ES2154560A1 - Composicion a base de derivados de cromanos y su uso para reducir quimicamente las reacciones oxidativas o inducidas por radicales libres. - Google Patents

Composicion a base de derivados de cromanos y su uso para reducir quimicamente las reacciones oxidativas o inducidas por radicales libres.

Info

Publication number
ES2154560A1
ES2154560A1 ES009801947A ES9801947A ES2154560A1 ES 2154560 A1 ES2154560 A1 ES 2154560A1 ES 009801947 A ES009801947 A ES 009801947A ES 9801947 A ES9801947 A ES 9801947A ES 2154560 A1 ES2154560 A1 ES 2154560A1
Authority
ES
Spain
Prior art keywords
free radicals
composition based
reduce oxidative
induced reactions
chroman derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009801947A
Other languages
English (en)
Other versions
ES2154560B1 (es
Inventor
Lambiez Fernando Pons
Gonzalez Raquel Delgado
Duena Antonio Parente
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lipotec SA
Original Assignee
Lipotec SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES009801947A priority Critical patent/ES2154560B1/es
Application filed by Lipotec SA filed Critical Lipotec SA
Priority to DK99500138T priority patent/DK1002533T3/da
Priority to EP99500138A priority patent/EP1002533B1/en
Priority to DE69904282T priority patent/DE69904282T2/de
Priority to ES99500138T priority patent/ES2189372T3/es
Priority to AT99500138T priority patent/ATE228836T1/de
Priority to PT99500138T priority patent/PT1002533E/pt
Priority to JP26062999A priority patent/JP4723705B2/ja
Publication of ES2154560A1 publication Critical patent/ES2154560A1/es
Application granted granted Critical
Publication of ES2154560B1 publication Critical patent/ES2154560B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Nutrition Science (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Fats And Perfumes (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Composición a base de derivados de cromanos y su uso para reducir químicamente las reacciones oxidativas o inducidas por radicales libres. Comprende la administración por vía tópica u oral de una cantidad efectiva de un compuesto de fórmula general A o B, donde R2 son iguales o diferentes y son seleccionados independientemente del grupo consistente en OH-, CH{sub,3}-, CF{sub,3}CH{sub,2}O- y CH{sub,3}O-.
ES009801947A 1998-09-16 1998-09-16 Composicion a base de derivados de cromanos y su uso para reducir quimicamente las reacciones oxidativas o inducidas por radicales libres. Expired - Lifetime ES2154560B1 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES009801947A ES2154560B1 (es) 1998-09-16 1998-09-16 Composicion a base de derivados de cromanos y su uso para reducir quimicamente las reacciones oxidativas o inducidas por radicales libres.
EP99500138A EP1002533B1 (en) 1998-09-16 1999-09-10 Use of chromanes and/or chromenes derivatives to prevent oxidative reactions induced by free radicals
DE69904282T DE69904282T2 (de) 1998-09-16 1999-09-10 Verwendung von Chromane und/oder Chromene Derivaten zur Vermeidung von freien Radikalen induzierten oxidativen Reaktionen
ES99500138T ES2189372T3 (es) 1998-09-16 1999-09-10 Uso de derivados de cromanos y/o cromenos para prevenir reacciones oxidativas inducidas por radicales libres.
DK99500138T DK1002533T3 (da) 1998-09-16 1999-09-10 Fremgangsmåde til kemisk reduktion af oxidative reaktioner eller disse, sominduceres af frie radikaler
AT99500138T ATE228836T1 (de) 1998-09-16 1999-09-10 Verwendung von chromane und/oder chromene derivaten zur vermeidung von freien radikalen induzierten oxidativen reaktionen
PT99500138T PT1002533E (pt) 1998-09-16 1999-09-10 Utilizacao de derivados de cromanos e/ou cromenos para prevenir reaccoes oxidativas induzidas por radicais livres
JP26062999A JP4723705B2 (ja) 1998-09-16 1999-09-14 酸化反応、または遊離基によって誘起される酸化反応を、化学的に減少させる方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009801947A ES2154560B1 (es) 1998-09-16 1998-09-16 Composicion a base de derivados de cromanos y su uso para reducir quimicamente las reacciones oxidativas o inducidas por radicales libres.

