ES2149203T3 - Peptido t y peptidos asociados destinados para el tratamiento de las inflamaciones, particularmente la esclerosis multiple. - Google Patents

Peptido t y peptidos asociados destinados para el tratamiento de las inflamaciones, particularmente la esclerosis multiple.

Info

Publication number
ES2149203T3
ES2149203T3 ES93907942T ES93907942T ES2149203T3 ES 2149203 T3 ES2149203 T3 ES 2149203T3 ES 93907942 T ES93907942 T ES 93907942T ES 93907942 T ES93907942 T ES 93907942T ES 2149203 T3 ES2149203 T3 ES 2149203T3
Authority
ES
Spain
Prior art keywords
absent
thr
ser
gly
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93907942T
Other languages
English (en)
Inventor
Anders Jorgen Andersen
Roger Aston
Peter Louis Carlen
Penelope Reed Doob
Douglas Kevin Macfadden
David James Phipps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advanced Immuni T Inc
Original Assignee
Advanced Immuni T Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK92645A external-priority patent/DK64592D0/da
Application filed by Advanced Immuni T Inc filed Critical Advanced Immuni T Inc
Application granted granted Critical
Publication of ES2149203T3 publication Critical patent/ES2149203T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PEPTIDO T Y SUS ANALOGOS LINEALES O CICLICOS DE LA FORMULA GENERAL (1): I-A-B-C-D-E-F-G-H-II, EN DONDE A ES ALA, GLY, VAL, SER, THR O AUSENTE, B ES ALA, GLY, VAL, SER, THR O AUSENTE; C ES SER, THR O AUSENTE, D ES SER, THR, ASN, GLU, ARG, ILE, LEU O AUSENTE, E ES SER, THR, ASP O AUSENTE, F ES THR, SER, ASN, ARG, GLN, LYS, TRP O AUSENTE, G ES TYR O AUSENTE, H ES THR, ARG, GLY, MET, MET (O), CYS, THR, GLY, O AUSENTE E I ES CYS O AUSENTE, II ES CYS, UN GRUPO AMIDA, GRUPO AMIDA SUSTITUIDO, UN GRUPO ESTER O AUSENTE, ESTANDO AL MENOS UNO DE LOS AMINO ACIDOS OPCIONALMENTE SUSTITUIDO POR UN CARBOHIDRATO POLIMERICO O MONOMERICO O DERIVADOS DE ELLOS, SIENDO REALIZADA TAL SUSTITUCION A TRAVES DE HIDROXILO Y/O AMIDO Y/O GRUPOS AMIDO DE LOS AMINO ACIDOS, QUE COMPRENDEN AL MENOS 4 AMINO ACIDOS, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, SE USAN EN EL TRATAMIENTO O PREVENCION DE INFLAMACION. EN PARTICULAR, LOS PEPTIDOS SE USAN EN EL TRATAMIENTO O PREVENCION DE ESCLEROSIS MULTIPLE, MIELOPATIAS (INCLUYENDO MIELOPATIA ASOCIADA CON HTLV-1) Y SINTOMAS Y ENFERMEDADES ASOCIADAS CON ACTIVACION INMUNE CRONICA, QUE INCLUYE SINDROME DE FATIGA, CHOQUE TOXICO, ARTRITIS, ENFERMEDAD INFLAMATORIA DEL INTESTINO Y RESPUESTAS ANFITRION CONTRA INJERTO E INJERTO CONTRA ANFITRION EN RECEPTORES DE TRANSPLANTE.
ES93907942T 1992-03-27 1993-03-29 Peptido t y peptidos asociados destinados para el tratamiento de las inflamaciones, particularmente la esclerosis multiple. Expired - Lifetime ES2149203T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85883292A 1992-03-27 1992-03-27
DK92645A DK64592D0 (da) 1992-05-14 1992-05-14 Peptider til terapeutisk behandling
US91511892A 1992-07-17 1992-07-17
US98767492A 1992-12-09 1992-12-09

Publications (1)

Publication Number Publication Date
ES2149203T3 true ES2149203T3 (es) 2000-11-01

Family

ID=27439352

Family Applications (2)

Application Number Title Priority Date Filing Date
ES99101349T Expired - Lifetime ES2222625T3 (es) 1992-03-27 1993-03-29 Peptido t y peptidos asociados destinados al tratamiento de la inflamacion incluyendo la esclerosis multiple.
ES93907942T Expired - Lifetime ES2149203T3 (es) 1992-03-27 1993-03-29 Peptido t y peptidos asociados destinados para el tratamiento de las inflamaciones, particularmente la esclerosis multiple.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES99101349T Expired - Lifetime ES2222625T3 (es) 1992-03-27 1993-03-29 Peptido t y peptidos asociados destinados al tratamiento de la inflamacion incluyendo la esclerosis multiple.

