ES2150105T3 - Piretanida amorfa, polimorfos de piretanida, proceso para su preparacion y su uso. - Google Patents
Piretanida amorfa, polimorfos de piretanida, proceso para su preparacion y su uso.Info
- Publication number
- ES2150105T3 ES2150105T3 ES96904993T ES96904993T ES2150105T3 ES 2150105 T3 ES2150105 T3 ES 2150105T3 ES 96904993 T ES96904993 T ES 96904993T ES 96904993 T ES96904993 T ES 96904993T ES 2150105 T3 ES2150105 T3 ES 2150105T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- piretanida
- sec
- peak
- piretanide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- UJEWTUDSLQGTOA-UHFFFAOYSA-N Piretanide Chemical compound C=1C=CC=CC=1OC=1C(S(=O)(=O)N)=CC(C(O)=O)=CC=1N1CCCC1 UJEWTUDSLQGTOA-UHFFFAOYSA-N 0.000 abstract 2
- 229960001085 piretanide Drugs 0.000 abstract 2
- 230000009102 absorption Effects 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000000862 absorption spectrum Methods 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Glass Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PIRETANIDA AMORFA QUE POSEE LAS CARACTERISTICAS SIGUIENTES: A) PICOS EXOTERMICOS A APROXIMADAMENTE 136{SUP,O}C Y APROXIMADAMENTE 209{SUP,O}C, B) UN PICO ENDOTERMICO A APROXIMADAMENTE 207{SUP,O}C, Y C) UN PUNTO DE FUSION DE APROXIMADAMENTE 225{SUP,O}C EN CURVAS TERMICAS DIFERENCIALES; D) UN PATRON DE HALO SIN PICO DE DIFRACCION (2{ZE}) EN ANALISIS DE DIFRACCION DE RAYOS X DE POLVO; Y E) ABSORCIONES CARACTERISTICAS HACIA 1700 CM{SUP,-1} Y 3200 DE INFRARROJO, Y QUE POSEE UNA SOLUBILIDAD SUPERIOR CERCA DE LA NEUTRALIDAD Y UNA ELEVADA BIODISPONIBILIDAD EFECTIVA EN FORMA DE ADMINISTRACION ORAL O INYECTADA, QUE SE PREPARA DISOLVIENDO PIRETANIDA EN UNA SOLUCION ACUOSA DE UNA BASE, AJUSTANDO EL VALOR DE PH DE LA SOLUCION CON UN ACIDO HASTA UN RANGO DE PH DESDE NO MENOS DE 3,87 HASTA NO MAS DE 4,37 Y RECUPERANDO EL PRECIPITADO QUE SE SEPARA DE ESTA FORMA, Y POLIMORFO DE PIRETANIDA QUE POSEE LAS CARACTERISTICAS SIGUIENTES: A) UN PICO ENDOTERMICO A APROXIMADAMENTE 132{SUP,O}C, B) UN PICO EXOTERMICO A APROXIMADAMENTE 143{SUP,O}C, Y C) UN PUNTO DE FUSION DE APROXIMADAMENTE 224{SUP,O}C EN CURVAS TERMICAS DIFERENCIALES; D) PICOS DE DIFRACCION (2{ZE}) A 10,5, 12,2, 15,6, 19,1, 19,9, 22,0, 22,8, 25,6, Y 30,6 EN ANALISIS DE DIFRACCION DE RAYOS X DE POLVO; Y E) ABSORCIONES CARACTERISTICAS HACIA 1700 CM{SUP-1} Y 3200 3500 CM{SUP,-1} EN EL ESPECTRO DE ABSORCION DE INFRARROJO, Y QUE POSEE UNA SOLUBILIDAD SUPERIOR CERCA DE LA NEUTRALIDAD Y UNA ELEVADA BIODISPONIBILIDAD EFECTIVA EN FORMA DE ADMINISTRACION ORAL O INYECTADA, QUE SE PREPARA DISOLVIENDO PIRETANIDA EN UNA SOLUCION ACUOSA DE UNA BASE, AJUSTANDO EL VALOR DE PH DE LA SOLUCION CON UN ACIDO HASTA UN RANGO DE PH DE MENOS DE 3,50 Y RECUPERANDO EL PRECIPITADO QUE SE SEPARA DE ESTA FORMA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03321695A JP3532988B2 (ja) | 1995-02-22 | 1995-02-22 | ピレタニドの新規な結晶多形およびその製造方法 |
| JP03321595A JP3532987B2 (ja) | 1995-02-22 | 1995-02-22 | 新規な無晶形ピレタニドおよびその製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2150105T3 true ES2150105T3 (es) | 2000-11-16 |
Family
ID=26371876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96904993T Expired - Lifetime ES2150105T3 (es) | 1995-02-22 | 1996-02-12 | Piretanida amorfa, polimorfos de piretanida, proceso para su preparacion y su uso. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6096779A (es) |
| EP (1) | EP0812320B1 (es) |
| KR (1) | KR100419355B1 (es) |
| CN (1) | CN1072215C (es) |
| AT (1) | ATE194607T1 (es) |
| BR (1) | BR9607295A (es) |
| CA (1) | CA2213693C (es) |
| DE (1) | DE69609314T2 (es) |
| DK (1) | DK0812320T3 (es) |
| ES (1) | ES2150105T3 (es) |
