ES2145011T3 - Medios de contraste gaseosos para ultrasonidos. - Google Patents
Medios de contraste gaseosos para ultrasonidos.Info
- Publication number
- ES2145011T3 ES2145011T3 ES92919150T ES92919150T ES2145011T3 ES 2145011 T3 ES2145011 T3 ES 2145011T3 ES 92919150 T ES92919150 T ES 92919150T ES 92919150 T ES92919150 T ES 92919150T ES 2145011 T3 ES2145011 T3 ES 2145011T3
- Authority
- ES
- Spain
- Prior art keywords
- ultrasounds
- contrast means
- gaseous contrast
- gas
- microbubbles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogen, Water And Hydrids (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Electron Sources, Ion Sources (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Medios de contraste para la mejora de imágenes de ultrasonidos, caracterizados porque comprenden microburbujas de un gas biocompatible en un vehículo líquido acuoso biocompatible, seleccionándose el gas de entre octafluoropropano, y decafluorobutano, donde dichas microburbujas tienen un diámetro de menos de 8 µm.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76131191A | 1991-09-17 | 1991-09-17 | |
| US761311 | 1991-09-17 | ||
| US07/893,657 US5409688A (en) | 1991-09-17 | 1992-06-05 | Gaseous ultrasound contrast media |
| US893657 | 1992-06-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2145011T3 true ES2145011T3 (es) | 2000-07-01 |
| ES2145011T5 ES2145011T5 (es) | 2008-02-01 |
Family
ID=27116965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92919150T Expired - Lifetime ES2145011T5 (es) | 1991-09-17 | 1992-09-02 | Medios de contraste gaseoso para ecografias. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5558094B1 (es) |
| EP (1) | EP0605477B2 (es) |
| JP (2) | JP3231768B2 (es) |
| KR (1) | KR100191303B1 (es) |
| AT (1) | ATE191346T1 (es) |
| AU (2) | AU679428C (es) |
| CA (1) | CA2119129C (es) |
| CZ (1) | CZ286149B6 (es) |
| DE (2) | DE605477T1 (es) |
| DK (1) | DK0605477T4 (es) |
| ES (1) | ES2145011T5 (es) |
| FI (1) | FI119466B (es) |
| GR (1) | GR3033908T3 (es) |
| HU (1) | HU218018B (es) |
| NO (1) | NO313577B1 (es) |
| RU (1) | RU2114637C1 (es) |
| SG (1) | SG54121A1 (es) |
| WO (1) | WO1993005819A1 (es) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656211A (en) | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
| US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| US5305757A (en) | 1989-12-22 | 1994-04-26 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
| US5149319A (en) * | 1990-09-11 | 1992-09-22 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids |
| US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US20020150539A1 (en) | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
| US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
| US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
| US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
| US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
| US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
| US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| US6989141B2 (en) * | 1990-05-18 | 2006-01-24 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US7083778B2 (en) | 1991-05-03 | 2006-08-01 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| IN172208B (es) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US6613306B1 (en) | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
| US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| US6875420B1 (en) | 1991-09-17 | 2005-04-05 | Amersham Health As | Method of ultrasound imaging |
| KR100191303B1 (ko) * | 1991-09-17 | 1999-06-15 | 씨. 큐웨이 스티븐 | 기체상의 초음파 조영제 및 초음파 조영제로서 사용하기 위한 기체를 선택하는 방법 |
| MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
| IL108416A (en) | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Phase shift colloids as ultrasound contrast agents |
| CA2154590C (en) * | 1993-01-25 | 2001-06-12 | Steven C. Quay | Phase shift colloids as ultrasound contrast agents |
| GB9305349D0 (en) * | 1993-03-16 | 1993-05-05 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US5701899A (en) * | 1993-05-12 | 1997-12-30 | The Board Of Regents Of The University Of Nebraska | Perfluorobutane ultrasound contrast agent and methods for its manufacture and use |
| US5695740A (en) * | 1993-05-12 | 1997-12-09 | The Board Of Regents Of The University Of Nebraska | Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide |
| US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
