ES2155660T3 - Derivados de bencimidazol, de benzoxazol y de benzotiazol, utilizables como inhibidores de la interleuquina 1beta. - Google Patents

Derivados de bencimidazol, de benzoxazol y de benzotiazol, utilizables como inhibidores de la interleuquina 1beta.

Info

Publication number
ES2155660T3
ES2155660T3 ES97401789T ES97401789T ES2155660T3 ES 2155660 T3 ES2155660 T3 ES 2155660T3 ES 97401789 T ES97401789 T ES 97401789T ES 97401789 T ES97401789 T ES 97401789T ES 2155660 T3 ES2155660 T3 ES 2155660T3
Authority
ES
Spain
Prior art keywords
group
interleuquina
bencimidazol
benzotiazol
1beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97401789T
Other languages
English (en)
Inventor
Nanteuil Guillaume De
Bernard Portevin
Jacqueline Bonnet
Armel Fradin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2155660T3 publication Critical patent/ES2155660T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPUESTO DE FORMULA (I): EN LA QUE: R1 REPRESENTA UN ATOMO DE HALOGENO, UN GRUPO HIDROXI, ALCOXI, TRIHALOGENOMETILO, AMINO, MERCAPTO, ALQUILTIO, TRIALQUILAMONIO, ARILOXI, ARILSULFONILO, ARILSULFONILOXI, CICLOALQUILOXI, CICLOALQUILTIO, BICICLOALQUILOXI O BICICLOALQUILTIO, Ra, Rb, IDENTICOS O DIFERENTES, REPRESENTAN UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, X REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE O UN GRUPO NR, Y REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE, UN GRUPO AMINO, SO2 O UNO DE LOS GRUPOS DEFINIDOS EN LA DESCRIPCION, R2 REPRESENTA UN GRUPO ARILO EVENTUALMENTE SUSTITUIDO, SUS ISOMEROS ASI COMO SUS SALES DE ADICION A UN ACIDO O A UNA BASE FARMACEUTICAMENTE ACEPTABLE. MEDICAMENTOS.
ES97401789T 1996-07-26 1997-07-24 Derivados de bencimidazol, de benzoxazol y de benzotiazol, utilizables como inhibidores de la interleuquina 1beta. Expired - Lifetime ES2155660T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9609416A FR2751649B1 (fr) 1996-07-26 1996-07-26 Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2155660T3 true ES2155660T3 (es) 2001-05-16

Family

ID=9494506

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97401789T Expired - Lifetime ES2155660T3 (es) 1996-07-26 1997-07-24 Derivados de bencimidazol, de benzoxazol y de benzotiazol, utilizables como inhibidores de la interleuquina 1beta.

Country Status (19)