Country Status (12)

Country Link
EP (2) EP0960886B1 (es)
JP (1) JP3520084B2 (es)
KR (1) KR100312300B1 (es)
AT (2) ATE194495T1 (es)
AU (3) AU684713B2 (es)
CA (1) CA2132516A1 (es)
DE (2) DE69329023T2 (es)
DK (2) DK0635027T3 (es)
ES (2) ES2222625T3 (es)
PT (1) PT960886E (es)
UA (1) UA41881C2 (es)
WO (1) WO1993020102A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739109A (en) * 1988-12-16 1998-04-14 Advanced Immunit Inc. Method of treating neuroinflammatory degenerative diseases
AU697847B2 (en) * 1993-09-24 1998-10-15 Advanced Immunit, Inc. Method for the treatment or prevention of eczema/dermatitis
DE69433817T2 (de) * 1993-09-24 2005-07-14 Advanced Immuni T, Inc. Lineare und cyklische peptide zur behandlung oder vorbeugung der crohn'schen krankheit und/oder der ulzerativen kolitis
EP1242109A4 (en) * 1999-11-09 2004-06-02 Advanced Immunit Inc METHOD FOR THE TREATMENT OF VIURUS DISEASES AND OTHER DISORDERS BY CHANGING THE IMMEDIATE GENE EXPRESSION BY ADMINISTERING PEPTIDE T
JP4611233B2 (ja) * 2005-04-06 2011-01-12 ニッタ株式会社 歩行訓練支援装置
US20140322251A1 (en) * 2013-04-26 2014-10-30 Michael Ruff Peptides for Progressive Treating Multi-Focal Leukoencephalopathy and Related Conditions
EP2832373B1 (en) * 2013-08-02 2017-04-12 Experimentelle Pharmakologie & Onkologie Berlin Buch Liposome for blocking site-specifically chemokine-related inflammatory processes in vascular diseases and metastasis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7544987A (en) * 1986-06-03 1988-01-11 Pert, C.B. Small peptides which inhibit binding to t-4 receptors
NZ221440A (en) * 1986-08-20 1991-11-26 Genetic Systems Corp Composition containing monoclonal antibodies/peptides useful in treating and diagnosing hiv infections
WO1988009338A1 (en) * 1987-05-22 1988-12-01 Syntbiotech, Inc. Synthetic peptides and a method of treating aids
ATE168698T1 (de) * 1988-05-27 1998-08-15 Us Health Zubereitungen zur verwendung bei der behandlung von psoriasis und von neuropsychiatrischen krankheiten
US5189022A (en) * 1988-05-27 1993-02-23 The United States Of America As Represented By The Secretary Of Health And Human Services Composition for the treatment of chronic fatigue syndrome

Also Published As

Publication number Publication date
JPH07507061A (ja) 1995-08-03
AU725680B2 (en) 2000-10-19
UA41881C2 (uk) 2001-10-15
DK0960886T3 (da) 2004-09-27
EP0635027A1 (en) 1995-01-25
ATE267838T1 (de) 2004-06-15
EP0960886B1 (en) 2004-05-26
EP0635027B1 (en) 2000-07-12
EP0960886A1 (en) 1999-12-01
JP3520084B2 (ja) 2004-04-19
ATE194495T1 (de) 2000-07-15
CA2132516A1 (en) 1993-10-14
PT960886E (pt) 2004-10-29
DK0635027T3 (da) 2000-10-02
KR950700931A (ko) 1995-02-20
AU718442B2 (en) 2000-04-13
ES2222625T3 (es) 2005-02-01
WO1993020102A1 (en) 1993-10-14
DE69333537T2 (de) 2005-06-16
AU684713B2 (en) 1998-01-08
AU3895393A (en) 1993-11-08
AU2254999A (en) 1999-05-20
AU6354298A (en) 1998-06-18
DE69329023D1 (de) 2000-08-17
KR100312300B1 (ko) 2002-03-20
DE69329023T2 (de) 2001-03-22
DE69333537D1 (de) 2004-07-01

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