ES2148332T3 - Procedimiento para la produccion de concentrado de inmunoglobulinas g. - Google Patents

Procedimiento para la produccion de concentrado de inmunoglobulinas g.

Info

Publication number
ES2148332T3
ES2148332T3 ES94918916T ES94918916T ES2148332T3 ES 2148332 T3 ES2148332 T3 ES 2148332T3 ES 94918916 T ES94918916 T ES 94918916T ES 94918916 T ES94918916 T ES 94918916T ES 2148332 T3 ES2148332 T3 ES 2148332T3
Authority
ES
Spain
Prior art keywords
procedure
production
concentrate
immunoglobulin concentrate
immunoglobulins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94918916T
Other languages
English (en)
Inventor
Miryana Burnouf
Dominique Dernis
Patrick Bonneel
Thierry Burnouf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AETSRN
Association pour lEssor de la Transfusion Sanguine dans la Region Nord
Original Assignee
AETSRN
Association pour lEssor de la Transfusion Sanguine dans la Region Nord
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AETSRN, Association pour lEssor de la Transfusion Sanguine dans la Region Nord filed Critical AETSRN
Application granted granted Critical
Publication of ES2148332T3 publication Critical patent/ES2148332T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN CONCENTRADO DE INMUNOGLOBULINAS G DE ORIGEN PLASMATICO Y AL PROCEDIMIENTO PARA SU PRODUCCION. ESTE PROCEDIMIENTO COMPRENDE UNA SUCESION DE SEPARACIONES CROMATOGRAFICAS, PERO NO PRECIPITACION DE ETANOL. EL PROCEDIMIENTO, COMPRENDE, ADEMAS, UN TRATAMIENTO DE INACTIVACION DEL VIRUS. LA INVENCION TAMBIEN SE REFIERE AL CONCENTRADO DE INMUNOGLOBULINAS G OBTENIDO POR EL CITADO PROCEDIMIENTO Y CUYA CALIDAD ES APROPIADA PARA TODO TIPO DE USOS TERAPEUTICOS, Y EN CONCRETO, PARA INYECCION POR VIA INTRAVENOSA.
ES94918916T 1993-06-14 1994-06-13 Procedimiento para la produccion de concentrado de inmunoglobulinas g. Expired - Lifetime ES2148332T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9307128A FR2706466B1 (fr) 1993-06-14 1993-06-14 Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.

Publications (1)

Publication Number Publication Date
ES2148332T3 true ES2148332T3 (es) 2000-10-16

Family

ID=9448094

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94918916T Expired - Lifetime ES2148332T3 (es) 1993-06-14 1994-06-13 Procedimiento para la produccion de concentrado de inmunoglobulinas g.

Country Status (16)

