ES2134787T3 - Derivados de poliaspartamida como agentes de adsorcion para acidos biliares, derivados de poliaspartamida cargados con acidos biliares, y procedimiento para su preparacion, asi como su utilizacion como medicamentos. - Google Patents

Derivados de poliaspartamida como agentes de adsorcion para acidos biliares, derivados de poliaspartamida cargados con acidos biliares, y procedimiento para su preparacion, asi como su utilizacion como medicamentos.

Info

Publication number
ES2134787T3
ES2134787T3 ES92121461T ES92121461T ES2134787T3 ES 2134787 T3 ES2134787 T3 ES 2134787T3 ES 92121461 T ES92121461 T ES 92121461T ES 92121461 T ES92121461 T ES 92121461T ES 2134787 T3 ES2134787 T3 ES 2134787T3
Authority
ES
Spain
Prior art keywords
acids
polyaspartamide
derivatives
medicines
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92121461T
Other languages
English (en)
Inventor
Volker Dr Krone
Axel Dr Walch
Stefan Dr Mullner
Ernold Dr Dr Granzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2134787T3 publication Critical patent/ES2134787T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/14—Polyamide-imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/36—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino acids, polyamines and polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/1092—Polysuccinimides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Detergent Compositions (AREA)

Abstract

SE DESCRIBEN DERIVADOS ALFA ARTAMIDA DE LA FORMULA GENERAL I EN DONDE RI, RII, RIII, RIV, R, S, T, U Y V TIENE EL SIGNIFICADO DADO. ABSORBEN ACIDOS BILIARES Y PUEDEN SER UTILIZADOS COMO MEDICAMENTO.
ES92121461T 1991-12-20 1992-12-17 Derivados de poliaspartamida como agentes de adsorcion para acidos biliares, derivados de poliaspartamida cargados con acidos biliares, y procedimiento para su preparacion, asi como su utilizacion como medicamentos. Expired - Lifetime ES2134787T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4142147 1991-12-20

Publications (1)

Publication Number Publication Date
ES2134787T3 true ES2134787T3 (es) 1999-10-16

Family

ID=6447596

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92121461T Expired - Lifetime ES2134787T3 (es) 1991-12-20 1992-12-17 Derivados de poliaspartamida como agentes de adsorcion para acidos biliares, derivados de poliaspartamida cargados con acidos biliares, y procedimiento para su preparacion, asi como su utilizacion como medicamentos.

Country Status (11)

