ES2145580T3 - Metodos y composiciones para analizar moleculas de acido nucleico que emplean tecnicas basadas en el tamaño. - Google Patents
Metodos y composiciones para analizar moleculas de acido nucleico que emplean tecnicas basadas en el tamaño.Info
- Publication number
- ES2145580T3 ES2145580T3 ES97905603T ES97905603T ES2145580T3 ES 2145580 T3 ES2145580 T3 ES 2145580T3 ES 97905603 T ES97905603 T ES 97905603T ES 97905603 T ES97905603 T ES 97905603T ES 2145580 T3 ES2145580 T3 ES 2145580T3
- Authority
- ES
- Spain
- Prior art keywords
- nucleic acid
- compositions
- methods
- size
- acid molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
SE DESCUBREN TAGS Y ENGARCES DISEÑADOS ESPECIFICAMENTE PARA UNA AMPLIA VARIEDAD DE REACCIONES DE ACIDOS NUCLEICOS, QUE SON ADECUADOS PARA UNA AMPLIA VARIEDAD DE REACCIONES DE ACIDOS NUCLEICOS EN LOS QUE SE REQUIERE LA SEPARACION DE MOLECULAS DE ACIDO NUCLEICO POR TAMAÑO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1453696P | 1996-01-23 | 1996-01-23 | |
| US2048796P | 1996-06-04 | 1996-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2145580T3 true ES2145580T3 (es) | 2000-07-01 |
Family
ID=26686209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97905603T Expired - Lifetime ES2145580T3 (es) | 1996-01-23 | 1997-01-23 | Metodos y composiciones para analizar moleculas de acido nucleico que emplean tecnicas basadas en el tamaño. |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP0962537B1 (es) |
| JP (2) | JP2000503845A (es) |
| KR (1) | KR100482915B1 (es) |
| CN (1) | CN1202260C (es) |
| AT (2) | ATE191515T1 (es) |
| AU (1) | AU717945B2 (es) |
| BR (1) | BR9707016A (es) |
| CA (1) | CA2243546C (es) |
| CZ (1) | CZ228598A3 (es) |
| DE (2) | DE69739465D1 (es) |
| DK (1) | DK0840804T3 (es) |
| ES (1) | ES2145580T3 (es) |
| GR (1) | GR3033887T3 (es) |
| HU (1) | HUP9901856A3 (es) |
| NZ (1) | NZ331043A (es) |
| PL (1) | PL328239A1 (es) |
| PT (1) | PT840804E (es) |
| WO (1) | WO1997027325A2 (es) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6401267B1 (en) | 1993-09-27 | 2002-06-11 | Radoje Drmanac | Methods and compositions for efficient nucleic acid sequencing |
| HUP9900459A3 (en) * | 1996-01-23 | 1999-11-29 | Rapigene Inc Bothell | Methods and compositions for detecting binding of ligand pair using non-fluorescent label |
| DE69735445T2 (de) | 1996-12-10 | 2006-08-10 | Sequenom, Inc., San Diego | Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung |
| US6699668B1 (en) | 1997-01-15 | 2004-03-02 | Xzillion Gmbh & Co. | Mass label linked hybridisation probes |
| ATE374836T1 (de) * | 1997-01-15 | 2007-10-15 | Xzillion Gmbh & Co Kg | Massenmarkierte hybridisierungssonden |
| US6060248A (en) * | 1997-02-24 | 2000-05-09 | Tm Technologies, Inc. | Process for selecting anti-sense oligonucleotides |
| AU738237B2 (en) * | 1997-07-22 | 2001-09-13 | Qiagen Genomics, Inc. | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques |
| AU9400398A (en) * | 1997-09-19 | 1999-04-05 | Genetrace Systems, Inc. | Dna typing by mass spectrometry with polymorphic dna repeat markers |
| US6289229B1 (en) | 1998-01-20 | 2001-09-11 | Scimed Life Systems, Inc. | Readable probe array for in vivo use |
| JP2003508378A (ja) * | 1999-08-31 | 2003-03-04 | キアジェン ジェノミックス, インコーポレイテッド | 光切断性結合を有するエナンチオマーに富む化合物およびそれに関連する方法 |