Country Link
US (1) US5972968A (es)
EP (1) EP0820990B1 (es)
JP (1) JPH1067753A (es)
CN (1) CN1090620C (es)
AT (1) ATE198744T1 (es)
AU (1) AU715751B2 (es)
BR (1) BR9704076A (es)
CA (1) CA2211444C (es)
DE (1) DE69703915T2 (es)
DK (1) DK0820990T3 (es)
ES (1) ES2155660T3 (es)
FR (1) FR2751649B1 (es)
GR (1) GR3035434T3 (es)
HU (1) HUP9701297A1 (es)
NO (1) NO308602B1 (es)
NZ (1) NZ328431A (es)
PL (1) PL321336A1 (es)
PT (1) PT820990E (es)
ZA (1) ZA976655B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9602029D0 (en) * 1996-02-01 1996-04-03 Fujisawa Pharmaceutical Co New heterocyclic compounds
FR2766822B1 (fr) * 1997-07-30 2001-02-23 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6248770B1 (en) * 1998-07-09 2001-06-19 Boehringer Ingelheim Pharma Kg Benzimidazoles having antithrombotic activity
CA2347939C (en) 1998-10-23 2006-10-10 Akira Matsumori Composition for the treatment of rheumatism, hepatitis or pancreatitis
US6451832B2 (en) 1999-12-23 2002-09-17 Boehringer Ingelheim Pharma Kg Benzimidazoles with antithrombotic activity
AU3653301A (en) 2000-01-28 2001-08-07 Merck & Co., Inc. Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug
US6660858B2 (en) 2001-03-28 2003-12-09 Lion Bioscience Ag 2-aminobenzoxazole derivatives and combinatorial libraries thereof
MX2007005290A (es) * 2004-11-02 2007-07-09 Pfizer Derivados de sulfonilbencimidazol.
PE20070335A1 (es) 2005-08-30 2007-04-21 Novartis Ag Benzimidazoles sustituidos y metodos para su preparacion
FR2891273B1 (fr) * 2005-09-27 2007-11-23 Aventis Pharma Sa NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet
MX2011007663A (es) * 2009-01-22 2011-08-15 Raqualia Pharma Inc Compuestos de sulfona heterociclica, saturada y sustituida en n, con actividad agonistica del receptor de cb2.
KR20110123253A (ko) 2009-03-05 2011-11-14 다이이찌 산쿄 가부시키가이샤 피리딘 유도체
BR112012010738A2 (pt) 2009-11-06 2019-09-24 Univ Vanderbilt ''aril e heteroaril sulfonas como potenciadores alostéricos de mglur4,composições e métodos de tratamento de disfunção neurológica''
TW201534597A (zh) 2013-06-20 2015-09-16 Ab Science 作為選擇性蛋白質激酶抑制劑之苯并咪唑衍生物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2290430A1 (fr) * 1974-11-06 1976-06-04 Aries Robert Nouveau mode de synthese d'esters carbamiques derives du benzimidazole
LU75684A1 (es) * 1976-08-27 1978-04-13
DE3067431D1 (en) * 1979-07-20 1984-05-17 Ciba Geigy Ag Coumarine compounds, processes for their manufacture as well as the intermediate products used perse and their utilisation for the dyeing or printing of textiles
GR78209B (es) * 1982-04-15 1984-09-26 May & Baker Ltd
US4430502A (en) * 1982-08-13 1984-02-07 The Upjohn Company Pyridinyl substituted benzimidazoles and quinoxalines
NZ221729A (en) * 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
JP2869561B2 (ja) * 1989-05-22 1999-03-10 大塚製薬株式会社 血小板粘着抑制剤
JPH06759B2 (ja) * 1989-09-22 1994-01-05 ファイザー製薬株式会社 新規なベンゾイミダゾール化合物
IE910278A1 (en) * 1990-02-16 1991-08-28 Ici Plc Heterocyclic compounds
JPH08294229A (ja) * 1995-04-20 1996-11-05 Nec Corp 半導体集積回路装置
JPH09169729A (ja) * 1995-12-19 1997-06-30 Green Cross Corp:The 非ペプチド型インターロイキン８拮抗剤
JP3243733B2 (ja) * 1996-08-07 2002-01-07 雪印乳業株式会社 新規イソキノリン誘導体
JP2007024865A (ja) * 2005-06-17 2007-02-01 Renesas Technology Corp 半導体装置
KR100861371B1 (ko) * 2007-06-25 2008-10-01 주식회사 하이닉스반도체 온도센서 및 이를 이용한 반도체 메모리 장치
JP2009058438A (ja) * 2007-08-31 2009-03-19 Toshiba Corp 温度検出回路
JP5888009B2 (ja) * 2012-03-08 2016-03-16 株式会社豊田中央研究所 温度センサ回路

Also Published As

Publication number Publication date
EP0820990A3 (fr) 1998-07-29
NO308602B1 (no) 2000-10-02
FR2751649A1 (fr) 1998-01-30
CA2211444A1 (fr) 1998-01-26
DE69703915D1 (de) 2001-02-22
HUP9701297A1 (hu) 1999-09-28
EP0820990B1 (fr) 2001-01-17
HU9701297D0 (en) 1997-09-29
NO973443L (no) 1998-01-27
CN1174192A (zh) 1998-02-25
EP0820990A2 (fr) 1998-01-28
CA2211444C (fr) 2002-07-09
DK0820990T3 (da) 2001-05-07
NZ328431A (en) 1997-12-19
PT820990E (pt) 2001-06-29
AU715751B2 (en) 2000-02-10
GR3035434T3 (en) 2001-05-31
ATE198744T1 (de) 2001-02-15
BR9704076A (pt) 1999-05-11
NO973443D0 (no) 1997-07-25
FR2751649B1 (fr) 1998-08-28
PL321336A1 (en) 1998-02-02
ZA976655B (en) 1998-02-10
US5972968A (en) 1999-10-26
DE69703915T2 (de) 2001-08-02
AU3017297A (en) 1998-02-05
CN1090620C (zh) 2002-09-11
JPH1067753A (ja) 1998-03-10

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