ES2147724T3 - Productos de reduccion de la rapamicina como agentes inmunosupresores, antiinflamatorios o antifungicos. - Google Patents
Productos de reduccion de la rapamicina como agentes inmunosupresores, antiinflamatorios o antifungicos.Info
- Publication number
- ES2147724T3 ES2147724T3 ES92303916T ES92303916T ES2147724T3 ES 2147724 T3 ES2147724 T3 ES 2147724T3 ES 92303916 T ES92303916 T ES 92303916T ES 92303916 T ES92303916 T ES 92303916T ES 2147724 T3 ES2147724 T3 ES 2147724T3
- Authority
- ES
- Spain
- Prior art keywords
- rapamicine
- inflammatory
- immunosuppressive
- antifungal agents
- reduction products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 title 1
- 239000003429 antifungal agent Substances 0.000 title 1
- 230000001506 immunosuppresive effect Effects 0.000 title 1
- 229940125721 immunosuppressive agent Drugs 0.000 title 1
- 239000003018 immunosuppressive agent Substances 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 241000222122 Candida albicans Species 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 abstract 1
- SIPUZPBQZHNSDW-UHFFFAOYSA-N bis(2-methylpropyl)aluminum Chemical compound CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 abstract 1
- 229940095731 candida albicans Drugs 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 150000002576 ketones Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Genetics & Genomics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE PRESENTAN PRODUCTOS DE LA FORMULA I OBTENIDOS A PARTIR DE LA REDUCCION QUIMICA DE UNO O MAS GRUPOS DE QUETONA EN LAS POSICIONES 15, 27 Y 33 DE LA RAPAMICINA CON HIDRURO DE DIISOBUTILALUMINIO O TRIACETOXIBOROHIDRURO DE SODIO; LOS PRODUCTOS HAN DEMOSTRADO TENER PROPIEDADES FARMACOLOGICAS QUE PODRIAN HACERLOS UTILES EN EL TRATAMIENTO DEL RECHAZO DE TRASPLANTES, ENFERMEDADES AUTOINMUNES, ENFERMEDADES INFLAMATORIAS E INFECCIONES POR CANDIDA ALBICANS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/696,692 US5102876A (en) | 1991-05-07 | 1991-05-07 | Reduction products of rapamycin |
| US07/741,714 US5138051A (en) | 1991-08-07 | 1991-08-07 | Rapamycin analogs as immunosuppressants and antifungals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2147724T3 true ES2147724T3 (es) | 2000-10-01 |
Family
ID=27105845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92303916T Expired - Lifetime ES2147724T3 (es) | 1991-05-07 | 1992-04-30 | Productos de reduccion de la rapamicina como agentes inmunosupresores, antiinflamatorios o antifungicos. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0512754B1 (es) |
| JP (1) | JP3108192B2 (es) |
| KR (1) | KR100230877B1 (es) |
| AT (1) | ATE194352T1 (es) |
| AU (1) | AU647616B2 (es) |
| DE (1) | DE69231215T2 (es) |
| DK (1) | DK0512754T3 (es) |
| ES (1) | ES2147724T3 (es) |
| FI (1) | FI97472C (es) |
| GR (1) | GR3034033T3 (es) |
| HU (1) | HU217868B (es) |
| MX (1) | MX9202031A (es) |
| NZ (1) | NZ242616A (es) |
| PH (1) | PH30228A (es) |
| PT (1) | PT512754E (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776943A (en) * | 1991-05-14 | 1998-07-07 | American Home Products Corporation | Rapamycin metabolites |
| US5118677A (en) * | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
| GB9302567D0 (en) * | 1993-02-10 | 1993-03-24 | Smithkline Beecham Plc | Novel compound |
| CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
| JP3480624B2 (ja) | 1995-06-09 | 2003-12-22 | シャープ株式会社 | 強誘電体薄膜被覆基板、その製造方法、及びキャパシタ構造素子 |
| JP3133922B2 (ja) | 1995-06-09 | 2001-02-13 | シャープ株式会社 | 強誘電体薄膜被覆基板、その製造方法、及びキャパシタ構造素子 |
| AU735648B2 (en) * | 1996-07-12 | 2001-07-12 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
| GB9826882D0 (en) * | 1998-12-07 | 1999-01-27 | Novartis Ag | Organic compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023262A (en) | 1990-08-14 | 1991-06-11 | American Home Products Corporation | Hydrogenated rapamycin derivatives |
-
1992
- 1992-04-28 FI FI921893A patent/FI97472C/fi not_active IP Right Cessation
- 1992-04-28 JP JP04109579A patent/JP3108192B2/ja not_active Expired - Fee Related
- 1992-04-30 MX MX9202031A patent/MX9202031A/es unknown
- 1992-04-30 ES ES92303916T patent/ES2147724T3/es not_active Expired - Lifetime
- 1992-04-30 EP EP92303916A patent/EP0512754B1/en not_active Expired - Lifetime
- 1992-04-30 PH PH44299A patent/PH30228A/en unknown
- 1992-04-30 HU HU9201468A patent/HU217868B/hu not_active IP Right Cessation
- 1992-04-30 PT PT92303916T patent/PT512754E/pt unknown
- 1992-04-30 DK DK92303916T patent/DK0512754T3/da active
- 1992-04-30 DE DE69231215T patent/DE69231215T2/de not_active Expired - Fee Related
- 1992-04-30 AT AT92303916T patent/ATE194352T1/de not_active IP Right Cessation
- 1992-05-01 KR KR1019920007431A patent/KR100230877B1/ko not_active Expired - Fee Related
- 1992-05-05 AU AU16008/92A patent/AU647616B2/en not_active Ceased
- 1992-05-05 NZ NZ24261692A patent/NZ242616A/en unknown
-
2000
- 2000-07-27 GR GR20000401723T patent/GR3034033T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP3108192B2 (ja) | 2000-11-13 |
| PH30228A (en) | 1997-02-05 |
| FI921893L (fi) | 1992-11-08 |
| ATE194352T1 (de) | 2000-07-15 |
| AU647616B2 (en) | 1994-03-24 |
| DK0512754T3 (da) | 2000-09-18 |
| AU1600892A (en) | 1992-11-12 |
| GR3034033T3 (en) | 2000-11-30 |
| NZ242616A (en) | 1994-07-26 |
| PT512754E (pt) | 2000-11-30 |
| DE69231215D1 (de) | 2000-08-10 |
| DE69231215T2 (de) | 2000-11-09 |
| EP0512754A1 (en) | 1992-11-11 |
| JPH05117279A (ja) | 1993-05-14 |
| HU217868B (hu) | 2000-04-28 |
| FI97472B (fi) | 1996-09-13 |
| FI921893A0 (fi) | 1992-04-28 |
| MX9202031A (es) | 1992-11-01 |
| KR100230877B1 (ko) | 1999-11-15 |
| HUT62589A (en) | 1993-05-28 |
| KR920021553A (ko) | 1992-12-18 |
| HU9201468D0 (en) | 1992-07-28 |
| EP0512754B1 (en) | 2000-07-05 |
| FI97472C (fi) | 1996-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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