| US6379889B1 (en) | 1999-11-04 | 2002-04-30 | Agilent Technologies, Inc. | Multiplexing methods for identifying nucleic acids using denaturing liquid chromatography |
| DE10021204A1 (de) * | 2000-04-25 | 2001-11-08 | Epigenomics Ag | Verfahren zur hochparallelen Analyse von Polymorphismen |
| US7160735B2 (en) | 2000-04-28 | 2007-01-09 | Monogram Biosciences, Inc. | Tagged microparticle compositions and methods |
| US7537938B2 (en) | 2000-04-28 | 2009-05-26 | Monogram Biosciences, Inc. | Biomarker detection in circulating cells |
| US7771929B2 (en) | 2000-04-28 | 2010-08-10 | Monogram Biosciences, Inc. | Tag library compounds, compositions, kits and methods of use |
| US6716634B1 (en) | 2000-05-31 | 2004-04-06 | Agilent Technologies, Inc. | Increasing ionization efficiency in mass spectrometry |
| DE10027040A1 (de) * | 2000-06-02 | 2001-12-06 | Basf Lynx Bioscience Ag | Verfahren zur Herstellung von DNA-Arrays |
| EP1170379A1 (en) * | 2000-06-30 | 2002-01-09 | Centre National de Genotypage | Sample generation for genotyping by mass spectrometry |
| FI115139B (fi) | 2001-01-10 | 2005-03-15 | Valtion Teknillinen | Menetelmä ja testipakkaus solu- tai kudosnäytteissä olevien polynukleotidien määrässä tapahtuvien vaihteluiden kvantitatiiviseen ja/tai vertailevaan arvioimiseen |
| DE10108453B4 (de) * | 2001-02-22 | 2005-10-20 | Bruker Daltonik Gmbh | Massenspektrometrische Mutationsanalyse mit photolytisch spaltbaren Primern |
| DE10112387B4 (de) * | 2001-03-15 | 2004-03-25 | Bruker Daltonik Gmbh | Massenspektrometrische Genotypisierung |
| PL373962A1 (en) | 2001-05-21 | 2005-09-19 | Aclara Biosciences, Inc. | Methods and compositions for analyzing proteins |
| WO2002094998A2 (en) | 2001-05-21 | 2002-11-28 | Aclara Biosciences, Inc. | Analyzing phosphorylated proteins |
| WO2002097112A2 (en) | 2001-05-26 | 2002-12-05 | Aclara Biosciences, Inc. | Catalytic amplification of multiplexed assay signals |
| AU2002362013B2 (en) * | 2001-11-21 | 2008-04-24 | Applied Biosystems, Llc. | Digital assay |
| US7192560B2 (en) | 2001-12-20 | 2007-03-20 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using anion exchange |
| US7347976B2 (en) | 2001-12-20 | 2008-03-25 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix |
| EP1465998A2 (en) | 2002-01-08 | 2004-10-13 | Bayer HealthCare AG | Single nucleotide polymorphisms predicting cardiovascular disease and medication efficacy |
| ATE358185T1 (de) * | 2002-02-01 | 2007-04-15 | Bruker Daltonik Gmbh | Mutationsanalyse mittels pcr und massenspektrometrie |
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| US7402397B2 (en) | 2002-05-21 | 2008-07-22 | Monogram Biosciences, Inc. | Detecting and profiling molecular complexes |
| US20040229294A1 (en) | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| FI20021325A0 (fi) * | 2002-07-05 | 2002-07-05 | Valtion Teknillinen | Menetelmä ja reagenssipakkaus yksittäisten polynukleotidien määrän määrittämiseksi |
| US7981600B2 (en) | 2003-04-17 | 2011-07-19 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene |
| US7939249B2 (en) | 2003-12-24 | 2011-05-10 | 3M Innovative Properties Company | Methods for nucleic acid isolation and kits using a microfluidic device and concentration step |
| GB0515323D0 (en) | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
| GB0518585D0 (en) | 2005-09-12 | 2005-10-19 | Electrophoretics Ltd | Mass labels |
| EP1936369A1 (en) * | 2006-12-20 | 2008-06-25 | Agilent Technologies, Inc. | Selective excitation of OH-containing solvents |
