ES2139800T3 - Preparaciones farmaceuticas liposomales inyectables. - Google Patents

Preparaciones farmaceuticas liposomales inyectables.

Info

Publication number
ES2139800T3
ES2139800T3 ES95113608T ES95113608T ES2139800T3 ES 2139800 T3 ES2139800 T3 ES 2139800T3 ES 95113608 T ES95113608 T ES 95113608T ES 95113608 T ES95113608 T ES 95113608T ES 2139800 T3 ES2139800 T3 ES 2139800T3
Authority
ES
Spain
Prior art keywords
pharmaceutical preparations
liposomal pharmaceutical
injectable liposomal
injectable
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95113608T
Other languages
English (en)
Inventor
Hans-Jurgen Dr Hamann
Peter Dr Serno
Matthias Dr Herboth
Peter Dr Kurka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2139800T3 publication Critical patent/ES2139800T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • External Artificial Organs (AREA)
  • Glass Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A FORMULACIONES INYECTABLES LIPOSOMALES ESTABLES PARA SUSTANCIAS ACTIVAS LIPOFILAS, DIFICILMENTE SOLUBLE EN FORMA DE LIPOSOMAS, QUE SE ESTABILIZAN MEDIANTE ACIDOS GRASOS DE CADENA CORTA, EN PARTICULAR PARA SUSTANCIAS ACTIVAS A PARTIR DEL GRUPO DE LA DIHIDROPIRIDINA.
ES95113608T 1994-09-12 1995-08-30 Preparaciones farmaceuticas liposomales inyectables. Expired - Lifetime ES2139800T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4432378A DE4432378A1 (de) 1994-09-12 1994-09-12 Injizierbare liposomale Arzneizubereitungen

Publications (1)

Publication Number Publication Date
ES2139800T3 true ES2139800T3 (es) 2000-02-16

Family

ID=6527981

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95113608T Expired - Lifetime ES2139800T3 (es) 1994-09-12 1995-08-30 Preparaciones farmaceuticas liposomales inyectables.

Country Status (28)

Country Link
US (1) US5653998A (es)
EP (1) EP0700679B1 (es)
JP (1) JPH0881361A (es)
KR (1) KR960009998A (es)
CN (1) CN1079668C (es)
AT (1) ATE187327T1 (es)
AU (1) AU698441B2 (es)
CA (1) CA2157849A1 (es)
CZ (1) CZ287975B6 (es)
DE (2) DE4432378A1 (es)
DK (1) DK0700679T3 (es)
EE (1) EE03377B1 (es)
ES (1) ES2139800T3 (es)
FI (1) FI954204A7 (es)
GR (1) GR3032664T3 (es)
HU (1) HUT73808A (es)
IL (1) IL115222A (es)
MY (1) MY111841A (es)
NO (1) NO311556B1 (es)
NZ (1) NZ272943A (es)
PL (1) PL181541B1 (es)
PT (1) PT700679E (es)
RU (1) RU2160099C2 (es)
SI (1) SI0700679T1 (es)
SK (1) SK281611B6 (es)
TW (1) TW359616B (es)
UA (1) UA29469C2 (es)
ZA (1) ZA957604B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
DE19709704C2 (de) 1997-03-10 1999-11-04 Michael Georgieff Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
KR20000003433A (ko) * 1998-06-29 2000-01-15 김영환 반도체소자의 커패시터 제조방법
ATE397488T1 (de) * 1998-11-13 2008-06-15 Heriot William A Vorrichtung zur herstellung von liposomen
WO2000069412A1 (en) * 1999-05-14 2000-11-23 Esperion Luv Development, Inc. Method of treating angina and/or anginal equivalents, and pharmaceutical compositions and kit related thereto
ATE341310T1 (de) * 2000-02-04 2006-10-15 Lipoxen Technologies Ltd Dehydratisierungs-/rehydratisierungsverfahren zur herstellung von liposome
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
JP4975964B2 (ja) 2002-06-26 2012-07-11 メディゲーネ アクチエンゲゼルシャフト 脂肪親和性化合物から成る陽イオン性リポソームの製法
DE10255195A1 (de) * 2002-11-27 2004-06-09 Lipoid Gmbh Micellare wasserlösliche Konzentrate
US20060222694A1 (en) * 2003-06-27 2006-10-05 Oh Choon K Stabilized topotecan liposomal composition and methods
US7345093B2 (en) * 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
EP1868571A4 (en) * 2005-03-02 2011-10-26 Univ Northeastern MITOCHONDRIOTROPIC PHOSPHOLIPIDE VESICLES
JP5846711B2 (ja) * 2005-06-09 2016-01-20 メダ アーベー 炎症性疾患の治療のための方法及び組成物
JP5178520B2 (ja) 2005-09-22 2013-04-10 メディバス エルエルシー 固体ポリマー送達組成物およびその使用法
JP5192384B2 (ja) 2005-09-22 2013-05-08 メディバス エルエルシー ビス−（α−アミノ）−ジオール−ジエステル含有ポリ（エステルアミド）およびポリ（エステルウレタン）組成物および使用の方法
WO2008000534A1 (de) * 2006-06-30 2008-01-03 Gertrud Langhoff Solubilisatformulierungen
JP6081058B2 (ja) * 2009-03-19 2017-02-15 第一三共株式会社 包装により安定保存された固形製剤
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
WO2011038068A1 (en) * 2009-09-23 2011-03-31 Formatech, Inc. Methods for the preparation of liposomes
IT1404011B1 (it) 2010-12-03 2013-11-08 Uni Degli Studi Magna Graecia Di Catanzaro Nanovettore coniugato con tsh per il trattamento del cancro della tiroide
PL226015B1 (pl) * 2011-03-03 2017-06-30 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Liposomowy preparat zawierajacy przeciwnowotworowa substancje aktywna, sposob jego wytwarzania i zawierajaca go kompozycja farmaceutyczna
EP2723801B1 (en) 2011-06-23 2017-01-18 DSM IP Assets B.V. New biodegradable polyesteramide copolymers for drug delivery
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
FR2979239A1 (fr) * 2011-08-25 2013-03-01 Trophos Liposome comprenant au moins un derive de cholesterol
EP2682106A1 (en) 2012-07-03 2014-01-08 Phares Pharmaceutical Research N.V. Method of solubilizing biologically active compounds
WO2014085914A1 (en) * 2012-12-06 2014-06-12 Misudan Enterprises Inc. Topical liposome compositions containing phenolic anti-inflammatory agents and their methods of preparation
CN107106509B (zh) 2014-12-18 2021-11-30 帝斯曼知识产权资产管理有限公司 用于递送酸敏感药物的药物递送系统
CA3160955A1 (en) 2019-11-12 2021-05-20 Dsm Ip Assets B.V. Polyesteramide copolymers possessing high glass transition temperatures
CN110898011B (zh) * 2019-11-27 2022-02-08 西南医科大学 一种依托咪酯纳米制剂及其制备方法
BR112022011989A2 (pt) * 2019-12-23 2022-09-06 Zambon Spa Processo para preparação de dispersões compreendendo ingredientes ativos imunossupressores inaláveis
JP7608086B2 (ja) * 2020-07-31 2025-01-06 東和薬品株式会社 シームレスカプセル

