DK0781278T3 - Nye benzothiepiner, som har aktivitet som inhibitorer af ileal galdsyretransport og taurocholatoptagelse - Google Patents

Nye benzothiepiner, som har aktivitet som inhibitorer af ileal galdsyretransport og taurocholatoptagelse

Info

Publication number: DK0781278T3
Authority: DK; Denmark
Prior art keywords: benzothiepines; inhibitors; activity; new; bile acid
Prior art date: 1994-09-13

Application number

DK95930289T

Other languages

English (en)

Inventor

Len Fang Lee

Samuel Joseph Tremont

Raymond Eugene Miller

Original Assignee

Monsanto Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-13

Filing date

1995-08-28

Publication date

2001-04-17

1995-08-28 Application filed by Monsanto Co filed Critical Monsanto Co

2001-04-17 Application granted granted Critical

2001-04-17 Publication of DK0781278T3 publication Critical patent/DK0781278T3/da

Links

NIGNBCLEMMGDQP-UHFFFAOYSA-N 1-benzothiepine Chemical class S1C=CC=CC2=CC=CC=C12 NIGNBCLEMMGDQP-UHFFFAOYSA-N 0.000 title abstract 2
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
239000003613 bile acid Substances 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
WBWWGRHZICKQGZ-HZAMXZRMSA-N taurocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 WBWWGRHZICKQGZ-HZAMXZRMSA-N 0.000 title 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK95930289T 1994-09-13 1995-08-28 Nye benzothiepiner, som har aktivitet som inhibitorer af ileal galdsyretransport og taurocholatoptagelse DK0781278T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US30552694A	1994-09-13	1994-09-13
PCT/US1995/010863 WO1996008484A1 (en)	1994-09-13	1995-08-28	Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Publications (1)

Publication Number	Publication Date
DK0781278T3 true DK0781278T3 (da)	2001-04-17

Family

ID=23181154

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95930289T DK0781278T3 (da)	1994-09-13	1995-08-28	Nye benzothiepiner, som har aktivitet som inhibitorer af ileal galdsyretransport og taurocholatoptagelse

Country Status (13)

Country	Link
EP (1)	EP0781278B1 (da)
JP (1)	JP3304093B2 (da)
CN (1)	CN1084741C (da)
AT (1)	ATE199718T1 (da)
AU (1)	AU700557B2 (da)
BR (1)	BR9508916A (da)
CA (1)	CA2199944A1 (da)
DE (1)	DE69520364T2 (da)
DK (1)	DK0781278T3 (da)
ES (1)	ES2155136T3 (da)
GR (1)	GR3035583T3 (da)
PT (1)	PT781278E (da)
WO (1)	WO1996008484A1 (da)

Families Citing this family (82)

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US6107494A (en) *	1994-09-13	2000-08-22	G.D. Searle And Company	Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6262277B1 (en)	1994-09-13	2001-07-17	G.D. Searle And Company	Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en)	1994-09-13	2001-07-31	G. D. Searle & Co.	Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
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PT1140190E (pt)	1998-12-23	2003-02-28	Searle Llc	Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares
EP1140186B1 (en)	1998-12-23	2003-06-04	G.D. Searle LLC.	Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
EP1342475A1 (en)	1998-12-23	2003-09-10	G.D. Searle LLC.	Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
CN1342091A (zh) *	1998-12-23	2002-03-27	G.D.瑟尔有限公司	心血管指征的联合用药
MXPA01006472A (es)	1998-12-23	2004-03-10	Searle Llc	Combinaciones de inhibidores de transporte de acido biliar ileal y derivados de acido fibrico para indicaciones cardiovasculares.
DK1140184T3 (da)	1998-12-23	2003-09-29	Searle Llc	Kombinationer af cholesterylestertransferproteinhæmmere og nikotinsyrederivater til hjertekar indikationer
DK1140185T3 (da)	1998-12-23	2003-09-29	Searle Llc	Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer
AU2157400A (en)	1998-12-23	2000-07-31	G.D. Searle & Co.	Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
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JP7665620B2 (ja)	2019-12-04	2025-04-21	アルビレオ・アクチボラグ	ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
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Family Cites Families (8)

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Publication number	Priority date	Publication date	Assignee	Title
US3287370A (en) *	1965-06-08	1966-11-22	Mcneilab Inc	Tetrahydrobenzothiepins
DE1593760A1 (de) *	1967-02-01	1972-06-08	Boehringer Sohn Ingelheim	Verfahren zur Herstellung neuer Benz-epinderivate
AU626881B2 (en) *	1988-07-14	1992-08-13	F. Hoffmann-La Roche Ag	Benzofused heterocyclics used as pharmaceuticals
FR2661676A1 (fr) *	1990-05-02	1991-11-08	Lipha	Derives d'amino benzocycloalcanes, procedes de preparation et medicaments les contenant.
WO1992018462A1 (en) *	1991-04-12	1992-10-29	Schering Corporation	Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase
GB9203347D0 (en) *	1992-02-17	1992-04-01	Wellcome Found	Hypolipidaemic compounds
FR2698873B1 (fr) *	1992-12-07	1995-02-24	Lipha	Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant.
DE102018100125A1 (de) *	2018-01-04	2019-07-04	Miele & Cie. Kg	Wasserzulaufsteuerung und Waschautomat

1995
- 1995-08-28 BR BR9508916A patent/BR9508916A/pt not_active Application Discontinuation
- 1995-08-28 PT PT95930289T patent/PT781278E/pt unknown
- 1995-08-28 AT AT95930289T patent/ATE199718T1/de not_active IP Right Cessation
- 1995-08-28 CA CA002199944A patent/CA2199944A1/en not_active Abandoned
- 1995-08-28 AU AU33736/95A patent/AU700557B2/en not_active Ceased
- 1995-08-28 ES ES95930289T patent/ES2155136T3/es not_active Expired - Lifetime
- 1995-08-28 JP JP51020596A patent/JP3304093B2/ja not_active Expired - Fee Related
- 1995-08-28 CN CN95195971A patent/CN1084741C/zh not_active Expired - Fee Related
- 1995-08-28 EP EP95930289A patent/EP0781278B1/en not_active Expired - Lifetime
- 1995-08-28 DK DK95930289T patent/DK0781278T3/da active
- 1995-08-28 WO PCT/US1995/010863 patent/WO1996008484A1/en not_active Ceased
- 1995-08-28 DE DE69520364T patent/DE69520364T2/de not_active Expired - Fee Related
2001
- 2001-03-15 GR GR20010400374T patent/GR3035583T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1162311A (zh)	1997-10-15
JPH10505830A (ja)	1998-06-09
EP0781278A1 (en)	1997-07-02
DE69520364D1 (de)	2001-04-19
ES2155136T3 (es)	2001-05-01
PT781278E (pt)	2001-08-30
ATE199718T1 (de)	2001-03-15
BR9508916A (pt)	1997-12-30
AU3373695A (en)	1996-03-29
JP3304093B2 (ja)	2002-07-22
AU700557B2 (en)	1999-01-07
CA2199944A1 (en)	1996-03-21
WO1996008484A1 (en)	1996-03-21
CN1084741C (zh)	2002-05-15
EP0781278B1 (en)	2001-03-14
GR3035583T3 (en)	2001-06-29
DE69520364T2 (de)	2001-09-13

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