ES2142936T3 - Metodo para detectar marihuana en una muestra de cabello. - Google Patents

Metodo para detectar marihuana en una muestra de cabello.

Info

Publication number
ES2142936T3
ES2142936T3 ES94907938T ES94907938T ES2142936T3 ES 2142936 T3 ES2142936 T3 ES 2142936T3 ES 94907938 T ES94907938 T ES 94907938T ES 94907938 T ES94907938 T ES 94907938T ES 2142936 T3 ES2142936 T3 ES 2142936T3
Authority
ES
Spain
Prior art keywords
sample
keratin
marijuana
protease
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94907938T
Other languages
English (en)
Inventor
Werner A Baumgartner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Psychemedics Corp
Original Assignee
Psychemedics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Psychemedics Corp filed Critical Psychemedics Corp
Application granted granted Critical
Publication of ES2142936T3 publication Critical patent/ES2142936T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4044—Concentrating samples by chemical techniques; Digestion; Chemical decomposition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N2001/002—Devices for supplying or distributing samples to an analysing apparatus
    • G01N2001/007—Devices specially adapted for forensic samples, e.g. tamper-proofing, sample tracking
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4742—Keratin; Cytokeratin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/963—Methods of stopping an enzyme reaction or stabilizing the test materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/901—Drugs of abuse, e.g. narcotics, amphetamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

SE PRESENTA UN METODO PARA EL ANALISIS DIRECTO DE UNA SUSTANCIA DE ANALISIS INDICATIVA DE LA EXPOSICION A LA MARIHUANA QUE SE ENCUENTRA EN ESTRUCTURA QUERATINIZADAS, POR EJEMPLO, CABELLOS, UÑAS DE LAS MANOS O DE LOS PIES, EL METODO COMPRENDE LA PREPARACION DE UNA MEZCLA QUE CONTIENE DITIOTREITOL O DITIOERITRITOL, UNA PROTEASA ADECUADA PARA LA DIGESTION DE LA ESTRUCTURA DE LA QUERATINA Y UNA MUESTRA DE LA ESTRUCTURA DE LA QUERATINA; PERMITIR QUE LA ENZIMA DIGIERA AL MENOS SUBSTANCIALMENTE LA MUESTRA DE LA ESTRUCTURA DE QUERATINA PARA FORMAR UNA SOLUCION DE DIGESTION, SEGUIDA POR LA MEZCLA DE LA SOLUCION DE DIGESTION CON UNA SUSPENSION DE UNA RESINA INTERCAMBIADORA DE IONES PARA ELIMINAR UNA SUSTANCIA DE REACCION DE INTERFERENCIA QUE SE ENCUENTRA NATURALMENTE EN EL CABELLO Y FINALMENTE LA EXPOSICION DE LA SOLUCION DE LA DIGESTION A UN ANALISIS PARA DETERMINAR LA IDENTIDAD Y LA CANTIDAD DE SUSTANCIAS DE LA MARIHUANA EN LA MUESTRA DE LA ESTRUCTURA DE QUERATINA. PARA ACELERAR EL METODO, PUEDE AÑADIRSE SULFATO CUPRICO A LA MEZCLA DESPUES DE LA DEGRADACION DE LA MUESTRA DE QUERATINA PARA DESACTIVAR EL ACTIVADOR. LA ENZIMA PUEDE SER UNA PROTEASA CON PAPAINA, QUIMIOPAPAINA Y PARA SU USO EN LA INVENCION SE PREFIERE LA PROTEASA K. EJEMPLARMENTE LAS RESINAS DE INTERCAMBIO DE IONES UTILES EN EL METODO DE ACUERDO CON LA INVENCION SON EL SEPHADEX DEAE (DIETILAMINOETIL SEPHADEX) Y SEPHAROSA DEAE (DIETILAMINOETIL SEPHAROSA).
ES94907938T 1993-02-03 1994-02-01 Metodo para detectar marihuana en una muestra de cabello. Expired - Lifetime ES2142936T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/012,724 US5466579A (en) 1987-12-28 1993-02-03 Hair analysis method

Publications (1)

Publication Number Publication Date
ES2142936T3 true ES2142936T3 (es) 2000-05-01

Family

ID=21756393

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94907938T Expired - Lifetime ES2142936T3 (es) 1993-02-03 1994-02-01 Metodo para detectar marihuana en una muestra de cabello.

