ES2147724T3 - RAPAMICINE REDUCTION PRODUCTS AS IMMUNOSUPPRESSIVE, ANTI-INFLAMMATORY OR ANTIFUNGAL AGENTS. - Google Patents
RAPAMICINE REDUCTION PRODUCTS AS IMMUNOSUPPRESSIVE, ANTI-INFLAMMATORY OR ANTIFUNGAL AGENTS.Info
- Publication number
- ES2147724T3 ES2147724T3 ES92303916T ES92303916T ES2147724T3 ES 2147724 T3 ES2147724 T3 ES 2147724T3 ES 92303916 T ES92303916 T ES 92303916T ES 92303916 T ES92303916 T ES 92303916T ES 2147724 T3 ES2147724 T3 ES 2147724T3
- Authority
- ES
- Spain
- Prior art keywords
- rapamicine
- inflammatory
- immunosuppressive
- antifungal agents
- reduction products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 title 1
- 239000003429 antifungal agent Substances 0.000 title 1
- 230000001506 immunosuppresive effect Effects 0.000 title 1
- 229940125721 immunosuppressive agent Drugs 0.000 title 1
- 239000003018 immunosuppressive agent Substances 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 241000222122 Candida albicans Species 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 abstract 1
- SIPUZPBQZHNSDW-UHFFFAOYSA-N bis(2-methylpropyl)aluminum Chemical compound CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 abstract 1
- 229940095731 candida albicans Drugs 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 150000002576 ketones Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE PRESENTAN PRODUCTOS DE LA FORMULA I OBTENIDOS A PARTIR DE LA REDUCCION QUIMICA DE UNO O MAS GRUPOS DE QUETONA EN LAS POSICIONES 15, 27 Y 33 DE LA RAPAMICINA CON HIDRURO DE DIISOBUTILALUMINIO O TRIACETOXIBOROHIDRURO DE SODIO; LOS PRODUCTOS HAN DEMOSTRADO TENER PROPIEDADES FARMACOLOGICAS QUE PODRIAN HACERLOS UTILES EN EL TRATAMIENTO DEL RECHAZO DE TRASPLANTES, ENFERMEDADES AUTOINMUNES, ENFERMEDADES INFLAMATORIAS E INFECCIONES POR CANDIDA ALBICANS.PRODUCTS OF FORMULA I ARE PRESENTED OBTAINED FROM THE CHEMICAL REDUCTION OF ONE OR MORE KETONE GROUPS IN POSITIONS 15, 27 AND 33 OF RAPAMICINE WITH DIISOBUTYLALUMINUM HYDRIDE OR SODIUM TRIACETOXIBOROHIDIDE; THE PRODUCTS HAVE DEMONSTRATED TO HAVE PHARMACOLOGICAL PROPERTIES THAT COULD MAKE THEM USEFUL IN THE TREATMENT OF TRANSPLANT REJECTION, AUTOIMMUNE DISEASES, INFLAMMATORY DISEASES AND INFECTIONS BY CANDIDA ALBICANS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/696,692 US5102876A (en) | 1991-05-07 | 1991-05-07 | Reduction products of rapamycin |
| US07/741,714 US5138051A (en) | 1991-08-07 | 1991-08-07 | Rapamycin analogs as immunosuppressants and antifungals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2147724T3 true ES2147724T3 (en) | 2000-10-01 |
Family
ID=27105845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92303916T Expired - Lifetime ES2147724T3 (en) | 1991-05-07 | 1992-04-30 | RAPAMICINE REDUCTION PRODUCTS AS IMMUNOSUPPRESSIVE, ANTI-INFLAMMATORY OR ANTIFUNGAL AGENTS. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0512754B1 (en) |
| JP (1) | JP3108192B2 (en) |
| KR (1) | KR100230877B1 (en) |
| AT (1) | ATE194352T1 (en) |
| AU (1) | AU647616B2 (en) |
| DE (1) | DE69231215T2 (en) |
| DK (1) | DK0512754T3 (en) |
| ES (1) | ES2147724T3 (en) |
| FI (1) | FI97472C (en) |
| GR (1) | GR3034033T3 (en) |
| HU (1) | HU217868B (en) |
| MX (1) | MX9202031A (en) |