| GR (1) | GR3034605T3 (es) |
| MX (1) | MX9706339A (es) |
| PT (1) | PT812320E (es) |
| WO (1) | WO1996026197A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW403740B (en) | 1997-06-10 | 2000-09-01 | Novartis Ag | Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide |
| DE10013289A1 (de) * | 2000-03-17 | 2001-09-20 | Knoll Ag | Torasemid enthaltende pharmazeutische Zubereitungen |
| HRP20000162B1 (en) | 2000-03-20 | 2004-06-30 | Pliva D D | Amorphous torasemide modification |
| BRPI0311176B8 (pt) | 2002-05-16 | 2021-05-25 | Janssen Sciences Ireland Uc | pseudopolimorfo na forma de etanolato, seu uso, processo de preparação do mesmo e composição farmacêutica |
| EA011862B1 (ru) * | 2004-03-24 | 2009-06-30 | Актавис Груп Хф. | Композиции рамиприла |
| GB2431579A (en) * | 2005-10-28 | 2007-05-02 | Arrow Int Ltd | Ramipril formulations |
| US20070098782A1 (en) * | 2005-10-28 | 2007-05-03 | Selamine Limited | Ramipril Formulation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2419970C3 (de) * | 1974-04-25 | 1980-06-12 | Hoechst Ag, 6000 Frankfurt | 3-<l-Pyrrolidinyl)-4-phenoxy-5sulfamoylbenzoesäure und Verfahren zu ihrer Herstellung |
| JPS5283547A (en) * | 1976-01-01 | 1977-07-12 | Hoechst Ag | Tertiary cyclic amine |
| DE2655331A1 (de) * | 1976-12-07 | 1978-06-08 | Hoechst Ag | Zubereitungsformen von 3-n-pyrrolidino-4-phenoxy-5-sulfamyl-benzoesaeure und verfahren zu ihrer herstellung |
| EP0243891B1 (en) * | 1986-04-29 | 1991-08-14 | Hoechst-Roussel Pharmaceuticals Incorporated | A laminar structure for administering a chemical at a controlled release rate |
| EP0465841A3 (en) * | 1990-06-13 | 1992-10-14 | Hoechst Aktiengesellschaft | Quick acting pharmaceutical inhalation forms of diuretics |
| JPH05230044A (ja) * | 1992-02-21 | 1993-09-07 | Hoechst Japan Ltd | ピレタニドの新規な結晶多形 |
-
1996
- 1996-02-12 DK DK96904993T patent/DK0812320T3/da active
- 1996-02-12 BR BR9607295A patent/BR9607295A/pt not_active IP Right Cessation
- 1996-02-12 ES ES96904993T patent/ES2150105T3/es not_active Expired - Lifetime
- 1996-02-12 CN CN96192081A patent/CN1072215C/zh not_active Expired - Lifetime
- 1996-02-12 PT PT96904993T patent/PT812320E/pt unknown
- 1996-02-12 DE DE69609314T patent/DE69609314T2/de not_active Expired - Lifetime
- 1996-02-12 AT AT96904993T patent/ATE194607T1/de active
- 1996-02-12 KR KR1019970705772A patent/KR100419355B1/ko not_active Expired - Lifetime
- 1996-02-12 CA CA002213693A patent/CA2213693C/en not_active Expired - Lifetime
- 1996-02-12 EP EP96904993A patent/EP0812320B1/en not_active Expired - Lifetime
- 1996-02-12 WO PCT/IB1996/000254 patent/WO1996026197A1/en not_active Ceased
- 1996-02-12 US US08/894,412 patent/US6096779A/en not_active Expired - Lifetime
-
1997
- 1997-08-20 MX MX9706339A patent/MX9706339A/es unknown
-
2000
- 2000-10-12 GR GR20000402289T patent/GR3034605T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1072215C (zh) | 2001-10-03 |
| KR19980702374A (ko) | 1998-07-15 |
| DE69609314D1 (de) | 2000-08-17 |
| MX9706339A (es) | 1998-07-31 |
| CN1175948A (zh) | 1998-03-11 |
| WO1996026197A1 (en) | 1996-08-29 |
| PT812320E (pt) | 2000-12-29 |
| BR9607295A (pt) | 1997-11-25 |
| KR100419355B1 (ko) | 2004-06-04 |
| ATE194607T1 (de) | 2000-07-15 |
| CA2213693C (en) | 2008-04-15 |
| US6096779A (en) | 2000-08-01 |
| EP0812320B1 (en) | 2000-07-12 |
| EP0812320A1 (en) | 1997-12-17 |
| HK1006783A1 (en) | 1999-03-19 |
| DE69609314T2 (de) | 2001-06-13 |
| GR3034605T3 (en) | 2001-01-31 |
| CA2213693A1 (en) | 1996-08-29 |
| DK0812320T3 (da) | 2003-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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