ES2137996T3 - 4-amino-n-(4-metil-4-piperidinil)-2-metoxibenzamidas, su preparacion y su empleo como antagonistas 5-ht2. - Google Patents

4-amino-n-(4-metil-4-piperidinil)-2-metoxibenzamidas, su preparacion y su empleo como antagonistas 5-ht2.

Info

Publication number
ES2137996T3
ES2137996T3 ES93917661T ES93917661T ES2137996T3 ES 2137996 T3 ES2137996 T3 ES 2137996T3 ES 93917661 T ES93917661 T ES 93917661T ES 93917661 T ES93917661 T ES 93917661T ES 2137996 T3 ES2137996 T3 ES 2137996T3
Authority
ES
Spain
Prior art keywords
compounds
hydrogen
halogen
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93917661T
Other languages
English (en)
Inventor
Josepha Eduarda Maria F Leysen
Daele Georges Henri Paul Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2137996T3 publication Critical patent/ES2137996T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN BENZAMIDAS DE PIPERIDINILO SUSTITUIDAS DE LA FORMULA (I), LAS SALES DEL ACIDO DE ADICION ACEPTABLES FARMACEUTICAMENTE DE LAS MISMAS Y LAS FORMAS ESTEREOISOMERICAS DE LAS MISMAS, EN DONDE R1 ES HIDROGENO O HALOGENO; R2 ES HALOGENO; R3 ES HIDROGENO O HALOGENO; R4 Y R5 CADA UNO INDEPENDIENTEMENTE SON HIDROGENO, ALQUILO C1-4 O HALOGENO ALQUILO C1-4; Y EL GRUPO NR4R5 TAMBIEN PUEDE SER AZIDO, ALK ES ALCANEDILO C2-4; COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS DE LA FORMULA (I) COMO INGREDIENTE ACTIVO; USO DE DICHOS COMPUESTOS COMO UNA MEDICINA; PROCESO PARA PREPARACION DE DICHOS COMPUESTOS; COMPUESTOS DE LA FORMULA (I) QUE CONTIENEN UN ISOTOPO RADIOACTIVO; PROCESO DE MARCADO DE SITIOS RECEPTORES DE 5HT2; Y PROCESO PARA FORMACION DE IMAGEN DE UN ORGANO.
ES93917661T 1992-07-17 1993-07-08 4-amino-n-(4-metil-4-piperidinil)-2-metoxibenzamidas, su preparacion y su empleo como antagonistas 5-ht2. Expired - Lifetime ES2137996T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91430692A 1992-07-17 1992-07-17

Publications (1)

Publication Number Publication Date
ES2137996T3 true ES2137996T3 (es) 2000-01-01

Family

ID=25434170

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93917661T Expired - Lifetime ES2137996T3 (es) 1992-07-17 1993-07-08 4-amino-n-(4-metil-4-piperidinil)-2-metoxibenzamidas, su preparacion y su empleo como antagonistas 5-ht2.

Country Status (16)

Country Link
US (3) US5498618A (es)
EP (1) EP0650475B1 (es)
JP (1) JP3257677B2 (es)
KR (1) KR100243535B1 (es)
AT (1) ATE184001T1 (es)
AU (1) AU668208B2 (es)
CA (1) CA2138150C (es)
DE (1) DE69326245T2 (es)
DK (1) DK0650475T3 (es)
ES (1) ES2137996T3 (es)
FI (1) FI109997B (es)
GR (1) GR3031820T3 (es)
HU (1) HUT71886A (es)
IL (1) IL106356A (es)
NO (1) NO303011B1 (es)
WO (1) WO1994002462A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319534D0 (en) * 1993-09-22 1993-11-10 Boots Co Plc Therapeutic agents
EP0647639A1 (fr) * 1993-10-11 1995-04-12 Sanofi Hétéroarylpipéridines, procédé pour leur préparation et compositions pharmaceutiques les contenant
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
US5919934A (en) * 1997-02-19 1999-07-06 The George Washington University Compounds, compositions, and methods for cancer imaging and therapy
WO2001000604A1 (fr) * 1999-06-30 2001-01-04 Santen Pharmaceutical Co., Ltd. Ligand de liaison avec le recepteur sigma-1 du cerveau
KR20010017625A (ko) * 1999-08-12 2001-03-05 윤재승 시사프라이드의 제조 방법
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
ITRM20050390A1 (it) * 2005-07-22 2007-01-23 Giuliani Spa Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico.
EP3233799B1 (en) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3233077B1 (en) 2014-12-19 2026-05-06 The Broad Institute, Inc. Dopamine d2 receptor ligands
CN110950843B (zh) * 2019-11-28 2022-12-27 广东东阳光药业有限公司 取代的苯酰胺衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1507462A (en) * 1974-03-21 1978-04-12 Gallardo Antonio Sa N-heterocyclic substituted benzamides methods for their preparation and compositions containing them
US4962115A (en) * 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
GB8718346D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa Substituted benzamides

