ES2149957T3 - Derivados aminicos y amidicos de la vitamina d. - Google Patents

Derivados aminicos y amidicos de la vitamina d.

Info

Publication number
ES2149957T3
ES2149957T3 ES95902896T ES95902896T ES2149957T3 ES 2149957 T3 ES2149957 T3 ES 2149957T3 ES 95902896 T ES95902896 T ES 95902896T ES 95902896 T ES95902896 T ES 95902896T ES 2149957 T3 ES2149957 T3 ES 2149957T3
Authority
ES
Spain
Prior art keywords
group
hydroxyl
alkylene
atom
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95902896T
Other languages
English (en)
Inventor
Robert Henry Hesse
Malathi Ramgopal
Sundara Setty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Medicine and Chemistry Inc
Original Assignee
Research Institute for Medicine and Chemistry Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Institute for Medicine and Chemistry Inc filed Critical Research Institute for Medicine and Chemistry Inc
Application granted granted Critical
Publication of ES2149957T3 publication Critical patent/ES2149957T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTA UN COMPUESTO DE LA FORMULA GENERAL (I) EN LA QUE R REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ORGANICO ALIFATICO, CICLOALIFATICO, ARALIFATICO O DE ARILO, O UN GRUPO DE AZILO QUE COMPRENDE EL GRUPO ORGANICO UNIDO AL ATOMO DE NITROGENO POR MEDIO DE UN GRUPO DE CARBONILO; R1 Y R2 SE SELECCIONAN CADA UNA DE ELLAS ENTRE GRUPOS DE ALQUILO INFERIOR Y DE CICLOALQUILO O JUNTO CON EL ATOMO DE CARBONO AL CUAL ESTAN UNIDAS FORMAN UN GRUPO DE CICLOALQUILO INFERIOR; R3 REPRESENTA UN GRUPO DE METILO QUE TIENE UNA CONFIGURACION {AL} O {BE}; Y REPRESENTA UN GRUPO DE ALQUILENO INFERIOR, ALQUENILENO O ALQUINILENO OPCIONALMENTE SUSTITUIDO POR UN GRUPO DE HIDROXILO, HIDROXILO ETERIFICADO O HIDROXILO ESTERIFICADO; Y A= REPRESENTA UNA MOLECULA DE CICLOHEXILIDENO, CARACTERISTICA DEL ANILLO A DE LA VITAMINA D 1{AL}-HIDROXILADA O UN ANALOGO DE LA MISMA. LOS COMPUESTOS ACTIVOS DE LA INVENCION EXHIBEN UNA BUENA ACTIVIDAD DE MODULACION CELULAR Y EN CIERTOS CASOS TAMBIEN PUEDEN TENER UN EFECTO SOBRE EL METABOLISMO DEL CALCIO.
ES95902896T 1993-12-13 1994-12-13 Derivados aminicos y amidicos de la vitamina d. Expired - Lifetime ES2149957T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939325415A GB9325415D0 (en) 1993-12-13 1993-12-13 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2149957T3 true ES2149957T3 (es) 2000-11-16

Family

ID=10746493

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95902896T Expired - Lifetime ES2149957T3 (es) 1993-12-13 1994-12-13 Derivados aminicos y amidicos de la vitamina d.

Country Status (22)

Country Link
US (1) US5786347A (es)
EP (1) EP0734376B1 (es)
JP (1) JP3779991B2 (es)
KR (1) KR100399661B1 (es)
CN (1) CN1080718C (es)
AT (1) ATE196468T1 (es)
AU (1) AU681223B2 (es)
CA (1) CA2178090A1 (es)
CZ (1) CZ291623B6 (es)
DE (1) DE69425980T2 (es)
DK (1) DK0734376T3 (es)
ES (1) ES2149957T3 (es)
FI (1) FI112360B (es)
GB (1) GB9325415D0 (es)
GR (1) GR3035028T3 (es)
HU (1) HU223469B1 (es)
IL (1) IL111975A (es)
NO (1) NO313800B1 (es)
NZ (1) NZ277086A (es)
PT (1) PT734376E (es)
WO (1) WO1995016672A1 (es)
ZA (1) ZA949921B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
AU728037B2 (en) * 1997-05-22 2001-01-04 Cephalon, Inc. Vitamin D analogues and their neuronal effects
US6043385A (en) * 1997-12-16 2000-03-28 Hoffman-La Roche Inc. Vitamin D derivatives
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
JP4269144B2 (ja) 2000-10-02 2009-05-27 エモリー ユニバーシティ 自己免疫疾患および炎症障害の処置のためのトリプトリドアナログ
WO2005027928A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism
TW200714580A (en) * 2005-10-14 2007-04-16 Formosa Lab Inc Process for preparing vitamin D analogs
EA201691980A1 (ru) 2009-01-27 2017-07-31 БЕРГ ЭлЭлСи Способы уменьшения побочных эффектов, связанных с химиотерапией
CN102655869B (zh) 2009-08-14 2016-08-10 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
US8987235B2 (en) 2011-05-17 2015-03-24 Wisconsin Alumni Research Foundation N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs and their uses
US8785603B2 (en) 2011-05-20 2014-07-22 Siemens Healthcare Diagnostics Inc. Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
US9244083B2 (en) 2012-11-30 2016-01-26 Siemens Healthcare Diagnostics Inc. Compositions and methods for detecting vitamin D
US9618523B2 (en) 2013-02-28 2017-04-11 Siemens Healthcare Diagnostics Inc. Methods and reagents for determining isomeric analytes
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
WO2019232095A1 (en) * 2018-05-30 2019-12-05 Translate Bio, Inc. Vitamin cationic lipids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0614455B1 (en) * 1991-11-07 1996-02-21 Research Institute For Medicine And Chemistry Inc. Vitamin d amide derivatives
JPH06107625A (ja) * 1992-01-13 1994-04-19 Asahi Chem Ind Co Ltd 新規な１α、２５−ジヒドロキシビタミンＤ誘導体、およびその製造法

Also Published As

Publication number Publication date
DK0734376T3 (da) 2000-12-11
HU9601622D0 (en) 1996-08-28
JP3779991B2 (ja) 2006-05-31
FI962440A7 (fi) 1996-06-12
HU223469B1 (hu) 2004-07-28
CZ170496A3 (en) 1997-02-12
FI112360B (fi) 2003-11-28
CN1141625A (zh) 1997-01-29
HUT75515A (en) 1997-05-28
DE69425980T2 (de) 2001-02-08
CA2178090A1 (en) 1995-06-22
JPH09511224A (ja) 1997-11-11
CZ291623B6 (cs) 2003-04-16
WO1995016672A1 (en) 1995-06-22
EP0734376A1 (en) 1996-10-02
AU1215895A (en) 1995-07-03
DE69425980D1 (de) 2000-10-26
ATE196468T1 (de) 2000-10-15
US5786347A (en) 1998-07-28
EP0734376B1 (en) 2000-09-20
GB9325415D0 (en) 1994-02-16
AU681223B2 (en) 1997-08-21
PT734376E (pt) 2000-12-29
FI962440A0 (fi) 1996-06-12
NZ277086A (en) 1997-04-24
NO962479D0 (no) 1996-06-12
NO962479L (no) 1996-08-12
IL111975A (en) 1999-07-14
ZA949921B (en) 1995-10-12
NO313800B1 (no) 2002-12-02
CN1080718C (zh) 2002-03-13
KR100399661B1 (ko) 2004-04-30
GR3035028T3 (en) 2001-03-30

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