ES2146676T3 - Amidas de esteres de acido sulfonamidocarbonilpiridin-2-carboxilico asi como sus piridin-n-oxidos, procedimiento para su preparacion y su empleo como medicamentos. - Google Patents

Amidas de esteres de acido sulfonamidocarbonilpiridin-2-carboxilico asi como sus piridin-n-oxidos, procedimiento para su preparacion y su empleo como medicamentos.

Info

Publication number
ES2146676T3
ES2146676T3 ES95103582T ES95103582T ES2146676T3 ES 2146676 T3 ES2146676 T3 ES 2146676T3 ES 95103582 T ES95103582 T ES 95103582T ES 95103582 T ES95103582 T ES 95103582T ES 2146676 T3 ES2146676 T3 ES 2146676T3
Authority
ES
Spain
Prior art keywords
piridin
sulfonamidocarbonyl
medicines
oxides
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95103582T
Other languages
English (en)
Inventor
Klaus Dr Weidmann
Martin Dr Bickel
Volkmar Gunzler-Pukall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2146676T3 publication Critical patent/ES2146676T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION SE REFIERE A SULFONAMIDO CARBONILPIRIDINA 2 AMIDA DE ESTER ACIDO CARBOXILICO Y SU OXIDO N - PIRIDINA SEGUN LA FORMULA GENERAL I LOS COMPUESTOS CONOCIDOS ENCUENTRAN UTILIZACION COMO MEDICAMENTO CONTRA ENFERMEDADES FIBROTICAS, COMO ELEMENTOS FIBROSUPRESIVOS COMO INHIBIDORES DE PROLILHIDROXILASA.
ES95103582T 1994-03-25 1995-03-13 Amidas de esteres de acido sulfonamidocarbonilpiridin-2-carboxilico asi como sus piridin-n-oxidos, procedimiento para su preparacion y su empleo como medicamentos. Expired - Lifetime ES2146676T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4410480A DE4410480A1 (de) 1994-03-25 1994-03-25 Sulfonamidocarbonylpyridin-2-carbonsäureesteramide sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
ES2146676T3 true ES2146676T3 (es) 2000-08-16

Family

ID=6513896

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95103582T Expired - Lifetime ES2146676T3 (es) 1994-03-25 1995-03-13 Amidas de esteres de acido sulfonamidocarbonilpiridin-2-carboxilico asi como sus piridin-n-oxidos, procedimiento para su preparacion y su empleo como medicamentos.

Country Status (19)