| US5855865A (en) * | 1993-07-02 | 1999-01-05 | Molecular Biosystems, Inc. | Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas |
| PL312387A1 (en) * | 1993-07-02 | 1996-04-15 | Molecular Biosystems Inc | Proteinous microbeads of encapsulated non-dissolving gas and method of making them and their application as ultrasonic visualisation medium |
| US5798091A (en) | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
| DK0711179T3 (da) | 1993-07-30 | 2005-02-14 | Imcor Pharmaceutical Co | Stabiliserede sammensætninger med mikrobobler til ultralyd |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| PT682530E (pt) * | 1993-12-15 | 2003-06-30 | Bracco Research Sa | Misturas de gases uteis como meios de contraste para ultrassons |
| US5406950A (en) * | 1993-12-23 | 1995-04-18 | Mallinckrodt Medical, Inc. | Inhalable contrast agent |
| US5736121A (en) | 1994-05-23 | 1998-04-07 | Imarx Pharmaceutical Corp. | Stabilized homogenous suspensions as computed tomography contrast agents |
| US5965109A (en) * | 1994-08-02 | 1999-10-12 | Molecular Biosystems, Inc. | Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier |
| US5730955A (en) * | 1994-08-02 | 1998-03-24 | Molecular Biosystems, Inc. | Process for making gas-filled microspheres containing a liquid hydrophobic barrier |
| US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
| WO1998053855A1 (en) * | 1997-05-30 | 1998-12-03 | Alliance Pharmaceutical Corp. | Methods and apparatus for monitoring and quantifying the movement of fluid |
| US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
| IL116328A (en) † | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
| US5830430A (en) | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
| US5560364A (en) * | 1995-05-12 | 1996-10-01 | The Board Of Regents Of The University Of Nebraska | Suspended ultra-sound induced microbubble cavitation imaging |
| US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
| US5674469A (en) * | 1995-06-07 | 1997-10-07 | Molecular Biosystems, Inc. | Gas-exchange method of making gas-filled microspheres |
| US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
| US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
| US5897851A (en) * | 1995-06-07 | 1999-04-27 | Sonus Pharmaceuticals, Inc. | Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging |
| US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
| US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| US5648098A (en) * | 1995-10-17 | 1997-07-15 | The Board Of Regents Of The University Of Nebraska | Thrombolytic agents and methods of treatment for thrombosis |
| US5840276A (en) * | 1996-01-11 | 1998-11-24 | Apfel Enterprises, Inc. | Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis |
| DE19602930A1 (de) * | 1996-01-18 | 1997-07-24 | Schering Ag | Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung |
| BR9707936B1 (pt) * | 1996-03-05 | 2010-12-14 | composiÇço formadora de imagem atravÉs de ultra-som. | |
| US6245747B1 (en) | 1996-03-12 | 2001-06-12 | The Board Of Regents Of The University Of Nebraska | Targeted site specific antisense oligodeoxynucleotide delivery method |
| US5728315A (en) * | 1996-05-01 | 1998-03-17 | Alliedsignal Inc. | Azeotrope-like compositions of trifluoromethane, carbon dioxide, ethane and hexafluoroethane |
| WO1997040679A1 (en) | 1996-05-01 | 1997-11-06 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
| US5849727A (en) * | 1996-06-28 | 1998-12-15 | Board Of Regents Of The University Of Nebraska | Compositions and methods for altering the biodistribution of biological agents |
| WO1998003205A2 (en) * | 1996-07-19 | 1998-01-29 | Sonus Pharmaceuticals, Inc. | Enhanced ultrasound contrast imaging using inhaled gases |
| US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
| US5846517A (en) | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
| ES2289188T3 (es) | 1996-09-11 | 2008-02-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Procedimiento para la obtencion de imagenes para el diagnostico usando un agente de contraste y un vasodilatador. |
| US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
| US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
| US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| US7452551B1 (en) | 2000-10-30 | 2008-11-18 | Imarx Therapeutics, Inc. | Targeted compositions for diagnostic and therapeutic use |
| US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
| US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
