ATE425989T1 - Proteinreinigungsverfahren - Google Patents
ProteinreinigungsverfahrenInfo
- Publication number
- ATE425989T1 ATE425989T1 AT02794380T AT02794380T ATE425989T1 AT E425989 T1 ATE425989 T1 AT E425989T1 AT 02794380 T AT02794380 T AT 02794380T AT 02794380 T AT02794380 T AT 02794380T AT E425989 T1 ATE425989 T1 AT E425989T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- purification process
- protein purification
- bind
- proteins
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000001742 protein purification Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 10
- 108090000623 proteins and genes Proteins 0.000 abstract 10
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 238000001042 affinity chromatography Methods 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34336301P | 2001-12-21 | 2001-12-21 | |
| US34718902P | 2002-01-08 | 2002-01-08 | |
| US36427202P | 2002-03-12 | 2002-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE425989T1 true ATE425989T1 (de) | 2009-04-15 |
Family
ID=27407561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02794380T ATE425989T1 (de) | 2001-12-21 | 2002-12-20 | Proteinreinigungsverfahren |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7122641B2 (de) |
| EP (1) | EP1463942B2 (de) |
| JP (1) | JP4363986B2 (de) |
| AT (1) | ATE425989T1 (de) |
| AU (1) | AU2002359816B2 (de) |
| CA (1) | CA2469815C (de) |
| DE (1) | DE60231651D1 (de) |
| ES (1) | ES2322945T5 (de) |
| MX (1) | MXPA04006053A (de) |
| PL (1) | PL374311A1 (de) |
| WO (1) | WO2003059935A2 (de) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406604B1 (en) | 1999-11-08 | 2002-06-18 | Norberto A. Guzman | Multi-dimensional electrophoresis apparatus |
| US7329388B2 (en) | 1999-11-08 | 2008-02-12 | Princeton Biochemicals, Inc. | Electrophoresis apparatus having staggered passage configuration |
| WO2003059935A2 (en) * | 2001-12-21 | 2003-07-24 | Immunex Corporation | Methods for purifying protein |
| ES2558303T3 (es) | 2002-09-11 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Método de purificación de proteínas |
| GB0304576D0 (en) * | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
| US7850970B2 (en) | 2003-08-26 | 2010-12-14 | The Regents Of The University Of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
| EP2336172B1 (de) * | 2003-10-27 | 2014-12-10 | Wyeth LLC | Entfernen von Aggregaten mit hohem Molekulargewicht durch Hydroxyapatitchromatographie |
| US8007725B2 (en) | 2003-11-07 | 2011-08-30 | Princeton Biochemicals, Inc. | Electrophoresis apparatus having valve system |
| CA2563310A1 (en) | 2003-11-07 | 2005-05-26 | Princeton Biochemicals, Inc. | Multi-dimensional electrophoresis apparatus |
| WO2005071410A1 (en) * | 2004-01-13 | 2005-08-04 | Tanox, Inc. | Detecting and quantifying host cell proteins in recombinant protein products |
| JP4872327B2 (ja) * | 2004-11-26 | 2012-02-08 | 東レ株式会社 | 改質されたインターロイキン−11とその製造方法 |
| AU2006223180B2 (en) * | 2005-03-11 | 2011-11-24 | Wyeth Llc | A method of weak partitioning chromatography |
| US20060240564A1 (en) * | 2005-04-20 | 2006-10-26 | Chia-Hui Shieh | pH gradient ion exchange LC-MS and mass compatible buffers |
| MX2007015476A (es) | 2005-06-14 | 2008-02-25 | Amgen Inc | Formulaciones de proteina autoamortiguadoras. |
| US7375188B2 (en) | 2005-07-29 | 2008-05-20 | Mallinckrodt Baker, Inc. | Vegetarian protein a preparation and methods thereof |
| MY185597A (en) * | 2005-09-20 | 2021-05-24 | Avantor Performance Mat Inc | Vegetarian protein a preparation and methods thereof |
