ES2133571T3 - Compuestos de benzazol para uso en terapia. - Google Patents

Compuestos de benzazol para uso en terapia.

Info

Publication number
ES2133571T3
ES2133571T3 ES94924946T ES94924946T ES2133571T3 ES 2133571 T3 ES2133571 T3 ES 2133571T3 ES 94924946 T ES94924946 T ES 94924946T ES 94924946 T ES94924946 T ES 94924946T ES 2133571 T3 ES2133571 T3 ES 2133571T3
Authority
ES
Spain
Prior art keywords
benzazole compounds
therapy use
breast cancer
benzothiazole
aminophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94924946T
Other languages
English (en)
Inventor
Malcolm Francis Graham Stevens
Carol Jane Mccall
Petrus Lelieveld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Campaign Technology Ltd
Original Assignee
Cancer Research Campaign Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Campaign Technology Ltd filed Critical Cancer Research Campaign Technology Ltd
Application granted granted Critical
Publication of ES2133571T3 publication Critical patent/ES2133571T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE EXPONEN COMPUESTOS DE BENZAZOL, EJEMPLIFICADOS POR 2-(4AMINOFENIL)BENZOTIAZOL Y ANALOGOS O SALES DEL MISMO, QUE EXHIBEN UNA ACTIVIDAD CITOTOXICA SELECTIVA MUY IMPORTANTE CON RESPECTO A CELULAS TUMORALES, ESPECIALMENTE CELULAS DEL CANCER DE MAMA, Y QUE PROPORCIONAN AGENTES QUIMIOTERAPEUTICOS POTENCIALMENTE UTILES PARA EL TRATAMIENTO DEL CANCER DE MAMA.
ES94924946T 1993-08-28 1994-08-30 Compuestos de benzazol para uso en terapia. Expired - Lifetime ES2133571T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939317949A GB9317949D0 (en) 1993-08-28 1993-08-28 Benzothiazole compounds

Publications (1)

Publication Number Publication Date
ES2133571T3 true ES2133571T3 (es) 1999-09-16

Family

ID=10741212

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94924946T Expired - Lifetime ES2133571T3 (es) 1993-08-28 1994-08-30 Compuestos de benzazol para uso en terapia.

Country Status (11)

Country Link
EP (1) EP0721336B1 (es)
JP (1) JPH09501944A (es)
AT (1) ATE182077T1 (es)
AU (1) AU690577B2 (es)
CA (1) CA2170508A1 (es)
DE (1) DE69419517T2 (es)
DK (1) DK0721336T3 (es)
ES (1) ES2133571T3 (es)
GB (1) GB9317949D0 (es)
GR (1) GR3031418T3 (es)
WO (1) WO1995006469A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9503946D0 (en) * 1995-02-28 1995-04-19 Cancer Res Campaign Tech Benzazole compounds
WO1997026919A2 (en) * 1996-01-24 1997-07-31 Warner-Lambert Company Method of imaging amyloid deposits
DE19620508A1 (de) * 1996-05-22 1997-11-27 Hoechst Ag Schwefelenthaltende heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung
GB9919673D0 (en) * 1999-08-20 1999-10-20 Cancer Res Campaign Tech 2-Arlybenzazole compounds
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
PT1334091E (pt) * 2000-08-24 2013-01-07 Univ Pittsburgh Derivados de tioflavina e seu uso no diagnóstico e terapia da doença de alzheimer
WO2002085903A2 (en) 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
RU2308270C1 (ru) * 2006-04-13 2007-10-20 Михаил Владимирович Кутушов Лекарственное средство
EP2170058B1 (en) * 2007-06-20 2013-07-03 Merck Sharp & Dohme Corp. Cetp inhibitors derived from benzoxazole arylamides
HUE056957T2 (hu) * 2014-08-29 2022-04-28 Chdi Foundation Inc Próbák huntingtin fehérjét megjelenítõ képalkotásra
PL3296294T3 (pl) * 2015-05-09 2020-08-24 Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd Związek do leczenia lub zapobiegania nowotworowi piersi
US11286241B2 (en) * 2018-09-07 2022-03-29 Glax Llc Compositions and methods for treating cancer
CN119185300B (zh) * 2024-05-13 2026-04-03 中国科学院化学研究所 化合物和联合药物在制备抗肿瘤药物中的应用
CN120247882B (zh) * 2025-04-01 2025-09-19 徐州市第一人民医院 一种氮杂环衍生的多芳基甲烷类抗肿瘤化合物及其合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2780628A (en) * 1955-12-07 1957-02-05 Lilly Co Eli 2-substituted aromatic thiazoles
FR1255312A (fr) * 1957-10-31 1961-03-10 Crookes Lab Ltd Dérivés des aryl-benzothiazoles et leur mode de préparation
GB1080246A (en) * 1965-07-22 1967-08-23 Twyford Lab Ltd 2-aryl-benzothiazole derivatives
GB1093355A (en) * 1965-07-29 1967-11-29 Twyford Lab Ltd 2-carbamoylphenylbenzothiazoles
JPS5721375A (en) * 1980-07-14 1982-02-04 Yamanouchi Pharmaceut Co Ltd 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation
LU85544A1 (fr) * 1984-09-19 1986-04-03 Cird Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
JPS61105975A (ja) * 1984-10-30 1986-05-24 Nec Corp 非直線補正回路
US4861897A (en) * 1987-06-22 1989-08-29 Ortho Pharmaceutical Corporation 2-Aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles
JPH01146875A (ja) * 1987-12-01 1989-06-08 Kanebo Ltd ベンゾチアゾール誘導体および該化合物を有効成分とする抗リウマチ剤
FR2684377B1 (fr) * 1991-12-02 1994-01-21 Synthelabo Derives de benzoxazole et de benzothiazole leur preparation et leur utilisation comme intermediaires de synthese.

Also Published As

Publication number Publication date
CA2170508A1 (en) 1995-03-09
DE69419517D1 (de) 1999-08-19
JPH09501944A (ja) 1997-02-25
EP0721336B1 (en) 1999-07-14
GR3031418T3 (en) 2000-01-31
WO1995006469A1 (en) 1995-03-09
EP0721336A1 (en) 1996-07-17
DK0721336T3 (da) 1999-11-29
AU7504994A (en) 1995-03-22
AU690577B2 (en) 1998-04-30
DE69419517T2 (de) 1999-10-28
ATE182077T1 (de) 1999-07-15
GB9317949D0 (en) 1993-10-13

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