Also Published As

Publication number Publication date
EP0650475A1 (en) 1995-05-03
DE69326245T2 (de) 2000-05-18
FI109997B (fi) 2002-11-15
CA2138150C (en) 2005-04-19
US5688814A (en) 1997-11-18
IL106356A0 (en) 1993-11-15
DE69326245D1 (de) 1999-10-07
JP3257677B2 (ja) 2002-02-18
HK1010730A1 (en) 1999-06-25
NO950136D0 (no) 1995-01-13
WO1994002462A1 (en) 1994-02-03
ATE184001T1 (de) 1999-09-15
IL106356A (en) 1997-06-10
AU4702993A (en) 1994-02-14
FI950180L (fi) 1995-01-16
AU668208B2 (en) 1996-04-26
KR100243535B1 (ko) 2000-03-02
NO303011B1 (no) 1998-05-18
HU9500138D0 (en) 1995-03-28
JPH07509234A (ja) 1995-10-12
FI950180A0 (fi) 1995-01-16
US5691358A (en) 1997-11-25
US5498618A (en) 1996-03-12
GR3031820T3 (en) 2000-02-29
DK0650475T3 (da) 2000-03-20
EP0650475B1 (en) 1999-09-01
KR950702183A (ko) 1995-06-19
CA2138150A1 (en) 1994-02-03
HUT71886A (en) 1996-02-28
NO950136L (no) 1995-02-03

Similar Documents

Publication Publication Date Title
ES2140391T3 (es) Derivados de dialcoxi-piridinil-bencimidazol, procedimiento para su preparacion y su uso farmaceutico.
ES2144412T3 (es) Derivados de bencimidazoles como antagonistas de 5-ht1a y 5ht2.
ES2075036T3 (es) 3-piperidinil-1,2-benzoisoxazoles.
CS195285A3 (en) Pyridazine derivatives substituted by cyclic amines and process forpreparing thereof
ES2053451T3 (es) Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles.
ES8601965A1 (es) Un procedimiento para la preparacion de una nueva serie de derivados de (1-piperidinilalquil)pirimidinona
ES8602763A1 (es) Un procedimiento para la preparacion de n-(heterociclilbiciclo)-4-piperidinaminas.
BR9408325A (pt) Composto composição farmacêutica e processo para a manufatura de um composto
ES2123039T3 (es) Nuevas 3-(hidroxi-bencilidenil)-indolin-2-onas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
ZA902142B (en) 4-fluorobenzoic derivatives,processes for preparing them and pharmaceutical compositions containing them
ES2065324T3 (es) N-(piridinil)-1h-indol-1-aminas, un procedimiento para su preparacion y su uso como medicamentos.
NO942952D0 (no) 11-benzaldoksin-17 ater, fremgangsmåte for deres fremstilling samt legemiddel inneholdende slike
ES2058504T3 (es) Derivados de piperidina y piperazina, procedimiento para preparar los mismos, y composiciones farmaceuticas que contienen los mismos.
ES2118203T3 (es) Nuevos derivados benzopiranicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES2058749T3 (es) Derivados 2-aminopirimidinona.
ES2052015T3 (es) Un metodo de preparacion de una composicion farmaceutica.
DE69326245D1 (de) 4-amino-n-(4-methyl-4-piperidinyl)-2-methoxybenzamide, deren herstellung und deren verwendung als 5-ht2-antagonisten
ES2126579T3 (es) Comprimidos de dispersion solida que contienen derivados de 1,4-dihidropiridina y procedimiento para su preparacion.
ATE25679T1 (de) Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung.
ES2053652T3 (es) N-(alquilideno sustituido)-1,2,3,4,-tetrahidro-9-acridinaminas, un procedimiento para su preparacion y su uso como medicamentos.
ES2059471T3 (es) Un procedimiento para preparar un derivado de rodamina.
AR023679A1 (es) Delta3-piperidinas triciclicas como antagonistas de alfa2, un proceso para su preparacion, una composicion farmaceutica y el uso del mismo para la elaboracion de un medicamento
MX9207396A (es) Imidazoles novedosos.
ES2061444T3 (es) Derivados de penemo.
ES2076201T3 (es) Derivados de 3-piperidinil-indazol antihipertensivos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 650475

Country of ref document: ES