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3515335C2 (de) * 1985-04-27 1995-01-26 Bayer Ag Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung
DE4117750A1 (de) * 1991-05-30 1992-12-24 Bayer Ag Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4207481A1 (de) * 1992-03-10 1993-09-16 Bayer Ag Liposomale wirkstoff-formulierungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
PL310344A1 (en) 1996-03-18
DE4432378A1 (de) 1996-03-14
CN1079668C (zh) 2002-02-27
FI954204L (fi) 1996-03-13
NZ272943A (en) 1996-07-26
HU9502654D0 (en) 1995-11-28
IL115222A0 (en) 1995-12-31
KR960009998A (ko) 1996-04-20
CN1128655A (zh) 1996-08-14
ZA957604B (en) 1996-04-15
FI954204A0 (fi) 1995-09-08
FI954204A7 (fi) 1996-03-13
DK0700679T3 (da) 2000-05-29
PT700679E (pt) 2000-05-31
AU3046495A (en) 1996-03-28
HUT73808A (en) 1996-09-30
DE59507372D1 (de) 2000-01-13
ATE187327T1 (de) 1999-12-15
SI0700679T1 (en) 2000-02-29
RU2160099C2 (ru) 2000-12-10
TW359616B (en) 1999-06-01
SK281611B6 (sk) 2001-05-10
AU698441B2 (en) 1998-10-29
EE9500063A (et) 1996-04-15
EP0700679A1 (de) 1996-03-13
EP0700679B1 (de) 1999-12-08
JPH0881361A (ja) 1996-03-26
CA2157849A1 (en) 1996-03-13
GR3032664T3 (en) 2000-06-30
PL181541B1 (pl) 2001-08-31
CZ287975B6 (cs) 2001-03-14
NO953578L (no) 1996-03-13
CZ234195A3 (en) 1996-03-13
MY111841A (en) 2001-01-31
SK112795A3 (en) 1997-02-05
UA29469C2 (uk) 2000-11-15
EE03377B1 (et) 2001-04-16
IL115222A (en) 1999-06-20
NO311556B1 (no) 2001-12-10
US5653998A (en) 1997-08-05
NO953578D0 (no) 1995-09-11

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