| US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| US6444192B1 (en) | 1999-02-05 | 2002-09-03 | The Regents Of The University Of California | Diagnostic imaging of lymph structures |
| GB9912356D0 (en) | 1999-05-26 | 1999-07-28 | Btg Int Ltd | Generation of microfoam |
| US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
| US6439236B1 (en) | 1999-10-25 | 2002-08-27 | The Board Of Regents Of The University Of Nebraska | Methods for inducing atrial and ventricular rhythms using ultrasound and microbubbles |
| US8512680B2 (en) | 2001-08-08 | 2013-08-20 | Btg International Ltd. | Injectables in foam, new pharmaceutical applications |
| RU2195263C1 (ru) * | 2001-10-10 | 2002-12-27 | Государственное учреждение Тверская государственная медицинская академия | Способ негативного контрастирования липосом для электронно-микроскопического исследования |
| US7358226B2 (en) * | 2003-08-27 | 2008-04-15 | The Regents Of The University Of California | Ultrasonic concentration of drug delivery capsules |
| ES2330341T5 (es) | 2003-11-17 | 2017-06-21 | Btg International Limited | Espuma terapéutica que comprende una solución esclerosante y una baja cantidad de nitrógeno gaseoso |
| US8048439B2 (en) | 2003-11-17 | 2011-11-01 | Btg International Ltd. | Therapeutic foam |
| ATE466596T1 (de) | 2004-01-20 | 2010-05-15 | Sunnybrook & Womens College | Hochfrequenz-ultraschall-darstellung mit kontrastmitteln |
| US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
| GB0509824D0 (en) | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Therapeutic foam |
| EP2200652B1 (en) | 2007-09-27 | 2018-03-21 | Children's Medical Center Corporation | Microbubbles and methods for oxygen delivery |
| US8529453B2 (en) * | 2008-01-23 | 2013-09-10 | Michalakis Averkiou | Respiratory-gated therapy assessment with ultrasonic contrast agents |
| US8846063B2 (en) | 2008-12-16 | 2014-09-30 | Kimberly-Clark Worldwide, Inc. | Personal care composition containing a volatile and a terpene alcohol |
| WO2013151682A1 (en) | 2012-04-06 | 2013-10-10 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
| US9713459B2 (en) | 2012-06-11 | 2017-07-25 | The Regents Of The University Of California | Method and system for in vivo hydrogen peroxide detection with ultrasound |
| ES2571481T3 (es) | 2012-06-26 | 2016-05-25 | Ge Healthcare As | Preparación de una composición que comprende microburbujas de gas |
| EP2968825A4 (en) | 2013-03-15 | 2016-09-07 | Childrens Medical Center | Gas-filled stabilized particles and methods of use |
| EP4154915A1 (en) | 2014-12-31 | 2023-03-29 | Lantheus Medical Imaging, Inc. | Lipid-encapsulated gas microsphere compositions and related methods |
| KR20180133527A (ko) | 2016-05-04 | 2018-12-14 | 랜티우스 메디컬 이메징, 인크. | 초음파 조영제의 제조 방법 및 장치 |
| US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
| US11147890B2 (en) | 2017-02-28 | 2021-10-19 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
| JP6653104B2 (ja) * | 2018-02-01 | 2020-02-26 | 高知県公立大学法人 | 軸受 |
| CN113412249A (zh) * | 2019-02-08 | 2021-09-17 | 大金工业株式会社 | 有机化合物的制造方法 |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| US4265251A (en) * | 1979-06-28 | 1981-05-05 | Rasor Associates, Inc. | Method of determining pressure within liquid containing vessel |
| US4657756A (en) * | 1980-11-17 | 1987-04-14 | Schering Aktiengesellschaft | Microbubble precursors and apparatus for their production and use |
| US4681119A (en) * | 1980-11-17 | 1987-07-21 | Schering Aktiengesellschaft | Method of production and use of microbubble precursors |
| JPS57150542A (en) * | 1981-03-13 | 1982-09-17 | Katashi Aoki | Injection, stretching, and blow molding machine |
| US4361979A (en) * | 1981-04-07 | 1982-12-07 | Brio Toy Ab | Connection element for making assemblies of toy units |
| US4533254A (en) * | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
| DE3141641A1 (de) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
| JPS5967229A (ja) * | 1982-10-08 | 1984-04-16 | Green Cross Corp:The | 超音波診断造影剤 |
| US4718433A (en) * | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
| US4572203A (en) * | 1983-01-27 | 1986-02-25 | Feinstein Steven B | Contact agents for ultrasonic imaging |
| DE3834705A1 (de) * | 1988-10-07 | 1990-04-12 | Schering Ag | Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln |
| US5141738A (en) * | 1983-04-15 | 1992-08-25 | Schering Aktiengesellschaft | Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof |
| US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
