ES2108425T3 - Analogos de atp sustituidos con n-alquilo-2. - Google Patents

Analogos de atp sustituidos con n-alquilo-2.

Info

Publication number
ES2108425T3
ES2108425T3 ES94905810T ES94905810T ES2108425T3 ES 2108425 T3 ES2108425 T3 ES 2108425T3 ES 94905810 T ES94905810 T ES 94905810T ES 94905810 T ES94905810 T ES 94905810T ES 2108425 T3 ES2108425 T3 ES 2108425T3
Authority
ES
Spain
Prior art keywords
sup
alkyl
sub
halogen
atp analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94905810T
Other languages
English (en)
Inventor
Anthony Howard Ingall
Peter Alan Cage
Nicholas David Kindon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra Pharmaceuticals Ltd
Astra USA Inc
Original Assignee
Astra Pharmaceuticals Ltd
Astra Pharmaceutical Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939302636A external-priority patent/GB9302636D0/en
Priority claimed from GB939325712A external-priority patent/GB9325712D0/en
Application filed by Astra Pharmaceuticals Ltd, Astra Pharmaceutical Products Inc filed Critical Astra Pharmaceuticals Ltd
Application granted granted Critical
Publication of ES2108425T3 publication Critical patent/ES2108425T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

HAN SIDO DESCUBIERTOS COMPUESTOS DE LA FORMULA (I) EN LA QUE R{SUP,1} Y R{SUP,2} REPRESENTAN INDEPENDIENTEMENTE HIDROGENO O HALOGENO, R{SUP,3} Y R{SUP,4} REPRESENTAN INDEPENDIENTEMENTE FENILO, O ALQUILO C{SUB,1-6} OPCIONALMENTE SUSTITUIDO POR UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE OR{SUP,5}, ALQUILTIO C{SUB,1-6}, NR{SUP,6}R{SUP,7}, FENILO, COOR{SUP,8} Y HALOGENO, R{SUP,5}, R{SUP,6}, R{SUP,7} Y R{SUP,8} INDEPENDIENTEMENTE REPRESENTAN HIDROGENO O ALQUILO C{SUB,1-6}, Y X REPRESENTA UNA MITAD ACIDICA Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. TAMBIEN SE DESCRIBE UN PROCESO PARA SU PRODUCCION Y COMPOSICIONES FARMACEUTICAS Y METODOS DE TRATAMIENTO QUE IMPLICAN SU USO.
ES94905810T 1993-02-10 1994-02-08 Analogos de atp sustituidos con n-alquilo-2. Expired - Lifetime ES2108425T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939302636A GB9302636D0 (en) 1993-02-10 1993-02-10 Compounds
GB939325712A GB9325712D0 (en) 1993-12-16 1993-12-16 Compounds

Publications (1)

Publication Number Publication Date
ES2108425T3 true ES2108425T3 (es) 1997-12-16

Family

ID=26302434

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94905810T Expired - Lifetime ES2108425T3 (es) 1993-02-10 1994-02-08 Analogos de atp sustituidos con n-alquilo-2.

Country Status (26)

Country Link
US (2) US5721219A (es)
EP (1) EP0683789B1 (es)
JP (1) JP3083156B2 (es)
KR (1) KR100315612B1 (es)
CN (1) CN1042430C (es)
AT (1) ATE159950T1 (es)
AU (1) AU679721B2 (es)
CA (1) CA2155673C (es)
CZ (1) CZ286050B6 (es)
DE (1) DE69406649T2 (es)
DK (1) DK0683789T3 (es)
ES (1) ES2108425T3 (es)
FI (1) FI110687B (es)
GR (1) GR3025995T3 (es)
HK (1) HK1002936A1 (es)
HU (1) HU221501B (es)
IL (1) IL108602A (es)
NO (1) NO305209B1 (es)
NZ (1) NZ261159A (es)
PL (1) PL175623B1 (es)
RU (1) RU2136693C1 (es)
SG (1) SG47943A1 (es)
SK (1) SK281309B6 (es)
TW (1) TW326045B (es)
UA (1) UA54366C2 (es)
WO (1) WO1994018216A1 (es)

