ES2145021T3 - Derivados de 1-bifenil-piridona, su preparacion y su uso como antagonistas de la angiotensina ii. - Google Patents

Derivados de 1-bifenil-piridona, su preparacion y su uso como antagonistas de la angiotensina ii.

Info

Publication number
ES2145021T3
ES2145021T3 ES93116404T ES93116404T ES2145021T3 ES 2145021 T3 ES2145021 T3 ES 2145021T3 ES 93116404 T ES93116404 T ES 93116404T ES 93116404 T ES93116404 T ES 93116404T ES 2145021 T3 ES2145021 T3 ES 2145021T3
Authority
ES
Spain
Prior art keywords
biphenyl
angiotensin
rest
piridone
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93116404T
Other languages
English (en)
Inventor
Jurgen Dr Dressel
Peter Dr Fey
Rudolf Dr Hanko
Walter Dr Hubsch
Thomas Dr Kramer
Ulrich E Dr Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2145021T3 publication Critical patent/ES2145021T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

BIFENILO TRISUSTITUIDO DE LA FORMULA GENERAL (I) EN DONDE R1 ES UN RESTO CARBOXILO, O UN RESTO ALCOXICARBONILO DE C1-C8, R2 ES ALQUILO DE C1-C8 DE CADENA RECTA O RAMIFICADA, R3 ES HALOGENO, HIDROXI, CIANO, ALCOXI DE C1-C6, ALQUILO DE C1-C8 DE CADENA RECTA O RAMIFICADA, TRIFLUOROMETILO, TRIFLUOROMETOXI, CARBOXAMIDO, CARBOXI, ALCOXICARBONILO DE C1-C8 O NITRO, Y R4 ES UN RESTO CARBOXILO, O ES TETRAZOLILO, Y SUS SALES. LOS COMPUESTOS BIFENILO SUSTITUIDOS PUEDEN SER UTILIZADOS COMO SUSTANCIA ACTIVA EN MEDICAMENTO, POR EJEMPLO COMO ANTAGONISTA DE ANGIOTENSINA II.
ES93116404T 1992-10-23 1993-10-11 Derivados de 1-bifenil-piridona, su preparacion y su uso como antagonistas de la angiotensina ii. Expired - Lifetime ES2145021T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4235933 1992-10-23
DE4319041A DE4319041A1 (de) 1992-10-23 1993-06-08 Trisubstituierte Biphenyle

Publications (1)

Publication Number Publication Date
ES2145021T3 true ES2145021T3 (es) 2000-07-01

Family

ID=25919778

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93116404T Expired - Lifetime ES2145021T3 (es) 1992-10-23 1993-10-11 Derivados de 1-bifenil-piridona, su preparacion y su uso como antagonistas de la angiotensina ii.

Country Status (22)

