ES2141276T3 - Derivados de ciclohexano, procedimiento para su preparacion y la utilizacion como inhibidores de glucosa-6-fosfatasa. - Google Patents
Derivados de ciclohexano, procedimiento para su preparacion y la utilizacion como inhibidores de glucosa-6-fosfatasa.Info
- Publication number
- ES2141276T3 ES2141276T3 ES95106760T ES95106760T ES2141276T3 ES 2141276 T3 ES2141276 T3 ES 2141276T3 ES 95106760 T ES95106760 T ES 95106760T ES 95106760 T ES95106760 T ES 95106760T ES 2141276 T3 ES2141276 T3 ES 2141276T3
- Authority
- ES
- Spain
- Prior art keywords
- sup
- glucose
- phosphatase
- inhibitors
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical class C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 title abstract 2
- 102000003638 Glucose-6-Phosphatase Human genes 0.000 title 1
- 108010086800 Glucose-6-Phosphatase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 208000000381 Familial Hypophosphatemia Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE DESCRIBE DERIVADOS CICLOHEXANO DE LA FORMULA I DONDE R{SUP.2} ES O - C{SUB.3} - C{SUB.5} - ALQUIL (R{SUP.11}, DONDE LA PARTE ALQUIL ES CICLICA O RAMIFICADA, DE CADENA RECTA Y R{SUP.11} ES FENIL, QUE ES SUSTITUIDO EVENTUALMENTE EN LA POSICION 4 CON FLUOR, CLORO O METIL, Y R{SUP.4} Y R{SUP.5} SON IGUALES O DIFERENTES Y REPRESENTAN H O OH ASI COMO SUS SALES TOLERABLES FISIOLOGICAMENTE. LOS COMPUESTOS POSEEN PROPIEDADES FARMACOLOGICAS VALIOSAS Y PUEDEN POR ELLO SER UTILIZADAS COMO MEDICAMENTOS PARA TRATAMIENTO DE ENFERMEDADES, QUE ESTAN LIGADAS A UNA ACTIVIDAD ELEVADA DEL SISTEMA GLUCOSA - 6 - FOSFATASA O CON UNA PRODUCCION DE GLUCOSA ELEVADA DEL HIGADO, O TRATAMIENTO DE LA DIABETES TIPO II, NO DEPENDIENTE DE INSULINA O DIABETES SENIL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4416433A DE4416433A1 (de) | 1994-05-10 | 1994-05-10 | Cyclohexan-Derivate, Verfahren zu ihrer Herstellung und die Verwendung der Verbindungen zur Behandlung von Krankheiten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2141276T3 true ES2141276T3 (es) | 2000-03-16 |
Family
ID=6517746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95106760T Expired - Lifetime ES2141276T3 (es) | 1994-05-10 | 1995-05-04 | Derivados de ciclohexano, procedimiento para su preparacion y la utilizacion como inhibidores de glucosa-6-fosfatasa. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5739147A (es) |
| EP (1) | EP0682024B1 (es) |
| JP (1) | JP3790564B2 (es) |
| KR (1) | KR100355690B1 (es) |
| CN (1) | CN1043643C (es) |
| AT (1) | ATE187454T1 (es) |
| AU (1) | AU683148B2 (es) |
| CA (1) | CA2149007C (es) |
| CZ (1) | CZ288443B6 (es) |
| DE (2) | DE4416433A1 (es) |
| DK (1) | DK0682024T3 (es) |
| ES (1) | ES2141276T3 (es) |
| FI (1) | FI110097B (es) |
| GR (1) | GR3032519T3 (es) |
| HU (1) | HU220865B1 (es) |
| NO (1) | NO304314B1 (es) |
| NZ (1) | NZ272082A (es) |
| PL (1) | PL180074B1 (es) |
| RU (1) | RU2140416C1 (es) |
| TW (1) | TW421648B (es) |
| UA (1) | UA41340C2 (es) |
| ZA (1) | ZA953726B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW526202B (en) | 1998-11-27 | 2003-04-01 | Shionogi & Amp Co | Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity |
| DK1248604T4 (da) | 2000-01-21 | 2012-05-21 | Novartis Ag | Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler |
| EP1385549A2 (en) * | 2001-03-12 | 2004-02-04 | Novartis AG | Combination of nateglinide or repaglinide with at least one further antidiabetic compound |
| FR2852957B1 (fr) * | 2003-03-31 | 2005-06-10 | Sod Conseils Rech Applic | Nouveaux derives d'imidazo-pyridine et leur utilisation en tant que medicament |
| PL1931350T5 (pl) | 2005-09-14 | 2021-11-15 | Takeda Pharmaceutical Company Limited | Podanie inhibitorów dipeptydylo-peptydazy |
| WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
| WO2011097079A1 (en) | 2010-02-03 | 2011-08-11 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60243016A (ja) * | 1984-05-17 | 1985-12-03 | Tsumura Juntendo Inc | 抗インフルエンザウイルス剤 |
| TW255880B (es) * | 1992-09-09 | 1995-09-01 | Hoechst Ag | |
| TW399041B (en) * | 1992-09-09 | 2000-07-21 | Hoechst Ag | Substituted cyclohexane derivatives, the preparation and the use for treating diseases |
| DE4408082A1 (de) * | 1994-03-10 | 1995-09-14 | Hoechst Ag | Substituierte Propan-Derivate, Verfahren zu ihrer Herstellung und die Anwendung der Verbindungen zur Behandlung von Krankheiten |
| DE4413402A1 (de) * | 1994-04-18 | 1995-10-19 | Hoechst Ag | Verfahren zur Herstellung von Zwischenprodukten für die Synthese von Glucose-6-Phosphatase-Inhibitoren sowie neue Zwischenprodukte |
-
1994
- 1994-05-10 DE DE4416433A patent/DE4416433A1/de not_active Withdrawn
-
1995
- 1995-04-13 TW TW084103596A patent/TW421648B/zh not_active IP Right Cessation
- 1995-05-04 ES ES95106760T patent/ES2141276T3/es not_active Expired - Lifetime
- 1995-05-04 DE DE59507361T patent/DE59507361D1/de not_active Expired - Lifetime
- 1995-05-04 EP EP95106760A patent/EP0682024B1/de not_active Expired - Lifetime
- 1995-05-04 AT AT95106760T patent/ATE187454T1/de not_active IP Right Cessation
- 1995-05-04 DK DK95106760T patent/DK0682024T3/da active
- 1995-05-05 UA UA95058403A patent/UA41340C2/uk unknown
- 1995-05-08 AU AU17923/95A patent/AU683148B2/en not_active Ceased
- 1995-05-08 FI FI952203A patent/FI110097B/fi not_active IP Right Cessation
- 1995-05-08 NZ NZ272082A patent/NZ272082A/en unknown
- 1995-05-08 CN CN95106014A patent/CN1043643C/zh not_active Expired - Fee Related
- 1995-05-09 CA CA002149007A patent/CA2149007C/en not_active Expired - Fee Related
- 1995-05-09 CZ CZ19951195A patent/CZ288443B6/cs not_active IP Right Cessation
- 1995-05-09 PL PL95308521A patent/PL180074B1/pl not_active IP Right Cessation
- 1995-05-09 KR KR1019950011205A patent/KR100355690B1/ko not_active Expired - Fee Related
- 1995-05-09 JP JP11035395A patent/JP3790564B2/ja not_active Expired - Fee Related
- 1995-05-09 ZA ZA953726A patent/ZA953726B/xx unknown
- 1995-05-09 HU HU9501368A patent/HU220865B1/hu not_active IP Right Cessation
- 1995-05-09 NO NO951820A patent/NO304314B1/no not_active IP Right Cessation
- 1995-05-10 RU RU95107147/04A patent/RU2140416C1/ru not_active IP Right Cessation
-
1997
- 1997-05-21 US US08/861,120 patent/US5739147A/en not_active Expired - Lifetime
-
2000
- 2000-01-31 GR GR20000400215T patent/GR3032519T3/el not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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