Country Link
US (2) US5714138A (es)
EP (1) EP0548794B1 (es)
JP (1) JPH0665372A (es)
AT (1) ATE180968T1 (es)
CA (1) CA2085782A1 (es)
DE (1) DE59209709D1 (es)
DK (1) DK0548794T3 (es)
ES (1) ES2134787T3 (es)
FI (1) FI925734A7 (es)
GR (1) GR3030882T3 (es)
NO (1) NO302482B1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE180968T1 (de) * 1991-12-20 1999-06-15 Hoechst Ag Polyaspartamidderivate als adsorptionsmittel für gallensäuren, mit gallensäuren beladene polyaspartamidderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel
DE69413590D1 (de) * 1993-04-23 1998-11-05 Rhone Poulenc Chimie Polyanhydroasparaginsäure und seine bioabbaubaren Hydrolyseprodukte
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
JP2002533414A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するための回腸胆汁酸輸送阻害剤および胆汁酸隔離剤の組み合わせ
EP1340510A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
JP2002533410A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤およびフィブリン酸誘導体の組み合わせ
CN1342090A (zh) 1998-12-23 2002-03-27 G·D·瑟尔有限公司 适用于心血管疾病的回肠胆汁酸转运抑制剂和贝酸衍生物的组合
US6489366B1 (en) 1998-12-23 2002-12-03 G. D. Searle, Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
PL348508A1 (en) 1998-12-23 2002-05-20 Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
WO2001068637A2 (en) 2000-03-10 2001-09-20 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
WO2003014193A1 (en) * 2001-08-03 2003-02-20 The Procter & Gamble Company Polyaspartate derivatives for use in detergent compositions
MXPA04003524A (es) 2001-11-02 2004-07-23 Searle Llc Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato.
BR0306643A (pt) 2002-01-17 2004-10-19 Pharmacia Corp Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical
FR2837710B1 (fr) * 2002-03-26 2005-07-08 Innovations Pharma Ag Composition topique a base de resines echangeuses d'ions, notamment pour le traitement des erythemes
CN108264639B (zh) * 2017-12-20 2020-08-07 湖北工业大学 一种温度pH双重响应性肉桂酸-聚天冬酰胺扼合物及其水相交联方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB747901A (en) * 1953-07-01 1956-04-18 Courtaulds Ltd Improvements in and relating to the treatment of synthetic polypeptides
GB1024393A (en) * 1963-03-30 1966-03-30 Asahi Chemical Ind Process for polymerizing n-carboxy-ª‡-amino acid anhydrides
FR1603159A (es) * 1967-07-20 1971-03-22
US3846380A (en) * 1972-10-31 1974-11-05 M Teranishi Polyamino acid derivatives and compositions containing same
GB1506217A (en) * 1975-08-26 1978-04-05 Taiho Pharmaceutical Co Ltd Oral antilipemic composition
US4363797A (en) * 1977-09-14 1982-12-14 Societe Anonyme Dite: L'oreal Polyaspartic acid derivatives, their preparation and their use in cosmetic composition
FR2424293A1 (fr) * 1978-04-27 1979-11-23 Oreal Nouveau procede de preparation de l'acide polydehydroaspartique
JPS6086124A (ja) * 1983-10-17 1985-05-15 Nitto Boseki Co Ltd 規則性ポリアミノ酸樹脂の製造方法
DE3626672A1 (de) * 1986-08-07 1988-02-11 Bayer Ag Polyasparaginamidsaeure
DE3700128A1 (de) * 1987-01-03 1988-07-14 Hoechst Ag Biologisch abbaubare poly- (hydroxyalkyl)- aminodicarbonsaeure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
US5516758A (en) * 1989-03-23 1996-05-14 Berlex Laboratories, Inc. Polyamides bearing functionalized side chains useful as water soluble hypolipidemic agents
JP2909500B2 (ja) * 1989-03-23 1999-06-23 ベルレックス、ラボラトリーズ、レンコーポレイテッド 水溶性抗高脂質血症剤として有用な官能化側鎖を有するポリアミド
DE4002736A1 (de) * 1990-01-31 1991-08-01 Hoechst Ag Biologisch abbaubare polymere, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
CA2040996A1 (en) * 1990-05-02 1991-11-03 Robert L. Albright Composition and method for controlling cholesterol
US5057597A (en) * 1990-07-03 1991-10-15 Koskan Larry P Process for the manufacture of anhydro polyamino acids and polyamino acids
ATE180968T1 (de) * 1991-12-20 1999-06-15 Hoechst Ag Polyaspartamidderivate als adsorptionsmittel für gallensäuren, mit gallensäuren beladene polyaspartamidderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel

Also Published As

Publication number Publication date
EP0548794B1 (de) 1999-06-09
US5714138A (en) 1998-02-03
EP0548794A3 (en) 1994-11-23
DK0548794T3 (da) 1999-12-06
FI925734A0 (fi) 1992-12-17
NO924921L (no) 1993-06-21
EP0548794A2 (de) 1993-06-30
FI925734L (fi) 1993-06-21
NO924921D0 (no) 1992-12-18
CA2085782A1 (en) 1993-06-21
FI925734A7 (fi) 1993-06-21
GR3030882T3 (en) 1999-11-30
US6036948A (en) 2000-03-14
ATE180968T1 (de) 1999-06-15
JPH0665372A (ja) 1994-03-08
DE59209709D1 (de) 1999-07-15
NO302482B1 (no) 1998-03-09

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