) 2010-06-04 2016-08-23 Biomerieux Method and kit for the prognosis of colorectal cancer
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
FR2970975B1 (fr) 2011-01-27 2016-11-04 Biomerieux Sa Procede et kit pour determiner in vitro le statut immunitaire d'un individu
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
ES2640570T3 (es) * 2012-10-18 2017-11-03 F. Hoffmann-La Roche Ag Ensayo de doble sonda para la detección de VHC
FR3000966B1 (fr) 2013-01-11 2016-10-28 Biomerieux Sa Procede pour etablir in vitro un pronostic de severite chez un patient en choc septique
CN104178562B (zh) 2013-05-21 2018-11-09 生物梅里埃股份公司 一种大肠癌预后试剂盒
WO2018075633A2 (en) * 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
EP3643792B1 (en) 2018-10-24 2021-09-15 Fujirebio Europe N.V. Detection and analysis of sequence variations in a target nucleic acid
CN117947214A (zh) * 2024-01-18 2024-04-30 圣湘生物科技股份有限公司 检测丙肝并分型的组合物、试剂盒及其用途
WO2025172242A1 (en) 2024-02-13 2025-08-21 bioMérieux Method of assessing the risk of death of a patient

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
JPH02167081A (ja) * 1988-12-21 1990-06-27 Tetsuo Nakamura 非Ａ非Ｂ型肝炎ウイルスゲノムＲＮＡ、ｃＤＮＡおよびウイルス抗原蛋白質
US5176994A (en) * 1988-12-21 1993-01-05 Immuno Japan Inc. Non-A, Non-B hepatitis virus genome RNA, cDNA and virus antigen protein
US5629158A (en) 1989-03-22 1997-05-13 Cemu Bitecknik Ab Solid phase diagnosis of medical conditions
US5043272A (en) * 1989-04-27 1991-08-27 Life Technologies, Incorporated Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers
JP2802125B2 (ja) * 1989-06-23 1998-09-24 キヤノン株式会社 核酸の検出方法
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
GB8924989D0 (en) * 1989-11-06 1989-12-28 Scotgen Ltd Method and device for the detection of antibiotic resistance
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5629153A (en) * 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
CA2044296A1 (en) * 1990-06-12 1991-12-13 Hiroaki Okamoto Oligonucleotide primers, and their application for high-fidelity detection of non-a, non-b hepatitis virus
DE69125066T2 (de) * 1990-07-11 1997-09-25 Shionogi Seiyaku K K Trading U cDNS-Sequenz und Detektion des Hepatitis C-Virus
WO1992002642A1 (en) * 1990-08-10 1992-02-20 Chiron Corporation Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus
US5620852A (en) 1990-11-14 1997-04-15 Hri Research, Inc. Nucleic acid preparation methods
EP0834575B1 (en) * 1990-12-06 2001-11-28 Affymetrix, Inc. (a Delaware Corporation) Identification of nucleic acids in samples
EP0511559A1 (en) * 1991-04-30 1992-11-04 F.Hoffmann-La Roche & Co. Aktiengesellschaft Oligonucleotide probe reagent
PL169880B1 (pl) * 1991-05-08 1996-09-30 Chiron Corp Sposób wytwarzania produktu hybrydyzacji z kwasem nukleinowym wirusa zapalenia watroby C PL PL PL
US6190864B1 (en) 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
US5428145A (en) * 1991-08-09 1995-06-27 Immuno Japan, Inc. Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems
ES2111589T3 (es) * 1991-08-27 1998-03-16 Hoffmann La Roche Metodos y reactivos para la deteccion de la hepatitis c.
EP0532258A2 (en) * 1991-09-09 1993-03-17 Immuno Japan Inc. Oligonucleotides and determination system of HCV genotypes
JPH06502770A (ja) 1991-09-12 1994-03-31 シーダーズ−サイナイ・メディカル・センター Ｃ型肝炎ウイルスｒｎａの直接検出法
US5173994A (en) * 1992-01-14 1992-12-29 The United States Of America As Represented By The Secretary Of Agriculture Fiber cleaning apparatus with air flow deflector
EP0642589A4 (en) * 1992-05-11 1997-05-21 Ribozyme Pharm Inc METHOD AND REAGENT TO INHIBIT VIRAL REPLICATION.
JPH06153961A (ja) 1992-11-27 1994-06-03 Imuno Japan:Kk Ｃ型肝炎ウイルス部分遺伝子、ならびにｃ型肝炎ウイルス遺 伝子の高感度検出法
DE69324678T2 (de) 1992-11-27 1999-12-09 Naamloze Vennootschap Innogenetics S.A., Gent Verfahren zur typisierung von hcv-isolaten
US5820852A (en) * 1996-11-26 1998-10-13 The Proctor & Gamble Company Oral compositions containing fluoride, pyrophosphate, and peroxide