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DE69406649T2 (de) * 1993-02-10 1998-03-05 Astra Pharmaceuticals Ltd., Kings Langley, Hertfordshire N-alkyl-2-substituierte atp-analoge
AU5584698A (en) * 1996-10-30 1998-05-22 University Of North Carolina At Chapel Hill, The P2y receptor antagonists
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US6686462B2 (en) * 1997-02-28 2004-02-03 The Regents Of The University Of California Antiviral compounds and methods of administration
SE9702680D0 (sv) * 1997-07-11 1997-07-11 Astra Pharma Prod New formulation
AU2003257524B2 (en) * 1997-07-11 2006-04-06 Astrazeneca Ab New formulation
FI104901B (fi) * 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US7598246B2 (en) * 1998-04-02 2009-10-06 Mbc Pharma, Inc. Bisphosphonate conjugates and methods of making and using the same
US6750340B2 (en) * 1998-04-02 2004-06-15 Mbc Research, Inc. Bisphosphonate conjugates and methods of making and using the same
US8586781B2 (en) 1998-04-02 2013-11-19 Mbc Pharma, Inc. Bone targeted therapeutics and methods of making and using the same
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
US6303774B1 (en) 1999-08-20 2001-10-16 Sri International Nucleoside pyrophosphate and triphosphate analogs and related compounds
SE9903345D0 (sv) 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
SE9904377D0 (sv) * 1999-12-01 1999-12-01 Astra Pharma Prod Pharmaceutical combinations
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
AR039558A1 (es) * 2000-08-21 2005-02-23 Inspire Pharmaceuticals Inc Composiciones y metodo para el tratamiento de glaucoma o hipertension ocular
US7132408B2 (en) 2000-08-21 2006-11-07 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US6897201B2 (en) 2000-08-21 2005-05-24 Inspire Pharmaceuticals, Inc. Compositions and methods for the treatment of glaucoma or ocular hypertension
US7115585B2 (en) 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US7452870B2 (en) 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
US7435724B2 (en) 2002-02-27 2008-10-14 Inspire Pharmaceutical, Inc. Degradation-resistant mononucleoside phosphate compounds
RU2004128943A (ru) * 2002-02-28 2005-04-20 Байота, Инк. (Us) Средства, имитирующие нуклеотиды, и их пролекарственные формы
RU2005104432A (ru) * 2002-07-18 2005-08-10 Санкио Компани, Лимитед (Jp) Лекарственная композиция для лечения артериосклероза
US20050192245A1 (en) * 2002-07-18 2005-09-01 Sankyo Company, Limited Medicinal composition for treating arteriosclerosis
KR101057082B1 (ko) 2002-11-21 2011-08-16 코와 가부시키가이샤 복막 투석법
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
EP1604669A1 (en) * 2004-06-10 2005-12-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of ATP analogues for treatment of cardiovascular diseases
US8759316B2 (en) * 2008-05-13 2014-06-24 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US20120141468A1 (en) * 2008-05-13 2012-06-07 Lisa Ruderman Chen Maintenance of platelet inhibition during antiplatelet therapy
US9427448B2 (en) 2009-11-11 2016-08-30 The Medicines Company Methods of treating, reducing the incidence of, and/or preventing ischemic events
US20130303477A1 (en) * 2008-05-13 2013-11-14 The Medicines Company Maintenance of Platelet Inhibition During Antiplatelet Therapy
WO2009140092A1 (en) * 2008-05-13 2009-11-19 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US10376532B2 (en) 2009-11-11 2019-08-13 Chiesi Farmaceutici, S.P.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
EP2498731B1 (en) 2009-11-11 2020-01-22 Chiesi Farmaceutici S.p.A. Methods of treating or preventing stent thrombosis
JP6577165B2 (ja) * 2011-01-26 2019-09-18 北京康倍得医▲藥▼技▲術▼▲開▼▲發▼有限公司 リボフラノシルプリン化合物、その調製方法、およびその使用
AU2012214396B2 (en) 2011-02-09 2017-04-27 Chiesi Farmaceutici S.P.A. Methods for treating pulmonary hypertension
AU2012290089B2 (en) 2011-08-01 2016-09-29 Mbc Pharma, Inc. Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
EP3978002A1 (en) 2013-03-09 2022-04-06 Chiesi Farmaceutici S.p.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
CN104447928A (zh) * 2013-09-13 2015-03-25 天津市汉康医药生物技术有限公司 坎格雷洛二水化合物
CN104447927A (zh) * 2013-09-13 2015-03-25 天津市汉康医药生物技术有限公司 坎格雷洛一水合物晶体及其制备方法
CN103772461A (zh) * 2014-01-06 2014-05-07 南京正科制药有限公司 一种坎格雷洛晶型ⅰ
EP3623364A1 (en) 2014-02-13 2020-03-18 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
CN105273025B (zh) * 2014-07-22 2019-07-26 上海医药工业研究院 一种制备坎格雷洛的中间体及其制备方法和应用
PE20221170A1 (es) 2015-01-14 2022-07-25 Chiesi Farm Spa Formulaciones farmaceuticas que comprenden cangrelor de alta pureza y metodos para la preparacion y uso de los mismos
CN105061431B (zh) * 2015-07-28 2017-03-29 山东百诺医药股份有限公司 6‑n‑（2‑（甲硫基）乙基）‑2‑（（3,3,3‑三氟丙基）硫代）‑9h‑嘌呤及其制备方法和应用
CN109232694A (zh) * 2015-11-06 2019-01-18 江苏恒瑞医药股份有限公司 制备坎格雷洛中间体的方法
CN107973832B (zh) * 2016-10-25 2021-11-12 上海医药工业研究院 6-n-[2-(甲硫基)乙基]-2-[(3，3，3-三氟丙基)硫代]腺苷的制法
CN107973798B (zh) * 2016-10-25 2020-04-24 上海医药工业研究院 2-[(3,3,3-三氟丙基)硫代]-6-氨基-9h-嘌呤及制法
CN106674322B (zh) * 2016-12-07 2019-04-16 上海博志研新药物技术有限公司 一种坎格雷洛中间体的纯化方法
WO2018185715A1 (en) * 2017-04-06 2018-10-11 Msn Laboratories Private Limited, R&D Center Improved process for the preparation of n6-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-5'-adenylic acid, monoanhydride with (dichloromethylene) bisphosphonic acid and its pharmaceutically acceptable salts
ES3067885T3 (en) 2017-06-23 2026-05-26 Chiesi Farm Spa Cangrelor for the treatment and/or prevention of shunt or stent thrombosis
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CN109912674A (zh) * 2017-12-12 2019-06-21 亚宝药业集团股份有限公司 一种坎格雷洛四钠盐的制备方法
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CN108033983B (zh) * 2018-02-09 2021-06-08 盐城锦明药业有限公司 一种2‐(3,3,3‐三氟丙基)硫代腺苷的合成方法
EP4289435A1 (en) 2022-06-07 2023-12-13 Université de Liège N-alkyl-2-substituted atp analogues for use as antibacterial agent

