ES2155546T3 - Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y el uso de preparaciones farmaceuticas basadas en estos compuestos, asi como medicamentos que los contienen. - Google Patents
Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y el uso de preparaciones farmaceuticas basadas en estos compuestos, asi como medicamentos que los contienen.Info
- Publication number
- ES2155546T3 ES2155546T3 ES96101977T ES96101977T ES2155546T3 ES 2155546 T3 ES2155546 T3 ES 2155546T3 ES 96101977 T ES96101977 T ES 96101977T ES 96101977 T ES96101977 T ES 96101977T ES 2155546 T3 ES2155546 T3 ES 2155546T3
- Authority
- ES
- Spain
- Prior art keywords
- atomos
- sub
- atoms
- rent
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
BENZOLSULFONILUREAS Y -TIOUREAS DE FORMULA I, DONDE R(1) ES HIDROGENO, ALQUILO CON 1, 2, 3, 4, 5, 6 O 7 ATOMOS DE C, CICLOALQUILO CON 3, 4, 5, 6 O 7 ATOMOS DE C; R(2) ES HIDROGENO, ALQUILO CON 1, 2, 3, 4, 5 O 6 ATOMOS DE C, ALCOXI CON CON 1, 2, 3, 4, 5 O 6 ATOMOS DE C, MERCAPTOALQUILO CON 1, 2, 3, 4, 5 O 6 ATOMOS DE C, CICLOALQUILO CON 3, 4, 5 O 6 ATOMOS DE C, Y OTRAS CADENAS DE C{SUB,1}-C{SUB,8}, EN LAS CUALES N ATOMOS DE C ESTAN SUSTITUIDOS POR HETEROATOMOS, P. E. O, N, S (N=1-4), F, CL; R(3) H, ALQUILO CON 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 O 12 ATOMOS DE C, CICLOALQUILO CON 3, 4, 5, 6, 7, 8, 9 O 10 ATOMOS DE C, FLUOROALQUILO CON 3, 4, 5 O 6 ATOMOS, O CADENAS DE C{SUB,1}C{SUB,10}, EN LAS CUALES N ATOMOS DE C ESTAN SUSTITUIDOS POR HETEROATOMOS, P. E. O, N, S (N=1, 2, 3 O 4); R(4) ES HIDROGENO, ALQUILO CON 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 O 12 ATOMOS DE C, CICLOALQUILO CON 3, 4, 5, 6, 7, 8, 9 O 10 ATOMOS DE C, FLUOROALQUILO CON 1, 2, 3, 4, 5 O 6 ATOMOS DE C, FLUOROCICLOALQUILO CON 3, 4, 5O 6 ATOMOS DE C, O CADENAS DE C{SUB,1}-C{SUB,10}, EN LAS CUALES N ATOMOS DE C ESTAN SUSTITUIDOS POR HETEROATOMOS, P. E. O, N, S (N=1, 2, 3 O 4); O R(3) Y R(4) FORMAN JUNTOS UN ANILLO (CH{SUB,2}){SUB,2-8}, EN EL CUAL UNO O VARIOS GRUPOS CH{SUB,2} PUEDEN ESTAR SUSTITUIDOS POR HETEROATOMOS; E ES OXIGENO O AZUFRE; X ES OXIGENO O AZUFRE; Y ES [CR(5)R(5){SUP,''})]{SUB,M}; SIENDO R(5) Y R(5{SUP,''}) INDEPENDIENTEMENTE UNO DE OTRO HIDROGENO O ALQUILO CON 1 O 2 ATOMOS DE C; DONDE LOS MIEMBROS DE [(CR(5)R(5{SUP,''})] PUEDEN SER IGUALES O DIFERENTES; Y M ES 1, 2, 3 O 4. TAMBIEN SUS SALES FARMACEUTICAMENTE ACEPTABLES, TIENE EFECTOS MUY IMPORTANTES EN EL SISTEMA CARDIOVASCULAR.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19505398A DE19505398A1 (de) | 1995-02-17 | 1995-02-17 | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und Verwendung pharmazeutischer Präparate auf Basis dieser Verbindungen sowie sie enthaltende Heilmittel |
| DE19522920A DE19522920A1 (de) | 1995-06-23 | 1995-06-23 | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und Verwendung pharmazeutischer Präparate auf Basis dieser Verbindungen sowie sie enthaltende Heilmittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2155546T3 true ES2155546T3 (es) | 2001-05-16 |
Family
ID=26012537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96101977T Expired - Lifetime ES2155546T3 (es) | 1995-02-17 | 1996-02-12 | Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y el uso de preparaciones farmaceuticas basadas en estos compuestos, asi como medicamentos que los contienen. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5880155A (es) |
| EP (1) | EP0727417B1 (es) |
| JP (1) | JP3905573B2 (es) |
| KR (1) | KR100432259B1 (es) |
| CN (1) | CN1060162C (es) |
| AR (1) | AR002708A1 (es) |
| AT (1) | ATE199541T1 (es) |
| AU (1) | AU700254B2 (es) |
| BR (1) | BR9600779A (es) |
| CA (1) | CA2169696C (es) |
| CZ (1) | CZ291793B6 (es) |
| DE (1) | DE59606531D1 (es) |
| DK (1) | DK0727417T3 (es) |
| ES (1) | ES2155546T3 (es) |
| FI (1) | FI120391B (es) |
| GR (1) | GR3035710T3 (es) |
| HR (1) | HRP960076B1 (es) |
| HU (1) | HU226462B1 (es) |
| IL (1) | IL117152A (es) |
| MY (1) | MY115795A (es) |
| NO (1) | NO305795B1 (es) |
| NZ (1) | NZ280992A (es) |
| PL (1) | PL181792B1 (es) |
| PT (1) | PT727417E (es) |
| RU (1) | RU2198872C2 (es) |
