ES2137113A1 - Nuevos derivados de triazolo-piridazinas heterociclicos. - Google Patents

Nuevos derivados de triazolo-piridazinas heterociclicos.

Info

Publication number
ES2137113A1
ES2137113A1 ES009701670A ES9701670A ES2137113A1 ES 2137113 A1 ES2137113 A1 ES 2137113A1 ES 009701670 A ES009701670 A ES 009701670A ES 9701670 A ES9701670 A ES 9701670A ES 2137113 A1 ES2137113 A1 ES 2137113A1
Authority
ES
Spain
Prior art keywords
group
aromatic group
triazolo
pyrido
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009701670A
Other languages
English (en)
Other versions
ES2137113B1 (es
Inventor
Ferrer Jordi Gracia
Crespo M Isabel Crespo
Noverola Armando Vega
Garcia Andres Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES009701670A priority Critical patent/ES2137113B1/es
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Priority to SK86-2000A priority patent/SK284046B6/sk
Priority to ES98940218T priority patent/ES2162466T3/es
Priority to KR1020007000932A priority patent/KR20010022353A/ko
Priority to PL338214A priority patent/PL191031B1/pl
Priority to NZ502356A priority patent/NZ502356A/xx
Priority to CNB988081210A priority patent/CN1135231C/zh
Priority to DK98940218T priority patent/DK1001955T3/da
Priority to JP2000505162A priority patent/JP4320118B2/ja
Priority to IDW20000180A priority patent/ID24506A/id
Priority to CZ2000333A priority patent/CZ290208B6/cs
Priority to AT98940218T priority patent/ATE207069T1/de
Priority to EP98940218A priority patent/EP1001955B1/en
Priority to BRPI9810829-8A priority patent/BR9810829B1/pt
Priority to IL13408198A priority patent/IL134081A/en
Priority to EEP200000052A priority patent/EE04313B1/xx
Priority to PCT/EP1998/004340 priority patent/WO1999006404A1/en
Priority to HU0004708A priority patent/HUP0004708A3/hu
Priority to SI9830042T priority patent/SI1001955T1/xx
Priority to CA002298935A priority patent/CA2298935A1/en
Priority to DE69802100T priority patent/DE69802100T2/de
Priority to PT78400158T priority patent/PT1001955E/pt
Priority to AU88612/98A priority patent/AU737709B2/en
Priority to TR2000/00243T priority patent/TR200000243T2/xx
Priority to HK00103595.3A priority patent/HK1024914B/en
Priority to RU2000104863/04A priority patent/RU2202552C2/ru
Priority to UA2000010486A priority patent/UA60339C2/uk
Priority to ZA986248A priority patent/ZA986248B/xx
Priority to TW087111560A priority patent/TW542837B/zh
Priority to MYPI98003421A priority patent/MY118796A/en
Priority to CO98042905A priority patent/CO4970780A1/es
Priority to EG88998A priority patent/EG24041A/xx
Priority to ARP980103719A priority patent/AR015927A1/es
Priority to PE1998000682A priority patent/PE111099A1/es
Publication of ES2137113A1 publication Critical patent/ES2137113A1/es
Priority to NO20000394A priority patent/NO315118B1/no
Priority to BG104112A priority patent/BG64448B1/bg
Priority to US09/496,019 priority patent/US6407108B1/en
Application granted granted Critical
Publication of ES2137113B1 publication Critical patent/ES2137113B1/es
Priority to US10/038,777 priority patent/US20020183326A1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nuevos derivados de triazolo-piridazinas heterocíclicos de fórmula (I): en donde R{sup,1 representa un átomo de hidrógeno o un grupo (CH{sub,2 ){sub,m -Y siendo m un número de 0 a 4 e Y representa una cadena hidrocarbonada, cíclica, heterocíclica saturada o un grupo aromático opcionalmente sustituido; R{sup,2 representa una cadena hidrocarbonada, cíclica o un grupo aromático opcionalmente sustituido; R{sup,3 es hidrógeno, halógeno, alquilo, alcoxi o nitro; y sales farmacéuticamente aceptables de los- mismos. Dichos compuestos son inhibidores de PDE 4 y tienen una actividad emética muy baja.
ES009701670A 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos. Expired - Lifetime ES2137113B1 (es)

