ATE236442T1 - Fluoreszierende cyaninfarbstoffe - Google Patents

Fluoreszierende cyaninfarbstoffe

Info

Publication number
ATE236442T1
ATE236442T1 AT98903434T AT98903434T ATE236442T1 AT E236442 T1 ATE236442 T1 AT E236442T1 AT 98903434 T AT98903434 T AT 98903434T AT 98903434 T AT98903434 T AT 98903434T AT E236442 T1 ATE236442 T1 AT E236442T1
Authority
AT
Austria
Prior art keywords
cyanine dyes
fluorescent cyanine
fluorescent
useful
reporter groups
Prior art date
Application number
AT98903434T
Other languages
English (en)
Inventor
Garrick Murray Little
Ramesh Raghavachari
Narasimhachari Narayanan
Harry Leonard Osterman
Original Assignee
Li Cor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Li Cor Inc filed Critical Li Cor Inc
Application granted granted Critical
Publication of ATE236442T1 publication Critical patent/ATE236442T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Saccharide Compounds (AREA)
AT98903434T 1997-01-10 1998-01-08 Fluoreszierende cyaninfarbstoffe ATE236442T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/781,326 US6027709A (en) 1997-01-10 1997-01-10 Fluorescent cyanine dyes
PCT/US1998/000475 WO1998030992A2 (en) 1997-01-10 1998-01-08 Fluorescent cyanine dyes

Publications (1)

Publication Number Publication Date
ATE236442T1 true ATE236442T1 (de) 2003-04-15

Family

ID=25122364

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98903434T ATE236442T1 (de) 1997-01-10 1998-01-08 Fluoreszierende cyaninfarbstoffe

Country Status (8)