Publications (2)

Publication Number Publication Date
ES2154560A1 true ES2154560A1 (es) 2001-04-01
ES2154560B1 ES2154560B1 (es) 2001-12-01

Family

ID=8305178

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009801947A Expired - Lifetime ES2154560B1 (es) 1998-09-16 1998-09-16 Composicion a base de derivados de cromanos y su uso para reducir quimicamente las reacciones oxidativas o inducidas por radicales libres.
ES99500138T Expired - Lifetime ES2189372T3 (es) 1998-09-16 1999-09-10 Uso de derivados de cromanos y/o cromenos para prevenir reacciones oxidativas inducidas por radicales libres.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES99500138T Expired - Lifetime ES2189372T3 (es) 1998-09-16 1999-09-10 Uso de derivados de cromanos y/o cromenos para prevenir reacciones oxidativas inducidas por radicales libres.

Country Status (7)

Country Link
EP (1) EP1002533B1 (es)
JP (1) JP4723705B2 (es)
AT (1) ATE228836T1 (es)
DE (1) DE69904282T2 (es)
DK (1) DK1002533T3 (es)
ES (2) ES2154560B1 (es)
PT (1) PT1002533E (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2310142A1 (es) * 2007-06-15 2008-12-16 Lipotec S.A Compuestos reguladores de la pigmentacion.