Priority Applications (38)

Application Number Priority Date Filing Date Title
ES009701670A ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.
PT78400158T PT1001955E (pt) 1997-07-29 1998-07-13 Derivados da 1,2,4-triazolo¬4,3-b|pirido¬3,2-d|piridazina e composicoes farmaceuticas que os contem
TR2000/00243T TR200000243T2 (tr) 1997-07-29 1998-07-13 1,2,4- triazol [4,3-B] pridol [3,2-D] piridazin türevleri ve bunları ihtiva eden farmasötik bileşimler.
PL338214A PL191031B1 (pl) 1997-07-29 1998-07-13 Związek o wzorze (I), sposób jego wytwarzania, kompozycja go zawierająca oraz zastosowanie
NZ502356A NZ502356A (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazine derivatives and pharmaceutical use as phosphodiesterase 4 inhibitors
CNB988081210A CN1135231C (zh) 1997-07-29 1998-07-13 1,2,4-三唑并[4,3b]吡啶并[3,2-d]哒嗪衍生物和含有它们的药用组合物
DK98940218T DK1001955T3 (da) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazinderivater og farmaceutiske præparater, der indeholder dem
JP2000505162A JP4320118B2 (ja) 1997-07-29 1998-07-13 １，２，４−トリアゾロ［４，３−ｂ］ピリド［３，２−ｄ］ピリダジン誘導体およびそれらを含有する製薬組成物
IDW20000180A ID24506A (id) 1997-07-29 1998-07-13 Turunan-turunan 1,2,4-triazolo [4,3-b] pirido [3,2-d]-piridazina dan komposisi-komposisi farmasi yang mengandung senyawa tersebut
CZ2000333A CZ290208B6 (cs) 1997-07-29 1998-07-13 Derivát 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazinu, způsob jeho přípravy, jeho pouľití a farmaceutický prostředek, který ho obsahuje
AT98940218T ATE207069T1 (de) 1997-07-29 1998-07-13 1,2,4-triazolo(4,3-b)pyrido(3,2- d)pyridazinderivate und diese enthaltende pharmaceutische zubereitungen
EP98940218A EP1001955B1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo 4,3-b]pyrido 3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
BRPI9810829-8A BR9810829B1 (pt) 1997-07-29 1998-07-13 composto heterocìclico, processo para preparar o mesmo, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica.
IL13408198A IL134081A (en) 1997-07-29 1998-07-13 History - 6 Aril 1, 2, 4 - Triazolo b] - 3, 4] Pyrido d] -2, 3] Pyridazine, their preparation and pharmaceutical preparations containing them
EEP200000052A EE04313B1 (et) 1997-07-29 1998-07-13 1,2,4-triasolo[4,3-b]pürido[3,2-d]püridasiini derivaadid, nende valmistamismeetod ja farmatseutiline kompositsioon ning nende kasutamine
PCT/EP1998/004340 WO1999006404A1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
HU0004708A HUP0004708A3 (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives, process for their preparation, their use and pharmaceutical compositions containing them
SI9830042T SI1001955T1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo 4,3-b)pyrido 3,2-d)pyridazine derivatives and pharmaceutical compositions containing them
CA002298935A CA2298935A1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
DE69802100T DE69802100T2 (de) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazinderivate und diese enthaltende pharmaceutische zubereitungen
SK86-2000A SK284046B6 (sk) 1997-07-29 1998-07-13 Deriváty 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazínu, spôsob ich prípravy, ich použitie a farmaceutické prostriedky s ich obsahom
ES98940218T ES2162466T3 (es) 1997-07-29 1998-07-13 Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.
KR1020007000932A KR20010022353A (ko) 1997-07-29 1998-07-13 1,2,4-트리아졸로[4,3-ｂ]피리도[3,2-ｄ]피리다진 유도체및 이를 포함하는 약제학적 조성물
HK00103595.3A HK1024914B (en) 1997-07-29 1998-07-13 1,2,4-triazolo 4,3-b]pyrido 3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
RU2000104863/04A RU2202552C2 (ru) 1997-07-29 1998-07-13 Производные 1,2,4-триазоло[4,3-b]пиридо[3,2-d]пиридазина, способ их получения, фармацевтическая композиция и способ ингибирования фосфодиэстеразы-4
UA2000010486A UA60339C2 (uk) 1997-07-29 1998-07-13 Похідна 1,2,4-триазоло[4,3-в]піридо[3,2-d]піридазину, спосіб її одержання та композиція, що її містить
AU88612/98A AU737709B2 (en) 1997-07-29 1998-07-13 1,2,4-triazolo{4,3-b}pyrido{3,2-d}pyridazine derivatives and pharmaceutical compositions containing them
ZA986248A ZA986248B (en) 1997-07-29 1998-07-14 New heterocylic compounds
TW087111560A TW542837B (en) 1997-07-29 1998-07-16 1,2,4-triazolo[4,3-b]pyrrido[3,2-d]pyridazine derivatives, process for their preparation and their use in medicine
MYPI98003421A MY118796A (en) 1997-07-29 1998-07-27 1,2,4-triazolo [4,3-b] pyrido [3,2-d] pyridazine derivatives and pharmaceutical compositions containing them
CO98042905A CO4970780A1 (es) 1997-07-29 1998-07-28 Nuevos compuestos heterociclicos de piridazina
EG88998A EG24041A (en) 1997-07-29 1998-07-29 New heterocyclic compounds
ARP980103719A AR015927A1 (es) 1997-07-29 1998-07-29 Compuesto de 1,2,4-triazolo[4,3-b)pirido[3,2-d)piridazina, procedimiento para su preparacion, composicion que lo comprende y su uso para preparar un medicamento.
PE1998000682A PE111099A1 (es) 1997-07-29 1998-07-30 Nuevos compuestos heterociclicos
NO20000394A NO315118B1 (no) 1997-07-29 2000-01-26 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazinderivater samt farmasöytiske sammensetninger inneholdende slike
BG104112A BG64448B1 (en) 1997-07-29 2000-01-27 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
US09/496,019 US6407108B1 (en) 1997-07-29 2000-01-28 1,2,4-triazolo(4,3-b)pyrido(3,2-d)pyridazine derivatives and pharmaceutical compositions containing them
US10/038,777 US20020183326A1 (en) 1997-07-29 2002-01-08 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazine derivatives and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009701670A ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.

Publications (2)

Publication Number Publication Date
ES2137113A1 true ES2137113A1 (es) 1999-12-01
ES2137113B1 ES2137113B1 (es) 2000-09-16

Family

ID=8300216

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009701670A Expired - Lifetime ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.
ES98940218T Expired - Lifetime ES2162466T3 (es) 1997-07-29 1998-07-13 Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES98940218T Expired - Lifetime ES2162466T3 (es) 1997-07-29 1998-07-13 Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.

Country Status (35)

Country Link
US (2) US6407108B1 (es)
EP (1) EP1001955B1 (es)
JP (1) JP4320118B2 (es)
KR (1) KR20010022353A (es)
CN (1) CN1135231C (es)
AR (1) AR015927A1 (es)
AT (1) ATE207069T1 (es)
AU (1) AU737709B2 (es)
BG (1) BG64448B1 (es)
BR (1) BR9810829B1 (es)
CA (1) CA2298935A1 (es)
CO (1) CO4970780A1 (es)
CZ (1) CZ290208B6 (es)
DE (1) DE69802100T2 (es)
DK (1) DK1001955T3 (es)
EE (1) EE04313B1 (es)
EG (1) EG24041A (es)
ES (2) ES2137113B1 (es)
HU (1) HUP0004708A3 (es)
ID (1) ID24506A (es)
IL (1) IL134081A (es)
MY (1) MY118796A (es)
NO (1) NO315118B1 (es)
NZ (1) NZ502356A (es)
PE (1) PE111099A1 (es)
PL (1) PL191031B1 (es)
PT (1) PT1001955E (es)
RU (1) RU2202552C2 (es)
SI (1) SI1001955T1 (es)
SK (1) SK284046B6 (es)
TR (1) TR200000243T2 (es)
TW (1) TW542837B (es)
UA (1) UA60339C2 (es)
WO (1) WO1999006404A1 (es)
ZA (1) ZA986248B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2792938B1 (fr) 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
CA2715683A1 (en) 1999-08-21 2001-03-01 Nycomed Gmbh Synergistic combination
WO2002080974A1 (en) * 2001-04-04 2002-10-17 Sankyo Company, Limited Novel medicinal use of cytokine production inhibitor
MXPA04002562A (es) * 2001-09-19 2004-05-31 Altana Pharma Ag Combinacion de un pde-4 y nsaid.
FR2832711B1 (fr) * 2001-11-26 2004-01-30 Warner Lambert Co Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
US7608716B2 (en) 2002-11-06 2009-10-27 Aska Pharmaceutical Co., Ltd. Pyrazolonaphthyridine derivative
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
RU2246496C1 (ru) * 2003-09-12 2005-02-20 Тец Виктор Вениаминович Вещество с противовирусной и антибактериальной активностью на основе производных 2,8-дитиоксо-1h-пирано[2,3-d, 6,5-d`] дипиримидина и их 10-аза-аналогов
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
AU2006258124B8 (en) * 2005-06-10 2010-01-07 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
CN101268073B (zh) * 2005-09-15 2011-10-19 Aska制药株式会社 杂环化合物、制备方法及其用途
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
JP2010500365A (ja) 2006-08-07 2010-01-07 インサイト・コーポレイション キナーゼ阻害剤としてのトリアゾロトリアジン
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
ES2560435T3 (es) 2006-11-22 2016-02-19 Incyte Holdings Corporation Imidazotriazinas e imidazopirimidinas como inhibidores de la quinasa
US20110112079A1 (en) * 2008-01-09 2011-05-12 Thomas Craig J Phosphodiesterase inhibitors
MX393622B (es) 2008-05-21 2025-03-24 Incyte Corp Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida y procesos relacionados con la preparacion de las mismas.
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
PH12012501361A1 (en) 2009-12-31 2012-10-22 Centro Nac De Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
JP5714030B2 (ja) 2010-02-03 2015-05-07 インサイト コーポレーションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｃ−Ｍｅｔ阻害剤としてのイミダゾ［１，２−ｂ］［１，２，４］トリアジン
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012251A1 (fr) * 1990-02-19 1991-08-22 Chugai Seiyaku Kabushiki Kaisha Nouveau compose heterocyclique condense et agent anti-asthme prepare a partir de ce compose
WO1993007146A1 (en) * 1991-10-09 1993-04-15 Syntex (U.S.A.) Inc. Benzo and pyrido pyridazinone and pyridazinthione compounds with pde iv inhibiting activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3122670A1 (de) 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
PH21834A (en) * 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
DE3677445D1 (de) * 1985-09-30 1991-03-14 Ciba Geigy Ag 2-substituierte-e-kondensierte(1,5-c)-pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
GB9514465D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
DE19510965A1 (de) * 1995-03-24 1996-09-26 Asta Medica Ag Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012251A1 (fr) * 1990-02-19 1991-08-22 Chugai Seiyaku Kabushiki Kaisha Nouveau compose heterocyclique condense et agent anti-asthme prepare a partir de ce compose
WO1993007146A1 (en) * 1991-10-09 1993-04-15 Syntex (U.S.A.) Inc. Benzo and pyrido pyridazinone and pyridazinthione compounds with pde iv inhibiting activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chemical Abstract, Vol. 91, No 17, 1979, (Columbus, OH, USA), pagina 25, resumen no 133826Z, ISHII, AKIO y col., "Inhibition of cyclic AMP phosphodiesterase activity by ecarazine hydrochloride, hydralazine and their metabolites". *

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