ES2156157T3 - Derivado de ciclopenteno heteroaromatico fusionado con una actividad antagonista de la endotelina. - Google Patents

Derivado de ciclopenteno heteroaromatico fusionado con una actividad antagonista de la endotelina.

Info

Publication number
ES2156157T3
ES2156157T3 ES94922382T ES94922382T ES2156157T3 ES 2156157 T3 ES2156157 T3 ES 2156157T3 ES 94922382 T ES94922382 T ES 94922382T ES 94922382 T ES94922382 T ES 94922382T ES 2156157 T3 ES2156157 T3 ES 2156157T3
Authority
ES
Spain
Prior art keywords
endotheline
heteroaromatic
derived
antagonist activity
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94922382T
Other languages
English (en)
Inventor
Kiyofumi Ishikawa
Toshio Nagase
Toshiaki Mase
Takashi Hayama
Masaki Ihara
Masaru Nishikibe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/165,880 external-priority patent/US5389620A/en
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Application granted granted Critical
Publication of ES2156157T3 publication Critical patent/ES2156157T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTA UN DERIVADO DEL CICLOPENTENO REPRESENTADO POR LA FORMULA GENERAL (I) Y UNA SAL FARMACOLOGICAMENTE ACEPTABLE DEL MISMO; EN DONDE AR1 Y AR2 REPRESENTAN CADA UNA FENILO, TIENILO, PIRIDILO, INLILO, BENZOFURANILO O DIHIDROBENZOFURANILO; A REPRESENTA UN GRUPO QUE SE COMBINA CON EL ENLACE DOBLE CARBONOCARBONO ADYACENTE PARA FORMAR UN ANILLO HETEROAROMATICO DE 5 O 6 MIEMBROS QUE CONTIENE ENTRE 1 Y 4 HETEROATOMOS SELECCIONADOS ENTRE EL GRUPO QUE CONSTA DE NITROGENO, OXIGENO Y AZUFRE; E Y REPRESENTA -CO-R4, SO{SUB,3}H, PO{SUB,3}H{SUB,2}, TETRAZOL-5-ILO, 2-OXO-3H-1, 2, 3, 5-OXATIADIAZOL-4-ILO O 5-OXO-4H-1, 2, 4OXADIAZOL-3-ILO.
ES94922382T 1993-08-18 1994-08-16 Derivado de ciclopenteno heteroaromatico fusionado con una actividad antagonista de la endotelina. Expired - Lifetime ES2156157T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP22510093 1993-08-18
JP28161393 1993-10-15
JP28567793 1993-10-21
US08/165,880 US5389620A (en) 1993-08-18 1993-12-14 Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
JP8591494 1994-03-30
PCT/JP1994/001357 WO1995005374A1 (en) 1993-08-18 1994-08-16 Fused heteroaromatic cyclopentene derivative having endothelin-antagonist activity

Publications (1)

Publication Number Publication Date
ES2156157T3 true ES2156157T3 (es) 2001-06-16

Family

ID=27525184

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94922382T Expired - Lifetime ES2156157T3 (es) 1993-08-18 1994-08-16 Derivado de ciclopenteno heteroaromatico fusionado con una actividad antagonista de la endotelina.

Country Status (12)

