ES2135564T3 - Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina. - Google Patents
Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina.Info
- Publication number
- ES2135564T3 ES2135564T3 ES94908221T ES94908221T ES2135564T3 ES 2135564 T3 ES2135564 T3 ES 2135564T3 ES 94908221 T ES94908221 T ES 94908221T ES 94908221 T ES94908221 T ES 94908221T ES 2135564 T3 ES2135564 T3 ES 2135564T3
- Authority
- ES
- Spain
- Prior art keywords
- proteins
- fibronectin
- factor xiii
- biological adhesive
- thrombin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 5
- 108010049003 Fibrinogen Proteins 0.000 title abstract 2
- 102000008946 Fibrinogen Human genes 0.000 title abstract 2
- 102000016359 Fibronectins Human genes 0.000 title abstract 2
- 108010067306 Fibronectins Proteins 0.000 title abstract 2
- 239000003364 biologic glue Substances 0.000 title abstract 2
- 229940012444 factor xiii Drugs 0.000 title abstract 2
- 229940012952 fibrinogen Drugs 0.000 title abstract 2
- FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 108010071289 Factor XIII Proteins 0.000 abstract 2
- 108090000190 Thrombin Proteins 0.000 abstract 2
- 239000012141 concentrate Substances 0.000 abstract 2
- 229960004072 thrombin Drugs 0.000 abstract 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 102000013566 Plasminogen Human genes 0.000 abstract 1
- 108010051456 Plasminogen Proteins 0.000 abstract 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 230000036760 body temperature Effects 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 238000000975 co-precipitation Methods 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 238000005185 salting out Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/021,302 US5395923A (en) | 1993-02-23 | 1993-02-23 | Process for the obtention of a biological adhesive made of concentrated coagulation factors by "salting-out" |
| PCT/CA1994/000105 WO1995023167A1 (en) | 1993-02-23 | 1994-02-28 | Process for the obtention of a biological adhesive comprising fibrinogen, factor xiii and fibronectin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2135564T3 true ES2135564T3 (es) | 1999-11-01 |
Family
ID=25683079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94908221T Expired - Lifetime ES2135564T3 (es) | 1993-02-23 | 1994-02-28 | Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5395923A (de) |
| EP (1) | EP0748337B1 (de) |
| JP (1) | JP3492694B2 (de) |
| AT (1) | ATE181738T1 (de) |
| AU (1) | AU678439B2 (de) |
| CA (1) | CA2113660C (de) |
| DE (1) | DE69419324T2 (de) |
| DK (1) | DK0748337T3 (de) |
| ES (1) | ES2135564T3 (de) |
| NO (1) | NO317699B1 (de) |
| RU (1) | RU2130946C1 (de) |
| WO (1) | WO1995023167A1 (de) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6054122A (en) | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US6117425A (en) * | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
| US6197325B1 (en) | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US5792835A (en) * | 1991-09-05 | 1998-08-11 | Baxter International Inc. | Method of preparing a topical fibrinogen complex |
| SE9301582D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Purification of plasma proteins |
| US5585007A (en) | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
| CA2207992A1 (en) * | 1995-01-16 | 1996-07-25 | Genevieve Krack | Self-supporting sheet-like material of cross-linked fibrin for preventing post operative adhesions |
| JPH08333277A (ja) * | 1995-06-05 | 1996-12-17 | Hoechst Japan Ltd | ヒト血液凝固第xiii因子の安定化された水性液製剤 |
| WO1998002098A1 (en) | 1996-07-12 | 1998-01-22 | Baxter International Inc. | A fibrin delivery device and method for forming fibrin on a surface |
| WO1998012274A1 (en) * | 1996-09-23 | 1998-03-26 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
| US8003705B2 (en) * | 1996-09-23 | 2011-08-23 | Incept Llc | Biocompatible hydrogels made with small molecule precursors |