| EP1816201A1 (de) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modifizierter Koagulationsfaktor VIIa mit verbesserter 'half-life'-Stabiltät |
| KR20140071452A (ko) * | 2006-04-05 | 2014-06-11 | 애브비 바이오테크놀로지 리미티드 | 항체 정제 |
| EP1867660A1 (de) | 2006-06-14 | 2007-12-19 | CSL Behring GmbH | Fusionsprotein welches proteolytisch geschnitten werden kann und einen Faktor der Blutgerinnungskaskade enthält |
| US7939632B2 (en) | 2006-06-14 | 2011-05-10 | Csl Behring Gmbh | Proteolytically cleavable fusion proteins with high molar specific activity |
| US20100234577A1 (en) * | 2006-06-14 | 2010-09-16 | Smithkline Beecham Corporation | Methods for purifying antibodies using ceramic hydroxyapatite |
| AU2007260185B2 (en) | 2006-06-14 | 2013-01-31 | Csl Behring Gmbh | Proteolytically cleavable fusion protein comprising a blood coagulation factor |
| EA017733B1 (ru) * | 2006-08-28 | 2013-02-28 | Арес Трейдинг С.А. | СПОСОБ ОЧИСТКИ Fc-СЛИТЫХ БЕЛКОВ |
| JP2010501622A (ja) * | 2006-08-28 | 2010-01-21 | アレス トレーディング ソシエテ アノニム | Fc−融合タンパク質の精製法 |
| DK2061803T4 (da) | 2006-08-28 | 2022-12-05 | Ares Trading Sa | Fremgangsmåde til oprensning af fc-holdige proteiner |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| TWI456062B (zh) | 2006-09-13 | 2014-10-11 | Abbvie Inc | 細胞培養改良 |
| US20100047252A1 (en) * | 2006-11-22 | 2010-02-25 | 3M Innovative Properties Company | Antibody with protein a selectivity |
| US7488807B2 (en) * | 2006-11-22 | 2009-02-10 | 3M Innovative Properties Company | Antibody with protein A selectivity |
| AU2007338298B2 (en) | 2006-12-22 | 2013-02-07 | Csl Behring Gmbh | Modified coagulation factors with prolonged in vivo half-life |
| EP2275431A3 (de) * | 2008-01-18 | 2011-05-25 | Bio-Rad Laboratories, Inc. | Erweiterte reinigung phosphorylierter und nicht phosphorylierter biomoleküle durch apatit-chromatographie |
| US20100058173A1 (en) * | 2008-08-28 | 2010-03-04 | Kabushiki Kaisha Toshiba | Display processing apparatus, display processing method, and computer program product |
| CA2736141C (en) * | 2008-09-23 | 2018-03-20 | F. Hoffmann-La Roche Ag | Purification of erythropoietin |
| AU2009347206C1 (en) | 2008-10-20 | 2016-12-08 | Abbvie Inc. | Isolation and purification of antibodies using Protein A affinity chromatography |
| MX2011004201A (es) | 2008-10-20 | 2011-05-24 | Abbott Lab | Desactivacion viral durante purificacion de anticuerpos. |
| EP2350130B1 (de) | 2008-10-31 | 2018-10-03 | Wyeth LLC | Aufreinigung von sauren proteinen durch chromatografie an keramischem hydroxyapatit |
| US8945895B2 (en) | 2009-07-31 | 2015-02-03 | Baxter International Inc. | Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof |
| JP2013512674A (ja) * | 2009-12-02 | 2013-04-18 | アクセルロン ファーマ, インコーポレイテッド | Fc融合タンパク質の血清半減期を増加させるための組成物および方法 |
| WO2011088225A1 (en) | 2010-01-15 | 2011-07-21 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
| WO2011146179A2 (en) * | 2010-05-18 | 2011-11-24 | Abbott Laboratories | Apparatus and process of purification of proteins |
| US8895707B2 (en) | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
| JP5881744B2 (ja) * | 2011-02-02 | 2016-03-09 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | アルカリ溶液でのアパタイトの表面中和方法 |
| EP2702077A2 (de) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Verfahren zur steuerung des galactosylierungsprofil von rekombinant exprimierten proteinen |
