ES2141462T3 - Dispositivo de separacion de toxinas en particular de citoquinas. - Google Patents
Dispositivo de separacion de toxinas en particular de citoquinas.Info
- Publication number
- ES2141462T3 ES2141462T3 ES96830049T ES96830049T ES2141462T3 ES 2141462 T3 ES2141462 T3 ES 2141462T3 ES 96830049 T ES96830049 T ES 96830049T ES 96830049 T ES96830049 T ES 96830049T ES 2141462 T3 ES2141462 T3 ES 2141462T3
- Authority
- ES
- Spain
- Prior art keywords
- plasmafiltrate
- ultrafiltrate
- column
- cytokines
- ionic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004127 Cytokines Human genes 0.000 title abstract 2
- 108090000695 Cytokines Proteins 0.000 title abstract 2
- 238000000926 separation method Methods 0.000 title 1
- 239000003053 toxin Substances 0.000 title 1
- 231100000765 toxin Toxicity 0.000 title 1
- 108700012359 toxins Proteins 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 4
- 238000010521 absorption reaction Methods 0.000 abstract 2
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 239000002250 absorbent Substances 0.000 abstract 1
- 230000002745 absorbent Effects 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229920005990 polystyrene resin Polymers 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3616—Batch-type treatment
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE REALIZA UNA RETIRADA EFECTIVA DE CITOQUINAS EN PACIENTES AGUDOS MEDIANTE EL SOMETIMIENTO PRIMERO DE LA SANGRE A PURIFICACION MEDIANTE ULTRAFILTRACION O PLASMAFILTRACION; SEGUIDAMENTE LA ALIMENTACION DE ULTRAFILTRADO O PLASMAFILTRADO A TRAVES DE UNA COLUMNA DE ABSORCION EN EL MATERIAL ABSORBENTE ES CARBON ACTIVADO NO CUBIERTO Y/O RESINAS DE POLIESTIRENO CON INTERCAMBIO IONICO O HIDROFOBICO, COMO AMBERLITE{SUP,TM}, AMBERCHROM{SUP,TM}, AMBERSORB{SUP,TM}, NORMALMENTE USADOS EN LA INDUSTRIA ALIMENTARIA; Y ENTONCES LA ADICION DEL ULTRAFILTRADO O PLASMAFILTRADO PURIFICADO CORRIENTE ABAJO RECUPERADO Y ACLARADO; PREFERIBLEMENTE EL ULTRAFILTRADO O PLASMAFILTRADO SE SOMETE A UNA FASE DE ABSORCION DOBLE, PRIMERO A TRAVES DE UNA COLUMNA DE CARBON ACTIVADO, Y POSTERIORMENTE A TRAVES DE UNA COLUMNA EQUIPADA CON RESINA DE INTERCAMBIO IONICO O HIDROFOBICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96830049A EP0787500B1 (en) | 1996-02-06 | 1996-02-06 | Device for extracorporeal removal of toxins, in particular cytokines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2141462T3 true ES2141462T3 (es) | 2000-03-16 |
Family
ID=8225805
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96830049T Expired - Lifetime ES2141462T3 (es) | 1996-02-06 | 1996-02-06 | Dispositivo de separacion de toxinas en particular de citoquinas. |
| ES99109637T Expired - Lifetime ES2234183T3 (es) | 1996-02-06 | 1996-02-06 | Separacion por absorcion de citoquinas de un paciente afectado por el fallo agudo de un organo. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99109637T Expired - Lifetime ES2234183T3 (es) | 1996-02-06 | 1996-02-06 | Separacion por absorcion de citoquinas de un paciente afectado por el fallo agudo de un organo. |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP0787500B1 (es) |
| CN (1) | CN1159951A (es) |
| AR (1) | AR005728A1 (es) |
| BR (1) | BR9700196B8 (es) |
| DE (2) | DE69634141T2 (es) |
| ES (2) | ES2141462T3 (es) |
| GR (1) | GR3032624T3 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6620382B1 (en) * | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
| US6287516B1 (en) * | 1998-07-10 | 2001-09-11 | Immunocept, L.L.C. | Hemofiltration systems, methods, and devices used to treat inflammatory mediator related disease |
| US6774102B1 (en) | 1999-09-29 | 2004-08-10 | Gambro Dialysatoren Gmbh & Co. Kg | Extracorporeal endotoxin removal method |
| US7291122B2 (en) * | 2000-03-24 | 2007-11-06 | Immunocept, L.L.C. | Hemofiltration methods for treatment of diseases in a mammal |
| US8535258B2 (en) | 2000-03-24 | 2013-09-17 | Immunocept, L.L.C. | Hemofiltration methods for treatment of diseases in a mammal |
| US6736972B1 (en) | 2000-03-24 | 2004-05-18 | Immunocept, L.L.C. | Method and system for providing therapeutic agents with hemofiltration for reducing inflammatory mediator related diseases |
| US6787040B2 (en) | 2000-05-16 | 2004-09-07 | Immunocept, L.L.C. | Method and system for colloid exchange therapy |
| US8597516B2 (en) | 2000-05-16 | 2013-12-03 | Immunocept, L.L.C. | Methods and systems for colloid exchange therapy |
| DE10118446A1 (de) * | 2001-04-12 | 2002-10-17 | Thomas Hartung | Prüfverfahren zur Untersuchung fließfähiger Medien auf Gehalte an mikrobiellen Toxinen |