| BR9806736A (pt) * | 1997-01-08 | 2000-02-29 | Bristol Myers Squibb Co | Aparelho centrìfugo com dispositivo de controle de temperatura. |
| US6132598A (en) * | 1997-01-08 | 2000-10-17 | Bristol-Myers Squibb Company | Centrifuge apparatus with temperature control means |
| US6630137B1 (en) | 1997-04-28 | 2003-10-07 | Eli Lilly And Company | Activated protein C formulations |
| NZ337828A (en) | 1997-04-28 | 2001-06-29 | Lilly Co Eli | Activated protein C formulations having a bulking agent and a salt |
| US5900270A (en) * | 1997-09-22 | 1999-05-04 | Cobe Laboratories, Inc. | Technique for testing and coating a microporous membrane |
| US5981254A (en) * | 1997-10-30 | 1999-11-09 | Haemacure Corporation | Process for producing thrombin from plasma |
| US6503527B1 (en) | 1997-11-17 | 2003-01-07 | Haemacure Corporation | Fibrin sealants or adhesives comprising a hyaluronic acid derivative material |
| BE1012536A3 (fr) | 1998-11-04 | 2000-12-05 | Baxter Int | Element muni d'une couche de fibrine sa preparation et son utilisation. |
| JP2002531217A (ja) * | 1998-12-04 | 2002-09-24 | チャンドラシェカー ピー. パサック, | 生体適合性架橋ポリマー |
| US6310036B1 (en) | 1999-01-09 | 2001-10-30 | Last Chance Tissue Adhesives Corporation | High strength, Bio-compatible tissue adhesive and methods for treating vigorously bleeding surfaces |
| JP4771594B2 (ja) * | 1999-02-12 | 2011-09-14 | バクスター アクチェンゲゼルシャフト | フィブリノーゲンおよびフィブロネクチンをベースとする製剤を生成するための方法ならびにこの方法により入手可能なタンパク質組成物 |
| ES2263451T3 (es) * | 1999-02-12 | 2006-12-16 | Baxter Aktiengesellschaft | Metodo para producir un preparado basado en fibrinogeno y fibronectina, asi como composiciones proteinicas que se pueden obtener segun este metodo. |
| US6610043B1 (en) | 1999-08-23 | 2003-08-26 | Bistech, Inc. | Tissue volume reduction |
| US7654998B1 (en) | 1999-08-23 | 2010-02-02 | Aeris Therapeutics, Inc. | Tissue volume reduction |
| HK1047754B (en) | 1999-12-23 | 2009-11-20 | Csl Limited | Separation of fibrinogen from plasma proteases |
| US7204981B2 (en) * | 2000-03-28 | 2007-04-17 | Eli Lilly And Company | Methods of treating diseases with activated protein C |
| CA2410567A1 (en) | 2000-05-24 | 2001-11-29 | Eli Lilly And Company | Formulations and use of activated protein c and protein c zymogen for treating hypercoagulable states |
| US6648911B1 (en) | 2000-11-20 | 2003-11-18 | Avantec Vascular Corporation | Method and device for the treatment of vulnerable tissue site |
| US20030229333A1 (en) * | 2002-02-22 | 2003-12-11 | Control Delivery Systems, Inc. | Methods for treating otic disorders |
| CA2475738A1 (en) * | 2002-03-08 | 2003-09-18 | Eli Lilly And Company | Activated protein c formulations |
| US7179391B2 (en) | 2002-05-24 | 2007-02-20 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7374678B2 (en) * | 2002-05-24 | 2008-05-20 | Biomet Biologics, Inc. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US7832566B2 (en) * | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| GB0216001D0 (en) | 2002-07-10 | 2002-08-21 | Nat Blood Authority | Process and composition |
| US7135027B2 (en) | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
| RU2224540C1 (ru) * | 2002-12-15 | 2004-02-27 | Люляева Ольга Дамировна | Биологический адгезивный клей |
| RU2253474C1 (ru) * | 2003-10-23 | 2005-06-10 | Айсина Роза Бакировна | Способ получения растворимого фибрин-мономера |
| US20060258995A1 (en) * | 2004-10-20 | 2006-11-16 | Pendharkar Sanyog M | Method for making a reinforced absorbable multilayered fabric for use in medical devices |
| AU2005295365B2 (en) * | 2004-10-20 | 2010-08-05 | Ethicon, Inc. | Absorbable hemostat |
| US9358318B2 (en) | 2004-10-20 | 2016-06-07 | Ethicon, Inc. | Method of making a reinforced absorbable multilayered hemostatic wound dressing |