Country Link
US (1) US5620996A (es)
EP (1) EP0673932B1 (es)
JP (1) JPH07278110A (es)
KR (1) KR950032126A (es)
AT (1) ATE193702T1 (es)
AU (1) AU688450B2 (es)
CA (1) CA2145475A1 (es)
CZ (1) CZ289536B6 (es)
DE (2) DE4410480A1 (es)
DK (1) DK0673932T3 (es)
ES (1) ES2146676T3 (es)
FI (1) FI951387L (es)
GR (1) GR3033706T3 (es)
HU (1) HUT72598A (es)
NO (1) NO304265B1 (es)
NZ (1) NZ270784A (es)
PL (1) PL180678B1 (es)
PT (1) PT673932E (es)
ZA (1) ZA952409B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0798296B1 (de) * 1996-03-21 2003-12-10 Lonza AG Verfahren zur Herstellung von Arylamiden Heteroaromatischer Carbonsäuren
SK283920B6 (sk) 1996-03-28 2004-05-04 Lonza Ag Spôsob výroby arylamidov heteroaromatických karboxylových kyselín
DK0806415T3 (da) * 1996-05-09 2000-06-05 Lonza Ag Fremgangsmåde til fremstilling af arylamider af heteroaromatiske carboxylsyrer
CA2209392C (en) * 1996-07-23 2007-02-20 Yves Bessard Process for preparing pyridinecarboxylic esters
US6169183B1 (en) 1996-07-23 2001-01-02 Lonza, Ltd. Process for preparing pyridinecarboxylic esters
DE19742951A1 (de) 1997-09-29 1999-04-15 Hoechst Schering Agrevo Gmbh Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung
DK2298301T3 (en) 2001-12-06 2018-10-01 Fibrogen Inc MEDICINALS FOR TREATMENT OF ANEMIA ASSOCIATED WITH Kidney Disease
EP2295060B1 (en) 2001-12-06 2018-10-31 Fibrogen, Inc. Treatment or prevention of ischemic or hypoxic conditions
US8124582B2 (en) * 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7618940B2 (en) * 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
EP1491527A1 (en) * 2003-06-25 2004-12-29 Bayer CropScience GmbH Process for preparing acylsulfamoylbenzamides
MX2007016160A (es) 2005-06-15 2008-03-07 Fibrogen Inc Uso de moduladoers de hif-1 alfa para el tratamiento contra el cancer.
KR100949975B1 (ko) * 2006-03-30 2010-03-29 엘지전자 주식회사 비디오 신호를 디코딩/인코딩하기 위한 방법 및 장치
PL3357911T3 (pl) 2006-06-26 2022-09-05 Akebia Therapeutics Inc. Inhibitory prolilohydroksylazy i sposoby ich użycia
US8962530B2 (en) * 2007-06-27 2015-02-24 Regents Of The University Of Colorado Inflammatory bowel disease therapies
NO2686520T3 (es) 2011-06-06 2018-03-17
JP2016521747A (ja) 2013-06-13 2016-07-25 アケビア セラピューティクス インコーポレイテッドＡｋｅｂｉａ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 貧血治療のための組成物及び方法
MY180626A (en) 2013-11-15 2020-12-03 Akebia Therapeutics Inc Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
US10150734B2 (en) 2015-01-23 2018-12-11 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
US11324734B2 (en) 2015-04-01 2022-05-10 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
CN105130888A (zh) * 2015-10-09 2015-12-09 中国药科大学 炔基吡啶类脯氨酰羟化酶抑制剂、其制备方法和医药用途
US11713298B2 (en) 2018-05-09 2023-08-01 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
WO2021117767A1 (ja) 2019-12-10 2021-06-17 田辺三菱製薬株式会社 含窒素ヘテロアリールカルボキサミド酢酸誘導体の製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0541042A1 (de) * 1991-11-05 1993-05-12 Hoechst Aktiengesellschaft Pyridin-2,4- und 2,5-dicarbonsäureamide und deren Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals

Also Published As

Publication number Publication date
PT673932E (pt) 2000-09-29
NO951149L (no) 1995-09-26
NZ270784A (en) 1997-02-24
NO951149D0 (no) 1995-03-24
GR3033706T3 (en) 2000-10-31
EP0673932A1 (de) 1995-09-27
FI951387A0 (fi) 1995-03-23
DE4410480A1 (de) 1995-09-28
DE59508440D1 (de) 2000-07-13
FI951387A7 (fi) 1995-09-26
AU1504395A (en) 1995-10-05
AU688450B2 (en) 1998-03-12
CZ73495A3 (en) 1995-11-15
FI951387L (fi) 1995-09-26
PL180678B1 (pl) 2001-03-30
JPH07278110A (ja) 1995-10-24
ZA952409B (en) 1995-11-28
HUT72598A (en) 1996-05-28
ATE193702T1 (de) 2000-06-15
NO304265B1 (no) 1998-11-23
DK0673932T3 (da) 2000-09-18
CZ289536B6 (cs) 2002-02-13
KR950032126A (ko) 1995-12-20
CA2145475A1 (en) 1995-09-26
EP0673932B1 (de) 2000-06-07
PL307847A1 (en) 1995-10-02
HK1011973A1 (en) 1999-07-23
US5620996A (en) 1997-04-15

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