ES2134376T3 - Derivados del tocoferol. - Google Patents
Derivados del tocoferol.Info
- Publication number
- ES2134376T3 ES2134376T3 ES95107593T ES95107593T ES2134376T3 ES 2134376 T3 ES2134376 T3 ES 2134376T3 ES 95107593 T ES95107593 T ES 95107593T ES 95107593 T ES95107593 T ES 95107593T ES 2134376 T3 ES2134376 T3 ES 2134376T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- compound
- thiol group
- bonding via
- tocopherol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical class OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- 150000003611 tocopherol derivatives Chemical class 0.000 abstract 2
- 108010024636 Glutathione Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
- 239000006096 absorbing agent Substances 0.000 abstract 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 230000001437 anti-cataract Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 239000008406 cosmetic ingredient Substances 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 229960003180 glutathione Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA INVENCION SUMINISTRA UN DERIVADO DEL TOCOFEROL DE LA SIGUIENTE FORMULA (I) O UNA SAL ACEPTABLE DEL MISMO; EN DONDE R{SUB, 1} Y R{SUB, 2} SON IGUALES O DIFERENTES Y CADA UNA REPRESENTA HIDROGENO O METIL; R{SUB,3} REPRESENTA UN {AL}AMINOACIDO, UN {OE}-AMINOACIDO, O UN PEPTIDO QUE SE UNE POR MEDIO DEL TERMINAL N DEL MISMO, EXCEPTO EN EL CASO DE LA CISTEINA O DE LA GLUTATIONA QUE TIENE UN GRUPO DE TIOL, QUE SE UNEN POR MEDIO DEL GRUPO DE TIOL. EL DERIVADO DEL TOCOFEROL DE ESTA INVENCION ES UN COMPUESTO QUE ES SOLUBLE EN AGUA Y PUEDE ESPERARSE QUE SEA UTIL COMO DROGA PARA LA MEJORA DE LAS FUNCIONES CEREBRALES Y COMO DROGA ANTICATARATAS. MAS AUN, ESTE COMPUESTO ES VALIOSO COMO ABSORBENTE DE UV, COMO INGREDIENTE PARA EL CUIDADO DE LA PIEL, O COMO ESTABILIZANTE PARA OTROS INGREDIENTES COSMETICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10648494 | 1994-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2134376T3 true ES2134376T3 (es) | 1999-10-01 |
Family
ID=14434754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95107593T Expired - Lifetime ES2134376T3 (es) | 1994-05-20 | 1995-05-18 | Derivados del tocoferol. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5606080A (es) |
| EP (1) | EP0683164B1 (es) |
| KR (1) | KR950032165A (es) |
| AT (1) | ATE182888T1 (es) |
| CA (1) | CA2148148A1 (es) |
| DE (1) | DE69511163T2 (es) |
| ES (1) | ES2134376T3 (es) |
| TW (1) | TW288014B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100195291B1 (ko) * | 1997-07-12 | 1999-06-15 | 서경배 | 비이온성 비타민 |
| CA2315679A1 (en) * | 1997-12-24 | 1999-07-08 | Senju Pharmaceutical Co., Ltd. | Vitamin e derivatives |
| KR20000000840A (ko) * | 1998-06-03 | 2000-01-15 | 김영대 | 신규한 폴리옥시프로필렌폴리옥시에틸렌 비타민 e 및 그의제조방법 |
| US6426362B1 (en) | 1999-10-08 | 2002-07-30 | Galileo Laboratories, Inc. | Formulations of tocopherols and methods of making and using them |
| US7034054B2 (en) * | 2000-12-15 | 2006-04-25 | Galileo Pharmaceuticals, Inc. | Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols |
| KR100453727B1 (ko) * | 2001-01-30 | 2004-10-20 | 김영대 | 신규한 폴리옥시프로필렌폴리옥시에틸렌 비타민 ｅ 및그의 제조방법 |
| KR100438402B1 (ko) * | 2001-05-30 | 2004-07-02 | 김영대 | 폴리옥시프로필렌-폴리옥시에틸렌 비타민 이를 이용한저점도 수중유형 유화 화장료 |
| AU2002352726A1 (en) | 2001-11-15 | 2003-06-10 | Galileo Laboratories, Inc. | Formulations and methods for treatment or amelioration of inflammatory conditions |
| US6858227B1 (en) | 2001-11-21 | 2005-02-22 | Sonus Pharmaceuticals, Inc. | Vitamin E conjugates |
| KR100488220B1 (ko) * | 2002-05-21 | 2005-05-06 | 김영대 | 폴리옥시프로필렌-폴리옥시에틸렌(ｐｏｐ-ｐｏｅ) 비타민ｅ를 함유한 나노에말션 화장료 조성물 및 그의 제조방법 |
| WO2005042539A1 (en) * | 2003-10-29 | 2005-05-12 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
| US20080045559A1 (en) * | 2003-10-29 | 2008-02-21 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
| US7790701B2 (en) | 2006-04-19 | 2010-09-07 | Gelest Technologies, Inc. | Silicon-based tocopherol derivatives |
| WO2011153353A1 (en) | 2010-06-02 | 2011-12-08 | The Board Of Trustees For The University Of Arkansas | Tocopherol derivatives and methods of use |
| MX379061B (es) | 2013-09-13 | 2025-03-04 | Bioventures Llc | Preparacion y uso de una composicion para la prevencion y mitigacion de los efectos de la radiacion. |
| US20160324914A1 (en) | 2015-05-05 | 2016-11-10 | Tocol Pharmaceuticals, Llc | Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH529746A (de) * | 1968-08-01 | 1972-10-31 | Spofa Vereinigte Pharma Werke | Verfahren zur Herstellung von Chromanderivaten |
| JPS57175186A (en) * | 1981-04-20 | 1982-10-28 | Fujimoto Seiyaku Kk | Novel vitamin e derivative and its preparation |
-
1995
- 1995-04-28 CA CA002148148A patent/CA2148148A1/en not_active Abandoned
- 1995-05-03 TW TW084104418A patent/TW288014B/zh active
- 1995-05-11 US US08/438,971 patent/US5606080A/en not_active Expired - Fee Related
- 1995-05-17 KR KR1019950012327A patent/KR950032165A/ko not_active Withdrawn
- 1995-05-18 ES ES95107593T patent/ES2134376T3/es not_active Expired - Lifetime
- 1995-05-18 DE DE69511163T patent/DE69511163T2/de not_active Expired - Fee Related
- 1995-05-18 EP EP95107593A patent/EP0683164B1/en not_active Expired - Lifetime
- 1995-05-18 AT AT95107593T patent/ATE182888T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0683164B1 (en) | 1999-08-04 |
| DE69511163D1 (de) | 1999-09-09 |
| KR950032165A (ko) | 1995-12-20 |
| ATE182888T1 (de) | 1999-08-15 |
| DE69511163T2 (de) | 1999-11-25 |
| TW288014B (es) | 1996-10-11 |
| EP0683164A1 (en) | 1995-11-22 |
| CA2148148A1 (en) | 1995-11-21 |
| US5606080A (en) | 1997-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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