Country Link
US (1) US6069236A (es)
EP (1) EP0703922B1 (es)
JP (1) JP4218980B2 (es)
AT (1) ATE193020T1 (es)
AU (1) AU7002394A (es)
BR (1) BR9406814A (es)
CA (1) CA2165203C (es)
CZ (1) CZ287186B6 (es)
DE (1) DE69424545T2 (es)
DK (1) DK0703922T3 (es)
ES (1) ES2148332T3 (es)
FR (1) FR2706466B1 (es)
GR (1) GR3034177T3 (es)
HU (1) HU218463B (es)
PT (1) PT703922E (es)
WO (1) WO1994029334A1 (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2270044T3 (en) * 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
IL140155A (en) * 1998-06-09 2005-12-18 Statens Seruminstitut Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
US6962700B1 (en) 2000-09-13 2005-11-08 Atopix Pharmaceuticals Corporation Method of manufacturing immune globulin
FR2824568B1 (fr) * 2001-05-11 2004-04-09 Lab Francais Du Fractionnement Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
EP1691820A4 (en) 2003-11-08 2010-03-03 Prothera Biolog PREPARATION AND COMPOSITION OF INTER ALPHA HEMMER PROTEINS FROM HUMAN PLASMA FOR THERAPEUTIC USE
EP1532983A1 (en) 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
TWI320788B (en) * 2005-05-25 2010-02-21 Hoffmann La Roche Method for the purification of antibodies
FR2895263B1 (fr) 2005-12-26 2008-05-30 Lab Francais Du Fractionnement Concentre d'immunoglobines g (lg) appauvri en anticorps anti-a et anti-b, et en igg polyreactives
WO2007136327A1 (en) * 2006-05-22 2007-11-29 Ge Healthcare Bio-Sciences Ab A method of producing igg
TWI489994B (zh) 2008-03-17 2015-07-01 Baxter Healthcare Sa 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
CN106928346B (zh) 2008-05-28 2021-09-07 普罗瑟拉生物公司 来自血液的间-α抑制物蛋白的制备和组合物
FR2939667B1 (fr) 2008-12-17 2012-01-27 Fractionnement Et Des Biotechonologies Lab Franc Composition d'immunoglobine g comme medicament pour le traitement de l'ictere neonatal par incompatibilite foetomaternelle dans le systeme abo
TWI445714B (zh) 2009-05-27 2014-07-21 Baxter Int 產製用於皮下使用之高濃度免疫球蛋白製備物之方法
US20100322943A1 (en) 2009-06-17 2010-12-23 Thomas Cantor Therapeutic and diagnostic affinity purified specific polyclonal antibodies
HUE028832T2 (en) 2009-09-17 2017-01-30 Baxalta Inc Stable co-formulation of hyaluronidase and immunoglobulin, as well as a process for its preparation
IT1397061B1 (it) 2009-12-28 2012-12-28 Kedrion Spa Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale.
WO2011095543A1 (en) 2010-02-04 2011-08-11 Csl Behring Ag Immunoglobulin preparation
EP2361636A1 (en) 2010-02-26 2011-08-31 CSL Behring AG Immunoglobulin preparation and storage system for an immunoglobulin preparation
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
US8796430B2 (en) 2010-05-26 2014-08-05 Baxter International Inc. Method to produce an immunoglobulin preparation with improved yield
WO2011150284A2 (en) 2010-05-26 2011-12-01 Baxter International Inc. Removal of serine proteases by treatment with finely divided silicon dioxide
KR20130124507A (ko) 2010-11-16 2013-11-14 옥타파마 아게 응고 인자 ＦＸＩ 및 ＦＸＩａ를 함유한 용액으로부터 ＦＸＩ 및 ＦＸＩａ를 감소시키고 및/또는 제거하는 방법
ES2811526T3 (es) 2010-12-30 2021-03-12 Lab Francais Du Fractionnement Glicoles como agentes de inactivación de patógenos
FR2974301B1 (fr) 2011-04-20 2013-08-23 Lab Francais Du Fractionnement Procede de preparation d'un produit plasmatique deplete en un ou plusieurs facteurs thrombogenes
ES2647925T3 (es) * 2011-05-12 2017-12-27 Csl Behring Gmbh Métodos para reducir los eventos adversos causados por preparados farmacéuticos que comprenden proteínas derivadas del plasma
FR2977893B1 (fr) 2011-07-11 2015-02-20 Lab Francais Du Fractionnement Procede de preparation d'un concentre d'immunoglobulines polyvalentes
SG11201400233TA (en) 2011-08-26 2014-08-28 Baxter Int Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
TWI629283B (zh) 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
CN107551269A (zh) 2012-02-29 2018-01-09 百深公司 周围神经的IgG刺激髓鞘再生
EP2636684A1 (en) 2012-03-09 2013-09-11 CSL Behring AG Prevention of infection
BR112014022240A2 (pt) 2012-03-09 2017-08-01 Csl Behring Ag composições compreendendo imunoglobulinas semelhantes à secretoras
EP2636681A1 (en) 2012-03-09 2013-09-11 CSL Behring AG Process for enriching IgA
WO2014039987A2 (en) 2012-09-09 2014-03-13 Prothera Biologics, Inc. Treatment of disease using inter-alpha inhibitor proteins
US20140206844A1 (en) 2013-01-18 2014-07-24 Prothera Biologics Methods for isolating blood products from an inter-alpha inhibitor protein-depleted blood product material
EP3016729B1 (fr) * 2013-07-05 2020-03-25 Laboratoire Francais du Fractionnement et des Biotechnologies Societe Anonyme Matrice de chromatographie d'affinité
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma
KR101917196B1 (ko) * 2014-03-11 2018-11-09 주식회사 녹십자홀딩스 면역글로불린의 정제방법
FR3018450B1 (fr) 2014-03-11 2016-04-15 Lab Francais Du Fractionnement Procede de preparation de proteines plasmatiques humaines
US9556253B2 (en) * 2014-12-02 2017-01-31 Hemarus Therapeutics Limited Process for increased yield of immunoglobulin from human plasma
ES2988823T3 (es) 2014-12-03 2024-11-21 Csl Behring Ag Producto farmacéutico con mayor estabilidad que comprende inmunoglobulinas
CN109789193A (zh) 2016-09-13 2019-05-21 普罗瑟拉生物公司 使用间α抑制蛋白治疗肺病的方法
FR3064485A1 (fr) 2017-03-31 2018-10-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Traitement d'une infection par le virus respiratoire syncytial
FR3064486A1 (fr) 2017-03-31 2018-10-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Prevention d'une infection par le virus respiratoire syncytial dans les voies respiratoires superieures
FR3064484A1 (fr) 2017-03-31 2018-10-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Composition d'immunoglobulines utiles pour traiter des infections virales
EP3615937B1 (en) 2017-04-25 2026-01-28 Prothera Biologics, Inc. Methods for quantifying inter-alpha inhibitor proteins
WO2021202373A1 (en) 2020-03-31 2021-10-07 Baxalta Incorporated A method to produce an immunoglobulin preparation from c-1 inhibitor depleted plasma
US11884702B2 (en) 2020-12-28 2024-01-30 Plasma Technologies, Llc Systems and methods for process scale isolation of immunoglobulin G
EP4423109A4 (en) 2021-10-27 2025-12-24 Plasma Tech Llc COMPOSITIONS AND METHODS FOR ISOLATING PROTEINS
EP4689667A1 (en) * 2023-03-29 2026-02-11 CSL Behring AG Methods of identifying immunoglobulin associated with adverse reactions
WO2025068923A2 (en) 2023-09-26 2025-04-03 Takeda Pharmaceutical Company Limited IMMUNOGLOBULIN FORMULATIONS DEPLETED IN IgA

