ES2155876T3 - Composiciones que contienen un ligando especifico alfa rar y por lo menos un acido graso. - Google Patents

Composiciones que contienen un ligando especifico alfa rar y por lo menos un acido graso.

Info

Publication number
ES2155876T3
ES2155876T3 ES95401696T ES95401696T ES2155876T3 ES 2155876 T3 ES2155876 T3 ES 2155876T3 ES 95401696 T ES95401696 T ES 95401696T ES 95401696 T ES95401696 T ES 95401696T ES 2155876 T3 ES2155876 T3 ES 2155876T3
Authority
ES
Spain
Prior art keywords
fatty acid
alfa
specific
compositions containing
rar binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95401696T
Other languages
English (en)
Inventor
Gerard Ailhaud
Paul Grimaldi
Irima Safonova
Braham Shroot
Uwe Reichert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Centre International de Recherches Dermatologiques Galderma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research and Development SNC, Centre International de Recherches Dermatologiques Galderma filed Critical Galderma Research and Development SNC
Application granted granted Critical
Publication of ES2155876T3 publication Critical patent/ES2155876T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Fats And Perfumes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A LA UTILIZACION DE NUEVAS ASOCIACIONES A BASE (I) DE AL MENOS UN LIGANDO (RETINOIDE) QUE PRESENTA UNA AFINIDAD PARA LOS RECEPTORES NUCLEARES DE ACIDO RETINOICO Y/O SUS ISOMEROS, PREFERENTEMENTE UN LIGANDO QUE PRESENTA UNA AFINIDAD ESPECIFICA PARA LOS RECEPTORES RARS Y TAMBIEN MAS PREFERENTEMENTE PARA EL RECEPTOR RA-{AL}, Y (II) DE AL MENOS UN ACIDO GRASO, COMO PRINCIPIOS ACTIVOS EN, O PARA LA FABRICACION DE, COMPOSICIONES FARMACEUTICAS MAS PARTICULARMENTE DESTINADAS A ESTIMULAR LA DIFERENCIACION DE LAS CELULAS PREADIPOCITARIAS EN CELULAS ADIPOCITARIAS, Y ESTO PARA PARTICULARMENTE CORREGIR UN EVENTUAL ESTADO DE INSULINORRESISTENCIA EXISTENTE EN EL SENO DE UN ORGANISMO VIVO Y TRATAR Y/O PREVENIR ASI, EN ESTE ORGANISMO, LAS DIFERENTES FISIOPATOLOGIAS QUE PUEDEN SER ASOCIADAS A TAL ESTADO, EN PARTICULAR LAS DIABETES DE TIPO II Y LAS ENFERMEDADES CARDIOVASCUALRES (HIPERTENSION, ARTERIOSCLEROSIS,..).
ES95401696T 1994-08-02 1995-07-17 Composiciones que contienen un ligando especifico alfa rar y por lo menos un acido graso. Expired - Lifetime ES2155876T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9409584A FR2723315B1 (fr) 1994-08-02 1994-08-02 Procede et composition pour stimuler la differenciation des cellules preadipocytaires et traitements therapeutiques associes

Publications (1)

Publication Number Publication Date
ES2155876T3 true ES2155876T3 (es) 2001-06-01

Family

ID=9465998

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95401696T Expired - Lifetime ES2155876T3 (es) 1994-08-02 1995-07-17 Composiciones que contienen un ligando especifico alfa rar y por lo menos un acido graso.

Country Status (9)

Country Link
US (4) US5728739A (es)
EP (1) EP0698392B1 (es)
JP (1) JP2755559B2 (es)
AT (1) ATE197763T1 (es)
AU (1) AU679642B2 (es)
CA (1) CA2155169C (es)
DE (1) DE69519496T2 (es)
ES (1) ES2155876T3 (es)
FR (1) FR2723315B1 (es)

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WO1997012853A1 (en) 1995-10-06 1997-04-10 Ligand Pharmaceuticals Incorporated Dimer-selective rxr modulators and methods for their use
RU2191007C2 (ru) * 1996-05-24 2002-10-20 Лиганд Фармасьютикалз Инкорпорейтед Способ лечения иhcд агонистами rxr
FR2752734B1 (fr) * 1996-09-02 1998-11-06 Cird Galderma Utilisation de retinoides pour la preparation d'un medicament destine a traiter les affections liees a une surexpression de vegf
US6166076A (en) * 1996-12-13 2000-12-26 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Taste enhancing food additives
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AU8588798A (en) * 1997-07-25 1999-02-16 Institut Pasteur Human peroxisome proliferator activated receptor gamma (ppargamma) gene re gulatory sequences and uses therefor
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US6437003B1 (en) 1997-10-31 2002-08-20 Jean-Baptiste Roullet Use of retinoids to treat high blood pressure and other cardiovascular disease
US20030008919A1 (en) * 1999-06-03 2003-01-09 Jean-Baptiste Roullet Use of retinoids to treat high blood pressure and other cardiovascular disease
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US6777231B1 (en) * 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
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Also Published As

Publication number Publication date
JPH0859459A (ja) 1996-03-05
DE69519496D1 (de) 2001-01-04
EP0698392A1 (fr) 1996-02-28
ATE197763T1 (de) 2000-12-15
DE69519496T2 (de) 2001-04-05
JP2755559B2 (ja) 1998-05-20
US5728739A (en) 1998-03-17
CA2155169C (fr) 1999-12-28
FR2723315A1 (fr) 1996-02-09
US6248791B1 (en) 2001-06-19
FR2723315B1 (fr) 1996-10-25
US5854292A (en) 1998-12-29
CA2155169A1 (fr) 1996-02-03
US5827897A (en) 1998-10-27
AU679642B2 (en) 1997-07-03
EP0698392B1 (fr) 2000-11-29
AU2723295A (en) 1996-02-29

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