| US7708152B2 (en) | 2005-02-07 | 2010-05-04 | Hanuman Llc | Method and apparatus for preparing platelet rich plasma and concentrates thereof |
| US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
| JP4974902B2 (ja) | 2005-02-07 | 2012-07-11 | ハヌマン リミテッド ライアビリティ カンパニー | 血小板に富んだ血漿の濃縮装置および濃縮方法 |
| CN1911440A (zh) * | 2005-08-08 | 2007-02-14 | 上海莱士血制品有限公司 | 一种用于形成纤维蛋白膜的试剂盒及其应用 |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US8430813B2 (en) * | 2006-05-26 | 2013-04-30 | Depuy Spine, Inc. | Illuminated surgical access system including a surgical access device and integrated light emitter |
| CA2677532A1 (en) * | 2007-02-06 | 2008-08-14 | Incept, Llc | Polymerization with precipitation of proteins for elution in physiological solution |
| US20090227689A1 (en) * | 2007-03-05 | 2009-09-10 | Bennett Steven L | Low-Swelling Biocompatible Hydrogels |
| US20090227981A1 (en) * | 2007-03-05 | 2009-09-10 | Bennett Steven L | Low-Swelling Biocompatible Hydrogels |
| WO2008127639A1 (en) | 2007-04-12 | 2008-10-23 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| US8067028B2 (en) * | 2007-08-13 | 2011-11-29 | Confluent Surgical Inc. | Drug delivery device |
| WO2009108890A1 (en) | 2008-02-27 | 2009-09-03 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| US8337711B2 (en) * | 2008-02-29 | 2012-12-25 | Biomet Biologics, Llc | System and process for separating a material |
| US8012077B2 (en) * | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
| JP5890182B2 (ja) | 2009-02-12 | 2016-03-22 | インセプト エルエルシー | ヒドロゲルプラグによる薬物送達 |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) * | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| RU2561676C1 (ru) * | 2014-04-07 | 2015-08-27 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Амурская Государственная Медицинская Академия" Министерства Здравоохранения Российской Федерации | Способ получения клеящей массы |
| US9932388B2 (en) | 2014-11-13 | 2018-04-03 | Hemarus Therapeutics Limited | Chromatographic process for producing high purity fibrinogen and thrombin |
| US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2826533A (en) * | 1954-03-15 | 1958-03-11 | Cutter Lab | Stable fibrinogen solutions and method for producing same |
| JPS5598196A (en) * | 1979-01-16 | 1980-07-25 | Meito Sangyo Kk | Fractionation of fibrinogen or its constituents and their use |
| AT359652B (de) * | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| AT390001B (de) * | 1984-09-28 | 1990-03-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern |
| DE3622642A1 (de) * | 1986-07-05 | 1988-01-14 | Behringwerke Ag | Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung |
| US4876241A (en) * | 1987-05-22 | 1989-10-24 | Armour Pharmaceutical Company | Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants |
| FR2618784B1 (fr) * | 1987-07-30 | 1990-04-06 | Lille Transfusion Sanguine | Concentre de proteines coagulables par la thrombine, son procede d'obtention et son utilisation a titre de colle biologique |
| US4877608A (en) * | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
| US5030215A (en) * | 1990-01-03 | 1991-07-09 | Cryolife, Inc. | Preparation of fibrinogen/factor XIII precipitate |
| WO1992013495A1 (en) * | 1991-02-07 | 1992-08-20 | Fibratek, Inc. | Fibrinogen based adhesive |
| EP0534178B1 (de) * | 1991-09-27 | 2001-04-18 | Omrix Biopharmaceuticals S.A. | Verbesserter Gewebekleber, zubereitet aus Kryopräzipitat |
| US5290918A (en) * | 1993-02-23 | 1994-03-01 | Haemacure Biotech Inc. | Process for the obtention of a biological adhesive made of concentrated coagulation factors by acidic precipitation |
-
1993
- 1993-02-23 US US08/021,302 patent/US5395923A/en not_active Expired - Lifetime
-
1994
- 1994-01-18 CA CA002113660A patent/CA2113660C/en not_active Expired - Fee Related
- 1994-02-28 DE DE69419324T patent/DE69419324T2/de not_active Expired - Lifetime
- 1994-02-28 AU AU61515/94A patent/AU678439B2/en not_active Ceased
