ES2144412T3 - Derivados de bencimidazoles como antagonistas de 5-ht1a y 5ht2. - Google Patents

Derivados de bencimidazoles como antagonistas de 5-ht1a y 5ht2.

Info

Publication number
ES2144412T3
ES2144412T3 ES92830427T ES92830427T ES2144412T3 ES 2144412 T3 ES2144412 T3 ES 2144412T3 ES 92830427 T ES92830427 T ES 92830427T ES 92830427 T ES92830427 T ES 92830427T ES 2144412 T3 ES2144412 T3 ES 2144412T3
Authority
ES
Spain
Prior art keywords
substituted
alkyl
mono
optionally
ht1a
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92830427T
Other languages
English (en)
Inventor
Marco Turconi
Giuseppe Bietti
Ettore Giraldo
Franco Borsini
Maura Bignotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Italia SpA
Original Assignee
Boehringer Ingelheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Italia SpA filed Critical Boehringer Ingelheim Italia SpA
Application granted granted Critical
Publication of ES2144412T3 publication Critical patent/ES2144412T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVADOS DE BENCIMIDAZOLONA FARMACOLOGICAMENTE ACTIVOS COMO RECEPTORES DE 5-HT1A Y 5-HT2, UTILES EN EL TRATAMIENTO DE ENFERMEDADES CNS DE FORMULA: DONDE R1 Y R2 PUEDEN SE AL MISMO TIEMPO O NO UN ATOMO DE HIDROGENO, HALOGENO, TRIFLUOROMETIL, C1-6 ALQUIL, C1-6 ALCOXI, C1-6 ALQUILTIO, C1-6 ACIL, CARBOXIL, C1-6 ALCOXIONO O DI-SUBSTITUIDO POR C1-4 ALQUIL, C1-6 ACILAMINO, C1-6 ALCOXICARBONILAMINO, CARBAMOIL OPCIONALMENTE N-MONO O DI-SUBSTITUIDO POR C1-4 ALQUIL, CIANO, C16 ALQUILSULFINIL, C1-6 ALQUILSULFONIL, AMINO SULFONIL OPCIONALMENTE N-MONO O DI-SUBSTITUIDO POR C1-4 ALQUIL, AMINOSULFONILAMINO N-MONO O DI-SUBSTITUIDO POR C1-4 ALQUIL, AMINOSULFONILAMINO; R3 ES HIDROGENO, C1-6 ALQUIL, C2-6 ALQUENIL O C2-C6 ALQUINIL; A ES -CONTE; B ES UN C2-6 ALQUIL LINEAL O RAMIFICADO, SATURADO O INSATURADO; M Y N SON AMBOS INDEPENDIENTEMENTE UN ENTERO DE 1 A 3; R4 ES UN ARIL, ARALQUIL, UN GRUPO HETEROARIL O HETEROARALQUIL, CADA GRUPO ESTA OPCIONALMENTE SUBSTITUIDO POR UNO O MAS SUBSTITUYENTES ELEGIDOS DE HALOGENO, TRIFLUOROMETIL, CIANO, C1-3 ALCOXI, C1-4 ACIDO ALQUILAND EN ADICION CON SUS SALES. SE DESCRIBEN TAMBIEN EL PROCESO PARA LA PREPARACION DE LOS COMPUESTOS DE FORMULA I Y LOS COMPUESTOS FARMACEUTICOS QUE LOS CONTIENEN.
ES92830427T 1991-07-30 1992-07-30 Derivados de bencimidazoles como antagonistas de 5-ht1a y 5ht2. Expired - Lifetime ES2144412T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912118A IT1251144B (it) 1991-07-30 1991-07-30 Derivati del benzimidazolone

Publications (1)

Publication Number Publication Date
ES2144412T3 true ES2144412T3 (es) 2000-06-16

Family

ID=11360463

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92830427T Expired - Lifetime ES2144412T3 (es) 1991-07-30 1992-07-30 Derivados de bencimidazoles como antagonistas de 5-ht1a y 5ht2.

