ES2149613T3 - Procedimiento de preparacion de microcapsulas de materias activas recubiertas por un polimero y nuevas microcapsulas obtenidas en particular segun dicho procedimiento. - Google Patents

Procedimiento de preparacion de microcapsulas de materias activas recubiertas por un polimero y nuevas microcapsulas obtenidas en particular segun dicho procedimiento.

Info

Publication number
ES2149613T3
ES2149613T3 ES97942080T ES97942080T ES2149613T3 ES 2149613 T3 ES2149613 T3 ES 2149613T3 ES 97942080 T ES97942080 T ES 97942080T ES 97942080 T ES97942080 T ES 97942080T ES 2149613 T3 ES2149613 T3 ES 2149613T3
Authority
ES
Spain
Prior art keywords
microcapsules
polymer
procedure
supercritical
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97942080T
Other languages
English (en)
Other versions
ES2149613T5 (es
Inventor
Jean-Pierre Benoit
Joel Richard
Curt Thies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mainelab SA
Original Assignee
Mainelab SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9496041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2149613(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mainelab SA filed Critical Mainelab SA
Application granted granted Critical
Publication of ES2149613T3 publication Critical patent/ES2149613T3/es
Publication of ES2149613T5 publication Critical patent/ES2149613T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE MICROCAPSULAS QUE COMPRENDE UNA SUSTANCIA ACTIVA REVESTIDA DE UNA CAPA DE POLIMERO PRACTICAMENTE POLAR, CARACTERIZADO PORQUE COMPRENDE LAS SIGUIENTES ETAPAS: PONER EN SUSPENSION UNA SUSTANCIA ACTIVA INSOLUBLE EN UNA SOLUCION DE POLIMERO PRACTICAMENTE POLAR EN UN SOLVENTE ORGANICO, SIENDO DICHO POLIMERO PRACTICAMENTE POLAR INSOLUBLE EN EL CO 2 LIQUIDO O EN ESTADO SUPERCRITICO, SIENDO DICHO SOLVENTE ORGANICO SOLUBLE EN EL CO SUB,2 LIQUIDO O SUPERCRITICO; PONER EN CONTACTO LA SUSPENSION CON CO 2 LIQUIDO O SUPERCRITICO PARA DESOLVATAR DE MANERA CONTROLADA EL POLIMERO Y GARANTIZAR LA COARCERVACION DEL POLIMERO; EXTRAER PRACTICAMENTE EL SOLVENTE MEDIANTE CO 2 EN E STADO SUPERCRITICO Y EVACUAR LA MEZCLA DE CO 2 /SOLVENTE; RECUPERAR LAS MICROCAPSULAS EN FORMA DE POLVO SECO. LA INVENCION SE REFIERE TAMBIEN A MICROCAPSULAS QUE COMPRENDEN UNA SUSTANCIA ACTIVA REVESTIDA CON UNA CAPA DE POLIMERO PRACTICAMENTE POLAR ELEGIDO EN EL GRUPO CONSTITUIDO POR LOS POLISACARIDOS, LOS DERIVADOS CELULOSICOS, LOS POLIMEROS ACRILICOS, METACRILICOS O DERIVADOS DE ESTERES VINILICOS, LOS POLIESTERES, LOS POLIAMIDAS, LOS POLIANHIDRIDOS, LOS POLIORTOESTERES Y LOS POLIFOSFACENOS, CARACTERIZADO PORQUE LA CAPA DE POLIMERO PRESENTA UNA LIGERA ENERGIA DE SUPERFICIE Y ESTA LIBRE DE SOLVENTE ORGANICO Y PORQUE LAS MICROCAPSULAS SON SUSCEPTIBLES DE OBTENERSE POR DICHO PROCEDIMIENTO.
ES97942080T 1996-09-25 1997-09-24 Procedimiento para la preparacion de microcapsulas de materias activas recubiertas por un polimero y nuevas microcapsulas obtenidas en particular segun dicho procedimiento. Expired - Lifetime ES2149613T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9611665 1996-09-25
FR9611665A FR2753639B1 (fr) 1996-09-25 1996-09-25 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede

Publications (2)

Publication Number Publication Date
ES2149613T3 true ES2149613T3 (es) 2000-11-01
ES2149613T5 ES2149613T5 (es) 2004-05-01

Family

ID=9496041

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97942080T Expired - Lifetime ES2149613T5 (es) 1996-09-25 1997-09-24 Procedimiento para la preparacion de microcapsulas de materias activas recubiertas por un polimero y nuevas microcapsulas obtenidas en particular segun dicho procedimiento.

