ES2153814T3 - Analogos de cc-1065 que tienen dos subunidades cpi. - Google Patents

Analogos de cc-1065 que tienen dos subunidades cpi.

Info

Publication number
ES2153814T3
ES2153814T3 ES89308920T ES89308920T ES2153814T3 ES 2153814 T3 ES2153814 T3 ES 2153814T3 ES 89308920 T ES89308920 T ES 89308920T ES 89308920 T ES89308920 T ES 89308920T ES 2153814 T3 ES2153814 T3 ES 2153814T3
Authority
ES
Spain
Prior art keywords
formula
components
subunities
cpi
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89308920T
Other languages
English (en)
Inventor
Robert C Kelly
Paul A Aristoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1989/003329 external-priority patent/WO1990002746A1/en
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of ES2153814T3 publication Critical patent/ES2153814T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UNOS COMPONENTES QUIMICOS DE FORMULA GENERAL (I) DONDE CPI1 Y CPI2 SON IGUALES ODIFERENTES Y ESTAN ELEGIDOS DE LA FORMULA (II) O (III), R5 Y R5'' SON ELEGIDOS DE UN ENLACE DIRECTO O UN GRUPO ACIL CARBONILO Y T ES UN AMINOCARBONILO, CARBONILAMINO, CARBONILOXILO Y FORMULA (IV) Y FORMULA (V). LOS COMPONENTES DE LA FORMULA (I) SON UTILIZADOS COMO ABSORVENTES DE CUZ UV, AGENTES ANTIBACTERIANOS Y SON PARTICULARMENTE UTILES COMO AGENTES ANTITUMORALES LOS COMPONENTES REPRESENTATIVOS DE LA FORMULA (I) HAN SIDO MOSTRADOS POR POSEER INTERVALOS UTILES DE ACTIVIDAD ANTITUMORAL EN ENSAYOS ESTANDARIZADOS CON ANILAMES DE LABORATORIO.
ES89308920T 1988-09-12 1989-09-04 Analogos de cc-1065 que tienen dos subunidades cpi. Expired - Lifetime ES2153814T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
PCT/US1989/003329 WO1990002746A1 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits

Publications (1)

Publication Number Publication Date
ES2153814T3 true ES2153814T3 (es) 2001-03-16

Family

ID=26779868

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89308920T Expired - Lifetime ES2153814T3 (es) 1988-09-12 1989-09-04 Analogos de cc-1065 que tienen dos subunidades cpi.

Country Status (3)

Country Link
EP (1) EP0359454B1 (es)
ES (1) ES2153814T3 (es)
MX (1) MX9203460A (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0520435A3 (en) * 1991-06-28 1993-05-05 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
ES2149768T3 (es) * 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
US5248691A (en) * 1992-09-03 1993-09-28 Eli Lilly And Company Furanoindolines
US5786377A (en) * 1993-11-19 1998-07-28 Universidad De Santiago De Compostela Pyrrolo 3,2-E!indol derivatives, process for the preparation thereof and applications
ES2074957B1 (es) * 1993-11-19 1996-06-16 Univ Santiago Compostela Nuevos derivados de pirrolo(3,2-e)indol, procedimiento para su preparacion y aplicaciones.
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
BRPI0510803A (pt) * 2004-05-12 2007-11-06 Proteotech Inc composto, composição farmacêutica, artigo de fabricação, métodos de tratar ou prevenir a formação, deposição, acúmulo ou persistência de fibrilas de amilóide e de fibrilas de sinucleìna, e de tratar, prevenir ou melhorar um ou mais sintomas de uma doença amilóide ou uma sinucleinopatia em um mamìfero, e, uso do composto
AU2009320481C1 (en) * 2008-11-03 2016-12-08 Syntarga B.V. Novel CC-1065 analogs and their conjugates
AU2015205574B2 (en) 2014-01-10 2019-08-15 Byondis B.V. Method for purifying Cys-linked antibody-drug conjugates
HUE029672T2 (en) 2014-01-10 2017-03-28 Synthon Biopharmaceuticals Bv Duokarmicin-ADCs for use in the treatment of endometrial cancer
CN105899236B (zh) 2014-01-10 2019-07-26 斯索恩生物制药有限公司 表现出改进的体内抗肿瘤活性的倍癌霉素adc
CN106459055B (zh) * 2014-01-27 2019-11-01 辉瑞大药厂 双功能细胞毒类药剂
US10870706B2 (en) 2015-03-20 2020-12-22 Pfizer Inc. Bifunctional cytotoxic agents containing the CTI pharmacophore

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
AU1299788A (en) * 1987-02-06 1988-08-24 Board Of Regents Of The University Of Washington, The Human proteins having anticoagulant and anti-inflammatory activity

Also Published As

Publication number Publication date
EP0359454B1 (en) 2000-12-27
MX9203460A (es) 1992-09-01
EP0359454A1 (en) 1990-03-21

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