Country Link
EP (1) EP0714897B1 (es)
JP (1) JP2847969B2 (es)
CN (1) CN1049219C (es)
AT (1) ATE199151T1 (es)
AU (1) AU675870B2 (es)
CA (1) CA2169737C (es)
DE (1) DE69426698T2 (es)
DK (1) DK0714897T3 (es)
ES (1) ES2156157T3 (es)
GR (1) GR3035620T3 (es)
PT (1) PT714897E (es)
WO (1) WO1995005374A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9800975A (es) * 1995-08-02 1998-04-30 Smithkline Beecham Corp Antagonistas de receptor de endotelina.
US6545031B1 (en) 1995-08-02 2003-04-08 Smithkline Beecham Corporation Endothelin receptor antagonists
US6162932A (en) * 1995-11-08 2000-12-19 Smithkline Beecham Corporation Stereoselective synthesis of endothelin receptor antagonists
US6080862A (en) * 1995-11-08 2000-06-27 Smithkline Beecham Corporation Stereoselective synthesis of endothelin receptor antagonists
EP0915699A4 (en) * 1995-11-08 2008-06-25 Smithkline Beecham Corp STEREPSELECTIVE SYNTHESIS OF ENDOTHELIN RECEPTOR ANTAGONISTS
EP0906108B1 (en) * 1996-04-04 2005-06-15 Banyu Pharmaceutical Co., Ltd. Endothelin antagonists for treating heart failure
CA2262676A1 (en) * 1996-08-09 1998-02-19 Merck & Co., Inc. Stereoselective deoxygenation reaction
US6030975A (en) * 1997-03-14 2000-02-29 Basf Aktiengesellschaft Carboxylic acid derivatives, their preparation and use in treating cancer
HUP0003689A3 (en) * 1997-09-05 2003-05-28 Warner Lambert Co Benzothiazine dioxide derivatives with endothelin antagonist activity, pharmaceutical compositions containing them and process for the preparation of known derivatives
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
WO1999037639A1 (en) * 1998-01-21 1999-07-29 Banyu Pharmaceutical Co., Ltd. Substituted 5-(2,2-difluoro-1,3-benzodioxol-5-yl) cyclopentenopyridine derivative
WO1999048530A1 (en) * 1998-03-23 1999-09-30 Merck & Co., Inc. Combination therapy for the treatment of benign prostatic hyperplasia
US6410554B1 (en) 1998-03-23 2002-06-25 Merck & Co., Inc. Combination therapy for the treatment of benign prostatic hyperplasia
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
MXPA04003625A (es) 2001-10-19 2004-12-02 Sotechnika Inc Sintesis de analogos de ciclosporina.
US20060089503A1 (en) * 2002-12-27 2006-04-27 Kaneka Corporation Processes for producing optically active 2-thiomethyl-3-phenylpropionic acid derivative and for producing intermediate therefor
US7148194B2 (en) 2002-12-30 2006-12-12 Kimberly-Clark Worldwide, Inc. Method to increase fibronectin
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
NZ549535A (en) 2004-03-17 2010-11-26 Novartis Ag Use of aliskiren for treating renal and other disorders
AR080683A1 (es) 2010-03-16 2012-05-02 Novartis Ag Composiciones farmaceuticas de aliskiren y metodos de administracion
JP7714554B2 (ja) * 2020-02-20 2025-07-29 ダウ グローバル テクノロジーズ エルエルシー ２－ベンゾイル安息香酸アルキルの合成のための効率的かつ選択的な経路

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59190956A (ja) * 1983-04-15 1984-10-29 金　明儒 ロカグラマイド化合物
US4845129A (en) * 1988-03-14 1989-07-04 Sandoz Pharm. Corp. Diaryl substituted cyclopentane and cyclopentene derivatives
HUT67665A (en) * 1991-11-05 1995-04-28 Smithkline Beckman Corp Indane and indene deriv.s as endothelin receptor antagonists, pharmaceutical compn.s contg. them and process for prepg. them
JP4066571B2 (ja) * 1999-02-17 2008-03-26 株式会社デンソー 携帯型光学情報読取り装置

Also Published As

Publication number Publication date
WO1995005374A1 (en) 1995-02-23
EP0714897A4 (en) 1996-11-20
CA2169737C (en) 2003-04-15
EP0714897B1 (en) 2001-02-14
DK0714897T3 (da) 2001-03-19
PT714897E (pt) 2001-05-31
GR3035620T3 (en) 2001-06-29
AU675870B2 (en) 1997-02-20
DE69426698D1 (de) 2001-03-22
JP2847969B2 (ja) 1999-01-20
ATE199151T1 (de) 2001-02-15
CN1049219C (zh) 2000-02-09
EP0714897A1 (en) 1996-06-05
DE69426698T2 (de) 2001-08-16
CN1129448A (zh) 1996-08-21
AU7351194A (en) 1995-03-14
CA2169737A1 (en) 1995-02-23

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