Country Status (12)

Country Link
US (1) US6183783B1 (es)
EP (1) EP0930936B2 (es)
JP (1) JP3509105B2 (es)
AT (1) ATE194926T1 (es)
CA (1) CA2267091C (es)
DE (1) DE69702666T3 (es)
DK (1) DK0930936T4 (es)
ES (1) ES2149613T5 (es)
FR (1) FR2753639B1 (es)
GR (1) GR3034627T3 (es)
PT (1) PT930936E (es)
WO (1) WO1998013136A1 (es)

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FR2809309B1 (fr) * 2000-05-23 2004-06-11 Mainelab Microspheres a liberation prolongee pour administration injectable
US6967028B2 (en) * 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
US6723363B2 (en) * 2000-08-29 2004-04-20 The Penn State Research Foundation Coating foods and pharmaceuticals with an edible polymer using carbon dioxide
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
EP1401404B1 (en) * 2001-05-30 2008-04-16 Csir Method of encapsulating an active substance
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
FR2830760B1 (fr) * 2001-10-12 2004-06-04 Pf Medicament Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique
GB0205868D0 (en) * 2002-03-13 2002-04-24 Univ Nottingham Polymer composite with internally distributed deposition matter
FR2837724B1 (fr) * 2002-03-28 2005-01-28 Centre Nat Rech Scient Capsules composites biocompatibles
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US7033602B1 (en) * 2002-06-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
US7070798B1 (en) 2002-06-21 2006-07-04 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US8506617B1 (en) 2002-06-21 2013-08-13 Advanced Cardiovascular Systems, Inc. Micronized peptide coated stent
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US6994867B1 (en) 2002-06-21 2006-02-07 Advanced Cardiovascular Systems, Inc. Biocompatible carrier containing L-arginine
US7794743B2 (en) * 2002-06-21 2010-09-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
US7056523B1 (en) 2002-06-21 2006-06-06 Advanced Cardiovascular Systems, Inc. Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine
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US7094256B1 (en) 2002-12-16 2006-08-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical device containing polycationic peptides
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US7083748B2 (en) * 2003-02-07 2006-08-01 Ferro Corporation Method and apparatus for continuous particle production using supercritical fluid
DE10306604A1 (de) * 2003-02-18 2004-08-26 Goldschmidt Ag Kosmetische Zubereitungen mit Wirkstoffen in Mikrokapseln
FR2854079B1 (fr) 2003-04-25 2007-11-30 Pf Medicament Procede de preparation de complexes moleculaires
WO2004098561A2 (en) 2003-05-08 2004-11-18 Nektar Therapeutics Uk Ltd Particulate materials
FR2857263B1 (fr) * 2003-07-09 2005-09-09 Sanofi Synthelabo Nouvelle composition pharmaceutique solide comprenant de l'amisulpride
FR2857592B1 (fr) * 2003-07-18 2006-02-24 Sod Conseils Rech Applic Nouveau procede de preparation de microparticules
US20080226704A1 (en) * 2004-03-23 2008-09-18 Makoto Kigoshi Method of Producing Coated Fine Particles
JP2005279334A (ja) * 2004-03-26 2005-10-13 Kao Corp 複合化粒子の製造方法
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
FR2874836B1 (fr) * 2004-09-09 2007-04-27 Pierre Fabre Medicament Sa Procede d'enrobage de poudres
ES2285605T3 (es) * 2005-06-11 2007-11-16 Tutech Innovation Gmbh Procedimiento para la microencapsulacion de sustancias organicas en forma de particula mediante rociado de un gas soporte hipercritico inerte junto con material de recubrimiento para las sustancias organicas en un lecho fluidizado de alta presion en un autoclave.
