ES2140858T3 - Analogos de somatostatina multi-tirosinados. - Google Patents

Analogos de somatostatina multi-tirosinados.

Info

Publication number
ES2140858T3
ES2140858T3 ES96917939T ES96917939T ES2140858T3 ES 2140858 T3 ES2140858 T3 ES 2140858T3 ES 96917939 T ES96917939 T ES 96917939T ES 96917939 T ES96917939 T ES 96917939T ES 2140858 T3 ES2140858 T3 ES 2140858T3
Authority
ES
Spain
Prior art keywords
inclusive
whole
sub
independently
somatostatin analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96917939T
Other languages
English (en)
Inventor
David H Coy
Eugene A Woltering
M Sue O'dorisio
Thomas M O'dorisio
William A Murphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Hospital Inc
Louisiana State University Medical Center Foundation
Tulane University
Ohio State University Research Foundation
Original Assignee
Childrens Hospital Inc
Louisiana State University Medical Center Foundation
Tulane University
Ohio State University Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hospital Inc, Louisiana State University Medical Center Foundation, Tulane University, Ohio State University Research Foundation filed Critical Childrens Hospital Inc
Application granted granted Critical
Publication of ES2140858T3 publication Critical patent/ES2140858T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE REVELAN METODOS Y COMPOSICIONES PARA EL DIAGNOSTICO Y TRATAMIENTO DE ENFERMEDADES QUE SE ACOMPAÑAN DE LA EXPRESION ABERRANTE DE UN RECEPTOR DE SOMATOSTATINA (P. EJ., CANCER) O DE UNA MAYOR PRODUCCION DE UN FACTOR REGULABLE POR LA SOMATOSTATINA (P. EJ., ACROMEGALIA). LOS COMPUESTOS OBJETO DE LA INVENCION TIENEN LAS SIGUIENTES FORMULAS GENERALES: A) (Y) SUB,N+1}P, B) (Y) SUB,N} TATINA, Y ES D N ES UN ENTERO DE 1 A 32, AMBOS INCLUSIVE, CADA Q, INDEPENDIENTEMENTE, ES UN ENTERO DE L A 32, AMBOS INCLUSIVE, Y CADA S, INDEPENDIENTEMENTE, ES UN ENTERO DE L A 32, AMBOS INCLUSIVE, DONDE Q Y S PUEDEN SER IGUALES O DIFERENTES, Y X REPRESENTA LA FORMULA D O L NDE M ES UN ENTERO DE 1 A 10, AMBOS INCLUSIVE.
ES96917939T 1995-06-05 1996-06-03 Analogos de somatostatina multi-tirosinados. Expired - Lifetime ES2140858T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/462,223 US5597894A (en) 1995-06-05 1995-06-05 Multi-tyrosinated somatostatin analogs

Publications (1)

Publication Number Publication Date
ES2140858T3 true ES2140858T3 (es) 2000-03-01

Family

ID=23835647

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96917939T Expired - Lifetime ES2140858T3 (es) 1995-06-05 1996-06-03 Analogos de somatostatina multi-tirosinados.

Country Status (14)

