ES2152947T3 - Una cepa de streptomyces avermitilis y compuestos de avermectina glicosilados. - Google Patents

Una cepa de streptomyces avermitilis y compuestos de avermectina glicosilados.

Info

Publication number
ES2152947T3
ES2152947T3 ES93907514T ES93907514T ES2152947T3 ES 2152947 T3 ES2152947 T3 ES 2152947T3 ES 93907514 T ES93907514 T ES 93907514T ES 93907514 T ES93907514 T ES 93907514T ES 2152947 T3 ES2152947 T3 ES 2152947T3
Authority
ES
Spain
Prior art keywords
cir
compounds
glycosylated
hydroxy
streptomyces avermitilis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93907514T
Other languages
English (en)
Inventor
Byron H Arison
Tanya Macneil
Marvin D Schulman
Douglas J Macneil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/855,311 external-priority patent/US5312753A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2152947T3 publication Critical patent/ES2152947T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/58—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

COMPUESTOS AVERMECTIN SON GLICOSILADOS EN LAS POSICIONES 4'',13CTIN AL MEDIO DE FERMENTACION DE UN GRUPO NUEVO DE STREPTOMYCES AVERMITILIS. LOS GRUPOS METILO 4''-HIDROXI, 13-HIDROXI Y 14A-HIDROXI DEL COMPUESTO AVERMECTIN SE GLICOXILAN CON UNA UNIDAD DE GLICOSILO, ESPECIFICAMENTE UN GRUPO OLEANDROSE. LA NUEVA CADENA OFRECE LA VENTAJA AÑADIDA DE NO PRODUCIR NINGUN PRODUCTO DE C5-O-METILACION. LOS COMPUESTOS SON ANTIHELMINTICOS Y AGENTES ANTIPARASITOS POTENTES, Y TAMBIEN SE PRESENTAN COMPOSICIONES PARA TALES USOS. LA PATENTE U.S. 3950360 DE AOKI ET AL, PRESENTA COMPUESTOS MILBEMICINA Y LA APLICACION DE LA PATENTE EUROPEA 242052 DE RUDD ET AL PRESENTA COMPUESTOS NEMEDECTINA CON UN GRUPO 25-HIDROXI Y UN GRUPO ALQUILO 25-INSATURADO.
ES93907514T 1992-03-23 1993-03-16 Una cepa de streptomyces avermitilis y compuestos de avermectina glicosilados. Expired - Lifetime ES2152947T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85531092A 1992-03-23 1992-03-23
US07/855,311 US5312753A (en) 1992-03-23 1992-03-23 Strain of streptomyces avermitilis capable of glycosylating avermectin compounds at the 13- and 14A positions

Publications (1)

Publication Number Publication Date
ES2152947T3 true ES2152947T3 (es) 2001-02-16

Family

ID=27127288

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93907514T Expired - Lifetime ES2152947T3 (es) 1992-03-23 1993-03-16 Una cepa de streptomyces avermitilis y compuestos de avermectina glicosilados.

Country Status (10)

Country Link
EP (1) EP0637244B1 (es)
JP (1) JP3263076B2 (es)
AT (1) ATE198493T1 (es)
AU (1) AU3809393A (es)
DE (1) DE69329821T2 (es)
DK (1) DK0637244T3 (es)
ES (1) ES2152947T3 (es)
GR (1) GR3035187T3 (es)
PT (1) PT637244E (es)
WO (1) WO1993018779A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4310750B2 (ja) 2003-06-11 2009-08-12 学校法人北里研究所 ストレプトマイセス属に属するネマデクチン生産能を有する菌株、該菌株を用いるネマデクチンの製造法
DE102007007750A1 (de) 2006-08-17 2008-02-21 Bayer Cropscience Ag Avermectinderivate
CN103772458B (zh) * 2012-10-25 2016-05-04 北大方正集团有限公司 一种尼莫克汀的提纯方法
CN105624229B (zh) * 2014-10-30 2019-01-08 牡丹江佰佳信生物科技有限公司 一种提高尼莫克汀产量的方法
CN108774626B (zh) * 2018-02-01 2020-11-17 上海莫息生物科技有限公司 一种生产尼莫克汀的方法和菌株
CN116744917A (zh) 2020-09-04 2023-09-12 礼蓝美国公司 适口调配物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4206205A (en) * 1977-10-03 1980-06-03 Merck & Co., Inc. Monosaccharide and aglycone derivatives of C-076
US4666937A (en) * 1985-03-04 1987-05-19 Merck & Co., Inc. Avermectin bioconversion products
CA1339481C (en) * 1988-10-18 1997-09-30 Shieh-Shung Tom Chen Anthelmintic bioconversion products
NZ238521A (en) * 1990-06-22 1992-12-23 Merck & Co Inc Process for the conversion of avermectin glycone to avermectin mono- and disaccharides by fermentation with streptomyces avermitilis ma6078
US5188944A (en) * 1990-06-22 1993-02-23 Merck & Co., Inc. Process for the glycosylation of avermectin agylcones
US5192671A (en) * 1991-06-26 1993-03-09 Merck & Co., Inc. Process for the glycosylation of avermectin compounds

Also Published As

Publication number Publication date
EP0637244A4 (en) 1995-07-12
JP3263076B2 (ja) 2002-03-04
DE69329821T2 (de) 2001-07-19
DK0637244T3 (da) 2001-01-29
JPH07505280A (ja) 1995-06-15
EP0637244A1 (en) 1995-02-08
GR3035187T3 (en) 2001-04-30
DE69329821D1 (de) 2001-02-08
PT637244E (pt) 2001-04-30
WO1993018779A1 (en) 1993-09-30
ATE198493T1 (de) 2001-01-15
EP0637244B1 (en) 2001-01-03
AU3809393A (en) 1993-10-21

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