ES2146209T3 - Conjugados sitio-especifica de inmunoglobulinas y marcadores detectables. - Google Patents

Conjugados sitio-especifica de inmunoglobulinas y marcadores detectables.

Info

Publication number
ES2146209T3
ES2146209T3 ES92902190T ES92902190T ES2146209T3 ES 2146209 T3 ES2146209 T3 ES 2146209T3 ES 92902190 T ES92902190 T ES 92902190T ES 92902190 T ES92902190 T ES 92902190T ES 2146209 T3 ES2146209 T3 ES 2146209T3
Authority
ES
Spain
Prior art keywords
immunoglobulin
conjugates
immunoglobulins
site
derivatized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92902190T
Other languages
English (en)
Inventor
Christopher Bieniarz
Mazhar Husain
Howard E Bond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2146209T3 publication Critical patent/ES2146209T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE PRESENTA UN PROCESO PARA PRODUCIR INMUNOGLOBULINA DERIVATIZADA Y CONJUGADOS DERIVADOS CON LA MISMA. LA INMUNOGLOBULINA DERIVATIZADA SE PRODUCE INTRODUCIENDO GRUPOS DE SULFRIDIL EN LA REGION FC DE UNA INMUNOGLOBULINA EN LA QUE LA PORCION FAB DE LA INMUNOGLOBULINA NO ES ALTERADA. LA INMUNOGLOBULINA DERIVATIZADA SE USA PARA PREPARAR CONJUGADOS CON VARIAS MOLECULAS DETECTABLES EN LOS QUE EXISTE UNA DISTANCIA CONTROLADA ENTRE LA REGION FC DE LA INMUNOGLOBULINA Y LA MOLECULA DETECTABLE. LOS CONJUGADOS SON PARTICULARMENTE UTILES PARA REALIZAR INMUNOENSAYOS, Y EXHIBEN UNA LONGEVIDAD MEJORADA, UNA GRAN ESPECIFICIDAD Y UNA BUENA SENSIBILIDAD.
ES92902190T 1990-12-07 1991-12-02 Conjugados sitio-especifica de inmunoglobulinas y marcadores detectables. Expired - Lifetime ES2146209T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/624,169 US5191066A (en) 1990-12-07 1990-12-07 Site-specific conjugation of immunoglobulins and detectable labels

Publications (1)

Publication Number Publication Date
ES2146209T3 true ES2146209T3 (es) 2000-08-01

Family

ID=24500943

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92902190T Expired - Lifetime ES2146209T3 (es) 1990-12-07 1991-12-02 Conjugados sitio-especifica de inmunoglobulinas y marcadores detectables.

Country Status (12)