Country Link
US (1) US5597894A (es)
EP (1) EP0833646B1 (es)
JP (1) JPH11507622A (es)
AT (1) ATE187075T1 (es)
AU (1) AU709506B2 (es)
CA (1) CA2222962A1 (es)
CZ (1) CZ386297A3 (es)
DE (1) DE69605419T2 (es)
DK (1) DK0833646T3 (es)
ES (1) ES2140858T3 (es)
GR (1) GR3032437T3 (es)
NZ (1) NZ310006A (es)
PT (1) PT833646E (es)
WO (1) WO1996039161A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US6492330B1 (en) * 1996-08-16 2002-12-10 National Institute Of Immunology Antiangiogenic drugs
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
AT405906B (de) * 1997-03-14 1999-12-27 Irene Dr Virgolini Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie
JP2001513114A (ja) * 1997-11-24 2001-08-28 ボード オブ スーパーバイザーズ オブ ルイジアナ ステイト ユニバーシティー アンド アグリカルチュラル アンド メカニカル カレッジ 放射性同位元素標識した化合物の組織への蓄積を促進するための方法
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
CA2246791A1 (en) * 1998-09-01 2000-03-01 Alison Buchan Treatment of endothelium with somatostatin analogues
US6465613B1 (en) * 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
US6600016B1 (en) * 1999-08-24 2003-07-29 Advanced Syntech Llc Multifunctionalized solid support resins for synthesis of combinatorial libraries and method for using the same
US6358491B1 (en) 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
US6579967B1 (en) 1999-12-14 2003-06-17 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
US6316414B1 (en) 2000-07-31 2001-11-13 Dabur Research Foundation Somatostatin analogs for the treatment of cancer
RU2352578C2 (ru) * 2001-03-06 2009-04-20 Иль Консорцио Феррара Ричерке Способ модуляции пролиферации клеток медуллярной карциномы щитовидной железы
US7019109B2 (en) * 2001-03-16 2006-03-28 The Salk Institute For Bilogical Studies SSTR1-selective analogs
US20020187099A1 (en) * 2001-05-16 2002-12-12 Rajesh Manchanda Stabilization of radionuclide-containing compositions
BR0212897A (pt) * 2001-09-21 2004-08-24 Univ Tulane Conjugados de análogos de somatostatina ou bombesina diagnóstica ou terapêutica e usos dos mesmos
US20030083241A1 (en) * 2001-11-01 2003-05-01 Young Charles W. Use of somatostatin receptor agonists in the treatment of human disorders of sleep hypoxia and oxygen deprivation
US7771727B2 (en) * 2002-03-01 2010-08-10 The Administrators Of The Tulane Educational Fund Conjugates of therapeutic or cytotoxic agents and biologically active peptides
US20030207811A1 (en) * 2002-05-03 2003-11-06 Schrier Bruce K. Method of treating retinopathy of prematurity using somatostatin analogs
AU2003259172A1 (en) * 2002-07-24 2004-02-09 The Salk Institute For Biological Studies Receptor (sstr4)- selective somatostatin analogs
JP2006522100A (ja) * 2003-03-10 2006-09-28 バイオジェン アイデック インク 標的化ペプチドに対するチオール媒介性薬物結合
US20070025910A1 (en) * 2005-07-29 2007-02-01 Norenberg Jeffrey P Anticancer therapy
WO2013007660A1 (en) 2011-07-08 2013-01-17 Biosynthema Inc. Enhanced in vivo targeting of radiolabelled peptides with the means of enzyme inhibitors
WO2014060606A1 (en) 2012-10-19 2014-04-24 Txp Pharma Gmbh Alpha- and gamma-msh analogues
HUE052977T2 (hu) * 2014-04-22 2021-06-28 Txp Pharma Gmbh Elágazó szénláncú aminosav-próbával rendelkezõ peptid analóg(ok)
WO2015162483A1 (en) * 2014-04-22 2015-10-29 Txp Pharma Gmbh Alpha- and gamma-msh analogues

