ES2145580T3 - Metodos y composiciones para analizar moleculas de acido nucleico que emplean tecnicas basadas en el tamaño. - Google Patents
Metodos y composiciones para analizar moleculas de acido nucleico que emplean tecnicas basadas en el tamaño.Info
- Publication number
- ES2145580T3 ES2145580T3 ES97905603T ES97905603T ES2145580T3 ES 2145580 T3 ES2145580 T3 ES 2145580T3 ES 97905603 T ES97905603 T ES 97905603T ES 97905603 T ES97905603 T ES 97905603T ES 2145580 T3 ES2145580 T3 ES 2145580T3
- Authority
- ES
- Spain
- Prior art keywords
- nucleic acid
- compositions
- methods
- size
- acid molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
SE DESCUBREN TAGS Y ENGARCES DISEÑADOS ESPECIFICAMENTE PARA UNA AMPLIA VARIEDAD DE REACCIONES DE ACIDOS NUCLEICOS, QUE SON ADECUADOS PARA UNA AMPLIA VARIEDAD DE REACCIONES DE ACIDOS NUCLEICOS EN LOS QUE SE REQUIERE LA SEPARACION DE MOLECULAS DE ACIDO NUCLEICO POR TAMAÑO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1453696P | 1996-01-23 | 1996-01-23 | |
| US2048796P | 1996-06-04 | 1996-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2145580T3 true ES2145580T3 (es) | 2000-07-01 |
Family
ID=26686209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97905603T Expired - Lifetime ES2145580T3 (es) | 1996-01-23 | 1997-01-23 | Metodos y composiciones para analizar moleculas de acido nucleico que emplean tecnicas basadas en el tamaño. |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP0840804B1 (es) |
| JP (2) | JP2000503845A (es) |
| KR (1) | KR100482915B1 (es) |
| CN (1) | CN1202260C (es) |
| AT (2) | ATE191515T1 (es) |
| AU (1) | AU717945B2 (es) |
| BR (1) | BR9707016A (es) |
| CA (1) | CA2243546C (es) |
| CZ (1) | CZ228598A3 (es) |
| DE (2) | DE69739465D1 (es) |
| DK (1) | DK0840804T3 (es) |
| ES (1) | ES2145580T3 (es) |
| GR (1) | GR3033887T3 (es) |
| HU (1) | HUP9901856A3 (es) |
| NZ (1) | NZ331043A (es) |
| PL (1) | PL328239A1 (es) |
| PT (1) | PT840804E (es) |
| WO (1) | WO1997027325A2 (es) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6401267B1 (en) | 1993-09-27 | 2002-06-11 | Radoje Drmanac | Methods and compositions for efficient nucleic acid sequencing |
| NZ331042A (en) * | 1996-01-23 | 1999-10-28 | Rapigene Inc | Methods and compositions for detecting binding of ligand pair using non-fluorescent label |
| CA2274587A1 (en) | 1996-12-10 | 1998-06-18 | Genetrace Systems Inc. | Releasable nonvolatile mass-label molecules |
| WO1998031830A1 (en) * | 1997-01-15 | 1998-07-23 | Brax Group Limited | Mass label linked hybridisation probes |
| US6699668B1 (en) | 1997-01-15 | 2004-03-02 | Xzillion Gmbh & Co. | Mass label linked hybridisation probes |
| US6060248A (en) * | 1997-02-24 | 2000-05-09 | Tm Technologies, Inc. | Process for selecting anti-sense oligonucleotides |
| CN1270598A (zh) * | 1997-07-22 | 2000-10-18 | 拉普吉恩公司 | 用于质谱分析核酸的方法和组合物 |
| US6090558A (en) * | 1997-09-19 | 2000-07-18 | Genetrace Systems, Inc. | DNA typing by mass spectrometry with polymorphic DNA repeat markers |
| US6289229B1 (en) | 1998-01-20 | 2001-09-11 | Scimed Life Systems, Inc. | Readable probe array for in vivo use |
| BR0013024A (pt) * | 1999-08-31 | 2002-06-18 | Qiagen Genomics Inc | Comtostos enantiomiericamente enriquecidos tendo ligação( ões ) fotoclivável( is ) e métodos relacionados aos mesmos |
