ES2139932T3 - Sistema terapeutico percutaneo a base de estradiol con aditivos higroscopicos. - Google Patents

Sistema terapeutico percutaneo a base de estradiol con aditivos higroscopicos.

Info

Publication number
ES2139932T3
ES2139932T3 ES95929856T ES95929856T ES2139932T3 ES 2139932 T3 ES2139932 T3 ES 2139932T3 ES 95929856 T ES95929856 T ES 95929856T ES 95929856 T ES95929856 T ES 95929856T ES 2139932 T3 ES2139932 T3 ES 2139932T3
Authority
ES
Spain
Prior art keywords
therapeutic system
estradiol
system based
percutaneous therapeutic
hygroscopic additives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95929856T
Other languages
English (en)
Inventor
Walter Muller
Michael Horstmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Application granted granted Critical
Publication of ES2139932T3 publication Critical patent/ES2139932T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN SISTEMA TERAPEUTICO SUBCUTANEO CONTENIENDO ESTRADIOL COMO PRINCIPIO ACTIVO CON ESTRUCTURA ESTRATIFICADA, CON UN SOPORTE QUE ES IMPERMEABLE AL PRINCIPIO ACTIVO Y A LA HUMEDAD, UNA MATRIZ QUE CONTIENE EL PRINCIPIO ACTIVO Y OPCIONALMENTE UNA CAPA DE PROTECCION SEPARABLE QUE CUBRE LA MATRIZ; SE CARACTERIZA PORQUE LA MATRIZ CONTIENE GLICERINA, LA CUAL LLEVA UN MAXIMO DE 1 % EN PESO DE AGUA O NO LLEVA NADA DE AGUA.
ES95929856T 1994-08-20 1995-08-12 Sistema terapeutico percutaneo a base de estradiol con aditivos higroscopicos. Expired - Lifetime ES2139932T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4429667A DE4429667C2 (de) 1994-08-20 1994-08-20 Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung

Publications (1)

Publication Number Publication Date
ES2139932T3 true ES2139932T3 (es) 2000-02-16

Family

ID=6526231

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95929856T Expired - Lifetime ES2139932T3 (es) 1994-08-20 1995-08-12 Sistema terapeutico percutaneo a base de estradiol con aditivos higroscopicos.

Country Status (22)

Country Link
US (1) US5902602A (es)
EP (1) EP0776199B1 (es)
JP (1) JP3825799B2 (es)
KR (1) KR100401136B1 (es)
CN (1) CN1078461C (es)
AT (1) ATE185067T1 (es)
AU (1) AU695970B2 (es)
CZ (1) CZ289397B6 (es)
DE (2) DE4429667C2 (es)
DK (1) DK0776199T3 (es)
ES (1) ES2139932T3 (es)
FI (1) FI118720B (es)
GR (1) GR3032218T3 (es)
HU (1) HU226959B1 (es)
IL (1) IL114949A (es)
MX (1) MX9701302A (es)
NO (1) NO313984B1 (es)
NZ (1) NZ291813A (es)
PL (1) PL180965B1 (es)
SK (1) SK281626B6 (es)
WO (1) WO1996005814A1 (es)
ZA (1) ZA956925B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698217A (en) * 1995-05-31 1997-12-16 Minnesota Mining And Manufacturing Company Transdermal drug delivery device containing a desiccant
DE19600347A1 (de) * 1996-01-08 1997-07-10 Lohmann Therapie Syst Lts Hauthaftende pharmazeutische Zubereitung, insbesondere TTS zur Abgabe von 17-beta-Estradiol an den menschlichen Organismus
DE19713141A1 (de) * 1996-03-29 1997-10-30 Labtec Gmbh Transdermales System mit Melatonin
DE19827732A1 (de) * 1998-06-22 1999-12-23 Rottapharm Bv Transdermales System vom Matrix-Typ zur Abgabe von Wirkstoffen mit einer hohen Abgaberate von Steroid-Hormonen und die Verwendung eines derartigen Systems zur Hormonersatztherapie
US10493049B2 (en) 2016-02-10 2019-12-03 Niracle LLC Applicator-based transdermal drug delivery system for administration of drugs in combination with topical formulations
JP2024540701A (ja) 2021-11-08 2024-11-01 リー・ウェイヨン 患者に薬物を送達するための経皮薬物送達システム

