ES2144046T3 - Procedimiento de conjugacion de nucleosidos antivirales con albumina humana lactosaminada. - Google Patents

Procedimiento de conjugacion de nucleosidos antivirales con albumina humana lactosaminada.

Info

Publication number
ES2144046T3
ES2144046T3 ES94901834T ES94901834T ES2144046T3 ES 2144046 T3 ES2144046 T3 ES 2144046T3 ES 94901834 T ES94901834 T ES 94901834T ES 94901834 T ES94901834 T ES 94901834T ES 2144046 T3 ES2144046 T3 ES 2144046T3
Authority
ES
Spain
Prior art keywords
human albumin
conjugation procedure
antiviral nucleosides
lactosaminated human
lactosaminated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94901834T
Other languages
English (en)
Inventor
Luigi Fiume
Corrado Busi
Stefano Giuseppina Di
Alessandro Mattioli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratori Baldacci SpA
Original Assignee
Laboratori Baldacci SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratori Baldacci SpA filed Critical Laboratori Baldacci SpA
Application granted granted Critical
Publication of ES2144046T3 publication Critical patent/ES2144046T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

LLEVANDO A CABO LA REACCION DE CONJUGACION DE UN NUCLEOSIDO FOSFORILADO ANTIVIRICO, PARTICULARMENTE MONOFOSFATO DE ADENINA ARABINOSURO, EN FORMA DE IMIDAZOLURO, CON ALBUMINA LACTOSAMINADA HUMANA EN UN PH SUPERIOR A 7.5, SE OBTIENEN RELACIONES MOLARES DE DROGA/L-HSA AL MENOS IGUALES QUE AQUELLOS QUE USAN ECDI SIN LOS PROBLEMAS Y EFECTOS SECUNDARIOS NEGATIVOS OBSERVADOS EN ESTOS ULTIMOS. PREFERIBLEMENTE LA REACCION DE CONJUGACION SE LLEVA A CABO A UNA TEMPERATURA DE 37 C Y UN PH DE 8.5 9.5.
ES94901834T 1992-11-23 1993-11-20 Procedimiento de conjugacion de nucleosidos antivirales con albumina humana lactosaminada. Expired - Lifetime ES2144046T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI922673A IT1256110B (it) 1992-11-23 1992-11-23 Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminata

Publications (1)

Publication Number Publication Date
ES2144046T3 true ES2144046T3 (es) 2000-06-01

Family

ID=11364330

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94901834T Expired - Lifetime ES2144046T3 (es) 1992-11-23 1993-11-20 Procedimiento de conjugacion de nucleosidos antivirales con albumina humana lactosaminada.

Country Status (11)

Country Link
US (1) US5594110A (es)
EP (1) EP0624098B1 (es)
AT (1) ATE190504T1 (es)
AU (1) AU5626294A (es)
DE (1) DE69328082T2 (es)
DK (1) DK0624098T3 (es)
ES (1) ES2144046T3 (es)
GR (1) GR3033611T3 (es)
IT (1) IT1256110B (es)
PT (1) PT624098E (es)
WO (1) WO1994012218A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5632915A (en) * 1994-08-29 1997-05-27 Gerber Garment Technology, Inc. Laser material processing apparatus and a work table therefor
US5693791A (en) * 1995-04-11 1997-12-02 Truett; William L. Antibiotics and process for preparation
US20020099013A1 (en) * 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
ITMI20010027A1 (it) * 2001-01-10 2002-07-10 Uni Di Bologna Dipartimento Di Composizioni teraputiche per una chemioterapia locoregionale non invasiva delle micrometastasi epatiche
US7169752B2 (en) * 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
CN106008699A (zh) 2006-09-08 2016-10-12 Ambrx公司 经修饰的人类血浆多肽或Fc骨架和其用途
HRP20192259T1 (hr) * 2009-04-15 2020-03-06 Abraxis Bioscience, Llc Pripravci nanočestica bez priona i metode njihove proizvodnje
US9534243B2 (en) 2013-02-07 2017-01-03 The United States Of America, As Represented By The Secretary Of Commerce Nucleotide analogs and process for making same enzyme

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1177381B (it) * 1984-12-11 1987-08-26 Baldacci Lab Spa Metodo per la preparazione di coniugati della adenina-9-beta-d-arabino furano-side 5' monofosfato con albumina umana lattosaminata, coniugati risultanti e relative composizioi terapeuticamente attive
IT1207507B (it) * 1985-10-21 1989-05-25 Baldacci Lab Spa Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.

Also Published As

Publication number Publication date
PT624098E (pt) 2000-08-31
ATE190504T1 (de) 2000-04-15
GR3033611T3 (en) 2000-10-31
DK0624098T3 (da) 2000-06-05
EP0624098A1 (en) 1994-11-17
US5594110A (en) 1997-01-14
ITMI922673A1 (it) 1994-05-23
EP0624098B1 (en) 2000-03-15
DE69328082T2 (de) 2000-08-24
AU5626294A (en) 1994-06-22
WO1994012218A1 (en) 1994-06-09
DE69328082D1 (de) 2000-04-20
ITMI922673A0 (it) 1992-11-23
IT1256110B (it) 1995-11-28

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