Country Link
US (1) US6027709A (de)
EP (1) EP1019887B1 (de)
JP (1) JP4361138B2 (de)
AT (1) ATE236442T1 (de)
AU (1) AU739930B2 (de)
CA (1) CA2278313C (de)
DE (1) DE69812982T2 (de)
WO (1) WO1998030992A2 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379897B1 (en) * 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
DE69825601T2 (de) * 1997-02-12 2005-04-28 Chan, Eugene Y, Brookline Verfahren zur analyse von polymeren
US6114350A (en) * 1999-04-19 2000-09-05 Nen Life Science Products, Inc. Cyanine dyes and synthesis methods thereof
DE19921234B4 (de) * 1999-05-07 2005-07-28 Few Chemicals Gmbh Cyanin-Farbstoffe
ATE429932T1 (de) * 2000-03-03 2009-05-15 Phanos Tech Inc Fluoreszierende im membran interkalierende proben und verfahren zu deren verwendung
US20030223935A1 (en) * 2001-03-05 2003-12-04 Gray Brian D. Fluorescent membrane intercalating probes and methods for their use
CA2403328A1 (en) * 2000-04-03 2001-10-11 Sun Chemical Corporation Mono- and bis-hydrazone pigments
JP2001288197A (ja) * 2000-04-10 2001-10-16 Fuji Photo Film Co Ltd 蛍光ヌクレオチド
DE10018199A1 (de) 2000-04-12 2001-10-31 Few Chemicals Gmbh Fluoreszenzmarker
US20070172866A1 (en) * 2000-07-07 2007-07-26 Susan Hardin Methods for sequence determination using depolymerizing agent
CN101525660A (zh) * 2000-07-07 2009-09-09 维西根生物技术公司 实时序列测定
US6397150B1 (en) 2000-07-27 2002-05-28 Visible Genetics Inc. Method and apparatus for sequencing of DNA using an internal calibrant
US7597878B2 (en) * 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
JP4989013B2 (ja) * 2000-09-19 2012-08-01 リ−コール インコーポレーティッド シアニン色素
DE10046215B4 (de) * 2000-09-19 2004-04-15 Institut für Chemo- und Biosensorik Münster e.V. i.Ins. Fluorochrome und deren Verwendung
DE60126297T2 (de) 2000-09-29 2007-11-15 Molecular Probes, Inc., Eugene Modifizierte carbocyaninfarbstoffe und deren konjugate
EP1317464B1 (de) * 2000-10-11 2009-05-13 Applera Corporation Fluoreszierende nukleobasekonjugate mit anionische linker
US6663847B1 (en) * 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
EP1341557A2 (de) * 2000-10-27 2003-09-10 Beth Israel Deaconess Medical Center Nichtisotopischer nachweis von osteoblastischer aktivität in vivo mittels modifizierten bisphosphonaten
US6331632B1 (en) * 2000-11-09 2001-12-18 Beckman Coulter, Inc. Cyanine dye phosphoramidites
AU2002227156A1 (en) * 2000-12-01 2002-06-11 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
EP1221465A1 (de) * 2001-01-03 2002-07-10 Innosense S.r.l. Symmetrische, monofunktionalisierte Polymethinfarbstoffe als Markierungsreagenzien
US6887690B2 (en) * 2001-06-22 2005-05-03 Pe Corporation Dye-labeled ribonucleotide triphosphates
US7668697B2 (en) * 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
JP4676654B2 (ja) * 2001-07-19 2011-04-27 富士フイルム株式会社 蛍光ヌクレオチド及びそれを用いた標識法
US6533396B2 (en) 2001-08-16 2003-03-18 Benq Corporation Printhead cartridge with asymmetrical contacts
US20050032060A1 (en) * 2001-08-31 2005-02-10 Shishir Shah Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
US7335470B2 (en) 2001-10-12 2008-02-26 Perkinelmer, Las, Inc. Compilations of nucleic acids and arrays and methods of using them
US7439346B2 (en) * 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
US6838289B2 (en) 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
US7222059B2 (en) * 2001-11-15 2007-05-22 Siemens Medical Solutions Diagnostics Electrophoretic trace simulator
WO2003079015A1 (en) * 2002-03-11 2003-09-25 Visen Medical, Inc. Optical imaging probes
US6916621B2 (en) * 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US7091348B2 (en) * 2002-07-01 2006-08-15 Guava Technologies, Inc. Fluorescent dyes, energy transfer couples and methods
US7754884B2 (en) * 2005-01-03 2010-07-13 Vanderbilt University Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging
US8188116B2 (en) * 2002-09-04 2012-05-29 Vanderbilt University Agents for therapy efficacy monitoring and deep tissue imaging
US7005518B2 (en) * 2002-10-25 2006-02-28 Li-Cor, Inc. Phthalocyanine dyes
US20040132092A1 (en) * 2003-01-03 2004-07-08 Stetson Christopher M. Determining the density of functional moieties on polymer reagents
US20090186343A1 (en) * 2003-01-28 2009-07-23 Visigen Biotechnologies, Inc. Methods for preparing modified biomolecules, modified biomolecules and methods for using same
ES2384170T3 (es) 2003-04-04 2012-07-02 F. Hoffmann-La Roche Ag Sistema mejorado de PCR multicolor a tiempo real
US7572581B2 (en) * 2003-06-30 2009-08-11 Roche Molecular Systems, Inc. 2′-terminator nucleotide-related methods and systems
US7619059B2 (en) * 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
US7727752B2 (en) * 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
CA2445420A1 (en) * 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7271265B2 (en) * 2003-08-11 2007-09-18 Invitrogen Corporation Cyanine compounds and their application as quenching compounds
ATE458200T1 (de) * 2003-09-12 2010-03-15 Life Technologies Corp Anwendungen des resonanzenergietransfers zwischen terbium und gfp
WO2005044086A2 (en) * 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal dna in amniotic fluid
EP2610315B1 (de) 2003-12-05 2016-08-31 Life Technologies Corporation Methinsubstituierte Cyaninfarbstoffverbindungen
US7446202B2 (en) 2003-12-05 2008-11-04 Molecular Probes, Inc. Cyanine dye compounds
US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
JP4127204B2 (ja) * 2003-12-17 2008-07-30 セイコーエプソン株式会社 液晶表示装置の製造方法
US7230117B2 (en) * 2004-07-12 2007-06-12 Beckman Coulter, Inc. Stable cyanine dye phosphoramidites
US7598390B2 (en) 2005-05-11 2009-10-06 Life Technologies Corporation Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use
US7737281B2 (en) * 2005-05-24 2010-06-15 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Purine based fluorescent dyes
US7569695B2 (en) * 2005-05-24 2009-08-04 Enzo Life Sciences, Inc. Dyes for the detection or quantification of desirable target molecules
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
FR2889700B1 (fr) * 2005-08-11 2012-11-23 Synthinnove Lab Marqueurs, leur procede de fabrication et leurs applications
WO2007028118A2 (en) 2005-09-02 2007-03-08 Visen Medical, Inc. Nicotinic acid and picolinic acid derived near-infrared fluorophores
EP1934211B1 (de) 2005-09-02 2017-01-11 Visen Medical, Inc. Biologisch kompatible fluoreszente farbstoffmarker, die n,n-disubstituierte sulfonamide enthalten
US7947256B2 (en) * 2005-09-02 2011-05-24 Visen Medical, Inc. Biocompatible fluorescent imaging agents
US20080091005A1 (en) * 2006-07-20 2008-04-17 Visigen Biotechnologies, Inc. Modified nucleotides, methods for making and using same
US20080241951A1 (en) * 2006-07-20 2008-10-02 Visigen Biotechnologies, Inc. Method and apparatus for moving stage detection of single molecular events
US20080241938A1 (en) * 2006-07-20 2008-10-02 Visigen Biotechnologies, Inc. Automated synthesis or sequencing apparatus and method for making and using same
RU2461004C2 (ru) * 2007-09-27 2012-09-10 Сисмекс Корпорейшн Набор реагентов для анализа образца и способ анализа образца
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
CA2723315A1 (en) 2008-04-30 2009-11-05 Ben-Gurion University Of The Negev Research And Development Authority Vascular delivery systems
JP5500875B2 (ja) * 2009-01-30 2014-05-21 キヤノン株式会社 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤
EP2435096A1 (de) 2009-05-27 2012-04-04 Lumicell Diagnostics, Inc. Verfahren und systeme zur räumlichen identifizierung anomaler zellen
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
EP2575848A4 (de) 2010-05-29 2016-09-07 Univ Ben Gurion Eingekapselte konjugate eines zellpenetrierenden peptids für diagnostische und therapeutische anwendungen
WO2012054749A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Cyanine dyes and their conjugates
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
EP3338617B1 (de) 2012-01-23 2020-08-19 Washington University Brillenbildgebungssysteme und- vorrichtungen
EP4449997A3 (de) 2013-03-14 2025-01-15 Lumicell, Inc. Medizinische bildgebungsvorrichtung und verfahren zur verwendung
EP3489309A1 (de) 2013-03-15 2019-05-29 Visen Medical, Inc. 4,4-disubstituierte cyclohexyl-verbrückte heptamethin-cyanin-farbstoffe und verwendungen davon
AR102743A1 (es) 2014-11-26 2017-03-22 Li Cor Inc Medios de contraste ir para imágenes por fluorescencia
US10806804B2 (en) 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
US10300153B2 (en) 2015-11-30 2019-05-28 Asthra, Llc Immunological detection of altered cells
CN106280533B (zh) * 2016-08-17 2018-03-09 赣南师范大学 一种近红外荧光染料及其合成方法和用于寄生虫荧光标记
AU2018250548A1 (en) 2017-04-11 2019-10-31 Li-Cor, Inc. Solid cyanine dyes
WO2019213543A1 (en) 2018-05-04 2019-11-07 Li-Cor, Inc. 2-[2-[4-[bis(2-sulfoethyl)amino]phenyl]ethenyl]-1-butyl-3,3-dimethyl-3h-indolium hemicyanine dyes for the detection of antibodies and other biomolecules
US20220025432A1 (en) * 2018-12-06 2022-01-27 Futuresynthesis Spólka Z O.O. Method for fluorescence labeling of biological materials, thermally removable fluorescent labels for this method, and methods of their preparation and use
WO2021119423A1 (en) 2019-12-13 2021-06-17 Washington University Near infrared fluorescent dyes, formulations and related methods
KR20240099319A (ko) 2021-10-26 2024-06-28 카리부 바이오사이언시스 인코포레이티드 엑소뉴클레아제-커플링된 실시간 엔도뉴클레아제 활성 검정
WO2025179039A1 (en) * 2024-02-20 2025-08-28 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Controlled linker length modulation of dna scaffolded dye aggregates
WO2026050087A1 (en) 2024-08-27 2026-03-05 Caribou Biosciences, Inc. Real-time crispr endonuclease activity assay

