ES2137511T3 - Compuestos que contienen un aceptor de michael, especialmente derivados de maleimida o acido maleico, directamente o indirectamente conectado a un cromoforo, y su uso en composiciones de proteccion solar de larga duracion. - Google Patents

Compuestos que contienen un aceptor de michael, especialmente derivados de maleimida o acido maleico, directamente o indirectamente conectado a un cromoforo, y su uso en composiciones de proteccion solar de larga duracion.

Info

Publication number
ES2137511T3
ES2137511T3 ES95918063T ES95918063T ES2137511T3 ES 2137511 T3 ES2137511 T3 ES 2137511T3 ES 95918063 T ES95918063 T ES 95918063T ES 95918063 T ES95918063 T ES 95918063T ES 2137511 T3 ES2137511 T3 ES 2137511T3
Authority
ES
Spain
Prior art keywords
chromophorus
maleimide
directly
long
maleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95918063T
Other languages
English (en)
Inventor
Bruce Everett Davison
Bryan Colin Nicholas Mor Jones
Charon Robin Ganellin
Paul Beaumont Bishop
David Vanguard Medica Lim Jack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ligand UK Development Ltd
Original Assignee
Vanguard Medica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanguard Medica Ltd filed Critical Vanguard Medica Ltd
Application granted granted Critical
Publication of ES2137511T3 publication Critical patent/ES2137511T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/94—Involves covalent bonding to the substrate

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS QUE SON UTILES COMO PROTECTORES SOLARES. LOS COMPUESTOS PERSISTEN EN LA PIEL DURANTE MUCHO MAS TIEMPO QUE LOS PROTECTORES SOLARES CONVENCIONALES PORQUE COMPRENDEN UN ACEPTOR DE MICHAEL LIGADO DIRECTA O INDIRECTAMENTE A UN CROMOFORO. EL ACEPTOR DE MICHAEL ES CAPAZ DE SUFRIR UNA REACCION A LA ADICCION CONJUGADA CON GRUPOS TID PRESENTES EN LOS RESIDUOS DE CISTEINA DE QUERATINA Y DE ESTA MANERA EL COMPUESTO ESTA QUIMICAMENTE LIGADO A LA PIEL Y NO SERA ELIMINADO POR LA INMERSION EN EL AGUA.
ES95918063T 1994-05-06 1995-05-09 Compuestos que contienen un aceptor de michael, especialmente derivados de maleimida o acido maleico, directamente o indirectamente conectado a un cromoforo, y su uso en composiciones de proteccion solar de larga duracion. Expired - Lifetime ES2137511T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9408994A GB9408994D0 (en) 1994-05-06 1994-05-06 Compounds

Publications (1)

Publication Number Publication Date
ES2137511T3 true ES2137511T3 (es) 1999-12-16

Family

ID=10754654

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95918063T Expired - Lifetime ES2137511T3 (es) 1994-05-06 1995-05-09 Compuestos que contienen un aceptor de michael, especialmente derivados de maleimida o acido maleico, directamente o indirectamente conectado a un cromoforo, y su uso en composiciones de proteccion solar de larga duracion.

Country Status (20)

Country Link
US (1) US5877204A (es)
EP (1) EP0758314B1 (es)
JP (1) JPH10502338A (es)
CN (1) CN1149866A (es)
AT (1) ATE184592T1 (es)
AU (1) AU698618B2 (es)
BR (1) BR9507624A (es)
CA (1) CA2189337A1 (es)
DE (1) DE69512229T2 (es)
DK (1) DK0758314T3 (es)
ES (1) ES2137511T3 (es)
FI (1) FI964444A7 (es)
GB (1) GB9408994D0 (es)
GR (1) GR3032104T3 (es)
IL (1) IL113639A0 (es)
NO (1) NO310718B1 (es)
NZ (1) NZ285132A (es)
RU (1) RU2162838C2 (es)
WO (1) WO1995030646A1 (es)
ZA (1) ZA953655B (es)