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US5049550A (en) * 1987-11-05 1991-09-17 Worcester Foundation For Experimental Biology Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents
WO1990011080A1 (en) * 1989-03-24 1990-10-04 Daiichi Pharmaceutical Co., Ltd. Drug for improving brain function
EP0579643A1 (en) 1991-04-06 1994-01-26 FISONS plc Atp analogues
GB9107236D0 (en) 1991-04-06 1991-05-22 Fisons Plc Compounds
DE69406649T2 (de) * 1993-02-10 1998-03-05 Astra Pharmaceuticals Ltd., Kings Langley, Hertfordshire N-alkyl-2-substituierte atp-analoge

Also Published As

Publication number Publication date
SK281309B6 (sk) 2001-02-12
CA2155673C (en) 2004-08-17
NO953126D0 (no) 1995-08-09
TW326045B (en) 1998-02-01
UA54366C2 (uk) 2003-03-17
KR100315612B1 (ko) 2002-06-20
HU221501B (en) 2002-10-28
EP0683789A1 (en) 1995-11-29
FI110687B (fi) 2003-03-14
WO1994018216A1 (en) 1994-08-18
PL310160A1 (en) 1995-11-27
RU2136693C1 (ru) 1999-09-10
DK0683789T3 (da) 1998-02-09
PL175623B1 (pl) 1999-01-29
FI953794A0 (fi) 1995-08-10
CA2155673A1 (en) 1994-08-18
SK99495A3 (en) 1996-02-07
NO953126L (no) 1995-09-28
DE69406649D1 (de) 1997-12-11
EP0683789B1 (en) 1997-11-05
US5955447A (en) 1999-09-21
AU5977094A (en) 1994-08-29
ATE159950T1 (de) 1997-11-15
NO305209B1 (no) 1999-04-19
CN1042430C (zh) 1999-03-10
JP3083156B2 (ja) 2000-09-04
FI953794L (fi) 1995-08-10
DE69406649T2 (de) 1998-03-05
HUT72464A (en) 1996-04-29
AU679721B2 (en) 1997-07-10
JPH08506335A (ja) 1996-07-09
CZ203295A3 (en) 1995-12-13
IL108602A0 (en) 1994-05-30
CZ286050B6 (cs) 1999-12-15
SG47943A1 (en) 1998-04-17
US5721219A (en) 1998-02-24
CN1119869A (zh) 1996-04-03
HK1002936A1 (en) 1998-09-25
GR3025995T3 (en) 1998-04-30
IL108602A (en) 1999-12-22
NZ261159A (en) 1997-06-24

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