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US5241060A (en) * 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US5571388A (en) * 1984-03-29 1996-11-05 Li-Cor, Inc. Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5091519A (en) * 1986-05-01 1992-02-25 Amoco Corporation Nucleotide compositions with linking groups
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US5151507A (en) * 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
DE3912046B4 (de) * 1988-09-02 2004-03-25 Carnegie Mellon University Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt
JPH07145148A (ja) * 1992-06-02 1995-06-06 Bio Sensor Kenkyusho:Kk ポリメチン系化合物およびそれを用いる測定方法
US5366623A (en) * 1992-09-11 1994-11-22 Colonel Clair Apparatus for magnetically treating a fluid
JP3176163B2 (ja) * 1993-01-28 2001-06-11 イビデン株式会社 蛍光標識試薬および蛍光免疫測定法
DE69407467T2 (de) * 1993-04-12 1998-04-16 Ibiden Co Ltd Harzzusammensetzungen und diese verwendende Leiterplatten
US5436134A (en) * 1993-04-13 1995-07-25 Molecular Probes, Inc. Cyclic-substituted unsymmetrical cyanine dyes
DE4326466A1 (de) * 1993-08-06 1995-02-09 Boehringer Mannheim Gmbh Infrarot-Farbstoff-markierte Nucleotide und ihre Verwendung in der Nucleinsäure-Detektion
JPH0783925A (ja) * 1993-09-17 1995-03-31 Ibiden Co Ltd 蛍光標識試薬および蛍光免疫測定法
JP3399598B2 (ja) * 1993-09-17 2003-04-21 イビデン株式会社 Ｎ−部分置換アミノグリカンを用いた免疫測定用標識試薬
US5622821A (en) * 1994-06-29 1997-04-22 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use
EP0800831B9 (de) * 1995-01-30 2004-11-10 Daiichi Pure Chemicals Co., Ltd. Diagnostisches markierungsmittel