- 1994-02-28 JP JP52203595A patent/JP3492694B2/ja not_active Expired - Fee Related
- 1994-02-28 EP EP94908221A patent/EP0748337B1/de not_active Expired - Lifetime
- 1994-02-28 AT AT94908221T patent/ATE181738T1/de not_active IP Right Cessation
- 1994-02-28 ES ES94908221T patent/ES2135564T3/es not_active Expired - Lifetime
- 1994-02-28 RU RU96119971A patent/RU2130946C1/ru active
- 1994-02-28 WO PCT/CA1994/000105 patent/WO1995023167A1/en not_active Ceased
- 1994-02-28 DK DK94908221T patent/DK0748337T3/da active
-
1996
- 1996-08-28 NO NO19963602A patent/NO317699B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09509183A (ja) | 1997-09-16 |
| EP0748337A1 (de) | 1996-12-18 |
| EP0748337B1 (de) | 1999-06-30 |
| NO963602D0 (no) | 1996-08-28 |
| DE69419324T2 (de) | 2000-03-02 |
| NO317699B1 (no) | 2004-12-06 |
| DK0748337T3 (da) | 2000-01-17 |
| NO963602L (no) | 1996-10-17 |
| AU6151594A (en) | 1995-09-11 |
| AU678439B2 (en) | 1997-05-29 |
| JP3492694B2 (ja) | 2004-02-03 |
| WO1995023167A1 (en) | 1995-08-31 |
| CA2113660A1 (en) | 1994-08-24 |
| RU2130946C1 (ru) | 1999-05-27 |
| ATE181738T1 (de) | 1999-07-15 |
| DE69419324D1 (de) | 1999-08-05 |
| CA2113660C (en) | 2000-05-16 |
| US5395923A (en) | 1995-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2135564T3 (es) | Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina. | |
| CA2113663A1 (en) | Process for the obtention of a biological adhesive made of concentrated coagulation factors by acidic precipitation | |
| US5589462A (en) | Method of preparing a biological adhesive enriched with platelet factors, and application | |
| Kornalik et al. | Prothrombin activation induced by Ecarin-a prothrombin converting enzyme from Echis carinatus venom | |
| US5407671A (en) | One-component tissue adhesive and a process for the production thereof | |
| AU724715B2 (en) | A stabilized mixture comprising fibrinogen | |
| US5260420A (en) | Concentrate of thrombin coagulable proteins, the method of obtaining same and therapeutical use thereof | |
| EP0180596B1 (de) | Verfahren zur verhütung der bindung des willebrand-faktors an menschliche blutplättchen und zur stimulierung der interaktion der plättchen mit gefässwänden | |
| DK1239895T3 (da) | Fremgangsmåde til fremstilling af en gel af autologe blodplader | |
| FR2448901A1 (fr) | Colle servant a reunir des tissus humains ou d'animaux, procede permettant sa fabrication et applications d'une telle colle | |
| ES2064439T3 (es) | Material adhesivo quirurgico. | |
| JPS6485096A (en) | Hybrid human protein c and biotechnological synthesis thereof | |
| BR9203763A (pt) | Cola para tecido;processo para a fabricacao de uma cola de fibrina e aplicacao de aprotinina,de uma protease de veneno de cobra e de batroxobina | |
| AT410216B (de) | Faktor x-analogon mit verbesserter aktivierbarkeit | |
| NO307384B1 (no) | Fremgangsmåte for spalting av proteiner og anvendelse av denne | |
| ATE510911T1 (de) | Prothrombin aktivierendes protein | |
| US20050265989A1 (en) | Non-toxic purification and activation of prothrombin and use thereof | |
| Latallo et al. | Fibrinolytic system of guinea pig serum | |
| DK59785D0 (da) | Fremgangsmaade til fremstilling af i det vaesentlige fibrinogenfrit ahf | |
| Kijkriengkraikul et al. | Preparation of thrombin from Human Cryo-removed Plasma using Russell’s Viper Venom Factor X Activator (RVV-X) | |
| Bernardes et al. | BjSP, a novel serine protease from Bothrops jararaca snake venom that degrades fibrinogen without forming fibrin clots | |
| Zhong | Role of the first epidermal growth factor-like domain in factor IX function. | |
| KR930005636A (ko) | 크리오침전물(cryoprecipitate)을 사용하여 제조한 개량된 티슈 글루(tissue glue) | |
| PT85226A (en) | Process for the preparation of novel trombolytic proteins |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 748337 Country of ref document: ES |