Country Link
US (1) US5191066A (es)
EP (1) EP0560912B1 (es)
JP (1) JP3390430B2 (es)
KR (1) KR930703347A (es)
AT (1) ATE190624T1 (es)
AU (1) AU659427B2 (es)
CA (1) CA2097920C (es)
DE (1) DE69132055T2 (es)
DK (1) DK0560912T3 (es)
ES (1) ES2146209T3 (es)
GR (1) GR3033553T3 (es)
WO (1) WO1992010507A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5561045A (en) * 1994-01-04 1996-10-01 Intracel Corporation Detection reagent, article, and immunoassay method
US5547833A (en) * 1994-01-04 1996-08-20 Intracel Corporation Radial flow assay, delivering member, test kit, and methods
US5596081A (en) * 1994-03-11 1997-01-21 University Of Kentucky Research Foundation Nucleotide or nucleoside photoaffinity compound modified antibodies, methods for their manufacture and use thereof as diagnostics and therapeutics
WO1996010585A1 (en) * 1994-09-30 1996-04-11 Inex Pharmaceuticals Corp. Glycosylated protein-liposome conjugates and methods for their preparation
US5736624A (en) * 1994-12-02 1998-04-07 Abbott Laboratories Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents
CA2184636C (fr) * 1995-01-23 2010-01-05 Pasteur Sanofi Diagnostics Conjugue immunoenzymatique, son procede de preparation et ses applications
EP1378525A3 (en) * 1996-06-07 2004-01-14 Neorx Corporation Humanized antibodies that bind to the antigen bound by antibody NR-LU-13 and their use in pretargeting methods
US20050033033A1 (en) * 1998-05-04 2005-02-10 Heinz Kohler Trans-membrane-antibody induced inhibition of apoptosis
US20040185039A1 (en) * 2002-08-30 2004-09-23 Heinz Kohler Therapeutic applications of noncovalent dimerizing antibodies
US7569674B2 (en) * 1998-05-04 2009-08-04 Innexus Biotechnology International Limited Autophilic antibodies
US6218160B1 (en) * 1997-10-31 2001-04-17 Roche Diagnostics Corporation Site-specific conjugation of glycoproteins
CA2326618A1 (en) * 1998-04-15 1999-10-21 Baxter International Inc. Inhibition of xenoreactive antibodies
US20090208418A1 (en) * 2005-04-29 2009-08-20 Innexus Biotechnology Internaltional Ltd. Superantibody synthesis and use in detection, prevention and treatment of disease
US6335155B1 (en) * 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
EP1131430B1 (en) * 1998-11-10 2007-01-17 Emory University Mitogenic regulators
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
US8110665B2 (en) 2003-11-13 2012-02-07 Hanmi Holdings Co., Ltd. Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
JP2007531513A (ja) 2003-11-13 2007-11-08 ハンミ ファーム．インダストリー カンパニー リミテッド 薬物のキャリアとして有用なＩｇＧＦｃ断片およびその製造方法
WO2006116742A2 (en) * 2005-04-28 2006-11-02 Ventana Medical Systems, Inc. Fluorescent nanoparticles conjugated to antibodies via a peg linker
WO2006116628A2 (en) * 2005-04-28 2006-11-02 Ventana Medical Systems, Inc. Enzymes conjugated to antiobodies via a peg heterobifuctional linker
ES2548518T3 (es) * 2005-11-23 2015-10-19 Ventana Medical Systems, Inc. Conjugado molecular
US20080108147A1 (en) * 2006-11-03 2008-05-08 Tie Wei Reduction of non-specific binding in immunoassays
WO2013016449A2 (en) 2011-07-26 2013-01-31 Indicator Systems International, Inc. Assays for the detection of microbes
US9388397B2 (en) 2013-02-15 2016-07-12 Research Development Foundation Deimmunized gelonin molecules and therapies
WO2015031698A1 (en) 2013-08-28 2015-03-05 Stem Centrx, Inc. Site-specific antibody conjugation methods and compositions
PE20160870A1 (es) 2013-11-06 2016-09-09 Abbvie Stemcentrx Llc Anticuerpos anti-claudina novedosos y metodos de uso
KR20160097336A (ko) 2013-12-12 2016-08-17 스템센트알엑스 인코포레이티드 신규 항-ｄｐｅｐ3 항체 및 이의 사용 방법
KR20170008202A (ko) 2014-02-21 2017-01-23 애브비 스템센트알엑스 엘엘씨 흑색종에 사용하기 위한 항-ｄｌｌ3 항체 및 약물 접합체
TW201617368A (zh) 2014-09-05 2016-05-16 史坦森特瑞斯公司 新穎抗ｍｆｉ２抗體及使用方法
WO2021235176A1 (ja) * 2020-05-22 2021-11-25 学校法人麻布獣医学園 アレルゲン不活化剤の評価方法及びアレルゲン不活化剤の評価キット
CN112067826B (zh) * 2020-09-15 2024-02-06 济南国科医工科技发展有限公司 基于高比活力碱性磷酸酶构建的NT-proBNP检测试剂盒及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140679A (en) * 1976-10-12 1979-02-20 Research Corporation Antigen-protein complex for blocking allergic reactions
SE427505B (sv) * 1977-03-04 1983-04-11 Pharmacia Diagnostics Ab Reagens till anvendning vid immunkemiska bestemningsmetoder
FR2437213A1 (fr) * 1978-09-28 1980-04-25 Cm Ind Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation
US4699784A (en) * 1986-02-25 1987-10-13 Center For Molecular Medicine & Immunology Tumoricidal methotrexate-antibody conjugate
FR2601679B1 (fr) * 1986-07-15 1990-05-25 Sanofi Sa Immunotoxines, procede de preparation et compositions pharmaceutiques en contenant
US4994385A (en) * 1987-10-30 1991-02-19 Abbott Laboratories Heterobifunctional coupling agents

Also Published As

Publication number Publication date
ATE190624T1 (de) 2000-04-15
DE69132055D1 (de) 2000-04-20
JP3390430B2 (ja) 2003-03-24
DK0560912T3 (da) 2000-07-24
AU9145291A (en) 1992-07-08
CA2097920C (en) 2003-11-04
EP0560912B1 (en) 2000-03-15
WO1992010507A1 (en) 1992-06-25
AU659427B2 (en) 1995-05-18
EP0560912A1 (en) 1993-09-22
US5191066A (en) 1993-03-02
DE69132055T2 (de) 2000-10-26
CA2097920A1 (en) 1992-06-08
EP0560912A4 (en) 1996-08-28
GR3033553T3 (en) 2000-09-29
KR930703347A (ko) 1993-11-29
JPH06504776A (ja) 1994-06-02

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