| US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| JPS6073621A (ja) * | 1983-09-30 | 1985-04-25 | Fuji Photo Film Co Ltd | 折畳み式カメラ |
| US4767610A (en) * | 1984-10-19 | 1988-08-30 | The Regents Of The University Of California | Method for detecting abnormal cell masses in animals |
| GB8504916D0 (en) * | 1985-02-26 | 1985-03-27 | Isc Chemicals Ltd | Emulsions of perfluorocarbons in aqueous media |
| US4684479A (en) * | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
| DE3529195A1 (de) * | 1985-08-14 | 1987-02-26 | Max Planck Gesellschaft | Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung |
| AU6621586A (en) * | 1985-11-18 | 1987-06-02 | University Of Texas System, The | Polychelating agents for image and spectral enhancement (and spectral shift) |
| US5284645A (en) * | 1987-08-05 | 1994-02-08 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems |
| US4927623A (en) * | 1986-01-14 | 1990-05-22 | Alliance Pharmaceutical Corp. | Dissolution of gas in a fluorocarbon liquid |
| US4987154A (en) * | 1986-01-14 | 1991-01-22 | Alliance Pharmaceutical Corp. | Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use |
| US4865836A (en) * | 1986-01-14 | 1989-09-12 | Fluoromed Pharmaceutical, Inc. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
| DE3785054T2 (de) * | 1986-01-24 | 1993-07-08 | Childrens Hosp Medical Center | Stabile emulsionen von stark fluorierten, organischen verbindungen. |
| EP0245019A3 (en) * | 1986-04-30 | 1989-05-10 | Michael A. Davis | Low density contrast medium for diagnosis of pathologic conditions |
| JPS6360943A (ja) * | 1986-09-01 | 1988-03-17 | Green Cross Corp:The | 超音波診断造影剤 |
| US5219538A (en) * | 1987-03-13 | 1993-06-15 | Micro-Pak, Inc. | Gas and oxygen carrying lipid vesicles |
| US4895876A (en) * | 1987-03-20 | 1990-01-23 | Air Products And Chemicals, Inc. | Concentrated stable fluorochemical aqueous emulsions containing triglycerides |
| US5354549A (en) * | 1987-07-24 | 1994-10-11 | Nycomed Imaging As | Iodinated esters |
| CN1013830B (zh) * | 1987-08-26 | 1991-09-11 | 宋振才 | B超胃肠造影剂的制造工艺 |
| IE61591B1 (en) * | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
| US4844882A (en) * | 1987-12-29 | 1989-07-04 | Molecular Biosystems, Inc. | Concentrated stabilized microbubble-type ultrasonic imaging agent |
| DE58908194D1 (de) * | 1988-02-05 | 1994-09-22 | Schering Ag | Ultraschallkontrastmittel, verfahren zu deren herstellung und deren verwendung als diagnostika und therapeutika. |
| US5171755A (en) * | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
| US4993415A (en) * | 1988-08-19 | 1991-02-19 | Alliance Pharmaceutical Corp. | Magnetic resonance imaging with perfluorocarbon hydrides |
| DE3828905A1 (de) * | 1988-08-23 | 1990-03-15 | Schering Ag | Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel |
| US4957656A (en) * | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
| GB8900376D0 (en) * | 1989-01-09 | 1989-03-08 | Nycomed As | Iodinated esters |
| US5114703A (en) * | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
| ES2045944T3 (es) * | 1989-08-30 | 1994-01-16 | Kali Chemie Ag | Procedimiento para la separacion de mezclas de compuestos hidrocarbonados parcialmente fluorados o perfluorados. |
| JPH062134B2 (ja) * | 1989-09-08 | 1994-01-12 | 株式会社東芝 | 超音波診断装置 |
| JPH02196730A (ja) * | 1989-12-15 | 1990-08-03 | Green Cross Corp:The | 超音波診断造影剤 |
| US5230882A (en) * | 1989-12-22 | 1993-07-27 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5228446A (en) * | 1989-12-22 | 1993-07-20 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
| US5209720A (en) * | 1989-12-22 | 1993-05-11 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes |
| US5123414A (en) * | 1989-12-22 | 1992-06-23 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| GB9003821D0 (en) * | 1990-02-20 | 1990-04-18 | Danbiosyst Uk | Diagnostic aid |
| IN172208B (es) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
| DE59107006D1 (de) * | 1990-04-25 | 1996-01-18 | Hoechst Ag | Pharmakologische Zubereitung, enthaltend Polyelektrolytkomplexe in mikropartikulärer Form und mindestens einen Wirkstoff. |
| US5137928A (en) * | 1990-04-26 | 1992-08-11 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
| AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| ES2112859T3 (es) * | 1990-06-01 | 1998-04-16 | Imarx Pharmaceutical Corp | Medios de contraste para la formacion de imagenes ecograficas. |