| GB0704764D0 (en) | 2007-03-12 | 2007-04-18 | Electrophoretics Ltd | Isobarically labelled reagents and methods of their use |
| US7888127B2 (en) * | 2008-01-15 | 2011-02-15 | Sequenom, Inc. | Methods for reducing adduct formation for mass spectrometry analysis |
| GB0809488D0 (en) | 2008-05-23 | 2008-07-02 | Electrophoretics Ltd | Mass spectrometric analysis |
| GB0811574D0 (en) * | 2008-06-24 | 2008-07-30 | Trillion Genomics Ltd | Characterising planar samples by mass spectrometry |
| EP2180065A1 (en) * | 2008-10-24 | 2010-04-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method of reducing the molecular weight of at least one PCR product for its detection while maintaining its identity |
| JP5283178B2 (ja) * | 2009-03-05 | 2013-09-04 | 株式会社島津製作所 | マトリックス支援レーザ脱離イオン化質量分析用マトリックス |
| GB0921665D0 (en) | 2009-12-10 | 2010-01-27 | Trillion Genomics Ltd | Phobes |
| EP2588144B1 (en) | 2010-07-02 | 2018-05-09 | Ventana Medical Systems, Inc. | Detecting targets using mass tags and mass spectrometry |
| US9305756B2 (en) | 2013-03-13 | 2016-04-05 | Agena Bioscience, Inc. | Preparation enhancements and methods of use for MALDI mass spectrometry |
| GB201322567D0 (en) | 2013-12-19 | 2014-02-05 | Electrophoretics Ltd | Mass labels |
| CN110687191A (zh) * | 2019-10-22 | 2020-01-14 | 宁波大学 | 基于基质辅助激光解吸电离飞行时间质谱与ftir光谱联用的微生物鉴定和分型方法 |
| CN113607829B (zh) * | 2021-06-11 | 2023-05-30 | 南京品生医学检验实验室有限公司 | 一种检测血清中5-羟色胺和褪黑素浓度的方法 |
| CN115337665B (zh) * | 2022-09-14 | 2023-05-30 | 洛阳理工学院 | 微通道萃取装置辅助从黄岑根中高效分离黄芩苷的方法 |
| EP4667939A1 (en) | 2024-06-21 | 2025-12-24 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Multiplex cancer cell profiling using ms-tagged probes containing an iminosydnone cleavable linker |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4709016A (en) * | 1982-02-01 | 1987-11-24 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
| US5516931A (en) * | 1982-02-01 | 1996-05-14 | Northeastern University | Release tag compounds producing ketone signal groups |
| US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| US5346670A (en) * | 1986-12-24 | 1994-09-13 | British Technology Group U.S.A. Inc. | Phthalocyanine and tetrabenztriazaporphyrin reagents |
| FI80476C (fi) * | 1987-10-09 | 1990-06-11 | Orion Yhtymae Oy | Foerbaettrat hybridisationsfoerfarande, vid foerfarandet anvaent redskap och reagensfoerpackning. |
| JP2634208B2 (ja) * | 1987-11-13 | 1997-07-23 | パイオニア・ハイ―ブレツド・インターナシヨナル・インコーポレイテツド | 制限断片長多型性分析方法及びその装置 |
| US5003059A (en) * | 1988-06-20 | 1991-03-26 | Genomyx, Inc. | Determining DNA sequences by mass spectrometry |
| DK220890D0 (da) * | 1990-09-14 | 1990-09-14 | Ole Buchardt | Fremgangsmaade til fremstilling af c-terminalt amiderede peptider |
| WO1993005183A1 (en) * | 1991-09-09 | 1993-03-18 | Baylor College Of Medicine | Method and device for rapid dna or rna sequencing determination by a base addition sequencing scheme |
| AU3919293A (en) * | 1992-03-27 | 1993-11-08 | University Of Maryland At Baltimore | Detection of gene mutations with mismatch repair enzymes |
| ES2204910T3 (es) * | 1992-10-01 | 2004-05-01 | The Trustees Of Columbia University In The City Of New York | Bibliotecas quimicas combinatorias complejas codificadas con señales. |