| SI (1) | SI9600050B (es) |
| SK (1) | SK282131B6 (es) |
| TR (1) | TR199600117A2 (es) |
| TW (1) | TW357141B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19546736A1 (de) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate |
| PT1270565E (pt) * | 1997-01-29 | 2004-09-30 | Pfizer | Furano-2-sulfonamida 4-substituida e sua utilizacao na preparacao de derivados de sulfonilureia |
| DE19832009A1 (de) | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate |
| DE10129704A1 (de) * | 2001-06-22 | 2003-01-02 | Aventis Pharma Gmbh | Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks |
| ES2333979T3 (es) | 2004-11-22 | 2010-03-03 | Eli Lilly And Company | Potenciadores de los receptores del glutamato. |
| CN104649945B (zh) * | 2015-02-05 | 2017-02-22 | 中国农业大学 | 一种磺酰脲类、磺酰胺基甲酸酯类化合物的制备方法 |
| WO2023020412A1 (zh) * | 2021-08-16 | 2023-02-23 | 中国科学院上海药物研究所 | 磺酰脲化合物、制备方法及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1198354B (de) * | 1963-09-25 | 1965-08-12 | Hoechst Ag | Verfahren zur Herstellung von Benzol-sulfonylharnstoffen |
| DE1185180B (de) * | 1963-10-19 | 1965-01-14 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| BE754454A (fr) * | 1969-08-06 | 1971-02-05 | Bayer Ag | Nouveaux composes hypoglycemiques du type d'arylsulfonylurees et d'arylsulfonylsemicarbazides contenant des groupes carbonamide |
| DE2413514C3 (de) * | 1974-03-21 | 1982-03-04 | Hoechst Ag, 6000 Frankfurt | N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung |
| US4927453A (en) * | 1986-10-17 | 1990-05-22 | E. I. Du Pont De Nemours And Company | Herbicidal sulfonamides |
| ATE146775T1 (de) * | 1993-02-23 | 1997-01-15 | Hoechst Ag | Substituierte benzolsulfonylharnstoffe und - thioharnstoffe- verfahren zu ihrer herstellung und ihre verwendung als pharmazeutika |
-
1995
- 1995-12-28 HU HU9503877A patent/HU226462B1/hu not_active IP Right Cessation
-
1996
- 1996-01-29 PL PL96312530A patent/PL181792B1/pl not_active IP Right Cessation
- 1996-02-12 AT AT96101977T patent/ATE199541T1/de active
- 1996-02-12 EP EP96101977A patent/EP0727417B1/de not_active Expired - Lifetime
- 1996-02-12 TW TW085101696A patent/TW357141B/zh not_active IP Right Cessation
- 1996-02-12 DE DE59606531T patent/DE59606531D1/de not_active Expired - Lifetime
- 1996-02-12 DK DK96101977T patent/DK0727417T3/da active
- 1996-02-12 PT PT96101977T patent/PT727417E/pt unknown
- 1996-02-12 ES ES96101977T patent/ES2155546T3/es not_active Expired - Lifetime
- 1996-02-14 CZ CZ1996435A patent/CZ291793B6/cs not_active IP Right Cessation
- 1996-02-14 CN CN96102017A patent/CN1060162C/zh not_active Expired - Fee Related
- 1996-02-15 HR HR960076A patent/HRP960076B1/xx not_active IP Right Cessation
- 1996-02-15 SK SK212-96A patent/SK282131B6/sk not_active IP Right Cessation
- 1996-02-15 FI FI960688A patent/FI120391B/fi not_active IP Right Cessation
- 1996-02-15 AU AU45559/96A patent/AU700254B2/en not_active Ceased
- 1996-02-15 NZ NZ280992A patent/NZ280992A/en not_active IP Right Cessation
- 1996-02-15 US US08/602,018 patent/US5880155A/en not_active Expired - Lifetime
- 1996-02-15 TR TR96/00117A patent/TR199600117A2/xx unknown
- 1996-02-15 IL IL11715296A patent/IL117152A/en not_active IP Right Cessation
- 1996-02-15 AR ARP960101391A patent/AR002708A1/es unknown
- 1996-02-16 RU RU96102852/04A patent/RU2198872C2/ru not_active IP Right Cessation
- 1996-02-16 MY MYPI96000622A patent/MY115795A/en unknown
- 1996-02-16 NO NO960628A patent/NO305795B1/no not_active IP Right Cessation
- 1996-02-16 BR BR9600779A patent/BR9600779A/pt not_active IP Right Cessation
- 1996-02-16 JP JP05263396A patent/JP3905573B2/ja not_active Expired - Fee Related
- 1996-02-16 KR KR1019960003823A patent/KR100432259B1/ko not_active Expired - Fee Related
- 1996-02-16 SI SI9600050A patent/SI9600050B/sl not_active IP Right Cessation
- 1996-02-16 CA CA002169696A patent/CA2169696C/en not_active Expired - Fee Related
-
1998
- 1998-06-04 US US09/090,403 patent/US5977177A/en not_active Expired - Lifetime
-
2001
- 2001-04-06 GR GR20010400560T patent/GR3035710T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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