Country Status (31)

Country Link
US (1) US5576318A (es)
EP (1) EP0526434B1 (es)
JP (1) JP2989667B2 (es)
KR (1) KR100263495B1 (es)
AT (1) ATE191910T1 (es)
AU (1) AU665366B2 (es)
CA (1) CA2114542C (es)
CZ (1) CZ281511B6 (es)
DE (1) DE69230926T2 (es)
DK (1) DK0526434T3 (es)
EE (1) EE03070B1 (es)
ES (1) ES2144412T3 (es)
FI (1) FI111460B (es)
GR (1) GR3033947T3 (es)
HU (2) HUT70195A (es)
IE (1) IE922464A1 (es)
IL (1) IL102665A (es)
IT (1) IT1251144B (es)
MX (1) MX9204139A (es)
NO (1) NO304070B1 (es)
NZ (1) NZ243777A (es)
PH (1) PH30998A (es)
PL (1) PL171329B1 (es)
PT (1) PT526434E (es)
RU (1) RU2096411C1 (es)
SG (1) SG52407A1 (es)
SK (1) SK279292B6 (es)
TW (1) TW209862B (es)
UA (1) UA42684C2 (es)
WO (1) WO1993003016A1 (es)
ZA (1) ZA925682B (es)

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WO2017076213A1 (zh) * 2015-11-02 2017-05-11 苏州旺山旺水生物医药有限公司 苯并咪唑类化合物、其制备方法及用途
WO2017076356A1 (zh) * 2015-11-05 2017-05-11 苏州晶云药物科技有限公司 氟班色林的新晶型及其制备方法
CN106749038A (zh) * 2015-11-25 2017-05-31 山东诚创医药技术开发有限公司 一种氟班色林的制备方法
CN106866546A (zh) * 2015-12-10 2017-06-20 常州爱诺新睿医药技术有限公司 氟班色林或其药学上可接受的盐与药用辅料的固体分散体及其制备方法
CN108699007A (zh) 2016-01-31 2018-10-23 孟晓明 氟班色林的新晶型及其制备方法及其用途
CN108349908B (zh) * 2016-02-02 2021-07-20 深圳市塔吉瑞生物医药有限公司 一种取代的苯并咪唑酮化合物及包含该化合物的组合物
CN107235913B (zh) * 2016-03-29 2020-07-10 苏州科伦药物研究有限公司 工业规模高效制造优质氟班色林的方法
CN106866582A (zh) * 2017-01-10 2017-06-20 广州隽沐生物科技有限公司 一种氟班色林中间体的制备方法
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AU2427592A (en) 1993-03-02
JP2989667B2 (ja) 1999-12-13
PH30998A (en) 1997-12-23
NO304070B1 (no) 1998-10-19
TW209862B (es) 1993-07-21
SK279292B6 (sk) 1998-09-09
IL102665A (en) 1996-10-31
DE69230926D1 (de) 2000-05-25
NO940306L (no) 1994-03-14
HU9400255D0 (en) 1994-05-30
FI940420A0 (fi) 1994-01-28
CA2114542C (en) 2004-02-24
IT1251144B (it) 1995-05-04
DK0526434T3 (da) 2000-07-17
CZ281511B6 (cs) 1996-10-16
HK1010725A1 (en) 1999-06-25
ITMI912118A0 (it) 1991-07-30
CA2114542A1 (en) 1993-02-18
HUT70195A (en) 1995-09-28
SG52407A1 (en) 1998-09-28
RU2096411C1 (ru) 1997-11-20
JPH06509575A (ja) 1994-10-27
ATE191910T1 (de) 2000-05-15
NO940306D0 (no) 1994-01-28
ZA925682B (en) 1994-01-31
WO1993003016A1 (en) 1993-02-18
UA42684C2 (uk) 2001-11-15
PL302163A1 (en) 1994-07-11
CZ17094A3 (en) 1994-05-18
DE69230926T2 (de) 2000-10-05
GR3033947T3 (en) 2000-11-30
US5576318A (en) 1996-11-19
IE922464A1 (en) 1993-02-10
MX9204139A (es) 1993-01-01
FI111460B (fi) 2003-07-31
AU665366B2 (en) 1996-01-04
EP0526434A1 (en) 1993-02-03
PT526434E (pt) 2000-08-31
SK10194A3 (en) 1994-12-07
KR100263495B1 (ko) 2000-11-01
EP0526434B1 (en) 2000-04-19
ITMI912118A1 (it) 1993-01-31
HU211256A9 (en) 1995-11-28
PL171329B1 (pl) 1997-04-30
FI940420A7 (fi) 1994-01-28
EE03070B1 (et) 1998-02-16
NZ243777A (en) 1995-04-27

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