ES2149691A1 - 2-4-[4-(4,5-dicloro-2metilimidazol-1-il)butil]-1-piperacinil -5-fluoropirimidina, su preparacion y su utilizacion terapeutica. - Google Patents

2-4-[4-(4,5-dicloro-2metilimidazol-1-il)butil]-1-piperacinil -5-fluoropirimidina, su preparacion y su utilizacion terapeutica.

Info

Publication number
ES2149691A1
ES2149691A1 ES009801201A ES9801201A ES2149691A1 ES 2149691 A1 ES2149691 A1 ES 2149691A1 ES 009801201 A ES009801201 A ES 009801201A ES 9801201 A ES9801201 A ES 9801201A ES 2149691 A1 ES2149691 A1 ES 2149691A1
Authority
ES
Spain
Prior art keywords
methylimidazol
fluoropyrimidine
piperazinyl
dichloro
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009801201A
Other languages
English (en)
Other versions
ES2149691B1 (es
Inventor
Vidal Ramon Merce
Constansa Jordi Frigola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2149691A1 publication Critical patent/ES2149691A1/es
Application granted granted Critical
Publication of ES2149691B1 publication Critical patent/ES2149691B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

2-{4-[4-(4,5-dicloro-2-metilimidazol-1-il)butil]-1-piperacinil 5-fluoropirimidina, su preparación y su utilización terapéutica. La presente invención se refiere al compuesto 2-{4-[4-(4,5-dicloro-2-metilimidazol-1-il)butil]-1-piperacinil -5-fluoropirimidina, así como a sus sales fisiológicamente aceptables, de fórmula:
ES009801201A 1997-06-02 1998-05-29 2-4-(4-(4,5-dicloro-2-metilimidazol-1-il)butil)-1-piperacinil)-5-fluoropirimidina, su preparacion y su utilizacion terapeutica. Expired - Fee Related ES2149691B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9706738A FR2763950B1 (fr) 1997-06-02 1997-06-02 2- {4- [4-(4,5-dichloro-2-methylimidazol-1-yl)butyl] -1- piperazinyl }-5-fluoropyrimidine, sa preparation et son utilisation therapeutique

Publications (2)

Publication Number Publication Date
ES2149691A1 true ES2149691A1 (es) 2000-11-01
ES2149691B1 ES2149691B1 (es) 2001-05-16

Family

ID=9507480

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009801201A Expired - Fee Related ES2149691B1 (es) 1997-06-02 1998-05-29 2-4-(4-(4,5-dicloro-2-metilimidazol-1-il)butil)-1-piperacinil)-5-fluoropirimidina, su preparacion y su utilizacion terapeutica.

Country Status (22)

Country Link
US (2) US6303608B1 (es)
EP (1) EP1007522B1 (es)
JP (1) JP4344890B2 (es)
KR (1) KR100556559B1 (es)
CN (1) CN1094491C (es)
AT (1) ATE228126T1 (es)
AU (1) AU732722B2 (es)
BR (1) BR9810240A (es)
CA (1) CA2292746A1 (es)
DE (1) DE69809564T2 (es)
DK (1) DK1007522T3 (es)
ES (1) ES2149691B1 (es)
FR (1) FR2763950B1 (es)
HU (1) HUP0002905A3 (es)
IL (1) IL133216A0 (es)
NO (1) NO318757B1 (es)
NZ (1) NZ501566A (es)
PL (1) PL190777B1 (es)
PT (1) PT1007522E (es)
RU (1) RU2191184C2 (es)
TR (1) TR199903001T2 (es)
WO (1) WO1998055476A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101152658B1 (ko) * 2009-04-30 2012-06-18 한국과학기술연구원 세로토닌 5-ｈｔ6 길항 활성 효과를 갖는 피페라진 화합물 함유 조성물
RU2660583C1 (ru) * 2017-08-15 2018-07-06 Общество С Ограниченной Ответственностью "Валента - Интеллект" Применение буспирона для лечения функционального головокружения