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US4291022A (en) * 1975-03-11 1981-09-22 Sandoz Ltd. Organic compounds
US4133782A (en) * 1976-06-07 1979-01-09 The Salk Institute For Biological Studies Somatostatin analogs with dissociated biological activities
DE2860734D1 (en) * 1977-06-08 1981-09-03 Merck & Co Inc Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them
DK153293C (da) * 1977-07-22 1988-11-14 Stamicarbon Katalysator til dehydrogenering af organiske forbindelser, isaer aminer, thioler og alkoholer, og fremgangsmaade til fremstilling deraf
US4211693A (en) * 1977-09-20 1980-07-08 The Salk Institute For Biological Studies Peptides with para-substituted phenylalanine
LU78191A1 (de) * 1977-09-28 1979-05-25 Ciba Geigy Ag Verfahren zur herstellung von neuen cyclopeptiden
US4190648A (en) * 1979-03-13 1980-02-26 Merck & Co., Inc. Peptides having somatostatin activity
US4316890A (en) * 1979-03-16 1982-02-23 Ciba-Geigy Corporation Peptides and processes for the manufacture thereof
US4328214A (en) * 1979-07-04 1982-05-04 Ciba-Geigy Corporation Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture
US4230617A (en) * 1979-07-05 1980-10-28 American Home Products Corporation Somatostatin analogues
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
CY1327A (en) * 1979-11-27 1986-06-27 Sandoz Ag Novel polypeptides,processes for their production,pharmaceutical compositions comprising said polypeptides and their use
US4369179A (en) * 1979-12-14 1983-01-18 Ciba-Geigy Corporation Acylpeptides
DD155985A5 (de) * 1979-12-21 1982-07-21 Ciba Geigy Ag Verfahren zur herstellung cyclischr octapeptide
DK81082A (da) * 1981-03-06 1982-09-07 Sandoz Ag Fremgangsmaade til fremstilling af polypeptider
US4360516A (en) * 1981-04-13 1982-11-23 Merck & Co., Inc. Modified D-retro cyclic hexapeptide somatostatin analogs
DE3264693D1 (en) * 1981-12-24 1985-08-14 Ciba Geigy Ag Cyclic octapeptides and pharmaceutical compositions thereof, and processes for their production and use
US4486415A (en) * 1983-08-15 1984-12-04 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4485101A (en) * 1983-10-11 1984-11-27 Administrators Of The Tulane Educational Fund Peptides
US4522813A (en) * 1983-10-27 1985-06-11 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4585755A (en) * 1985-04-29 1986-04-29 Merck & Co., Inc. Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
US5070878A (en) * 1988-11-14 1991-12-10 Neoprobe Corporation Detector and localizer for low energy radiation emissions
US4801803A (en) * 1987-03-17 1989-01-31 Neoprobe Corporation Detector and localizer for low energy radiation emissions
NO893088L (no) * 1988-08-18 1990-02-19 Syntex Inc Fremgangsmaate for fremstilling av terapeutisk virksomme somatostatinlignende cykliske peptidforbindelser.
US4889991A (en) * 1988-09-23 1989-12-26 Neoprobe Corporation Gamma radiation detector with enhanced signal treatment
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
ATE120374T1 (de) * 1989-07-20 1995-04-15 Sandoz Ag Markierte polypeptidderivate.
WO1991009056A1 (en) * 1989-12-08 1991-06-27 The Administrators Of The Tulane Educational Fund Octapeptide analogs of somatostatin having threonine at the sixth position
US5008546A (en) * 1990-06-18 1991-04-16 The Regents Of The University Of California Intraoperative beta probe and method of using the same
HU207104B (en) * 1991-01-25 1993-03-01 Biosignal Kutato Fejlesztoe Kf Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
CA2079896A1 (en) * 1991-02-08 1992-08-09 Arthur E. Bogden Method of treating benign and malignant proliferative skin disease
US5462926A (en) * 1992-07-27 1995-10-31 Biomeasure, Inc. Neuromedin B receptor antagonists which demonstrate selectivity
US5590656A (en) * 1992-09-15 1997-01-07 The Ohio State University Research Foundation Application of peptide/cell receptor kinetics utilizing radiolabeled somatostatin congeners in the in situ, in vivo detection and differentiation of neoplastic tissue
NO940080L (no) * 1993-01-12 1994-07-13 Sandoz Ag Polypeptider , fremgangsmåte for deres fremstilling og farmasöytiske preparater derav

Also Published As

Publication number Publication date
DE69605419T2 (de) 2000-06-08
AU709506B2 (en) 1999-09-02
PT833646E (pt) 2000-04-28
WO1996039161A1 (en) 1996-12-12
NZ310006A (en) 1998-12-23
AU6031796A (en) 1996-12-24
US5597894A (en) 1997-01-28
EP0833646B1 (en) 1999-12-01
EP0833646A1 (en) 1998-04-08
CA2222962A1 (en) 1996-12-12
GR3032437T3 (en) 2000-05-31
DE69605419D1 (de) 2000-01-05
JPH11507622A (ja) 1999-07-06
ATE187075T1 (de) 1999-12-15
CZ386297A3 (cs) 1998-07-15
DK0833646T3 (da) 2000-05-08
EP0833646A4 (en) 1998-05-27

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