ES2146116T3 - Marcadores unidos destinados para ser utilizados en la sintesis quimica combinatoria. - Google Patents

Marcadores unidos destinados para ser utilizados en la sintesis quimica combinatoria.

Info

Publication number
ES2146116T3
ES2146116T3 ES97941492T ES97941492T ES2146116T3 ES 2146116 T3 ES2146116 T3 ES 2146116T3 ES 97941492 T ES97941492 T ES 97941492T ES 97941492 T ES97941492 T ES 97941492T ES 2146116 T3 ES2146116 T3 ES 2146116T3
Authority
ES
Spain
Prior art keywords
united
chemical synthesis
markers intended
combinatory
combinatory chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97941492T
Other languages
English (en)
Inventor
Jill Edie Hochlowski
Thomas J Sowin
Daniel W Norbeck
Anne-Laure Marie Grillot
Rolf E Swenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2146116T3 publication Critical patent/ES2146116T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Steroid Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA LA CODIFICACION E IDENTIFICACION DE LOS MIEMBROS INDIVIDUALES DE UNA LIBRERIA QUIMICA COMBINATORIA SINTETIZADA EN UNA PLURALIDAD DE SOPORTES SOLIDOS QUE SOPORTAN UNA SINTESIS POR MEZCLA Y SEPARACION. EL PROCESO CONSISTE EN MARCAR LOS SOPORTES SOLIDOS CON UN IDENTIFICADOR DE CODIFICACION QUE SE ACOPLA AL SOPORTE SOLIDO Y QUE SE PUEDE DECODIFICAR A TRAVES DE UNA ESPECTROSCOPIA POR RAYOS INFRARROJOS O RAMAN CUANDO ESTAN DIRECTAMENTE ACOPLADOS AL SOPORTE.
ES97941492T 1996-09-13 1997-09-10 Marcadores unidos destinados para ser utilizados en la sintesis quimica combinatoria. Expired - Lifetime ES2146116T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71371096A 1996-09-13 1996-09-13
US08/923,206 US6355490B1 (en) 1996-09-13 1997-09-04 Attached tags for use in combinatorial chemistry synthesis

Publications (1)

Publication Number Publication Date
ES2146116T3 true ES2146116T3 (es) 2000-07-16

Family

ID=27109033

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97941492T Expired - Lifetime ES2146116T3 (es) 1996-09-13 1997-09-10 Marcadores unidos destinados para ser utilizados en la sintesis quimica combinatoria.

Country Status (9)

Country Link
US (2) US6355490B1 (es)
EP (1) EP0879219B1 (es)
JP (1) JP2002501474A (es)
AT (1) ATE190049T1 (es)
CA (1) CA2237298A1 (es)
DE (1) DE69701352T2 (es)
ES (1) ES2146116T3 (es)
MX (1) MX9803806A (es)
WO (1) WO1998011036A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6352854B1 (en) 1995-04-25 2002-03-05 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6319668B1 (en) 1995-04-25 2001-11-20 Discovery Partners International Method for tagging and screening molecules
US6340588B1 (en) 1995-04-25 2002-01-22 Discovery Partners International, Inc. Matrices with memories
US6168913B1 (en) * 1997-10-14 2001-01-02 Abbott Laboratories Coding combinatorial libraries with fluorine tags
JP2003522934A (ja) * 1997-12-17 2003-07-29 アヴェンティス ファーマシューティカルズ インコーポレイテッド フッ素ｎｍｒを用いる固相反応の定量方法および定量試薬
AP1296A (en) * 1997-12-17 2004-09-06 Aventis Pharma Inc Method and reagents for the quantification of solid-phase reactions using fluorine NMR.
US6599753B1 (en) 1998-06-24 2003-07-29 Aventis Pharmaceuticals Inc. Method and reagents for the quantification of solid-phase reactions using fluorine NMR
US7433035B2 (en) * 1998-06-29 2008-10-07 San Diego State University Research Foundation Detection of carbon halogen bonds
US20030232388A1 (en) * 1999-09-27 2003-12-18 Kreimer David I. Beads having identifiable Raman markers
US20040023293A1 (en) * 1999-09-27 2004-02-05 Kreimer David I. Biochips for characterizing biological processes
US20020132371A1 (en) * 1999-09-27 2002-09-19 Kreimer David I. Amplification of analyte detection by substrates having particle structures with receptors
US20020045266A1 (en) * 2000-02-08 2002-04-18 Hicham Fenniri Method for determining the structure of an active member of a chemical library
US6707548B2 (en) 2001-02-08 2004-03-16 Array Bioscience Corporation Systems and methods for filter based spectrographic analysis
US20020151041A1 (en) * 2001-03-15 2002-10-17 Kreimer David I. Enhancing surfaces for analyte detection
US6611327B2 (en) * 2001-03-23 2003-08-26 Intel Corporation Detection of contaminants on low wavelength masks
US7572642B2 (en) * 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
DE60324778D1 (de) 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
US20040026684A1 (en) * 2002-04-02 2004-02-12 Nanosys, Inc. Nanowire heterostructures for encoding information
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
US20040214232A1 (en) * 2002-08-16 2004-10-28 Burke Martin D. Generation of skeletal diversity within a combinatorial library
EP1545762A2 (en) * 2002-09-27 2005-06-29 Carlsberg A/S Spatially encoded polymer matrix
CN102838654B (zh) 2002-10-30 2016-05-18 纽韦卢森公司 合成双功能复合物的方法
DE60330406D1 (de) 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US20070134733A1 (en) * 2003-07-10 2007-06-14 Parallax Biosystems, Inc. Raman signature probes and their use in the detection and imaging of molecular processes and structures
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
US20090239211A1 (en) * 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
LT3018206T (lt) 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
ITMI20061606A1 (it) * 2006-08-09 2008-02-10 Dipharma Spa Procedimento per la preparazione di composti nitrilici
US20110049239A1 (en) * 2009-04-20 2011-03-03 Kukushkin Igor V Method for storing and coding information with raman-active substances
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
US20210311069A1 (en) * 2018-08-21 2021-10-07 The Board Of Trustees Of The Leland Stanford Junior University Isotopically-encoded nanoparticles for multimodal high-order multiplexed detection and imaging

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0604552B1 (en) 1991-09-18 1997-02-12 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
HUT72495A (en) 1992-10-01 1996-05-28 Cold Spring Harbor Lab Complex combinatorial chemical libraries encoded with tags
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
GB2304410B (en) 1995-08-22 1998-11-25 Zeneca Ltd Method for monitoring solid phase reactions
US5786218A (en) * 1996-08-16 1998-07-28 Zeneca Limited Method for monitoring solid phase reactions

Also Published As

Publication number Publication date
EP0879219A1 (en) 1998-11-25
WO1998011036A1 (en) 1998-03-19
DE69701352T2 (de) 2000-10-19
DE69701352D1 (de) 2000-04-06
ATE190049T1 (de) 2000-03-15
EP0879219B1 (en) 2000-03-01
CA2237298A1 (en) 1998-03-19
JP2002501474A (ja) 2002-01-15
US6274385B1 (en) 2001-08-14
MX9803806A (es) 1998-09-30
US6355490B1 (en) 2002-03-12

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