Families Citing this family (32)

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ATE293951T1 (de) 1997-12-08 2005-05-15 Univ Arizona State Langwirkende, chemisch widerstandfähige haut- weichmachende, -feuchthaltemittel und -verstärker
US7601691B2 (en) * 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
WO2002076414A2 (en) 2001-03-07 2002-10-03 The Procter & Gamble Company Cosmetic topical composition comprising a functional aromatic derivative bonding agent
JP2004536039A (ja) 2001-03-07 2004-12-02 ザ プロクター アンド ギャンブル カンパニー 環式イミドカーボネートに基づく化粧品結合剤を含む局所用組成物
WO2002072043A2 (en) 2001-03-07 2002-09-19 The Procter & Gamble Company Topical composition comprising a 1, 2-heteroatom constituted diene cosmetic bonding agent
CA2448227A1 (en) 2001-03-07 2002-09-19 The Procter & Gamble Company Topical composition comprising a diazonium salt-based cosmetic bonding agent
CN1535136A (zh) 2001-03-07 2004-10-06 宝洁公司 包括官能化的基于酸酐的化妆品键合剂的局部组合物
CN1496251A (zh) 2001-03-07 2004-05-12 包括功能性酰化化妆品键合剂的局部组合物
EP1370235A2 (en) 2001-03-07 2003-12-17 The Procter & Gamble Company Topical composition comprising an aldehyde or ketone-based cosmetic bonding agent
WO2002072060A2 (en) 2001-03-07 2002-09-19 The Procter & Gamble Company Topical composition comprising a three membered cyclic compound-based cosmetic bonding agent
MXPA03008107A (es) 2001-03-07 2003-12-12 Procter & Gamble Composicion topica que comprende un agente enlazante cosmetico con grupo funcional alquilico.
JP2004532253A (ja) 2001-05-30 2004-10-21 ザ プロクター アンド ギャンブル カンパニー 活性化トランス構造化粧品結合剤を含む局所用組成物
CA2448065A1 (en) 2001-05-30 2002-12-05 The Procter & Gamble Company Topical cosmetic composition comprising an alpha-beta-unsaturated ester as bonding agent
WO2004019858A2 (en) * 2002-08-30 2004-03-11 Isp Investments Inc. Natural feel polymers
DE10358432B4 (de) * 2003-12-13 2005-12-01 Ziegler Mechanische Werkstatt, Metallgewebe Und Arbeitsschutz Gmbh Federspanner
US8591885B2 (en) * 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US7022861B1 (en) 2004-06-10 2006-04-04 Sandia National Laboratories Thermally cleavable surfactants
DE102004039281A1 (de) 2004-08-13 2006-02-23 Merck Patent Gmbh UV Filter
DE102005047647A1 (de) 2005-10-05 2007-04-12 Merck Patent Gmbh a,a'-Dihydroxyketonderivate und deren Verwendung als UV-Filter
DE102005058542A1 (de) * 2005-12-08 2007-06-14 Merck Patent Gmbh Erythruloseester als UV Filter
US20090099074A1 (en) * 2007-01-10 2009-04-16 Conjuchem Biotechnologies Inc. Modulating food intake
JP5119767B2 (ja) * 2007-07-05 2013-01-16 コニカミノルタアドバンストレイヤー株式会社 光学フィルム、偏光板、その製造方法及び液晶表示装置
US20100158829A1 (en) * 2008-12-24 2010-06-24 Conopco, Inc., D/B/A Unilever Method and Composition for Color Modulation
WO2014085545A1 (en) * 2012-11-30 2014-06-05 The University Of Chicago Methods and compositions involving rad51 inhibitors
CN111542297A (zh) * 2018-10-25 2020-08-14 孙益民 防晒制剂
TWI692467B (zh) * 2018-12-28 2020-05-01 健裕生技股份有限公司 促進心肌再生之化合物、其製法、醫藥品及其用途
JP6768868B2 (ja) * 2019-03-29 2020-10-14 健裕生技股▲分▼有限公司 心筋再生を促進させるための化合物、その調製方法及びこれらの使用
JP7668621B2 (ja) * 2019-03-29 2025-04-25 健裕生技股▲分▼有限公司 心筋再生を促進させるための化合物、その調製方法、医薬組成物及びこれらの使用
US11124472B2 (en) 2019-04-08 2021-09-21 Genhealth Pharma Co., Ltd. Myocardial regeneration promoting compounds, preparation method thereof, and pharmaceutical composition
EP3725763A1 (en) * 2019-04-17 2020-10-21 Genhealth Pharma Co., Ltd. Myocardial regeneration promoting compounds, preparation method thereof, pharmaceutical composition, and their use
JP2023507516A (ja) * 2019-12-19 2023-02-22 スキノシヴ 接着性光防護化合物及びその使用
TW202408453A (zh) * 2022-06-22 2024-03-01 法商肌膚歐希芙公司 多重光保護化合物及其用途