Also Published As

Publication number Publication date
US6891026B2 (en) 2005-05-10
EP1197568A2 (en) 2002-04-17
US20030036053A1 (en) 2003-02-20
AU681612B2 (en) 1997-09-04
ATE507312T1 (de) 2011-05-15
EP0637342A1 (en) 1995-02-08
US5846704A (en) 1998-12-08
WO1994012670A3 (en) 1994-07-21
US6548244B2 (en) 2003-04-15
EP1197568A3 (en) 2004-04-14
CA2128528C (en) 2012-02-14
HK1047961A1 (en) 2003-03-14
ATE179459T1 (de) 1999-05-15
US7258982B2 (en) 2007-08-21
EP1197568B1 (en) 2011-04-27
US6887985B2 (en) 2005-05-03
US6495670B1 (en) 2002-12-17
WO1994012670A2 (en) 1994-06-09
JP4251407B2 (ja) 2009-04-08
EP0905258A2 (en) 1999-03-31
GR3030641T3 (en) 1999-10-29
DE69324678D1 (de) 1999-06-02
EP0637342B1 (en) 1999-04-28
US6051696A (en) 2000-04-18
US6171784B1 (en) 2001-01-09
US20020168626A1 (en) 2002-11-14
DE69334357D1 (de) 2011-06-09
SG46456A1 (en) 1998-02-20
DE69324678T2 (de) 1999-12-09
AU5628294A (en) 1994-06-22
CA2128528A1 (en) 1994-06-09
US20020106638A1 (en) 2002-08-08
US20040191768A1 (en) 2004-09-30
DK0637342T3 (da) 1999-11-01
JPH07503143A (ja) 1995-04-06
EP0905258A3 (en) 2001-01-31
JP2005040145A (ja) 2005-02-17

Similar Documents

Publication Publication Date Title
ES2133529T3 (es) Procedimiento para tipificar aislamientos de hcv.
Springer et al. Purification and structural characterisation of human HLA-linked B-cell antigens
NO944967D0 (no) Nye sekvenser av hepatitt C virus genotyper og anvendelse derav som terapeutiske og diagnostiske midler
ES2068323T3 (es) Adn-polimerasa de t7.
DE3688920D1 (de) Hybride Polypeptide und Verfahren zu deren Herstellung.
NO984229L (no) Forbindelser og fremgangsmÕter for immunoterapi og immunodiagnose av prostatakreft
ES2103741T3 (es) Reacciones de sintesis de dna (in vitro) que emplean dna polimerasa de phi 29 modificada y un fragmento de dna que codifica dicha polimerasa.
CY1105282T1 (el) Διαγνωση της κοιλιοκακης με τη χρηση ενος επιτοπιου της γλιαδινης
DK0506825T3 (da) Rekombinante ekspressionsvektorer og oprensningsfremgangsmåder til Thermus thermophilus-DNA-polymerase
ATE310819T1 (de) Säugetieren apoptosis inhibitorprotein genfamilie,primers, probes und verfahren zur nachweis
CA2192940A1 (en) Nucleotide sequences of pestivirus strains, polypeptides encoded by these sequences and use thereof for diagnosis and prevention of pestivirus infections
ES2134852T3 (es) Una linea celular tratada por ingenieria genetica para detectar el virus herpes simple infeccioso y metodo para ello.
KR890000517A (ko) 하이브리드 단백질 c 및 이의 제조방법
DE3889927D1 (de) Kennzeichnung und nachweis von mit autoimmunkrankheiten assoziierten sequenzen.
SE8802944D0 (sv) Materials for patch testing
DE3683910D1 (de) Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate.
NZ220398A (en) A reagent for rendering biological media transparent and its use for analysis of these
DE3855634D1 (de) Innerhalb des alpha-Locus gelegenes T-Zell-Rezeptor-Gen und DNA-Konstruktionen
DK0643719T3 (da) Nukleinsyresekvenser, som koder for eller er komplementære til nukleinsyresekvenser, som koder for interleukin 9-receptor
Natsuume-Sakai et al. Structural polymorphism of murine C4 and its linkage to H-2.
MX9702863A (es) Proteinas asociadas con el hipocampo, secuencias de adn que codifican para las mismas y usos de las mismas.
DE69128181D1 (de) Enzymtests
NZ233328A (en) Polypeptides produced by hepatocytes infected with p. falciparum; nucleic acid probes
Genaux The comparative amino acid composition of five hemoglobins from the genus Microtus
Corbin Evolutionary relationships in the avian genus Columba as indicated by ovalbumin tryptic peptides

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 637342

Country of ref document: ES