| US6379889B1 (en) | 1999-11-04 | 2002-04-30 | Agilent Technologies, Inc. | Multiplexing methods for identifying nucleic acids using denaturing liquid chromatography |
| DE10021204A1 (de) * | 2000-04-25 | 2001-11-08 | Epigenomics Ag | Verfahren zur hochparallelen Analyse von Polymorphismen |
| US7537938B2 (en) | 2000-04-28 | 2009-05-26 | Monogram Biosciences, Inc. | Biomarker detection in circulating cells |
| US7160735B2 (en) | 2000-04-28 | 2007-01-09 | Monogram Biosciences, Inc. | Tagged microparticle compositions and methods |
| US7771929B2 (en) | 2000-04-28 | 2010-08-10 | Monogram Biosciences, Inc. | Tag library compounds, compositions, kits and methods of use |
| US6716634B1 (en) | 2000-05-31 | 2004-04-06 | Agilent Technologies, Inc. | Increasing ionization efficiency in mass spectrometry |
| DE10027040A1 (de) * | 2000-06-02 | 2001-12-06 | Basf Lynx Bioscience Ag | Verfahren zur Herstellung von DNA-Arrays |
| EP1170379A1 (en) * | 2000-06-30 | 2002-01-09 | Centre National de Genotypage | Sample generation for genotyping by mass spectrometry |
| FI115139B (fi) * | 2001-01-10 | 2005-03-15 | Valtion Teknillinen | Menetelmä ja testipakkaus solu- tai kudosnäytteissä olevien polynukleotidien määrässä tapahtuvien vaihteluiden kvantitatiiviseen ja/tai vertailevaan arvioimiseen |
| DE10108453B4 (de) | 2001-02-22 | 2005-10-20 | Bruker Daltonik Gmbh | Massenspektrometrische Mutationsanalyse mit photolytisch spaltbaren Primern |
| DE10112387B4 (de) * | 2001-03-15 | 2004-03-25 | Bruker Daltonik Gmbh | Massenspektrometrische Genotypisierung |
| WO2002095356A2 (en) | 2001-05-21 | 2002-11-28 | Aclara Biosciences, Inc. | Methods and compositions for analyzing proteins |
| HUP0501021A3 (en) | 2001-05-21 | 2006-06-28 | Aclara Biosciences Inc Mountai | Methods and compositions for analyzing proteins |
| US7358052B2 (en) | 2001-05-26 | 2008-04-15 | Monogram Biosciences, Inc. | Catalytic amplification of multiplexed assay signals |
| AU2002362013B2 (en) * | 2001-11-21 | 2008-04-24 | Applied Biosystems, Llc. | Digital assay |
| US7347976B2 (en) | 2001-12-20 | 2008-03-25 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix |
| US7192560B2 (en) | 2001-12-20 | 2007-03-20 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using anion exchange |
| EP1465998A2 (en) | 2002-01-08 | 2004-10-13 | Bayer HealthCare AG | Single nucleotide polymorphisms predicting cardiovascular disease and medication efficacy |
| ATE358185T1 (de) * | 2002-02-01 | 2007-04-15 | Bruker Daltonik Gmbh | Mutationsanalyse mittels pcr und massenspektrometrie |
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| US20040229294A1 (en) | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| US7402397B2 (en) | 2002-05-21 | 2008-07-22 | Monogram Biosciences, Inc. | Detecting and profiling molecular complexes |
| FI20021325A0 (fi) * | 2002-07-05 | 2002-07-05 | Valtion Teknillinen | Menetelmä ja reagenssipakkaus yksittäisten polynukleotidien määrän määrittämiseksi |
| US7981600B2 (en) | 2003-04-17 | 2011-07-19 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene |
| US7939249B2 (en) | 2003-12-24 | 2011-05-10 | 3M Innovative Properties Company | Methods for nucleic acid isolation and kits using a microfluidic device and concentration step |
| GB0515323D0 (en) | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
| GB0518585D0 (en) | 2005-09-12 | 2005-10-19 | Electrophoretics Ltd | Mass labels |