Country Link
US (2) US5596006A (es)
EP (1) EP0594019B1 (es)
JP (1) JPH06199838A (es)
KR (1) KR100304225B1 (es)
CN (1) CN1040435C (es)
AT (1) ATE189893T1 (es)
AU (1) AU670315B2 (es)
CA (1) CA2108814A1 (es)
CZ (1) CZ283482B6 (es)
DE (2) DE4319041A1 (es)
DK (1) DK0594019T3 (es)
ES (1) ES2145021T3 (es)
FI (1) FI934646A7 (es)
GR (1) GR3033207T3 (es)
HU (1) HUT65819A (es)
IL (1) IL107333A (es)
MX (1) MX9306419A (es)
NO (1) NO304651B1 (es)
NZ (1) NZ250002A (es)
PT (1) PT594019E (es)
SK (1) SK279675B6 (es)
TW (1) TW248555B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle
AU2001277731A1 (en) 2000-08-09 2002-02-18 Welfide Corporation Fused bicyclic amide compounds and medicinal use thereof
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
AU2002351412B2 (en) 2001-12-21 2010-05-20 Exelixis Patent Company Llc Modulators of LXR
ES2251292B1 (es) * 2004-04-20 2007-07-01 Inke, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de sus intermedios de sintesis.
WO2006130901A1 (en) * 2005-06-07 2006-12-14 Bayer Healthcare Ag Control of metabolic abnormalities
DE102005030522A1 (de) * 2005-06-30 2007-01-04 Bayer Healthcare Ag Salz des Embusartans
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
DE102007028320A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028406A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028407A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028319A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
EP2138178A1 (en) 2008-06-28 2009-12-30 Bayer Schering Pharma Aktiengesellschaft Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma
BR112014027952B1 (pt) 2012-05-10 2022-06-21 Bayer Pharma Aktiengesellschaft Anticorpos monoclonais humanos capazes de se ligarem ao fator de coagulação xi, seu uso, composição farmacêutica e medicamento os compreendendo, ácido nucleico que o codifica, bem como vetor
KR102614588B1 (ko) 2018-08-20 2023-12-18 삼성디스플레이 주식회사 표시 장치의 제조 방법
WO2024159724A1 (zh) * 2023-02-03 2024-08-08 科莱博(江苏)科技股份有限公司 一种邻联苯基噁唑啉化合物及其合成方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3800785A1 (de) * 1988-01-09 1989-07-20 Hoechst Ag Substituierte 7-(pyridazin-5-yl)-3,5-dihydroxyheptan(en)- saeuren, ihre entsprechenden (delta)-lactone bzw. derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
EP0403158A3 (en) * 1989-06-14 1991-12-18 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
DK0403159T3 (da) * 1989-06-14 2000-08-14 Smithkline Beecham Corp Imidazolylalkensyrer
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
EP0485410A1 (en) * 1989-07-06 1992-05-20 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern A detector for monitoring low molecular weight compounds
AU640417B2 (en) * 1989-10-25 1993-08-26 Smithkline Beecham Corporation Substituted 5-((tetrazolyl)alkenyl)imidazoles
DE69030622T2 (de) * 1989-12-25 1997-08-14 Nippon Steel Corp Blech aus einer intermetallischen titan-aluminiumverbimdung und verfahren zu ihrer herstellung
EP0453210A3 (en) * 1990-04-19 1993-01-13 Imperial Chemical Industries Plc Pyridine derivatives
AU653734B2 (en) * 1990-06-19 1994-10-13 Meiji Seika Kabushiki Kaisha Substituted 4-biphenylmethoxypyridine derivatives
US5250548A (en) * 1990-09-10 1993-10-05 Abbott Laboratories Angiotensin II receptor antagonists
IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
CN1068109A (zh) * 1991-02-16 1993-01-20 菲索斯有限公司 新的血管紧张肽ii拮抗剂及其制剂的制备和应用
DE4221583A1 (de) * 1991-11-12 1993-05-13 Bayer Ag Substituierte biphenylpyridone
DK0643704T3 (da) * 1991-11-18 2004-01-19 Merck & Co Inc Tetrazolylphenylboronsyremellemprodukter til syntese af All-receptor antagonister
US5130439A (en) * 1991-11-18 1992-07-14 Lo Young S Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle

Also Published As

Publication number Publication date
SK279675B6 (sk) 1999-02-11
US5863930A (en) 1999-01-26
KR100304225B1 (ko) 2004-05-10
IL107333A (en) 1998-01-04
EP0594019A1 (de) 1994-04-27
MX9306419A (es) 1994-05-31
FI934646L (fi) 1994-04-24
US5596006A (en) 1997-01-21
NO304651B1 (no) 1999-01-25
AU4754193A (en) 1994-05-05
TW248555B (es) 1995-06-01
CA2108814A1 (en) 1994-04-24
NZ250002A (en) 1995-03-28
PT594019E (pt) 2000-08-31
DE59309956D1 (de) 2000-03-30
FI934646A7 (fi) 1994-04-24
EP0594019B1 (de) 2000-02-23
FI934646A0 (fi) 1993-10-21
AU670315B2 (en) 1996-07-11
DE4319041A1 (de) 1994-04-28
HUT65819A (en) 1994-07-28
GR3033207T3 (en) 2000-08-31
NO933591L (no) 1994-04-25
ATE189893T1 (de) 2000-03-15
KR940009174A (ko) 1994-05-20
JPH06199838A (ja) 1994-07-19
DK0594019T3 (da) 2000-07-03
CZ283482B6 (cs) 1998-04-15
NO933591D0 (no) 1993-10-07
CZ221793A3 (en) 1994-05-18
HU9302997D0 (en) 1994-01-28
CN1089260A (zh) 1994-07-13
IL107333A0 (en) 1994-01-25
CN1040435C (zh) 1998-10-28
SK116993A3 (en) 1994-11-09

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