ES2135390T3 - Regulacion, dependiente del ciclo de la celula, de la fosforilacion de un producto genico de retinoblastoma humano. - Google Patents

Regulacion, dependiente del ciclo de la celula, de la fosforilacion de un producto genico de retinoblastoma humano.

Info

Publication number
ES2135390T3
ES2135390T3 ES91901398T ES91901398T ES2135390T3 ES 2135390 T3 ES2135390 T3 ES 2135390T3 ES 91901398 T ES91901398 T ES 91901398T ES 91901398 T ES91901398 T ES 91901398T ES 2135390 T3 ES2135390 T3 ES 2135390T3
Authority
ES
Spain
Prior art keywords
regulation
cell cycle
phosphorilation
dependent
cell proliferation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901398T
Other languages
English (en)
Inventor
Yuen Kai Fung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Canji Inc
Original Assignee
Canji Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canji Inc filed Critical Canji Inc
Application granted granted Critical
Publication of ES2135390T3 publication Critical patent/ES2135390T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/22—Testing for sterility conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4736—Retinoblastoma protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)

Abstract

EN EL CAMPO DE LA REGULACION DE LA PROLIFERACION CELULAR, SE REVELA UN METODO DE INHIBICION O PREVENCION DE PROLIFERACION CELULAR. SE SINTETIZA EL RB, UNA PROTEINA ESTABLE CODIFICADA POR EL GEN DEL RETINOBLASTOMA (RB1), EN TODAS LAS FASES DEL CICLO CELULAR. SE SUBFOSFORILIZA EL RB RECIEN SINTETIZADO DURANTE LAS FASES G0 Y G1, PERO SE FOSFORILIZA EN MUCHOS LUGARES EN EL LIMITE G1/S Y DURANTE LA FASE S. LAS CELULAS HL-60 PIERDEN SU CAPACIDAD PARA MULTIPLICAR EL RB, RECIEN SINTETIZADO, DE FOSFORILATO CUANDO SE INDUCE A DIFERENCIAR TERMINALMENTE MEDIANTE PRODUCTOS QUIMICOS, TALES COMO EL SULFOXIDO DE DIMETILO, EL ACIDO RETINOICO Y EL ACIDO BUTIRICO. SE REVELA UN METODO DE UTILIZACION DE ESTOS PRODUCTOS QUIMICOS PARA INHIBIR O PREVENIR LA PROLIFERACION CELULAR EN CELULAS QUE CONTENGAN RB.
ES91901398T 1989-12-07 1990-12-07 Regulacion, dependiente del ciclo de la celula, de la fosforilacion de un producto genico de retinoblastoma humano. Expired - Lifetime ES2135390T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44728289A 1989-12-07 1989-12-07

Publications (1)

Publication Number Publication Date
ES2135390T3 true ES2135390T3 (es) 1999-11-01

Family

ID=23775728

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901398T Expired - Lifetime ES2135390T3 (es) 1989-12-07 1990-12-07 Regulacion, dependiente del ciclo de la celula, de la fosforilacion de un producto genico de retinoblastoma humano.

Country Status (17)

Country Link
EP (1) EP0504289B1 (es)
JP (1) JP3080402B2 (es)
KR (1) KR100203959B1 (es)
CN (1) CN1052607A (es)
AT (1) ATE184653T1 (es)
AU (1) AU653142B2 (es)
CA (1) CA2070660A1 (es)
DE (1) DE69033289T2 (es)
ES (1) ES2135390T3 (es)
FI (1) FI922615A7 (es)
IE (1) IE904400A1 (es)
IL (1) IL96575A (es)
NO (1) NO922168L (es)
NZ (1) NZ236391A (es)
PT (1) PT96110A (es)
WO (1) WO1991009114A1 (es)
ZA (1) ZA909755B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223842B1 (en) 1986-08-11 2007-05-29 Massachusetts Eye And Ear Infirmary Detection of proteins whose absence is associated with a neoplasm
US7384735B1 (en) 1986-08-11 2008-06-10 Massachusetts Eye And Ear Infirmary Retinoblastoma nucleic acids
US5851991A (en) * 1987-08-31 1998-12-22 The Regents Of The University Of California Therapeutic use of the retinoblastoma susceptibility gene product
US7105156B1 (en) 1987-09-17 2006-09-12 The Regents Of The University Of California Method of using an adenoviral vector encoding a retinoblastoma protein to treat hyperproliferating cells
TW346397B (en) * 1991-10-17 1998-12-01 Univ California Cell cycle controlling compositions and methods of using same
US5969120A (en) * 1993-09-03 1999-10-19 Research Development Foundation Mutants of the RB and P53 genes
ZA946595B (en) * 1993-09-03 1996-02-28 Res Dev Foundation Mutants of the retinoblastoma and P53 genes and uses thereof
GB9506050D0 (en) 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
JPH10507266A (ja) 1994-10-17 1998-07-14 オステオミーター・ビオ・テク・エー／エス 体液中のコラーゲンの断片化パターンの評価とコラーゲンの代謝に関連する疾患の診断
WO1996015245A1 (en) * 1994-11-11 1996-05-23 Arch Development Corporation A process of inhibiting non-neoplastic pathological cell proliferation
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
GB9617616D0 (en) 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
ES2160985T3 (es) 1996-12-09 2001-11-16 Osteometer Biotech As Ensayos de tipo sandwich para fragmentos de colageno.
US6117646A (en) * 1997-09-22 2000-09-12 Osteometer Biotech A/S Assaying protein fragments in body fluids
CN116769011B (zh) * 2023-07-12 2026-01-16 德阳市人民医院 一种视网膜母细胞瘤蛋白突变体及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5888801A (ja) * 1981-11-20 1983-05-27 Hitachi Ltd 磁気デイスク記憶装置
US4694023A (en) * 1982-06-28 1987-09-15 Usv Pharmaceutical Corporation Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis and allergic responses
US4797762A (en) * 1987-09-22 1989-01-10 Micropolis Corporation Stress free winchester drive shaft mounting

Also Published As

Publication number Publication date
EP0504289A4 (en) 1993-03-31
IE904400A1 (en) 1991-06-19
JP3080402B2 (ja) 2000-08-28
FI922615A0 (fi) 1992-06-05
KR100203959B1 (ko) 1999-06-15
NO922168D0 (no) 1992-06-01
NZ236391A (en) 2001-07-27
DE69033289T2 (de) 2000-01-05
PT96110A (pt) 1991-09-30
ZA909755B (en) 1991-09-25
EP0504289A1 (en) 1992-09-23
IL96575A (en) 1995-05-26
WO1991009114A1 (en) 1991-06-27
CA2070660A1 (en) 1991-06-08
DE69033289D1 (de) 1999-10-21
NO922168L (no) 1992-07-15
AU7038991A (en) 1991-07-18
AU653142B2 (en) 1994-09-22
ATE184653T1 (de) 1999-10-15
EP0504289B1 (en) 1999-09-15
IL96575A0 (en) 1991-09-16
FI922615L (fi) 1992-06-05
JPH05503421A (ja) 1993-06-10
CN1052607A (zh) 1991-07-03
FI922615A7 (fi) 1992-06-05

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