ES2148332T3 - Procedimiento para la produccion de concentrado de inmunoglobulinas g. - Google Patents

Procedimiento para la produccion de concentrado de inmunoglobulinas g.

Info

Publication number
ES2148332T3
ES2148332T3 ES94918916T ES94918916T ES2148332T3 ES 2148332 T3 ES2148332 T3 ES 2148332T3 ES 94918916 T ES94918916 T ES 94918916T ES 94918916 T ES94918916 T ES 94918916T ES 2148332 T3 ES2148332 T3 ES 2148332T3
Authority
ES
Spain
Prior art keywords
procedure
production
concentrate
immunoglobulin concentrate
immunoglobulins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94918916T
Other languages
English (en)
Inventor
Miryana Burnouf
Dominique Dernis
Patrick Bonneel
Thierry Burnouf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AETSRN
Association pour lEssor de la Transfusion Sanguine dans la Region Nord
Original Assignee
AETSRN
Association pour lEssor de la Transfusion Sanguine dans la Region Nord
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AETSRN, Association pour lEssor de la Transfusion Sanguine dans la Region Nord filed Critical AETSRN
Application granted granted Critical
Publication of ES2148332T3 publication Critical patent/ES2148332T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN CONCENTRADO DE INMUNOGLOBULINAS G DE ORIGEN PLASMATICO Y AL PROCEDIMIENTO PARA SU PRODUCCION. ESTE PROCEDIMIENTO COMPRENDE UNA SUCESION DE SEPARACIONES CROMATOGRAFICAS, PERO NO PRECIPITACION DE ETANOL. EL PROCEDIMIENTO, COMPRENDE, ADEMAS, UN TRATAMIENTO DE INACTIVACION DEL VIRUS. LA INVENCION TAMBIEN SE REFIERE AL CONCENTRADO DE INMUNOGLOBULINAS G OBTENIDO POR EL CITADO PROCEDIMIENTO Y CUYA CALIDAD ES APROPIADA PARA TODO TIPO DE USOS TERAPEUTICOS, Y EN CONCRETO, PARA INYECCION POR VIA INTRAVENOSA.
ES94918916T 1993-06-14 1994-06-13 Procedimiento para la produccion de concentrado de inmunoglobulinas g. Expired - Lifetime ES2148332T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9307128A FR2706466B1 (fr) 1993-06-14 1993-06-14 Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.

Publications (1)

Publication Number Publication Date
ES2148332T3 true ES2148332T3 (es) 2000-10-16

Family

ID=9448094

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94918916T Expired - Lifetime ES2148332T3 (es) 1993-06-14 1994-06-13 Procedimiento para la produccion de concentrado de inmunoglobulinas g.

Country Status (16)

Country Link
US (1) US6069236A (es)
EP (1) EP0703922B1 (es)
JP (1) JP4218980B2 (es)
AT (1) ATE193020T1 (es)
AU (1) AU7002394A (es)
BR (1) BR9406814A (es)
CA (1) CA2165203C (es)
CZ (1) CZ287186B6 (es)
DE (1) DE69424545T2 (es)
DK (1) DK0703922T3 (es)
ES (1) ES2148332T3 (es)
FR (1) FR2706466B1 (es)
GR (1) GR3034177T3 (es)
HU (1) HU218463B (es)
PT (1) PT703922E (es)
WO (1) WO1994029334A1 (es)

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JP4685238B2 (ja) * 1998-06-09 2011-05-18 ツエー・エス・エル・ベーリング・アクチエンゲゼルシヤフト 静脈投与用免疫グロブリン及び他の免疫グロブリン生成物の製造法
US6962700B1 (en) 2000-09-13 2005-11-08 Atopix Pharmaceuticals Corporation Method of manufacturing immune globulin
FR2824568B1 (fr) * 2001-05-11 2004-04-09 Lab Francais Du Fractionnement Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
EP3087991A1 (en) 2003-11-08 2016-11-02 Prothera Biologics Composition of inter-alpha inhibitor proteins from human plasma for therapeutic use
EP1532983A1 (en) * 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
TWI391399B (zh) * 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法
FR2895263B1 (fr) 2005-12-26 2008-05-30 Lab Francais Du Fractionnement Concentre d'immunoglobines g (lg) appauvri en anticorps anti-a et anti-b, et en igg polyreactives
WO2007136327A1 (en) * 2006-05-22 2007-11-29 Ge Healthcare Bio-Sciences Ab A method of producing igg
TWI532498B (zh) 2008-03-17 2016-05-11 巴克斯特保健公司 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
TR201808152T4 (tr) 2008-05-28 2018-07-23 Prothera Biologics Inc Kandan inter-alfa inhibitör proteinlerinin hazırlanması ve bunların bileşimi.
FR2939667B1 (fr) 2008-12-17 2012-01-27 Fractionnement Et Des Biotechonologies Lab Franc Composition d'immunoglobine g comme medicament pour le traitement de l'ictere neonatal par incompatibilite foetomaternelle dans le systeme abo
MY157239A (en) 2009-05-27 2016-05-13 Baxalta Inc A method to produce a highly concentrated immunoglobulin preparation for subcutaneous use
US20100322943A1 (en) 2009-06-17 2010-12-23 Thomas Cantor Therapeutic and diagnostic affinity purified specific polyclonal antibodies
CN102655853B (zh) 2009-09-17 2015-07-29 巴克斯特卫生保健有限公司 透明质酸酶和免疫球蛋白的稳定的复合制剂及其使用方法
IT1397061B1 (it) 2009-12-28 2012-12-28 Kedrion Spa Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale.
JP6078344B2 (ja) 2010-02-04 2017-02-08 ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト 免疫グロブリン製剤
EP2361636A1 (en) 2010-02-26 2011-08-31 CSL Behring AG Immunoglobulin preparation and storage system for an immunoglobulin preparation
US8772462B2 (en) 2010-05-26 2014-07-08 Baxter International Inc. Removal of serine proteases by treatment with finely divided silicon dioxide
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
US8796430B2 (en) 2010-05-26 2014-08-05 Baxter International Inc. Method to produce an immunoglobulin preparation with improved yield
RU2649363C2 (ru) 2010-11-16 2018-04-02 Октафарма Аг СПОСОБЫ СНИЖЕНИЯ И/ИЛИ УДАЛЕНИЯ FXI и FXIa ИЗ РАСТВОРОВ, СОДЕРЖАЩИХ УКАЗАННЫЕ ФАКТОРЫ СВЕРТЫВАНИЯ
SG191781A1 (en) 2010-12-30 2013-08-30 Lab Francais Du Fractionnement Glycols as pathogen inactivating agents
FR2974301B1 (fr) 2011-04-20 2013-08-23 Lab Francais Du Fractionnement Procede de preparation d'un produit plasmatique deplete en un ou plusieurs facteurs thrombogenes
ES2647925T3 (es) * 2011-05-12 2017-12-27 Csl Behring Gmbh Métodos para reducir los eventos adversos causados por preparados farmacéuticos que comprenden proteínas derivadas del plasma
FR2977893B1 (fr) 2011-07-11 2015-02-20 Lab Francais Du Fractionnement Procede de preparation d'un concentre d'immunoglobulines polyvalentes
MY165164A (en) 2011-08-26 2018-02-28 Baxalta Inc Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
TWI629283B (zh) 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
DK2820042T3 (da) 2012-02-29 2019-10-28 Baxalta GmbH Igg-stimuleret remyelinisering af perifere nerver
EP2636681A1 (en) 2012-03-09 2013-09-11 CSL Behring AG Process for enriching IgA
EP2636684A1 (en) 2012-03-09 2013-09-11 CSL Behring AG Prevention of infection
MX360245B (es) 2012-03-09 2018-10-26 Csl Behring Ag Composiciones que comprenden inmunoglobulinas de tipo secretor.
WO2014039987A2 (en) 2012-09-09 2014-03-13 Prothera Biologics, Inc. Treatment of disease using inter-alpha inhibitor proteins
US20140206844A1 (en) * 2013-01-18 2014-07-24 Prothera Biologics Methods for isolating blood products from an inter-alpha inhibitor protein-depleted blood product material
US10611826B2 (en) 2013-07-05 2020-04-07 Laboratoire Français Du Fractionnement Et Des Biotechnologies Affinity chromatography matrix
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma
FR3018450B1 (fr) 2014-03-11 2016-04-15 Lab Francais Du Fractionnement Procede de preparation de proteines plasmatiques humaines
WO2015137530A1 (ko) * 2014-03-11 2015-09-17 주식회사 녹십자홀딩스 면역글로불린의 정제방법
US9556253B2 (en) * 2014-12-02 2017-01-31 Hemarus Therapeutics Limited Process for increased yield of immunoglobulin from human plasma
HUE052280T2 (hu) 2014-12-03 2021-04-28 Csl Behring Ag Immunoglobulinokat tartalmazó megnövelt stabilitású gyógyszerészeti termék
US20190269765A1 (en) 2016-09-13 2019-09-05 Prothera Biologics, Inc. Methods for treating pulmonary disease using inter-alpha inhibitor proteins
FR3064484A1 (fr) 2017-03-31 2018-10-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Composition d'immunoglobulines utiles pour traiter des infections virales
FR3064486A1 (fr) 2017-03-31 2018-10-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Prevention d'une infection par le virus respiratoire syncytial dans les voies respiratoires superieures
FR3064485A1 (fr) 2017-03-31 2018-10-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Traitement d'une infection par le virus respiratoire syncytial
AU2018258466B2 (en) 2017-04-25 2025-05-22 Prothera Biologics, Inc. Methods for quantifying inter-alpha inhibitor proteins
CA3173539A1 (en) 2020-03-31 2021-10-07 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation from c-1 inhibitor depleted plasma
CN116802206A (zh) 2020-12-28 2023-09-22 等离子体技术有限责任公司 用于生产规模的免疫球蛋白g分离系统和方法
CA3203540A1 (en) * 2020-12-28 2022-07-07 Eugene ZURLO Systems and methods for process scale isolation of immunoglobulin g
EP4689667A1 (en) * 2023-03-29 2026-02-11 CSL Behring AG Methods of identifying immunoglobulin associated with adverse reactions
CN121985959A (zh) 2023-09-26 2026-05-05 武田药品工业株式会社 耗减IgA的免疫球蛋白制剂

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NL7511055A (nl) * 1975-09-19 1977-03-22 Leuven Res & Dev Vzw Trombosetest.
US4136094A (en) * 1977-08-31 1979-01-23 The Regents Of The University Of Minnesota Preparation of intravenous human and animal gamma globulins and isolation of albumin
ES8203612A1 (es) * 1981-06-04 1982-04-01 Landerlan Sa Lab Procedimiento de preparacion de imuno globulina g nativa li-bre de actividad anticomplementaria
FR2543448A1 (fr) * 1983-04-01 1984-10-05 Rhone Poulenc Spec Chim Procede de fractionnement du plasma
US4841024A (en) * 1986-09-15 1989-06-20 Becton Dickinson And Company Purification of antibodies
DE3640513A1 (de) * 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
DE3641115A1 (de) * 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
US4806346A (en) * 1986-12-16 1989-02-21 American Home Products Corporation Method for isolation of antigen specific immunoglobulin
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
US5177194A (en) * 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
DE4118912C1 (es) * 1991-06-08 1992-07-02 Biotest Pharma Gmbh, 6072 Dreieich, De

Also Published As

Publication number Publication date
BR9406814A (pt) 2000-05-30
FR2706466B1 (fr) 1995-08-25
JPH09500369A (ja) 1997-01-14
WO1994029334A1 (fr) 1994-12-22
DK0703922T3 (da) 2000-11-13
PT703922E (pt) 2000-11-30
HU9503557D0 (en) 1996-02-28
EP0703922B1 (fr) 2000-05-17
ATE193020T1 (de) 2000-06-15
HU218463B (hu) 2000-09-28
HUT74272A (en) 1996-11-28
FR2706466A1 (fr) 1994-12-23
DE69424545T2 (de) 2001-01-18
EP0703922A1 (fr) 1996-04-03
US6069236A (en) 2000-05-30
CA2165203A1 (fr) 1994-12-22
JP4218980B2 (ja) 2009-02-04
CZ287186B6 (en) 2000-10-11
DE69424545D1 (de) 2000-06-21
CA2165203C (fr) 2009-08-18
CZ328795A3 (en) 1996-07-17
GR3034177T3 (en) 2000-11-30
AU7002394A (en) 1995-01-03

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