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19941595A1 (de) * 1999-09-01 2001-03-08 Basf Ag Verwendung von anellierten Benzolderivaten als Antioxidans oder Radikalfänger in kosmetischen Zubereitungen
EP1267813A2 (de) * 2000-03-31 2003-01-02 Henkel Kommanditgesellschaft auf Aktien Verwendung von protease-inhibitoren in der kosmetik und pharmazie
FR2808189B1 (fr) 2000-04-28 2004-03-05 Oreal Lipochroman-6 comme inhibiteur de no-synthase et utilisations
DE10259014A1 (de) * 2002-12-16 2004-06-24 Henkel Kgaa Antioxidans-Kombinationen mit6,7-disubstituierten 2,2-Dialkylchromanen oder-chromenen
DE102004039729A1 (de) * 2004-08-16 2006-03-09 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an (-)2-Hydroxymethyl-2-Methyl-6-hydroxychromen bzw. einen Extrakt aus Pilzen der Art Daedalea quercina, (-)2-Hydroxymethyl-2-Methyl-6-hydrocychromen enthaltend
DE102006062501A1 (de) 2006-12-28 2008-07-03 Henkel Kgaa Kosmetische und dermatologische Öl-in-Wasser-Emulsionen mit selbstkonservierenden Eigenschaften
EP2113242A1 (en) * 2008-05-02 2009-11-04 Pangaea Laboratories Limited Antioxidant for use in cosmetic, medicated and pharmaceutical preparations
FR2934490B1 (fr) * 2008-08-01 2010-09-17 Lvmh Rech Utilisation dans une composition cosmetique du lipochroman-6 pour ameliorer l'eclat du teint de la peau, notamment du visage
DE102009017612A1 (de) * 2009-04-20 2010-10-21 Henkel Ag & Co. Kgaa Hautbehandlungsmittel gegen Hautalterung I
DE102009026414A1 (de) 2009-05-22 2010-11-25 Henkel Ag & Co. Kgaa Hautbehandlung zur Porenverfeinerung
DE102009027024A1 (de) 2009-06-18 2010-12-23 Henkel Ag & Co. Kgaa Antifalten-Kosmetikum mit Antioxidantien
DE102009027105A1 (de) * 2009-06-23 2010-12-30 Henkel Ag & Co. Kgaa Sonnenschutzzusammensetzungen mit verbessertem antioxidativen Potenzial
DE102009027199A1 (de) * 2009-06-25 2010-12-30 Henkel Ag & Co. Kgaa UV-Schutz-Kosmetikum
DE102010062915A1 (de) * 2010-12-13 2012-06-14 Henkel Ag & Co. Kgaa Synergistische Wirkstoffkombination zum Schutz der Haut vor IR-Strahlung
DE102011079256A1 (de) * 2011-07-15 2013-01-17 Henkel Ag & Co. Kgaa Sonnenschutzzusammensetzungen mit verbessertem antioxidativen Potenzial zum Schutz der Haut vor IR-Strahlung
JP2017088496A (ja) * 2014-03-19 2017-05-25 三菱化学株式会社 皮膚外用剤
JP2018535970A (ja) * 2015-11-02 2018-12-06 ルブリゾル アドバンスド マテリアルズ， インコーポレイテッド 汚染作用から皮膚を保護するための組成物およびその施用
DE102016225095B4 (de) 2016-12-15 2024-08-29 Henkel Ag & Co. Kgaa "Kosmetische Gesichtspflegeformulierungen zur Stimulierung der körpereigenen Abwehr gegen freie Radikale"
KR101784331B1 (ko) * 2017-02-27 2017-10-12 주식회사 아제라바이오텍 아쿠아포린-3의 발현을 증가시키는 6,7-디메톡시-2,2-디메틸-2h-크로멘 및 이의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0445735A1 (en) * 1990-03-09 1991-09-11 Sansho Seiyaku Co., Ltd. Melanogenesis-inhibiting endermic preparation
EP0655239A1 (en) * 1993-11-25 1995-05-31 Lipotec, S.A. Liposomes encapsulating doxorubicine
WO1996020187A2 (en) * 1994-12-23 1996-07-04 Alcon Laboratories, Inc. Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
FR2695387B1 (fr) * 1992-09-09 1994-10-21 Adir Nouveaux composés benzopyraniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
WO1996011670A1 (en) * 1994-10-14 1996-04-25 The Liposome Company, Inc. Ether lipid liposomes and their therapeutic use
EP0869773B1 (en) * 1995-12-15 2004-03-24 National Research Council Of Canada Archaeosomes, archaeosomes containing coenzyme q 10, and other types of liposomes containing coenzyme q 10 as adjuvants and as delivery vehicles
CA2319131A1 (en) * 1998-01-26 1999-07-29 Walter H. Moos Mitochondria protecting agents for treating mitochondria associated diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0445735A1 (en) * 1990-03-09 1991-09-11 Sansho Seiyaku Co., Ltd. Melanogenesis-inhibiting endermic preparation
EP0655239A1 (en) * 1993-11-25 1995-05-31 Lipotec, S.A. Liposomes encapsulating doxorubicine
WO1996020187A2 (en) * 1994-12-23 1996-07-04 Alcon Laboratories, Inc. Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Bioorganic Medicinal Chemistry, Vol. 1, no 3, 1993, paginas 219-225. J. IRRURE et al. "Inhibition of rat liver microsomal lipid peroxidation elicited by 2,2-dimethyl-chromenes and chromans containing fluorinated moieties resistant to cytochrome P-450 metabolism". Todo el documento. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2310142A1 (es) * 2007-06-15 2008-12-16 Lipotec S.A Compuestos reguladores de la pigmentacion.
ES2310142B1 (es) * 2007-06-15 2009-12-04 Lipotec S.A Compuestos reguladores de la pigmentacion.

Also Published As

Publication number Publication date
ATE228836T1 (de) 2002-12-15
DK1002533T3 (da) 2003-03-17
JP4723705B2 (ja) 2011-07-13
ES2189372T3 (es) 2003-07-01
EP1002533A1 (en) 2000-05-24
EP1002533B1 (en) 2002-12-04
DE69904282T2 (de) 2003-11-06
DE69904282D1 (de) 2003-01-16
ES2154560B1 (es) 2001-12-01
PT1002533E (pt) 2003-04-30
JP2000095684A (ja) 2000-04-04

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