| US8911992B2 (en) * | 2011-04-28 | 2014-12-16 | Bio-Rad Laboratories, Inc. | DNA removal in target molecule purification |
| EP2718328A4 (de) | 2011-06-08 | 2014-12-24 | Acceleron Pharma Inc | Zusammensetzungen und verfahren zur erhöhung der halbwertszeit von serum |
| EP3628327A1 (de) | 2011-06-24 | 2020-04-01 | The Regents of the University of Colorado, A Body Corporate | Zusammensetzungen, verfahren und verwendung für alpha-1-antitrypsin-fusionsmoleküle |
| BR112014000352A2 (pt) | 2011-07-08 | 2017-02-14 | Merck Sharp & Dohe Corp | método de purificar uma proteína de fusão-fc, proteínas de fusão contendo fc purificada, tnfr:fc purificada, e tnfr:fc elevadamente purificada |
| AU2013202648B2 (en) | 2012-01-10 | 2016-05-19 | Konkuk University | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| US9815695B2 (en) | 2012-05-30 | 2017-11-14 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| HK1211981A1 (en) | 2012-09-02 | 2016-06-03 | Abbvie Inc. | Methods to control protein heterogeneity |
| US9816102B2 (en) | 2012-09-13 | 2017-11-14 | Indiana University Research And Technology Corporation | Compositions and systems for conferring disease resistance in plants and methods of use thereof |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| EP3395423B1 (de) * | 2013-03-14 | 2023-09-20 | Amgen Inc. | Entfernung von ausgelaufenen affinitätsreinigungsliganden |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| CN105392569B (zh) | 2014-06-23 | 2019-08-20 | 生物辐射实验室股份有限公司 | 磷灰石预处理 |
| US10099157B2 (en) | 2014-06-23 | 2018-10-16 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
| GB2528301A (en) * | 2014-07-17 | 2016-01-20 | Univ Newcastle | Biomolecule separation using apatite |
| US10814305B2 (en) * | 2016-09-29 | 2020-10-27 | Bio-Rad Laboratories, Inc. | Agarose-filled ceramic apatite |
| AU2017345490B2 (en) | 2016-10-21 | 2022-07-07 | Amgen Inc. | Pharmaceutical formulations and methods of making the same |
| US12516102B1 (en) * | 2017-02-09 | 2026-01-06 | Bracco Suisse Sa | Process for the purification of soluble PSGL-1 protein variants |
| CN112996801A (zh) * | 2018-11-26 | 2021-06-18 | 北卡罗来纳州大学 | 用于捕获宿主细胞蛋白的肽配体 |
| EP4106897A4 (de) | 2020-02-19 | 2023-10-25 | Bio-Rad Laboratories, Inc. | Verfahren zur herstellung von polymergefülltem chromatografieharz |
| EP4142792A4 (de) * | 2020-05-01 | 2024-11-27 | Kashiv Biosciences, LLC | Verbessertes verfahren zur reinigung von protein |
| WO2022140389A1 (en) | 2020-12-22 | 2022-06-30 | Amgen Inc. | Cell culture method |
| CN121712571A (zh) * | 2023-08-15 | 2026-03-20 | 百时美施贵宝公司 | 陶瓷羟基磷灰石色谱流通法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4745183A (en) * | 1984-02-21 | 1988-05-17 | Bio-Rad Laboratories, Inc. | Use of hydroxylapatite for the analysis and preparation of purified monoclonal antibodies |
| DE3738541A1 (de) * | 1987-11-13 | 1989-05-24 | Hoechst Ag | Verfahren zur isolierung und reinigung von hirudin |
| JPH0774231B2 (ja) | 1986-12-11 | 1995-08-09 | 東燃株式会社 | 抗体の分離方法 |
| US4933286A (en) * | 1987-03-30 | 1990-06-12 | Plant Cell Research Institute, Inc. | Purification of apase-11 and retrieval of the nematode resistance gene |
| US5115101A (en) * | 1988-06-08 | 1992-05-19 | Miles Inc. | Removal of protein A from antibody preparations |
| JPH022937A (ja) | 1988-06-17 | 1990-01-08 | Toray Ind Inc | 酵素標識抗体の分離精製方法 |
| JPH03139292A (ja) | 1989-05-22 | 1991-06-13 | Toray Ind Inc | ヒトインタ―ロイキン―6に対するモノクロ―ナル抗体 |
| US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| ATE194384T1 (de) * | 1989-09-12 | 2000-07-15 | Hoffmann La Roche | Tnf-bindende proteine |