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7511055A (nl) * 1975-09-19 1977-03-22 Leuven Res & Dev Vzw Trombosetest.
US4136094A (en) * 1977-08-31 1979-01-23 The Regents Of The University Of Minnesota Preparation of intravenous human and animal gamma globulins and isolation of albumin
ES502788A0 (es) * 1981-06-04 1982-04-01 Landerlan Sa Lab Procedimiento de preparacion de imuno globulina g nativa li-bre de actividad anticomplementaria
FR2543448A1 (fr) * 1983-04-01 1984-10-05 Rhone Poulenc Spec Chim Procede de fractionnement du plasma
US4841024A (en) * 1986-09-15 1989-06-20 Becton Dickinson And Company Purification of antibodies
DE3640513A1 (de) * 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
DE3641115A1 (de) * 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
US4806346A (en) * 1986-12-16 1989-02-21 American Home Products Corporation Method for isolation of antigen specific immunoglobulin
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
US5177194A (en) * 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
DE4118912C1 (es) * 1991-06-08 1992-07-02 Biotest Pharma Gmbh, 6072 Dreieich, De

Also Published As

Publication number Publication date
HU218463B (hu) 2000-09-28
EP0703922B1 (fr) 2000-05-17
DK0703922T3 (da) 2000-11-13
JPH09500369A (ja) 1997-01-14
CA2165203A1 (fr) 1994-12-22
BR9406814A (pt) 2000-05-30
HU9503557D0 (en) 1996-02-28
HUT74272A (en) 1996-11-28
US6069236A (en) 2000-05-30
CA2165203C (fr) 2009-08-18
JP4218980B2 (ja) 2009-02-04
GR3034177T3 (en) 2000-11-30
FR2706466B1 (fr) 1995-08-25
DE69424545T2 (de) 2001-01-18
EP0703922A1 (fr) 1996-04-03
PT703922E (pt) 2000-11-30
DE69424545D1 (de) 2000-06-21
AU7002394A (en) 1995-01-03
WO1994029334A1 (fr) 1994-12-22
CZ328795A3 (en) 1996-07-17
ATE193020T1 (de) 2000-06-15
CZ287186B6 (en) 2000-10-11
FR2706466A1 (fr) 1994-12-23

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