| EP1936369A1 (en) * | 2006-12-20 | 2008-06-25 | Agilent Technologies, Inc. | Selective excitation of OH-containing solvents |
| GB0704764D0 (en) | 2007-03-12 | 2007-04-18 | Electrophoretics Ltd | Isobarically labelled reagents and methods of their use |
| US7888127B2 (en) | 2008-01-15 | 2011-02-15 | Sequenom, Inc. | Methods for reducing adduct formation for mass spectrometry analysis |
| GB0809488D0 (en) | 2008-05-23 | 2008-07-02 | Electrophoretics Ltd | Mass spectrometric analysis |
| GB0811574D0 (en) * | 2008-06-24 | 2008-07-30 | Trillion Genomics Ltd | Characterising planar samples by mass spectrometry |
| EP2180065A1 (en) * | 2008-10-24 | 2010-04-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method of reducing the molecular weight of at least one PCR product for its detection while maintaining its identity |
| JP5283178B2 (ja) * | 2009-03-05 | 2013-09-04 | 株式会社島津製作所 | マトリックス支援レーザ脱離イオン化質量分析用マトリックス |
| GB0921665D0 (en) | 2009-12-10 | 2010-01-27 | Trillion Genomics Ltd | Phobes |
| WO2012003478A2 (en) | 2010-07-02 | 2012-01-05 | Ventana Medical Systems, Inc. | Detecting targets using mass tags and mass spectrometry |
| US9305756B2 (en) | 2013-03-13 | 2016-04-05 | Agena Bioscience, Inc. | Preparation enhancements and methods of use for MALDI mass spectrometry |
| GB201322567D0 (en) | 2013-12-19 | 2014-02-05 | Electrophoretics Ltd | Mass labels |
| CN110687191A (zh) * | 2019-10-22 | 2020-01-14 | 宁波大学 | 基于基质辅助激光解吸电离飞行时间质谱与ftir光谱联用的微生物鉴定和分型方法 |
| CN113607829B (zh) * | 2021-06-11 | 2023-05-30 | 南京品生医学检验实验室有限公司 | 一种检测血清中5-羟色胺和褪黑素浓度的方法 |
| CN115337665B (zh) * | 2022-09-14 | 2023-05-30 | 洛阳理工学院 | 微通道萃取装置辅助从黄岑根中高效分离黄芩苷的方法 |
| EP4667939A1 (en) | 2024-06-21 | 2025-12-24 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Multiplex cancer cell profiling using ms-tagged probes containing an iminosydnone cleavable linker |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516931A (en) * | 1982-02-01 | 1996-05-14 | Northeastern University | Release tag compounds producing ketone signal groups |
| US4709016A (en) * | 1982-02-01 | 1987-11-24 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
| US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| US5346670A (en) * | 1986-12-24 | 1994-09-13 | British Technology Group U.S.A. Inc. | Phthalocyanine and tetrabenztriazaporphyrin reagents |
| FI80476C (fi) * | 1987-10-09 | 1990-06-11 | Orion Yhtymae Oy | Foerbaettrat hybridisationsfoerfarande, vid foerfarandet anvaent redskap och reagensfoerpackning. |
| CA1323553C (en) * | 1987-11-03 | 1993-10-26 | Timothy George Helentjaris | Method and device for improved restriction fragment length polymorphism analysis |
| US5003059A (en) * | 1988-06-20 | 1991-03-26 | Genomyx, Inc. | Determining DNA sequences by mass spectrometry |
| DK220890D0 (da) * | 1990-09-14 | 1990-09-14 | Ole Buchardt | Fremgangsmaade til fremstilling af c-terminalt amiderede peptider |
| WO1993005183A1 (en) * | 1991-09-09 | 1993-03-18 | Baylor College Of Medicine | Method and device for rapid dna or rna sequencing determination by a base addition sequencing scheme |
| WO1993020233A1 (en) * | 1992-03-27 | 1993-10-14 | University Of Maryland At Baltimore | Detection of gene mutations with mismatch repair enzymes |
