ES2186164T3 - Kodaistatinas a, b, c y d, un procedimiento para su produccion y su uso. - Google Patents

Kodaistatinas a, b, c y d, un procedimiento para su produccion y su uso.

Info

Publication number
ES2186164T3
ES2186164T3 ES98924129T ES98924129T ES2186164T3 ES 2186164 T3 ES2186164 T3 ES 2186164T3 ES 98924129 T ES98924129 T ES 98924129T ES 98924129 T ES98924129 T ES 98924129T ES 2186164 T3 ES2186164 T3 ES 2186164T3
Authority
ES
Spain
Prior art keywords
sub
kodaistatinas
procedure
production
codaistatins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98924129T
Other languages
English (en)
Inventor
Nirogi Ramakrishna
Keshavapura Swamy
Erra Koteswara Sat Vijayakumar
Suresh Rudra Nadkarni
Kenia Jayvanti
Andreas W Herling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Application granted granted Critical
Publication of ES2186164T3 publication Critical patent/ES2186164T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Las codaistatinas A y B, compuestos de fórmula molecular C{sub,35}H{sub,34}O{sub,11} y las codaistatinas C y D, compuestos de fórmula molecular C{sub,35}H{sub,34}O{sub,12}, tienen actividad antidiabética.
ES98924129T 1997-04-18 1998-04-17 Kodaistatinas a, b, c y d, un procedimiento para su produccion y su uso. Expired - Lifetime ES2186164T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97106453 1997-04-18
EP97109900 1997-06-18
EP97120536 1997-11-24

Publications (1)

Publication Number Publication Date
ES2186164T3 true ES2186164T3 (es) 2003-05-01

Family

ID=27238189

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98924129T Expired - Lifetime ES2186164T3 (es) 1997-04-18 1998-04-17 Kodaistatinas a, b, c y d, un procedimiento para su produccion y su uso.

Country Status (14)

Country Link
US (1) US6166070A (es)
EP (1) EP0973760B1 (es)
JP (1) JP3993643B2 (es)
CN (1) CN1252797A (es)
AR (1) AR012449A1 (es)
AT (1) ATE227711T1 (es)
AU (1) AU736137B2 (es)
BR (1) BR9809104A (es)
CA (1) CA2286822C (es)
DE (1) DE69809405T2 (es)
DK (1) DK0973760T3 (es)
ES (1) ES2186164T3 (es)
PT (1) PT973760E (es)
WO (1) WO1998047888A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2252211C2 (ru) 1999-10-25 2005-05-20 Авентис Фарма Дойчланд Гмбх Ароматические дикетопроизводные, способы получения и применение данных соединений в качестве фармацевтических средств
CN108929293B (zh) * 2017-05-25 2021-08-13 上海交通大学医学院附属仁济医院 丁烯酸内酯类化合物的制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW255880B (es) * 1992-09-09 1995-09-01 Hoechst Ag
TW399041B (en) * 1992-09-09 2000-07-21 Hoechst Ag Substituted cyclohexane derivatives, the preparation and the use for treating diseases
JPH09202797A (ja) * 1996-01-24 1997-08-05 Sankyo Co Ltd ５α−還元酵素阻害化合物ｄ１０６７３３１

Also Published As

Publication number Publication date
WO1998047888A1 (en) 1998-10-29
AR012449A1 (es) 2000-10-18
DE69809405T2 (de) 2003-07-10
EP0973760B1 (en) 2002-11-13
JP3993643B2 (ja) 2007-10-17
AU736137B2 (en) 2001-07-26
CA2286822A1 (en) 1998-10-29
ATE227711T1 (de) 2002-11-15
CN1252797A (zh) 2000-05-10
DE69809405D1 (de) 2002-12-19
AU7644298A (en) 1998-11-13
US6166070A (en) 2000-12-26
CA2286822C (en) 2008-07-29
BR9809104A (pt) 2000-08-01
DK0973760T3 (da) 2003-03-03
EP0973760A1 (en) 2000-01-26
PT973760E (pt) 2003-03-31
JP2001524092A (ja) 2001-11-27

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