ES2142586T3 - Maleato de (r)-(z)-1-azabiciclo(2.2.1)heptan-3-ona,o-(3-(3-metoxifenil)-2-propinil)oxima como un agente farmaceutico. - Google Patents

Maleato de (r)-(z)-1-azabiciclo(2.2.1)heptan-3-ona,o-(3-(3-metoxifenil)-2-propinil)oxima como un agente farmaceutico.

Info

Publication number
ES2142586T3
ES2142586T3 ES96915757T ES96915757T ES2142586T3 ES 2142586 T3 ES2142586 T3 ES 2142586T3 ES 96915757 T ES96915757 T ES 96915757T ES 96915757 T ES96915757 T ES 96915757T ES 2142586 T3 ES2142586 T3 ES 2142586T3
Authority
ES
Spain
Prior art keywords
propinil
metoxifenil
azabiciclo
ona
heptan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96915757T
Other languages
English (en)
Inventor
Howard Yoshihisa Ando
Stephen Douglas Barrett
Juan Carlos Jaen
Steven Edward Rose
Haile Tecle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2142586T3 publication Critical patent/ES2142586T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA SAL MALEATO [1:1] DE [R) - (Z)] - 1 AZABICICLO[2,2,1]HEPTAN - 3 - ONA,O - [3 - (3 - METOXIFENIL) -2 PROPINIL]OXIMA, UN CONOCIDO AGONISTA MUSCARINICO, TIENE PROPIEDADES UNICAS FRENTE A OTRAS SALES DEL COMPUESTO, CONVIRTIENDOLO EN UN PRODUCTO FARMACEUTICO DE INTERES.
ES96915757T 1995-06-07 1996-05-13 Maleato de (r)-(z)-1-azabiciclo(2.2.1)heptan-3-ona,o-(3-(3-metoxifenil)-2-propinil)oxima como un agente farmaceutico. Expired - Lifetime ES2142586T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/474,622 US5534522A (en) 1995-06-07 1995-06-07 (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent

Publications (1)

Publication Number Publication Date
ES2142586T3 true ES2142586T3 (es) 2000-04-16

Family

ID=23884337

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96915757T Expired - Lifetime ES2142586T3 (es) 1995-06-07 1996-05-13 Maleato de (r)-(z)-1-azabiciclo(2.2.1)heptan-3-ona,o-(3-(3-metoxifenil)-2-propinil)oxima como un agente farmaceutico.

Country Status (24)

Country Link
US (1) US5534522A (es)
EP (1) EP0839148B1 (es)
JP (1) JPH11506723A (es)
KR (1) KR100383031B1 (es)
CN (1) CN1063181C (es)
AT (1) ATE187967T1 (es)
BG (1) BG63571B1 (es)
CA (1) CA2219753A1 (es)
CZ (1) CZ286528B6 (es)
DE (1) DE69605800T2 (es)
DK (1) DK0839148T3 (es)
EA (1) EA000381B1 (es)
EE (1) EE03971B1 (es)
ES (1) ES2142586T3 (es)
GE (1) GEP19991874B (es)
GR (1) GR3032772T3 (es)
HU (1) HUP9802499A3 (es)
NO (1) NO308901B1 (es)
NZ (1) NZ307946A (es)
PL (1) PL323796A1 (es)
SK (1) SK282824B6 (es)
UA (1) UA46032C2 (es)
WO (1) WO1996040687A1 (es)
ZA (1) ZA964764B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
US6528529B1 (en) * 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US7544681B2 (en) 2001-09-27 2009-06-09 Ramot At Tel Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
MXPA06003661A (es) * 2003-10-02 2006-06-05 Pharmacia & Upjohn Co Llc Sales y polimorfos de un compuesto de indolinona sustituido con pirrol.
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
ES2400772T3 (es) * 2005-06-07 2013-04-12 Ramot At Tel Aviv University Ltd. Sales novedosas de fármacos psicotrópicos conjugados y procedimientos para la preparación de las mismas
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
ES2393933T3 (es) 2006-07-17 2013-01-02 Ramot, At Tel Aviv University Ltd. Conjugados que comprenden un fármaco psicotrópico o un agonista GABA y un ácido orgánico y su uso para el tratamiento del dolor y otros transtornos del SNC
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US8207369B2 (en) 2008-02-11 2012-06-26 Ramot At Tel-Aviv University Ltd. Conjugates for treating neurodegenerative diseases and disorders
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2509603A1 (en) 2009-12-09 2012-10-17 Biolinerx Ltd. Methods of improving cognitive functions
US8377929B2 (en) 2010-02-24 2013-02-19 Ramot At Tel-Aviv University Ltd. Crystalline forms of the tri-mesylate salt of perphenazine-GABA and process of producing the same
WO2012038963A1 (en) 2010-09-22 2012-03-29 Ramot At Tel-Aviv University Ltd. An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same
JP5997931B2 (ja) * 2011-05-25 2016-09-28 石原産業株式会社 農園芸用殺菌剤組成物及び植物病害の防除方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346911A (en) * 1990-03-06 1994-09-13 Warner-Lambert Company Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment
US5306718A (en) * 1990-03-06 1994-04-26 Warner-Lambert Company Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment

Also Published As

Publication number Publication date
EP0839148A1 (en) 1998-05-06
US5534522A (en) 1996-07-09
HK1018055A1 (en) 1999-12-10
SK282824B6 (sk) 2002-12-03
EA000381B1 (ru) 1999-06-24
NO308901B1 (no) 2000-11-13
UA46032C2 (uk) 2002-05-15
NO975704L (no) 1998-01-30
KR19990022572A (ko) 1999-03-25
DK0839148T3 (da) 2000-05-22
NZ307946A (en) 2001-03-30
KR100383031B1 (ko) 2003-10-17
PL323796A1 (en) 1998-04-27
BG102078A (en) 1998-11-30
EE03971B1 (et) 2003-02-17
GEP19991874B (en) 1999-12-06
CN1063181C (zh) 2001-03-14
CZ381797A3 (cs) 1998-05-13
HUP9802499A3 (en) 1999-06-28
CZ286528B6 (cs) 2000-05-17
CN1186493A (zh) 1998-07-01
ATE187967T1 (de) 2000-01-15
AU5744996A (en) 1996-12-30
AU697954B2 (en) 1998-10-22
DE69605800D1 (de) 2000-01-27
EP0839148B1 (en) 1999-12-22
CA2219753A1 (en) 1996-12-19
DE69605800T2 (de) 2000-11-16
GR3032772T3 (en) 2000-06-30
BG63571B1 (bg) 2002-05-31
HUP9802499A2 (hu) 1999-04-28
JPH11506723A (ja) 1999-06-15
SK164497A3 (en) 1998-06-03
WO1996040687A1 (en) 1996-12-19
EA199800007A1 (ru) 1998-06-25
EE9700316A (et) 1998-06-15
NO975704D0 (no) 1997-12-05
ZA964764B (en) 1997-01-08

Similar Documents

Publication Publication Date Title
NO973923L (no) Nye taxoider, deres fremstilling samt farmasöytiske preparater inneholdende forbindelsene
NO964939D0 (no) Fremgangsmåte for fremstilling av virkestoffpreparater i form av en fast lösning av virkestoffet i en polymermatriks, samt virkestoffpreparater fremstilt ved hjelp av denne fremgangsmåte
ZA965752B (en) Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents.
MX9602683A (es) Compuestos de 6-dimetilaminometil-1-fenil-ciclohexano como substancias farmaceuticamente activas.
IL163584A0 (en) Ph-sensitive polymer
ES2158327T3 (es) Derivados de benzo(g)quinolina.
EE05091B1 (et) Oligosahhariidid, nende valmistamismeetod ja kasutamine ning farmatseutilised kompositsioonid
MX9605023A (es) Compuestos substituidos de imidazolidin-2,4-diona como substancias farmaceuticamente activas.
UA32543C2 (uk) Арилацетаміди, що мають анальгетичну дію, спосіб їх одержання, фармацевтична композиція та спосіб її одержання
PL318282A1 (en) Benzoyl derivatives and method of obtaining them
CA2298462A1 (en) 2-benzoyl-cyclohexane-1,3-dione as herbicides
IL117091A0 (en) Methylphenyloxazolidinone derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
MA22941A1 (fr) Derives de 4-benzoylisoxazole, procede pour leur praparation et compositions herbicides les contenant.
EA199800007A1 (ru) [r-(z)]-1-азабицикло[2,2,1]гептан-3-он,о-[3-(3-метоксифенил)-2-пропинил]оксим малеат в качестве фармацевтического средства
DE69229339D1 (de) Kristallines tiagabinehydrochlorid-monohydrat, seine herstellung und verwendung
AU1657100A (en) 4-trifluoromethyl-3-oxazolylpyridines, method for producing them, products containing the same, and their use as pesticides
FR2728171B1 (fr) Production de formulations desinfectantes biocides, a base d'ions peracetiques
EP1539718A4 (en) 1,2,4-TRIAZOL DERIVATIVE, METHOD FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF
FI964429L (fi) Menetelmä 1-(3-trialkyylisilyylifenyyli)-2,2,2-trifluorimetyylietanonin johdannaisten valmistamiseksi
DE60123105D1 (de) Verfahren zur Herstellung von 4'-O-substituierten 4'-Demethyl-1 desoxypodophyllotoxinderivaten und geometrischen Isomeren davon ,und Antikrebspräparat, das diese enthält
FR2652590B1 (fr) Exopolymere extracellulaire, son procede de preparation et compositions pharmaceutiques le contenant.
ZA966347B (en) Process for the preparation of 1,4-butenediol.
CA2265881A1 (en) Nodulisporic acid derivatives
ZA995559B (en) Improved process for the production of an n-acyl derivative of O,S-dialkyl phosphoroamidothioate.
ZA200102818B (en) Process for the preparation of 4,4'-dihalogen-O-hydroxydiphenyl compounds.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 839148

Country of ref document: ES