Also Published As

Publication number Publication date
EP1019887A2 (de) 2000-07-19
EP1019887B1 (de) 2003-04-02
CA2278313C (en) 2008-03-18
AU6020698A (en) 1998-08-03
DE69812982D1 (de) 2003-05-08
WO1998030992A3 (en) 1998-11-12
AU739930B2 (en) 2001-10-25
JP2001511195A (ja) 2001-08-07
CA2278313A1 (en) 1998-07-16
US6027709A (en) 2000-02-22
DE69812982T2 (de) 2003-11-13
WO1998030992A2 (en) 1998-07-16
JP4361138B2 (ja) 2009-11-11

Similar Documents

Publication Publication Date Title
DE69812982D1 (de) Fluoreszierende cyaninfarbstoffe
ATE315066T1 (de) Cyaninfarbstoffe
EA200100773A1 (ru) Замещенные 1-гетероциклические диариламины
DE69006417D1 (de) Neuer fluoreszierender Farbstoff.
BR9807502B1 (pt) compostos orgÂnicos, processo para sua preparaÇço, bem como composiÇço e aplicaÇço dos mesmos.
ES2145580T3 (es) Metodos y composiciones para analizar moleculas de acido nucleico que emplean tecnicas basadas en el tamaño.
DE69807496D1 (de) Elektrische zusammenschaltung für farbstoffbehälter
DE69811368D1 (de) Selbst-kontrastierende, retroreflektierende fahrbahnmarkierungsbänder
DE69814173D1 (de) Reifen von somatischen embryonen
DE69809854D1 (de) Direkt beschreibbare Trockenflachdruckformen
ATE284407T1 (de) Pyrimidinderivate als markierte bindungspartner
DE59608872D1 (de) Naphthalinlactamimid-Fluoreszenzfarbstoffe
BR0007922A (pt) Compostos calcilìticos
DE69106925D1 (de) Härtbare fluoreszierende Siloxanzusammensetzungen.
DE60012249D1 (de) Markierende Fluoreszenzfarbstoffe
DE69523816D1 (de) Heterocyclisch substituierte blausensibilisierende Farbstoffe
EA199800753A1 (ru) Бензотиофены, составы их содержащие и способы с их использованием
DE59807840D1 (de) Disazofarbstoffe
DE69833989D1 (de) Heptamethincyaninverbindung
DE69707698D1 (de) Anthrachinonpolysulfonamidfarbstoffe
DE50101195D1 (de) Cyaninfarbstoffe als fluoreszenzmarker
FI971587A0 (fi) Solmuryhmien käyttö sijaintitietona
DE69826029D1 (de) Acetyl-coa-carboxylase von candida albicans
EA200001080A1 (ru) Способ получения r-(+)-6-карбоксамидо-3-n-метиламино-1,2,3,4-тетрагидрокарбазола
DE69519440D1 (de) Verbesserte, änderbare zusammensetzung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties