ES2148681T3 - Compuestos de benzotiofeno de uso farmaceutico. - Google Patents
Compuestos de benzotiofeno de uso farmaceutico.Info
- Publication number
- ES2148681T3 ES2148681T3 ES96301534T ES96301534T ES2148681T3 ES 2148681 T3 ES2148681 T3 ES 2148681T3 ES 96301534 T ES96301534 T ES 96301534T ES 96301534 T ES96301534 T ES 96301534T ES 2148681 T3 ES2148681 T3 ES 2148681T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- rdurule
- aryl
- compounds
- progestin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 239000000262 estrogen Substances 0.000 abstract 3
- 229940011871 estrogen Drugs 0.000 abstract 3
- 239000000583 progesterone congener Substances 0.000 abstract 3
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- XBQNZPDIRJPFAI-UHFFFAOYSA-N 3,3-dimethylpyrrolidine Chemical compound CC1(C)CCNC1 XBQNZPDIRJPFAI-UHFFFAOYSA-N 0.000 abstract 1
- RDEHRKLSYJBKDV-UHFFFAOYSA-N 3,4-dimethylpyrrolidine Chemical compound CC1CNCC1C RDEHRKLSYJBKDV-UHFFFAOYSA-N 0.000 abstract 1
- KYINPWAJIVTFBW-UHFFFAOYSA-N 3-methylpyrrolidine Chemical compound CC1CCNC1 KYINPWAJIVTFBW-UHFFFAOYSA-N 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010027304 Menopausal symptoms Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical group OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 201000010260 leiomyoma Diseases 0.000 abstract 1
- 229960004296 megestrol acetate Drugs 0.000 abstract 1
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229940053934 norethindrone Drugs 0.000 abstract 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 abstract 1
- XSXHWVKGUXMUQE-UHFFFAOYSA-N osmium dioxide Inorganic materials O=[Os]=O XSXHWVKGUXMUQE-UHFFFAOYSA-N 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001072 progestational effect Effects 0.000 abstract 1
- 229960003387 progesterone Drugs 0.000 abstract 1
- 239000000186 progesterone Substances 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 208000010579 uterine corpus leiomyoma Diseases 0.000 abstract 1
- 201000007954 uterine fibroid Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA UN COMPUESTO DE FORMULA I DONDE R{SUB,1} ES H, OH, HALO, OCO(C{SUB,1}-C{SUB,6} ALQUILO), OCO(ARILO), OSO{SUB,2} (C{SUB,4}-C{SUB,6} ALQUILO), OCOO (C{SUB,1}-C{SUB,6} ALQUILO),OCOO(ARILO), OCONH(C{SUB,1}-C{SUB,6} ALQUILO), O OCON(C{SUB,1}-C{SUB,6}ALQUILO){SUB,2}; R{SUB,2} ES ARILO, C{SUB,1}-C{SUB,6} ALQUILO, C{SUB,3}-C{SUB,6} CICLOALQUILO, O 4-CICLOHEXANOL; R{SUB,3} ES O(CH{SUB,2}){SUB,2} O O(CH{SUB,2}){SUB,3}; R{SUB,4} Y R{SUB,5} SON OPCIONALMENTE CO(CH{SUB,2}){SUB,3}, CO(CH{SUB,2}){SUB,4}, C{SUB,1}-C{SUB,6} ALQUILO, O R{SUB,4} Y R{SUB,5} SE COMBINA PARA FORMAR, CON EL NITROGENO PARA EL QUE ELLOS ESTAN LIGADOS, PIPERIDINA, MORFOLINA, PIRROLIDINA, 3METILPIROLLIDINA, 3,3-DIMETILPIROLLIDINA, 3,4-DIMETILPIROLLIDINA, AZEPINA O PIPECOLINA; R{SUB,6} ES C=CH{SUB,2}, CH(C{SUB,1}-C{SUB,5}ALQUILO), CH(C{SUB,2}-C{SUB,5} ALQUENILO), C=CH(C{SUB,1}-C{SUB,5} ALQUILO, CH(ARILO),C(OH)(C{SUB,1}C{SUB,5}ALQUILO), C(OH)(C{SUB,2}-C{SUB,5}ALQUENILO), C(OH)ARILO; Y SALES DE LAS MISMA ACEPTABLES FARMACEUTICAMENTE. LA PRESENTE INVENCION PROPORCIONA POSTERIORMENTE COMPOSICIONES FARMACEUTICAS CONTENIENDO COMPUESTOS DE LA FORMULA I, OPCIONALMENTE CONTENIENDO ESTROGENO O PROGESTINA, Y EL USO DE DICHOS COMPUESTOS SOLOS, O EN COMBINACION CON ESTROGENO O PROGESTINA, PARA ALIVIAR LOS SINTOMAS DEL SINDROME POSTMENOPAUSICO, PARTICULARMENTE OSTEOPOROSIS, CONDICIONES CARDIOVASCULARES PATOLOGICAMENTE RELACIONADAS Y CANCER DEPENDIENTE DE ESTROGENO. COMO SE USA AQUI , EL TERMINO "PROGESTINA" INCLUYE COMPUESTOS QUE CONTIENEN ACTIVIDAD PROGESTINACIONAL, COMO POR EJEMPLO, PROGESTERONA, NORETILNODRELO, NONGESTROL, ACETATO MEGESTROL, NORETINDRONE. LOS COMPUESTOS DE LA PRESENTE INVENCION TAMBIEN SON UTILES PARA LA INHIBICION DE ENFERMEDADES DE LAS FIBRAS UTERINAS Y ENDOMETRIOSIS EN MUJERES Y PROLIFERACION DE CELULAS MUSCULARES SUAVIZANTES DE LA AORTA, PARTICULARMENTE RESTENOSIS EN HUMANOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/402,415 US6395755B1 (en) | 1995-03-10 | 1995-03-10 | Benzothiophene pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2148681T3 true ES2148681T3 (es) | 2000-10-16 |
Family
ID=23591799
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96301534T Expired - Lifetime ES2148681T3 (es) | 1995-03-10 | 1996-03-06 | Compuestos de benzotiofeno de uso farmaceutico. |
| ES99202800T Expired - Lifetime ES2205702T3 (es) | 1995-03-10 | 1996-03-06 | Compuesto farmaceuticos de benzotiofeno. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99202800T Expired - Lifetime ES2205702T3 (es) | 1995-03-10 | 1996-03-06 | Compuesto farmaceuticos de benzotiofeno. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6395755B1 (es) |
| EP (2) | EP0731100B1 (es) |
| JP (1) | JPH11501930A (es) |
| AT (2) | ATE195519T1 (es) |
| AU (1) | AU697502B2 (es) |
| BR (1) | BR9607775A (es) |
| CA (1) | CA2214261A1 (es) |
| DE (2) | DE69609748T2 (es) |
| DK (1) | DK0731100T3 (es) |
| ES (2) | ES2148681T3 (es) |
| GR (1) | GR3034762T3 (es) |
| IL (1) | IL117398A (es) |
| PT (1) | PT731100E (es) |
| SI (1) | SI0731100T1 (es) |
| WO (1) | WO1996028155A1 (es) |
| ZA (1) | ZA961883B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432982B1 (en) * | 1996-02-21 | 2002-08-13 | Eli Lilly And Company | Benzothiophenes, and formulations and methods using same |
| EP0801066A1 (en) * | 1996-03-12 | 1997-10-15 | Eli Lilly And Company | Heterocyclic substituted benzothiophenes and pharmaceutical compositions |
| CA2214072C (en) * | 1996-08-29 | 2006-11-14 | Eli Lilly And Company | Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods |
| CA2214196A1 (en) * | 1996-09-26 | 1998-03-26 | Eli Lilly And Company | Benzo[b]indeno[2,1-d]thiophene compounds, intermediates, processes, compositions and methods |
| CA2216592C (en) * | 1996-10-24 | 2006-07-18 | Brian Stephen Muehl | Benzothiophene compounds, intermediates, compositions, and methods |
| ES2259376T3 (es) | 2001-05-22 | 2006-10-01 | Eli Lilly And Company | 1,2,3,4-tetrahidroquinolinas 2-sustituidas y sus derivados, composiciones y procedimientos. |
| ES2236536T3 (es) | 2001-05-22 | 2005-07-16 | Eli Lilly And Company | Derivados tetrahidroquinolino para la inhibicion de enfermedades asociadas con la privacion de estrogenos o con una respuesta fisiologica aberrante a estrogenos endogenos. |
| WO2003011282A1 (en) | 2001-07-31 | 2003-02-13 | Pfizer Products Inc. | Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins |
| US20070066595A1 (en) * | 2004-01-22 | 2007-03-22 | Dodge Jeffrey A | Selective estrogen receptor modulators |
| GR1005694B (el) * | 2005-06-08 | 2007-10-22 | Αλεξης Μιχαηλ | Ιστοειδικα αντιοιστρογονα ειδικα για τον αλφα υποδοχεα των οιστρογονων |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1300575B (de) * | 1965-05-21 | 1969-08-07 | Bristol Myers Co | Benzo[b]thiophene |
| US3947470A (en) | 1974-06-20 | 1976-03-30 | Smithkline Corporation | Substituted benzofurans and benzothiophenes |
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| IT1154888B (it) * | 1980-11-12 | 1987-01-21 | Menarini Sas | Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione |
| IL65404A0 (en) * | 1981-04-03 | 1982-07-30 | Lilly Co Eli | Benzothiophene compounds and process for preparing them |
| US4380635A (en) | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| IL65379A0 (en) * | 1981-04-03 | 1982-05-31 | Lilly Co Eli | Process for preparing acylated benzothiophenes |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US4851554A (en) | 1987-04-06 | 1989-07-25 | University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzofuran derivatives |
| WO1989002893A1 (en) * | 1987-09-30 | 1989-04-06 | The University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzothiophene derivatives |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| FR2665444B1 (fr) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
| DE4117512A1 (de) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
| TW366342B (en) | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
| US5482949A (en) | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US5523309A (en) * | 1995-03-10 | 1996-06-04 | Eli Lilly And Company | Benzofuran pharmaceutical compounds |
-
1995
- 1995-03-10 US US08/402,415 patent/US6395755B1/en not_active Expired - Fee Related
-
1996
- 1996-03-06 PT PT96301534T patent/PT731100E/pt unknown
- 1996-03-06 AT AT96301534T patent/ATE195519T1/de not_active IP Right Cessation
- 1996-03-06 DE DE69609748T patent/DE69609748T2/de not_active Expired - Fee Related
- 1996-03-06 EP EP96301534A patent/EP0731100B1/en not_active Expired - Lifetime
- 1996-03-06 EP EP99202800A patent/EP0953568B1/en not_active Expired - Lifetime
- 1996-03-06 AT AT99202800T patent/ATE247100T1/de not_active IP Right Cessation
- 1996-03-06 ES ES96301534T patent/ES2148681T3/es not_active Expired - Lifetime
- 1996-03-06 SI SI9630256T patent/SI0731100T1/xx unknown
- 1996-03-06 ES ES99202800T patent/ES2205702T3/es not_active Expired - Lifetime
- 1996-03-06 DK DK96301534T patent/DK0731100T3/da active
- 1996-03-06 DE DE69629500T patent/DE69629500T2/de not_active Expired - Fee Related
- 1996-03-07 JP JP8527729A patent/JPH11501930A/ja active Pending
- 1996-03-07 BR BR9607775A patent/BR9607775A/pt not_active Application Discontinuation
- 1996-03-07 AU AU53048/96A patent/AU697502B2/en not_active Ceased
- 1996-03-07 CA CA002214261A patent/CA2214261A1/en not_active Abandoned
- 1996-03-07 IL IL11739896A patent/IL117398A/xx not_active IP Right Cessation
- 1996-03-07 ZA ZA9601883A patent/ZA961883B/xx unknown
- 1996-03-07 WO PCT/US1996/003164 patent/WO1996028155A1/en not_active Ceased
-
2000
- 2000-11-07 GR GR20000402451T patent/GR3034762T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0953568B1 (en) | 2003-08-13 |
| AU697502B2 (en) | 1998-10-08 |
| DK0731100T3 (da) | 2000-09-18 |
| EP0953568A1 (en) | 1999-11-03 |
| ES2205702T3 (es) | 2004-05-01 |
| ZA961883B (en) | 1997-09-08 |
| DE69629500D1 (de) | 2003-09-18 |
| JPH11501930A (ja) | 1999-02-16 |
| IL117398A0 (en) | 1996-07-23 |
| ATE247100T1 (de) | 2003-08-15 |
| PT731100E (pt) | 2001-01-31 |
| WO1996028155A1 (en) | 1996-09-19 |
| CA2214261A1 (en) | 1996-09-19 |
| ATE195519T1 (de) | 2000-09-15 |
| AU5304896A (en) | 1996-10-02 |
| IL117398A (en) | 2000-11-21 |
| SI0731100T1 (en) | 2001-02-28 |
| EP0731100B1 (en) | 2000-08-16 |
| US6395755B1 (en) | 2002-05-28 |
| DE69609748D1 (de) | 2000-09-21 |
| BR9607775A (pt) | 1998-07-07 |
| MX9706737A (es) | 1997-11-29 |
| DE69609748T2 (de) | 2001-04-12 |
| GR3034762T3 (en) | 2001-02-28 |
| EP0731100A1 (en) | 1996-09-11 |
| DE69629500T2 (de) | 2004-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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