ES2145466T3 - Procedimiento para la purificacion del factor viii por cromatografia de afinidad. - Google Patents

Procedimiento para la purificacion del factor viii por cromatografia de afinidad.

Info

Publication number
ES2145466T3
ES2145466T3 ES96923903T ES96923903T ES2145466T3 ES 2145466 T3 ES2145466 T3 ES 2145466T3 ES 96923903 T ES96923903 T ES 96923903T ES 96923903 T ES96923903 T ES 96923903T ES 2145466 T3 ES2145466 T3 ES 2145466T3
Authority
ES
Spain
Prior art keywords
factor viii
purification
procedure
affinity chromatography
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96923903T
Other languages
English (en)
Inventor
Gert Muller-Berghaus
Bernd Potzsch
Horst Schwinn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAX PLANCK INST fur PHYSIOLOGI
Original Assignee
MAX PLANCK INST fur PHYSIOLOGI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8166248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2145466(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by MAX PLANCK INST fur PHYSIOLOGI filed Critical MAX PLANCK INST fur PHYSIOLOGI
Application granted granted Critical
Publication of ES2145466T3 publication Critical patent/ES2145466T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION TRATA DE UN PROCEDIMIENTO PARA LA PURIFICACION POR CROMATOGRAFIA DE AFINIDAD DEL FACTOR VIII, CARACTERIZADO PORQUE SE PONE EN CONTACTO UN LIQUIDO BIOLOGICO QUE CONTIENE UN FACTOR VIII CON FACTOR VON - WILLEBRAND CELULAR INMOVILIZADO, O UN DERIVADO EN TALES CONDICIONES, QUE SE REALIZA UNA ADSORCION DEL FACTOR VIII EN EL FACTOR VON WILLEBRAND INMOVILIZADO O SU DERIVADO, SE QUITAN LAS IMPUREZAS Y SE ELUYE EL FACTOR VIII ADSORBIDO.
ES96923903T 1996-06-24 1996-06-24 Procedimiento para la purificacion del factor viii por cromatografia de afinidad. Expired - Lifetime ES2145466T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1996/002746 WO1997049730A1 (de) 1996-06-24 1996-06-24 Verfahren zur affinitätschromatographischen aufreinigung von faktor viii

Publications (1)

Publication Number Publication Date
ES2145466T3 true ES2145466T3 (es) 2000-07-01

Family

ID=8166248

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96923903T Expired - Lifetime ES2145466T3 (es) 1996-06-24 1996-06-24 Procedimiento para la purificacion del factor viii por cromatografia de afinidad.

Country Status (4)

Country Link
US (1) US6143179A (es)
EP (1) EP0910581B1 (es)
ES (1) ES2145466T3 (es)
WO (1) WO1997049730A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605222B1 (en) * 1998-05-20 2003-08-12 Baxter Aktiengesellschaft Method for producing a factor VIII/von Willebrand factor complex
CA2821711C (en) 2010-12-15 2017-10-10 Baxter International Inc. Eluate collection using conductivity gradient

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
US5543502A (en) * 1986-06-24 1996-08-06 Novo Nordisk A/S Process for producing a coagulation active complex of factor VIII fragments
US5200510A (en) * 1987-06-16 1993-04-06 Zymogenetics, Inc. Method for purifying factor viii:c, von willebrand factor and complexes thereof
US5605884A (en) * 1987-10-29 1997-02-25 Rhone-Poulenc Rorer Pharmaceuticals Inc. Factor VIII formulations in high ionic strength media
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
DE19521313A1 (de) * 1995-06-12 1996-12-19 Max Planck Inst Fuer Physiolog Verfahren zur affinitätschromatographischen Aufreinigung von Faktor VIII

Also Published As

Publication number Publication date
WO1997049730A1 (de) 1997-12-31
EP0910581B1 (de) 2000-04-05
US6143179A (en) 2000-11-07
EP0910581A1 (de) 1999-04-28

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