| US5565324A (en) * | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| CA2153387A1 (en) * | 1993-01-07 | 1994-07-21 | Hubert Koester | Dna sequencing by mass spectrometry |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| HUP9900459A3 (en) * | 1996-01-23 | 1999-11-29 | Rapigene Inc Bothell | Methods and compositions for detecting binding of ligand pair using non-fluorescent label |
| DE69739304D1 (de) * | 1996-01-23 | 2009-04-23 | Operon Biotechnologies Inc | Verfahren und Zusammensetzungen zur Bestimmung von Sequenzen von Nukleinsäure-Molekülen |
-
1997
- 1997-01-23 CN CNB971925550A patent/CN1202260C/zh not_active Expired - Fee Related
- 1997-01-23 EP EP99110780A patent/EP0962537B1/en not_active Expired - Lifetime
- 1997-01-23 CA CA002243546A patent/CA2243546C/en not_active Expired - Fee Related
- 1997-01-23 EP EP97905603A patent/EP0840804B1/en not_active Expired - Lifetime
- 1997-01-23 AU AU22448/97A patent/AU717945B2/en not_active Ceased
- 1997-01-23 DK DK97905603T patent/DK0840804T3/da active
- 1997-01-23 ES ES97905603T patent/ES2145580T3/es not_active Expired - Lifetime
- 1997-01-23 CZ CZ982285A patent/CZ228598A3/cs unknown
- 1997-01-23 HU HU9901856A patent/HUP9901856A3/hu unknown
- 1997-01-23 AT AT97905603T patent/ATE191515T1/de not_active IP Right Cessation
- 1997-01-23 BR BR9707016-5A patent/BR9707016A/pt not_active Application Discontinuation
- 1997-01-23 PL PL97328239A patent/PL328239A1/xx unknown
- 1997-01-23 JP JP9526981A patent/JP2000503845A/ja not_active Withdrawn
- 1997-01-23 KR KR10-1998-0705637A patent/KR100482915B1/ko not_active Expired - Fee Related
- 1997-01-23 WO PCT/US1997/001046 patent/WO1997027325A2/en not_active Ceased
- 1997-01-23 PT PT97905603T patent/PT840804E/pt unknown
- 1997-01-23 DE DE69739465T patent/DE69739465D1/de not_active Expired - Lifetime
- 1997-01-23 NZ NZ331043A patent/NZ331043A/xx unknown
- 1997-01-23 DE DE69701612T patent/DE69701612T2/de not_active Expired - Lifetime
- 1997-01-23 AT AT99110780T patent/ATE434054T1/de not_active IP Right Cessation
-
2000
- 2000-07-05 GR GR20000401572T patent/GR3033887T3/el not_active IP Right Cessation
-
2008
- 2008-03-04 JP JP2008054175A patent/JP2008200040A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR9707016A (pt) | 2000-01-04 |
| PL328239A1 (en) | 1999-01-18 |
| NZ331043A (en) | 1999-01-28 |
| KR19990081924A (ko) | 1999-11-15 |
| EP0962537A3 (en) | 2004-02-11 |
| EP0840804B1 (en) | 2000-04-05 |
| JP2008200040A (ja) | 2008-09-04 |
| KR100482915B1 (ko) | 2005-09-12 |
| JP2000503845A (ja) | 2000-04-04 |
| GR3033887T3 (en) | 2000-11-30 |
| ATE434054T1 (de) | 2009-07-15 |
| WO1997027325A2 (en) | 1997-07-31 |
| DK0840804T3 (da) | 2000-07-17 |
| DE69739465D1 (de) | 2009-07-30 |
| CN1212020A (zh) | 1999-03-24 |
| AU717945B2 (en) | 2000-04-06 |
| EP0840804A1 (en) | 1998-05-13 |
| HUP9901856A3 (en) | 2001-10-29 |
| DE69701612T2 (de) | 2000-08-31 |
| ATE191515T1 (de) | 2000-04-15 |
| WO1997027325A3 (en) | 1998-04-02 |
| EP0962537B1 (en) | 2009-06-17 |
| CA2243546A1 (en) | 1997-07-31 |
| AU2244897A (en) | 1997-08-20 |
| PT840804E (pt) | 2000-10-31 |
| HUP9901856A2 (hu) | 1999-09-28 |
| DE69701612D1 (de) | 2000-05-11 |
| CA2243546C (en) | 2008-04-15 |
| EP0962537A2 (en) | 1999-12-08 |
| CZ228598A3 (cs) | 1998-12-16 |
| CN1202260C (zh) | 2005-05-18 |
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| Date | Code | Title | Description |
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| FG2A | Definitive protection |
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