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040861B1 (en) * 1979-01-11 1985-04-17 Key Pharmaceuticals, Inc. Polymeric diffusion matrix and method of its preparation
US4438139A (en) * 1979-08-14 1984-03-20 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing estrogens
CA1163559A (en) * 1980-07-09 1984-03-13 Alec D. Keith Polymeric diffusion matrix for administration of drugs
DE3333240A1 (de) * 1983-09-12 1985-03-28 Schering AG, 1000 Berlin und 4709 Bergkamen Mittel zur transdermalen applikation von arzneimittelwirkstoffen
ZA853488B (en) * 1984-05-10 1986-12-30 American Home Prod Transdermal dosage form
US4810499A (en) * 1984-10-01 1989-03-07 Biotek, Inc. Transdermal drug delivery system and method
US4788062A (en) * 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
US4816258A (en) * 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
US4764379A (en) * 1987-08-24 1988-08-16 Alza Corporation Transdermal drug delivery device with dual permeation enhancers
US4863738A (en) * 1987-11-23 1989-09-05 Alza Corporation Skin permeation enhancer compositions using glycerol monooleate
US4855294A (en) * 1988-09-06 1989-08-08 Theratech, Inc. Method for reducing skin irritation associated with drug/penetration enhancer compositions
DD279818A1 (de) * 1989-02-06 1990-06-20 Jenapharm Veb Verfahren zur herstellung eines medizinischen pflasters
DE3933460A1 (de) * 1989-10-06 1991-04-18 Lohmann Therapie Syst Lts Oestrogenhaltiges wirkstoffpflaster
AR246186A1 (es) * 1989-11-17 1994-07-29 Beta Pharm Co Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica.
DE4210165A1 (de) * 1991-07-30 1993-02-04 Schering Ag Transdermale therapeutische systeme
US5518734A (en) * 1991-09-25 1996-05-21 Beta Pharmaceuticals Co. Transdermal delivery system for estradiol and process for manufacturing said device
DE4210711A1 (de) * 1991-10-31 1993-05-06 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Transdermale therapeutische systeme mit kristallisationsinhibitoren
JPH08501529A (ja) * 1992-06-11 1996-02-20 セラテック・インコーポレイテッド 皮膚透過薬剤投与緩和のグリセリン使用
DE59409873D1 (de) * 1993-04-20 2001-10-25 Hexal Ag Wirkstoffpflaster

Also Published As

Publication number Publication date
KR970705381A (ko) 1997-10-09
WO1996005814A1 (de) 1996-02-29
EP0776199A1 (de) 1997-06-04
AU3344995A (en) 1996-03-14
ZA956925B (en) 1996-03-25
ATE185067T1 (de) 1999-10-15
NO970360D0 (no) 1997-01-28
CN1078461C (zh) 2002-01-30
US5902602A (en) 1999-05-11
SK281626B6 (sk) 2001-05-10
NO970360L (no) 1997-01-28
JP3825799B2 (ja) 2006-09-27
HUT77085A (hu) 1998-03-02
SK22097A3 (en) 1997-07-09
HU226959B1 (en) 2010-03-29
FI118720B (fi) 2008-02-29
CN1155835A (zh) 1997-07-30
IL114949A0 (en) 1995-12-08
IL114949A (en) 1998-12-27
MX9701302A (es) 1998-05-31
DE4429667A1 (de) 1996-02-22
AU695970B2 (en) 1998-08-27
GR3032218T3 (en) 2000-04-27
DK0776199T3 (da) 2000-04-10
JPH10504313A (ja) 1998-04-28
FI970701L (fi) 1997-02-19
FI970701A0 (fi) 1997-02-19
NZ291813A (en) 1998-01-26
KR100401136B1 (ko) 2004-03-31
NO313984B1 (no) 2003-01-13
CZ50997A3 (en) 1997-06-11
PL319013A1 (en) 1997-07-21
CZ289397B6 (cs) 2002-01-16
EP0776199B1 (de) 1999-09-29
PL180965B1 (pl) 2001-05-31
DE59506962D1 (de) 1999-11-04
DE4429667C2 (de) 1996-07-11

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