| JPH03291300A (ja) | 1989-12-28 | 1991-12-20 | Mitsui Toatsu Chem Inc | ポリクローナル抗体の分離方法 |
| GB9007657D0 (en) * | 1990-04-04 | 1990-05-30 | Connaught Lab | Purification of a pertussis outer membrane protein(omp69) |
| JPH04368399A (ja) | 1991-06-12 | 1992-12-21 | Toagosei Chem Ind Co Ltd | 抗体の分離方法 |
| JP2961986B2 (ja) | 1991-08-22 | 1999-10-12 | 東亞合成株式会社 | ポリクローナル抗体の分離精製方法 |
| DE4205938A1 (de) * | 1992-02-27 | 1993-09-02 | Medac Klinische Spezialpraep | Immunotoxine |
| JP3178080B2 (ja) | 1992-04-28 | 2001-06-18 | チッソ株式会社 | 抗体の分離精製方法 |
| US5278284A (en) * | 1992-05-14 | 1994-01-11 | Miller Brewing Company | Protein purification method |
| US6099830A (en) * | 1994-08-09 | 2000-08-08 | Zymogenetics, Inc. | Methods for stimulating erythropoiesis using hematopoietic proteins |
| US5641655A (en) * | 1994-11-30 | 1997-06-24 | Zymogenetics, Inc. | Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide |
| JPH08188599A (ja) | 1995-01-09 | 1996-07-23 | Toagosei Co Ltd | IgY抗体の分離精製方法 |
| US5744587A (en) * | 1995-06-07 | 1998-04-28 | Zymogenetics, Inc. | Method for purifying thrombopoietin |
| EP0950067B1 (de) * | 1996-11-27 | 2007-08-29 | Genentech, Inc. | Affinitätsreinigung von polypeptiden an einer protein a-matrix |
| CA2289665C (en) * | 1997-06-13 | 2005-08-09 | Genentech, Inc. | Protein recovery by chromatography followed by filtration upon a charged layer |
| WO2003059935A2 (en) * | 2001-12-21 | 2003-07-24 | Immunex Corporation | Methods for purifying protein |
| WO2003059936A2 (en) * | 2002-01-10 | 2003-07-24 | Syngenta Participations Ag | Phytophthora Infestans CDC 14 Phosphatase Gene, Protein and Methods of Use |
-
2002
- 2002-12-20 WO PCT/US2002/041159 patent/WO2003059935A2/en not_active Ceased
- 2002-12-20 EP EP02794380A patent/EP1463942B2/de not_active Expired - Lifetime
- 2002-12-20 CA CA2469815A patent/CA2469815C/en not_active Expired - Fee Related
- 2002-12-20 JP JP2003560037A patent/JP4363986B2/ja not_active Expired - Lifetime
- 2002-12-20 AU AU2002359816A patent/AU2002359816B2/en not_active Expired
- 2002-12-20 AT AT02794380T patent/ATE425989T1/de not_active IP Right Cessation
- 2002-12-20 ES ES02794380T patent/ES2322945T5/es not_active Expired - Lifetime
- 2002-12-20 US US10/327,495 patent/US7122641B2/en not_active Expired - Lifetime
- 2002-12-20 PL PL02374311A patent/PL374311A1/xx not_active Application Discontinuation
- 2002-12-20 DE DE60231651T patent/DE60231651D1/de not_active Expired - Lifetime
- 2002-12-20 MX MXPA04006053A patent/MXPA04006053A/es active IP Right Grant
-
2006
- 2006-09-13 US US11/520,921 patent/US7476722B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60231651D1 (de) | 2009-04-30 |
| ES2322945T3 (es) | 2009-07-02 |
| EP1463942A4 (de) | 2005-01-19 |
| ES2322945T5 (es) | 2012-10-17 |
| WO2003059935A2 (en) | 2003-07-24 |
| AU2002359816A1 (en) | 2003-07-30 |
| EP1463942B1 (de) | 2009-03-18 |
| CA2469815C (en) | 2011-05-03 |
| EP1463942A2 (de) | 2004-10-06 |
| US7122641B2 (en) | 2006-10-17 |
| US20070010661A1 (en) | 2007-01-11 |
| JP2005538686A (ja) | 2005-12-22 |
| US20030166869A1 (en) | 2003-09-04 |
| JP4363986B2 (ja) | 2009-11-11 |
| MXPA04006053A (es) | 2005-03-31 |
| EP1463942B2 (de) | 2012-06-20 |
| AU2002359816B2 (en) | 2006-07-13 |
| PL374311A1 (en) | 2005-10-03 |
| WO2003059935A3 (en) | 2003-10-16 |
| US7476722B2 (en) | 2009-01-13 |
| CA2469815A1 (en) | 2003-07-24 |
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