| NZ (1) | NZ242616A (en) |
| PH (1) | PH30228A (en) |
| PT (1) | PT512754E (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776943A (en) * | 1991-05-14 | 1998-07-07 | American Home Products Corporation | Rapamycin metabolites |
| US5118677A (en) * | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
| GB9302567D0 (en) * | 1993-02-10 | 1993-03-24 | Smithkline Beecham Plc | Novel compound |
| CH686761A5 (en) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Pharmaceutical formulations. |
| JP3480624B2 (en) | 1995-06-09 | 2003-12-22 | シャープ株式会社 | Ferroelectric thin film coated substrate, method of manufacturing the same, and capacitor structure element |
| JP3133922B2 (en) | 1995-06-09 | 2001-02-13 | シャープ株式会社 | Ferroelectric thin film coated substrate, method of manufacturing the same, and capacitor structure element |
| WO1998002441A2 (en) | 1996-07-12 | 1998-01-22 | Ariad Pharmaceuticals, Inc. | Non immunosuppressive antifungal rapalogs |
| GB9826882D0 (en) * | 1998-12-07 | 1999-01-27 | Novartis Ag | Organic compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023262A (en) | 1990-08-14 | 1991-06-11 | American Home Products Corporation | Hydrogenated rapamycin derivatives |
-
1992
- 1992-04-28 FI FI921893A patent/FI97472C/en not_active IP Right Cessation
- 1992-04-28 JP JP04109579A patent/JP3108192B2/en not_active Expired - Fee Related
- 1992-04-30 DK DK92303916T patent/DK0512754T3/en active
- 1992-04-30 ES ES92303916T patent/ES2147724T3/en not_active Expired - Lifetime
- 1992-04-30 MX MX9202031A patent/MX9202031A/en unknown
- 1992-04-30 EP EP92303916A patent/EP0512754B1/en not_active Expired - Lifetime
- 1992-04-30 DE DE69231215T patent/DE69231215T2/en not_active Expired - Fee Related
- 1992-04-30 PH PH44299A patent/PH30228A/en unknown
- 1992-04-30 AT AT92303916T patent/ATE194352T1/en not_active IP Right Cessation
- 1992-04-30 PT PT92303916T patent/PT512754E/en unknown
- 1992-04-30 HU HU9201468A patent/HU217868B/en not_active IP Right Cessation
- 1992-05-01 KR KR1019920007431A patent/KR100230877B1/en not_active Expired - Fee Related
- 1992-05-05 NZ NZ24261692A patent/NZ242616A/en unknown
- 1992-05-05 AU AU16008/92A patent/AU647616B2/en not_active Ceased
-
2000
- 2000-07-27 GR GR20000401723T patent/GR3034033T3/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI97472C (en) | 1996-12-27 |
| KR920021553A (en) | 1992-12-18 |
| GR3034033T3 (en) | 2000-11-30 |
| MX9202031A (en) | 1992-11-01 |
| HU217868B (en) | 2000-04-28 |
| NZ242616A (en) | 1994-07-26 |
| DE69231215D1 (en) | 2000-08-10 |
| AU1600892A (en) | 1992-11-12 |
| FI921893A0 (en) | 1992-04-28 |
| JPH05117279A (en) | 1993-05-14 |
| EP0512754B1 (en) | 2000-07-05 |
| FI921893L (en) | 1992-11-08 |
| ATE194352T1 (en) | 2000-07-15 |
| JP3108192B2 (en) | 2000-11-13 |
| DK0512754T3 (en) | 2000-09-18 |
| DE69231215T2 (en) | 2000-11-09 |
| KR100230877B1 (en) | 1999-11-15 |
| EP0512754A1 (en) | 1992-11-11 |
| PT512754E (en) | 2000-11-30 |
| FI97472B (en) | 1996-09-13 |
| AU647616B2 (en) | 1994-03-24 |
| HU9201468D0 (en) | 1992-07-28 |
| PH30228A (en) | 1997-02-05 |
| HUT62589A (en) | 1993-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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