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382637A1 (fr) * 1989-02-09 1990-08-16 Laboratorios Del Dr. Esteve, S.A. Dérivés de pyrimidinyl-piperazinyl-alkyl azolès avec activité anxiolytique et/ou tranquillisante
ES2042385A1 (es) * 1991-01-28 1993-12-01 Esteve Labor Dr Procedimientos de preparacion de derivados de aril (o heteroaril)-piperazinil-alquilazoles.
ES2089974A1 (es) * 1993-11-25 1996-10-01 Esteve Labor Dr Utilizacion de los derivados de 1-(4-)4-aril (o heteroaril)-1-piperazinil)-butil)-1-h-azol para la preparacion de medicamentos destinados al tratamiento de los trastornos de la secrecion gastrica.
WO1997021439A1 (fr) * 1995-12-12 1997-06-19 Laboratorios Del Dr. Esteve, S.A. Medicament destine au traitement des troubles obsessifs compulsifs, de l'apnee du sommeil, des dysfonctions sexuelles, de l'emese et du mal des transports

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665161B1 (fr) * 1990-07-26 1992-11-27 Esteve Labor Dr Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382637A1 (fr) * 1989-02-09 1990-08-16 Laboratorios Del Dr. Esteve, S.A. Dérivés de pyrimidinyl-piperazinyl-alkyl azolès avec activité anxiolytique et/ou tranquillisante
ES2042385A1 (es) * 1991-01-28 1993-12-01 Esteve Labor Dr Procedimientos de preparacion de derivados de aril (o heteroaril)-piperazinil-alquilazoles.
ES2089974A1 (es) * 1993-11-25 1996-10-01 Esteve Labor Dr Utilizacion de los derivados de 1-(4-)4-aril (o heteroaril)-1-piperazinil)-butil)-1-h-azol para la preparacion de medicamentos destinados al tratamiento de los trastornos de la secrecion gastrica.
WO1997021439A1 (fr) * 1995-12-12 1997-06-19 Laboratorios Del Dr. Esteve, S.A. Medicament destine au traitement des troubles obsessifs compulsifs, de l'apnee du sommeil, des dysfonctions sexuelles, de l'emese et du mal des transports

Also Published As

Publication number Publication date
HUP0002905A3 (en) 2002-01-28
KR20010013274A (ko) 2001-02-26
FR2763950A1 (fr) 1998-12-04
ES2149691B1 (es) 2001-05-16
AU7917098A (en) 1998-12-21
PT1007522E (pt) 2003-04-30
US6303608B1 (en) 2001-10-16
EP1007522A1 (fr) 2000-06-14
US6346620B1 (en) 2002-02-12
AU732722B2 (en) 2001-04-26
CA2292746A1 (fr) 1998-12-10
PL190777B1 (pl) 2006-01-31
TR199903001T2 (xx) 2000-07-21
HUP0002905A2 (hu) 2001-06-28
CN1094491C (zh) 2002-11-20
NO318757B1 (no) 2005-05-02
CN1261888A (zh) 2000-08-02
KR100556559B1 (ko) 2006-03-06
IL133216A0 (en) 2001-03-19
NZ501566A (en) 2001-06-29
JP4344890B2 (ja) 2009-10-14
JP2002501539A (ja) 2002-01-15
EP1007522B1 (fr) 2002-11-20
FR2763950B1 (fr) 2002-09-20
RU2191184C2 (ru) 2002-10-20
NO995894L (no) 2000-02-01
DK1007522T3 (da) 2003-03-17
NO995894D0 (no) 1999-12-01
DE69809564D1 (de) 2003-01-02
DE69809564T2 (de) 2003-07-10
ATE228126T1 (de) 2002-12-15
PL337113A1 (en) 2000-07-31
WO1998055476A1 (fr) 1998-12-10
BR9810240A (pt) 2000-09-05

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