Country Status (8)

Country Link
US (1) US5466579A (es)
EP (1) EP0634014B1 (es)
JP (1) JP3424828B2 (es)
AT (1) ATE188292T1 (es)
CA (1) CA2133560C (es)
DE (1) DE69422339T2 (es)
ES (1) ES2142936T3 (es)
WO (1) WO1994018561A1 (es)

Families Citing this family (25)

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Publication number Priority date Publication date Assignee Title
US6022693A (en) * 1987-12-28 2000-02-08 Psychemedics Corporation Hair analysis method
FI101809B1 (fi) * 1996-06-11 1998-08-31 Valtion Teknillinen Menetelmä näytteen analysoimiseksi hiilihydraattimatriisista
US5910419A (en) * 1997-05-06 1999-06-08 Johnson; Ted Donald Method for forensically screening hair samples for the presence of cannabinoids
US5981204A (en) * 1997-05-06 1999-11-09 Johnson; Ted Donald Method for forensically screening hair samples for the presence of cannabinoids
WO1999041989A1 (en) * 1998-02-23 1999-08-26 Monfort, Inc. Method and system for dehairing animals
DE10123711A1 (de) * 2001-05-15 2003-02-27 Wolfgang Altmeyer Verfahren zur Bestimmung der Herkunft biologischer Materialien
US20040043500A1 (en) * 2002-08-27 2004-03-04 Rumps J Eric Wafer-scale microwave digestion apparatus and methods
DE10353746A1 (de) * 2003-11-17 2005-06-09 Basf Ag Verfahren zum Entfernen von Hornsubstanzen aus Häuten toter Tiere
US7465586B2 (en) 2004-11-03 2008-12-16 Labone, Inc. Oral detection test for cannabinoid use
US7629129B1 (en) * 2005-04-26 2009-12-08 The United States Of America As Represented By The Secretary Of The Army Hair follicle bulb as a biodosimeter
CA2943923C (en) * 2008-04-29 2018-02-06 Psychemedics Corporation Solid phase multi-analyte assay
US8084215B2 (en) 2008-04-29 2011-12-27 Psychemedics Corporation Non-proteolytic method for the determination of analytes in keratinized structures
EP2948135B1 (en) 2013-01-25 2019-01-02 Case Western Reserve University Compositions and methods for the treatment of pervasive development disorders
ITPI20130026A1 (it) * 2013-04-06 2014-10-07 Univ Pisa Metodo e dispositivo per analisi di droghe d'abuso su materiale cheratinico
EP3667325B1 (en) 2013-08-28 2023-10-04 Psychemedics Corporation Integrity testing of hair samples
MX2016012403A (es) 2014-03-27 2017-06-14 Bird Rock Bio Inc Anticuerpos que se unen al receptor cannabinoide 1 (cb1) humano.
PE20181199A1 (es) 2015-09-30 2018-07-23 Bird Rock Bio Inc Anticuerpos que se unen al receptor cannabinoide 1 (cb1) humano
CN105651573B (zh) * 2016-01-05 2018-05-01 中国科学院华南植物园 一种植物叶表皮毛脱除方法
CN113341135A (zh) * 2018-07-30 2021-09-03 杭州莱和生物技术有限公司 一种荧光免疫检测毛发痕量毒品的试剂盒及其图像检测方法与系统
CN109085350A (zh) * 2018-09-05 2018-12-25 徐多麒 一种提取毛发中毒品的溶液及其应用方法
CN110231323A (zh) * 2019-07-04 2019-09-13 广州大陌检测技术有限公司 毛发提取液、制备方法和应用以及毒品检测方法
EP4028159A1 (en) * 2019-09-10 2022-07-20 Pierce Biotechnology, Inc. Sample preparation compositions, devices, systems and methods
CN110987548A (zh) * 2019-10-11 2020-04-10 广州万孚生物技术股份有限公司 毛发中毒品检测方法、前处理试剂与试剂盒
CN112748240A (zh) * 2020-12-24 2021-05-04 南京北成光生物科技有限公司 一种用于检测毛发中毒品的试剂盒及其检测方法
CN115060562B (zh) * 2022-06-27 2023-05-05 上海凯创生物技术有限公司 一种毛发毒品痕量检测提取液及其制备、使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3785771A (en) * 1969-08-19 1974-01-15 Du Pont Method and apparatus for analyzing a liquid containing macromolecules that would interfere with the analysis
US4273867A (en) * 1979-04-05 1981-06-16 Mallinckrodt, Inc. Method and reagent for counteracting lipemic interference
US6949344B1 (en) * 1987-12-28 2005-09-27 Psychemical Corporation Hair analysis method
CA2004068C (en) * 1988-12-16 2001-06-19 Werner A. Baumgartner Hair analysis method
JP2837921B2 (ja) * 1990-05-22 1998-12-16 サイケメディクス コーポレイション 毛髪分析法

Also Published As

Publication number Publication date
WO1994018561A1 (en) 1994-08-18
US5466579A (en) 1995-11-14
ATE188292T1 (de) 2000-01-15
DE69422339T2 (de) 2000-08-24
CA2133560A1 (en) 1994-08-18
CA2133560C (en) 2002-01-15
EP0634014B1 (en) 1999-12-29
DE69422339D1 (de) 2000-02-03
EP0634014A1 (en) 1995-01-18
JP3424828B2 (ja) 2003-07-07
EP0634014A4 (en) 1996-02-07
JPH07508099A (ja) 1995-09-07

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