| WO2003009885A2 (en) * | 2001-07-25 | 2003-02-06 | Immunocept, L.L.C. | Hemofiltration systems, methods and devices used to treat inflammatory mediator related disease |
| US20040228829A1 (en) * | 2003-03-11 | 2004-11-18 | Roberts Craig P. | Plasma detoxification system and methods of use |
| US8038638B2 (en) | 2004-02-23 | 2011-10-18 | Hemolife Medical, Inc. | Plasma detoxification and volume control system and methods of use |
| GB0408521D0 (en) * | 2004-04-16 | 2004-05-19 | Carbon Technologies Nv | Treatment of sepsis |
| JP2008503273A (ja) | 2004-06-21 | 2008-02-07 | ヘモライフ メディカル, インコーポレイテッド | 血漿無毒化および体積制御システムならびに使用方法 |
| US8339447B2 (en) | 2004-10-21 | 2012-12-25 | Truevision Systems, Inc. | Stereoscopic electronic microscope workstation |
| DE102004054747A1 (de) * | 2004-11-12 | 2006-05-24 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zur Abreicherung wenigstens einer Komponente eines fluiden Mediums |
| EP1886704B1 (en) * | 2005-03-31 | 2016-09-28 | Toray Industries, Inc. | Adsorbent and column for extracorporeal circulation |
| ES2348189T3 (es) * | 2007-01-12 | 2010-12-01 | Bellco S.R.L. | Kit para el tratamiento de enfermedades relacionadas con inflamacion sistematica. |
| US8672869B2 (en) | 2007-10-30 | 2014-03-18 | Bellco S.R.L. | Kit, system and method of treating myeloma patients |
| JP5249737B2 (ja) * | 2008-12-10 | 2013-07-31 | 旭化成メディカル株式会社 | 血液からウイルス及びサイトカインを除去するシステム |
| US20130256227A1 (en) * | 2011-09-12 | 2013-10-03 | Medtronic, Inc. | Polystyrene sulfonate resin for use with a hemodialysis system having a controlled compliance dialysis circuit |
| EP2679302A1 (de) | 2012-06-28 | 2014-01-01 | Zentrum für biomedizinische Technologie der Donau- Universität Krems | Selektives Sorptionsmittel für die extrakorporale Blutreinigung |
| CN103223197A (zh) * | 2013-04-23 | 2013-07-31 | 天津市阳权医疗器械有限公司 | 用于毒血症血液净化的医疗器械组合装置 |
| MX376935B (es) * | 2013-06-24 | 2025-03-07 | Exthera Medical Corp | Sistema de filtración de sangre que contiene substrato recubierto con manosa. |
| EP3185926B1 (de) | 2014-08-26 | 2018-11-28 | 3M Innovative Properties Company | System zur entfernung von proinflammatorischen mediatoren sowie von granulozyten und monozyten aus blut |
| TWI845594B (zh) | 2019-01-11 | 2024-06-21 | 瑞士商馬可控股股份有限公司 | 血漿解毒方法及系統 |
| CN116618027B (zh) * | 2022-02-10 | 2025-11-14 | 江苏恰瑞生物科技有限公司 | 一种提升树脂微球吸附量的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2722025A1 (de) * | 1977-05-16 | 1978-11-30 | Hoechst Ag | Membraneinheit, vorrichtung mit membraneinheit und verfahren zur blutreinigung |
| WO1990012632A1 (en) * | 1989-04-19 | 1990-11-01 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Process for removing c-reactive protein and anti-phosphorylcholine antibodies from biological fluids |
| IT1241588B (it) * | 1990-03-09 | 1994-01-19 | Sorin Biomedica Emodialisi S R | Apparecchiatura per la depurazione del sangue, particolarmente per il trattamento di pazienti affetti da insufficienza renale, e procedimentoo per produzione di liquido di reinfusione per emodiafiltrazione (hdf) |
| JP3276456B2 (ja) * | 1993-04-28 | 2002-04-22 | 旭メディカル株式会社 | エンドトキシン及び/又はサイトカインの吸着材及び該吸着材を用いた浄化血液の取得装置 |
-
1996
- 1996-02-06 EP EP96830049A patent/EP0787500B1/en not_active Expired - Lifetime
- 1996-02-06 DE DE69634141T patent/DE69634141T2/de not_active Expired - Lifetime
- 1996-02-06 EP EP99109637A patent/EP0958839B1/en not_active Expired - Lifetime
- 1996-02-06 ES ES96830049T patent/ES2141462T3/es not_active Expired - Lifetime
- 1996-02-06 ES ES99109637T patent/ES2234183T3/es not_active Expired - Lifetime
- 1996-02-06 DE DE69605395T patent/DE69605395T2/de not_active Expired - Lifetime
-
1997
- 1997-02-05 BR BRPI9700196A patent/BR9700196B8/pt not_active IP Right Cessation
- 1997-02-06 CN CN97100704A patent/CN1159951A/zh active Pending
- 1997-02-06 AR ARP970100469A patent/AR005728A1/es unknown
-
2000
- 2000-02-10 GR GR20000400322T patent/GR3032624T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9700196B8 (pt) | 2021-06-22 |
| ES2234183T3 (es) | 2005-06-16 |
| GR3032624T3 (en) | 2000-05-31 |
| DE69634141D1 (de) | 2005-02-03 |
| EP0787500A1 (en) | 1997-08-06 |
| BR9700196B1 (pt) | 2014-03-18 |
| DE69634141T2 (de) | 2005-12-22 |
| EP0958839B1 (en) | 2004-12-29 |
| BR9700196A (pt) | 1998-09-29 |
| EP0958839A3 (en) | 1999-12-15 |
| DE69605395T2 (de) | 2000-06-08 |
| EP0958839A2 (en) | 1999-11-24 |
| DE69605395D1 (de) | 2000-01-05 |
| AR005728A1 (es) | 1999-07-14 |
| EP0787500B1 (en) | 1999-12-01 |
| CN1159951A (zh) | 1997-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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