WO2007011989A2 (en) * 2005-07-15 2007-01-25 Map Pharmaceuticals, Inc. Multiple active pharmaceutical ingredients combined in discrete inhalation particles and formulations thereof
EP1904219A4 (en) * 2005-07-15 2011-07-27 Map Pharmaceuticals Inc METHOD FOR FORMING PARTICLES
EP1757361A1 (en) * 2005-08-23 2007-02-28 Feyecon Development & Implementation B.V. Process for the preparation of encapsulates through precipitation
ATE481165T1 (de) * 2005-12-22 2010-10-15 Inst Nat Sante Rech Med Verfahren zur herstellung von teilchen aus einer emulsion in überkritischem oder flüssigem co2
KR100802278B1 (ko) * 2006-12-26 2008-02-11 재단법인서울대학교산학협력재단 분자회합이론에 의한 초임계유체를 이용한 비타민 케이를 함유하는 나노구조체 제조방법
DK2425820T3 (en) 2007-02-11 2015-07-13 Map Pharmaceuticals Inc A method for the therapeutic administration of DHE in order to enable quick relief of migraine, while minimizing the adverse event profile
US9186640B2 (en) * 2007-08-28 2015-11-17 Pepsico, Inc. Delivery and controlled release of encapsulated lipophilic nutrients
US20100272859A1 (en) * 2007-08-28 2010-10-28 Pepsico, Inc. Delivery and controlled release of encapsulated water-insoluble flavorants
FR2925488B1 (fr) * 2007-12-19 2011-12-23 Snpe Materiaux Energetiques Desensibilisation par enrobage de cristaux de substances energetiques explosives ; cristaux de telles substances enrobes, materiaux energetiques.
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CA2730760A1 (en) * 2008-07-16 2010-01-21 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles containing bioactive peptides
CN102170871B (zh) * 2008-07-31 2013-04-17 费伊肯有限公司 微胶囊化物及其制备方法
US20100291221A1 (en) * 2009-05-15 2010-11-18 Robert Owen Cook Method of administering dose-sparing amounts of formoterol fumarate-budesonide combination particles by inhalation
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition
KR102152751B1 (ko) * 2012-09-28 2020-09-07 (주)아모레퍼시픽 식물 유래 당단백질을 포함하는 마이크로캡슐
CA2895816C (en) 2012-12-21 2021-02-23 Map Pharmaceuticals, Inc. 8'-hydroxy-dihydroergotamine compounds and compositions
GB201317756D0 (en) * 2013-10-08 2013-11-20 Critical Pharmaceuticals Ltd New process
JP6516980B2 (ja) * 2014-07-29 2019-05-22 学校法人福岡大学 二酸化炭素と親二酸化炭素系界面活性剤を用いた機能性高分子複合化粒子及びその製造方法
RU2710193C1 (ru) * 2019-02-12 2019-12-24 Федеральное государственное унитарное предприятие "Центральный научно-исследовательский институт химии и механики" (ФГУП "ЦНИИХМ") Способ инкапсулирования частиц твердых реакционно-способных веществ
JP2025056807A (ja) * 2022-03-04 2025-04-09 株式会社トクヤマ 超臨界液体を用いて製造される微小中空粒子

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Also Published As

Publication number Publication date
US6183783B1 (en) 2001-02-06
EP0930936A1 (fr) 1999-07-28
PT930936E (pt) 2000-12-29
ATE194926T1 (de) 2000-08-15
GR3034627T3 (en) 2001-01-31
ES2149613T5 (es) 2004-05-01
EP0930936B2 (fr) 2003-08-27
FR2753639B1 (fr) 1998-12-11
DE69702666T2 (de) 2001-04-12
CA2267091C (fr) 2006-07-04
JP2001504452A (ja) 2001-04-03
DK0930936T4 (da) 2003-12-22
DK0930936T3 (da) 2000-11-06
DE69702666D1 (de) 2000-08-31
DE69702666T3 (de) 2004-05-13
FR2753639A1 (fr) 1998-03-27
CA2267091A1 (fr) 1998-04-02
WO1998013136A1 (fr) 1998-04-02
EP0930936B1 (fr) 2000-07-26
JP3509105B2 (ja) 2004-03-22

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