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US3322817A (en) * 1963-03-15 1967-05-30 Nat Starch Chem Corp Aromatic and aliphatic esters of hydroxy benzophenone derivatives
US3489739A (en) * 1966-09-08 1970-01-13 Rohm & Haas Novel carboalkoxyphenyl acrylates and polymers thereof
FR1568382A (es) * 1968-04-09 1969-05-23
US3751449A (en) * 1969-06-26 1973-08-07 Minnesota Mining & Mfg Cycloaliphatic and phenylalkyl acrylates and vinyl esters
FR2278331A1 (fr) * 1974-01-24 1976-02-13 Roussel Uclaf Nouveaux acides carboxyliques et leurs derives, leur application comme medicaments et leur procede de preparation
HU175454B (hu) * 1977-07-25 1980-08-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh predel'nykh i chastichno predel'nykh n-acil-pirrol-2,5-dionov
US4999186A (en) * 1986-06-27 1991-03-12 The Procter & Gamble Company Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn
EP0251398B1 (en) * 1986-06-27 1992-08-12 The Procter & Gamble Company Novel chromophores, sunscreen compositions and methods for preventing sunburn
JP2752384B2 (ja) * 1988-08-19 1998-05-18 帝人株式会社 紫外線吸収性化粧料
FR2638354B1 (fr) * 1988-10-28 1993-10-15 Oreal Compositions cosmetiques filtrantes, leur utilisation pour la protection de la peau et des cheveux contre le rayonnement ultraviolet, nouveaux derives de la 5-benzylidene 3-oxa cyclopentanone utilises dans ces compositions et leur procede de preparation
JP2883107B2 (ja) * 1989-07-10 1999-04-19 塩野義製薬株式会社 紫外線吸収皮膚保護剤組成物

Also Published As

Publication number Publication date
BR9507624A (pt) 1997-10-07
RU2162838C2 (ru) 2001-02-10
DE69512229D1 (de) 1999-10-21
EP0758314B1 (en) 1999-09-15
US5877204A (en) 1999-03-02
GR3032104T3 (en) 2000-03-31
DK0758314T3 (da) 2000-03-27
NZ285132A (en) 1999-06-29
AU2413695A (en) 1995-11-29
ZA953655B (en) 1996-11-05
DE69512229T2 (de) 2000-04-20
WO1995030646A1 (en) 1995-11-16
FI964444L (fi) 1997-01-03
AU698618B2 (en) 1998-11-05
CA2189337A1 (en) 1995-11-16
NO964675L (no) 1997-01-06
CN1149866A (zh) 1997-05-14
ATE184592T1 (de) 1999-10-15
IL113639A0 (en) 1995-08-31
NO310718B1 (no) 2001-08-20
FI964444A7 (fi) 1997-01-03
JPH10502338A (ja) 1998-03-03
EP0758314A1 (en) 1997-02-19
NO964675D0 (no) 1996-11-05
FI964444A0 (fi) 1996-11-05
GB9408994D0 (en) 1994-06-22

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