ES2142586T3 - Maleato de (r)-(z)-1-azabiciclo(2.2.1)heptan-3-ona,o-(3-(3-metoxifenil)-2-propinil)oxima como un agente farmaceutico. - Google Patents

Maleato de (r)-(z)-1-azabiciclo(2.2.1)heptan-3-ona,o-(3-(3-metoxifenil)-2-propinil)oxima como un agente farmaceutico.

Info

Publication number
ES2142586T3
ES2142586T3 ES96915757T ES96915757T ES2142586T3 ES 2142586 T3 ES2142586 T3 ES 2142586T3 ES 96915757 T ES96915757 T ES 96915757T ES 96915757 T ES96915757 T ES 96915757T ES 2142586 T3 ES2142586 T3 ES 2142586T3
Authority
ES
Spain
Prior art keywords
propinil
metoxifenil
azabiciclo
ona
heptan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96915757T
Other languages
English (en)
Inventor
Howard Yoshihisa Ando
Stephen Douglas Barrett
Juan Carlos Jaen
Steven Edward Rose
Haile Tecle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2142586T3 publication Critical patent/ES2142586T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA SAL MALEATO [1:1] DE [R) - (Z)] - 1 AZABICICLO[2,2,1]HEPTAN - 3 - ONA,O - [3 - (3 - METOXIFENIL) -2 PROPINIL]OXIMA, UN CONOCIDO AGONISTA MUSCARINICO, TIENE PROPIEDADES UNICAS FRENTE A OTRAS SALES DEL COMPUESTO, CONVIRTIENDOLO EN UN PRODUCTO FARMACEUTICO DE INTERES.
ES96915757T 1995-06-07 1996-05-13 Maleato de (r)-(z)-1-azabiciclo(2.2.1)heptan-3-ona,o-(3-(3-metoxifenil)-2-propinil)oxima como un agente farmaceutico. Expired - Lifetime ES2142586T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/474,622 US5534522A (en) 1995-06-07 1995-06-07 (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent

Publications (1)

Publication Number Publication Date
ES2142586T3 true ES2142586T3 (es) 2000-04-16

Family

ID=23884337

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96915757T Expired - Lifetime ES2142586T3 (es) 1995-06-07 1996-05-13 Maleato de (r)-(z)-1-azabiciclo(2.2.1)heptan-3-ona,o-(3-(3-metoxifenil)-2-propinil)oxima como un agente farmaceutico.

Country Status (24)

Country Link
US (1) US5534522A (es)
EP (1) EP0839148B1 (es)
JP (1) JPH11506723A (es)
KR (1) KR100383031B1 (es)
CN (1) CN1063181C (es)
AT (1) ATE187967T1 (es)
BG (1) BG63571B1 (es)
CA (1) CA2219753A1 (es)
CZ (1) CZ286528B6 (es)
DE (1) DE69605800T2 (es)
DK (1) DK0839148T3 (es)
EA (1) EA000381B1 (es)
EE (1) EE03971B1 (es)
ES (1) ES2142586T3 (es)
GE (1) GEP19991874B (es)
GR (1) GR3032772T3 (es)
HU (1) HUP9802499A3 (es)
NO (1) NO308901B1 (es)
NZ (1) NZ307946A (es)
PL (1) PL323796A1 (es)
SK (1) SK282824B6 (es)
UA (1) UA46032C2 (es)
WO (1) WO1996040687A1 (es)
ZA (1) ZA964764B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US7544681B2 (en) 2001-09-27 2009-06-09 Ramot At Tel Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
EP1670785B1 (en) * 2003-10-02 2010-07-07 Pharmacia & Upjohn Company LLC Salts and polymorphs of a pyrrole-substituted indolinone compound
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
JP5284779B2 (ja) * 2005-06-07 2013-09-11 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド コンジュゲート化された向精神薬の新規な塩およびその調製方法
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1928437A2 (en) * 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2051735B1 (en) 2006-07-17 2012-08-29 Ramot, at Tel Aviv University Ltd. Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use treating pain and other cns disorders
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2009101616A1 (en) 2008-02-11 2009-08-20 Ramot At Tel Aviv University Ltd. Novel conjugates for treating neurodegenerative diseases and disorders
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2011070579A1 (en) 2009-12-09 2011-06-16 Biolinerx Ltd. Methods of improving cognitive functions
US8377929B2 (en) 2010-02-24 2013-02-19 Ramot At Tel-Aviv University Ltd. Crystalline forms of the tri-mesylate salt of perphenazine-GABA and process of producing the same
WO2012038963A1 (en) 2010-09-22 2012-03-29 Ramot At Tel-Aviv University Ltd. An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same
JP5997931B2 (ja) * 2011-05-25 2016-09-28 石原産業株式会社 農園芸用殺菌剤組成物及び植物病害の防除方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346911A (en) * 1990-03-06 1994-09-13 Warner-Lambert Company Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment
US5306718A (en) * 1990-03-06 1994-04-26 Warner-Lambert Company Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment

Also Published As

Publication number Publication date
EA199800007A1 (ru) 1998-06-25
CZ381797A3 (cs) 1998-05-13
HK1018055A1 (en) 1999-12-10
HUP9802499A3 (en) 1999-06-28
KR19990022572A (ko) 1999-03-25
BG102078A (en) 1998-11-30
NO975704L (no) 1998-01-30
US5534522A (en) 1996-07-09
CN1186493A (zh) 1998-07-01
DE69605800T2 (de) 2000-11-16
NO975704D0 (no) 1997-12-05
BG63571B1 (bg) 2002-05-31
AU5744996A (en) 1996-12-30
AU697954B2 (en) 1998-10-22
CZ286528B6 (cs) 2000-05-17
GEP19991874B (en) 1999-12-06
CA2219753A1 (en) 1996-12-19
SK164497A3 (en) 1998-06-03
KR100383031B1 (ko) 2003-10-17
SK282824B6 (sk) 2002-12-03
DK0839148T3 (da) 2000-05-22
JPH11506723A (ja) 1999-06-15
PL323796A1 (en) 1998-04-27
NZ307946A (en) 2001-03-30
UA46032C2 (uk) 2002-05-15
NO308901B1 (no) 2000-11-13
EE9700316A (et) 1998-06-15
EA000381B1 (ru) 1999-06-24
WO1996040687A1 (en) 1996-12-19
HUP9802499A2 (hu) 1999-04-28
DE69605800D1 (de) 2000-01-27
GR3032772T3 (en) 2000-06-30
EE03971B1 (et) 2003-02-17
EP0839148B1 (en) 1999-12-22
CN1063181C (zh) 2001-03-14
EP0839148A1 (en) 1998-05-06
ZA964764B (en) 1997-01-08
ATE187967T1 (de) 2000-01-15

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