| US5215680A (en) * | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
| FR2665705B1 (fr) * | 1990-08-09 | 1993-07-30 | Atta | Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical. |
| CA2068334C (en) * | 1990-10-05 | 1996-09-03 | Bracco International B.V. | Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography |
| US5236693A (en) * | 1990-11-14 | 1993-08-17 | Brigham And Women's Hospital | Medical ultrasound contrast agent and method of using same |
| DE4100470A1 (de) * | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echokontrastmittel |
| US5370901A (en) * | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
| US5107842A (en) * | 1991-02-22 | 1992-04-28 | Molecular Biosystems, Inc. | Method of ultrasound imaging of the gastrointestinal tract |
| GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
| GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
| US5205290A (en) * | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| US5496535A (en) * | 1991-04-12 | 1996-03-05 | Alliance Pharmaceutical Corp. | Fluorocarbon contrast media for use with MRI and radiographic imaging |
| SE470086B (sv) * | 1991-04-23 | 1993-11-08 | Kabi Pharmacia Ab | Organspecifik emulsion |
| US5147631A (en) * | 1991-04-30 | 1992-09-15 | Du Pont Merck Pharmaceutical Company | Porous inorganic ultrasound contrast agents |
| DK0586524T3 (es) * | 1991-06-03 | 1997-05-20 | Nycomed Imaging As | |
| DE69233119T2 (de) * | 1991-06-18 | 2004-05-13 | Imarx Pharmaceutical Corp., Tucson | Neue liposomale arzneimittelfreisetzungssysteme |
| CA2112905A1 (en) * | 1991-07-05 | 1993-01-21 | Michael R. Violante | Ultrasmall non-aggregated porous particles entrapping gas-bubbles |
| FI940027A7 (fi) * | 1991-07-05 | 1994-01-04 | Nycomed Imaging As | Parannuksia itse varjoaineisiin tai parannuksia, jotka liittyvät niihi n |
| FR2679150A1 (fr) * | 1991-07-17 | 1993-01-22 | Atta | Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations. |
| DE4127442C2 (de) * | 1991-08-17 | 1996-08-22 | Udo Dr Gros | Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung |
| US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
| KR100191303B1 (ko) * | 1991-09-17 | 1999-06-15 | 씨. 큐웨이 스티븐 | 기체상의 초음파 조영제 및 초음파 조영제로서 사용하기 위한 기체를 선택하는 방법 |
| WO1993006869A1 (en) * | 1991-10-04 | 1993-04-15 | Mallinckrodt Medical, Inc. | Gaseous ultrasound contrast agents |
| US5344640A (en) * | 1991-10-22 | 1994-09-06 | Mallinckrodt Medical, Inc. | Preparation of apatite particles for medical diagnostic imaging |
| JPH07501331A (ja) * | 1991-11-19 | 1995-02-09 | イマアーレクス・フアーマシユーチカル・コーポレーシヨン | 改良された診断用の造影のためのゲル粒子造影剤 |
| IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| US5344393A (en) * | 1992-02-28 | 1994-09-06 | Alliance Pharmaceutical Corp. | Use of synthetic oxygen carriers to facilitate oxygen delivery |
| US5406950A (en) * | 1993-12-23 | 1995-04-18 | Mallinckrodt Medical, Inc. | Inhalable contrast agent |
-
1992
- 1992-09-02 KR KR1019940700881A patent/KR100191303B1/ko not_active Expired - Lifetime
- 1992-09-02 DE DE0605477T patent/DE605477T1/de active Pending
- 1992-09-02 HU HU9400786A patent/HU218018B/hu unknown
- 1992-09-02 EP EP92919150A patent/EP0605477B2/en not_active Expired - Lifetime
- 1992-09-02 AT AT92919150T patent/ATE191346T1/de active
- 1992-09-02 RU RU94030382/14A patent/RU2114637C1/ru active
- 1992-09-02 CA CA002119129A patent/CA2119129C/en not_active Expired - Lifetime
- 1992-09-02 ES ES92919150T patent/ES2145011T5/es not_active Expired - Lifetime
- 1992-09-02 JP JP50605493A patent/JP3231768B2/ja not_active Expired - Fee Related
- 1992-09-02 WO PCT/US1992/007250 patent/WO1993005819A1/en not_active Ceased
- 1992-09-02 DE DE69230885T patent/DE69230885T3/de not_active Expired - Lifetime
- 1992-09-02 AU AU25503/92A patent/AU679428C/en not_active Expired
- 1992-09-02 DK DK92919150T patent/DK0605477T4/da active
- 1992-09-02 CZ CZ1994612A patent/CZ286149B6/cs not_active IP Right Cessation
- 1992-09-02 SG SG1996001218A patent/SG54121A1/en unknown
-
1994
- 1994-03-16 NO NO19940956A patent/NO313577B1/no not_active IP Right Cessation
- 1994-03-16 FI FI941242A patent/FI119466B/fi not_active IP Right Cessation
-
1995
- 1995-02-01 US US08382253 patent/US5558094B1/en not_active Expired - Lifetime
-
1997
- 1997-10-03 AU AU39959/97A patent/AU3995997A/en not_active Abandoned
-
2000
- 2000-04-12 JP JP2000150619A patent/JP2001026554A/ja active Pending
- 2000-07-05 GR GR20000401593T patent/GR3033908T3/el unknown
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