| EP0665897B1 (en) * | 1992-10-01 | 2003-07-09 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5565324A (en) * | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| CA2153387A1 (en) * | 1993-01-07 | 1994-07-21 | Hubert Koester | Dna sequencing by mass spectrometry |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| NZ331042A (en) * | 1996-01-23 | 1999-10-28 | Rapigene Inc | Methods and compositions for detecting binding of ligand pair using non-fluorescent label |
| EP0868535B9 (en) * | 1996-01-23 | 2007-05-09 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
-
1997
- 1997-01-23 DE DE69739465T patent/DE69739465D1/de not_active Expired - Lifetime
- 1997-01-23 CZ CZ982285A patent/CZ228598A3/cs unknown
- 1997-01-23 EP EP97905603A patent/EP0840804B1/en not_active Expired - Lifetime
- 1997-01-23 ES ES97905603T patent/ES2145580T3/es not_active Expired - Lifetime
- 1997-01-23 HU HU9901856A patent/HUP9901856A3/hu unknown
- 1997-01-23 AT AT97905603T patent/ATE191515T1/de not_active IP Right Cessation
- 1997-01-23 WO PCT/US1997/001046 patent/WO1997027325A2/en not_active Ceased
- 1997-01-23 NZ NZ331043A patent/NZ331043A/xx unknown
- 1997-01-23 PL PL97328239A patent/PL328239A1/xx unknown
- 1997-01-23 DK DK97905603T patent/DK0840804T3/da active
- 1997-01-23 JP JP9526981A patent/JP2000503845A/ja not_active Withdrawn
- 1997-01-23 EP EP99110780A patent/EP0962537B1/en not_active Expired - Lifetime
- 1997-01-23 DE DE69701612T patent/DE69701612T2/de not_active Expired - Lifetime
- 1997-01-23 CN CNB971925550A patent/CN1202260C/zh not_active Expired - Fee Related
- 1997-01-23 CA CA002243546A patent/CA2243546C/en not_active Expired - Fee Related
- 1997-01-23 AU AU22448/97A patent/AU717945B2/en not_active Ceased
- 1997-01-23 BR BR9707016-5A patent/BR9707016A/pt not_active Application Discontinuation
- 1997-01-23 AT AT99110780T patent/ATE434054T1/de not_active IP Right Cessation
- 1997-01-23 KR KR10-1998-0705637A patent/KR100482915B1/ko not_active Expired - Fee Related
- 1997-01-23 PT PT97905603T patent/PT840804E/pt unknown
-
2000
- 2000-07-05 GR GR20000401572T patent/GR3033887T3/el not_active IP Right Cessation
-
2008
- 2008-03-04 JP JP2008054175A patent/JP2008200040A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR100482915B1 (ko) | 2005-09-12 |
| WO1997027325A2 (en) | 1997-07-31 |
| GR3033887T3 (en) | 2000-11-30 |
| ATE434054T1 (de) | 2009-07-15 |
| KR19990081924A (ko) | 1999-11-15 |
| ATE191515T1 (de) | 2000-04-15 |
| HUP9901856A3 (en) | 2001-10-29 |
| HUP9901856A2 (hu) | 1999-09-28 |
| EP0962537A2 (en) | 1999-12-08 |
| PT840804E (pt) | 2000-10-31 |
| EP0962537B1 (en) | 2009-06-17 |
| NZ331043A (en) | 1999-01-28 |
| BR9707016A (pt) | 2000-01-04 |
| CZ228598A3 (cs) | 1998-12-16 |
| DE69739465D1 (de) | 2009-07-30 |
| EP0962537A3 (en) | 2004-02-11 |
| CA2243546C (en) | 2008-04-15 |
| DE69701612D1 (de) | 2000-05-11 |
| DK0840804T3 (da) | 2000-07-17 |
| EP0840804B1 (en) | 2000-04-05 |
| JP2008200040A (ja) | 2008-09-04 |
| EP0840804A1 (en) | 1998-05-13 |
| JP2000503845A (ja) | 2000-04-04 |
| DE69701612T2 (de) | 2000-08-31 |
| PL328239A1 (en) | 1999-01-18 |
| AU717945B2 (en) | 2000-04-06 |
| CN1202260C (zh) | 2005-05-18 |
| WO1997027325A3 (en) | 1998-04-02 |
| CA2243546A1 (en) | 1997-07-31 |
| AU2244897A (en) | 1997-08-20 |
| CN1212020A (zh) | 1999-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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